This new volume of "Current Topics in Developmental Biology" covers the area of mechanisms in regeneration. With an international board of authors, it provides a comprehensive set of reviews covering such topics as control of growth during regeneration, skeletal muscle degeneration and regeneration in mammals and flies, and suppression of regeneration in mammals.
Covers the area of mechanisms in regenerationInternational board of authors Provides a comprehensive set of reviews

"Polyphenols in Human Health and Disease" documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more.
Explores neuronal protection by polyphenol metabolites and their application to medical careDefines modulation of enzyme actions to help researchers see and study polyphenols mechanisms of action, leading to clinical applicationsIncludes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases"

This special volume of "Progress in Molecular Biology and Translational Science" focuses on chronobiology.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Perfect for... Understanding diseases and disorders Increasing test scores in class Improving scores on the NCLEX(R) examination

Rely on over 200 full-color flash cards for the most critical clinical information about common diseases and disorders. Color-coded by body system, these handy cards familiarize students with the great deal of pathophysiologic information they must master.

Handbook of Opium: History and Basis of Opioids in Therapeutics traces the history of poppy from its prehistory, its use in Greek and Egyptian medicine through the European Renaissance, and the opioid epidemic of the present day. The book explores the discovery of morphine and its alkaloids, reviews its biosynthetic process, and covers the evolution of synthetic opioids. Further, it reviews the biological effects of opium and the molecular basis of its actions, including future perspectives in clinical applications with therapeutic targets. The book is interspersed with numerous notes on the events and great minds in history and medicine who advocated, analyzed and advanced opium through history. The book is a comprehensive review on opium, covering a breadth of topics, including its history, botany, chemistry, trade, physiology, clinical use and molecular biology, with numerous references, tables, vignettes and illustrations included for additional understanding.

This book focuses on the nutrients and nutraceuticals that promote active and healthy ageing - recently defined by the WHO as the process of development and maintenance of functional capacity that allows well-being at an advanced stage of life. There has been a rapid rise in the use of nutritional interventions as well as specific nutraceuticals in the management of multifactorial aspects of clinical health outcomes. Written by leading experts this book comprehensively discusses the various ageing phenotypes and age-related diseases. It also assesses the nutritional status of the elderly and the various epidemiological factors that influence it. It reviews the role of dietary fiber in disease-free and fully functional ageing. Further, the book explores the benefits of polyphenols, which are secondary plant metabolites, in protecting against cancer, cardiovascular diseases, and various neurodegenerative diseases.

This detailed new edition aims to provide a range of methods and protocols for studying vascular morphogenesis in vivo and in vitro to reflect up-to-date advances in the field. Of note, the book explores endothelial cell signaling is currently understood to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Vascular Morphogenesis: Methods and Protocols, Second Edition will serve as an ideal guide to this area of study for a broad audience amongst cell biologists, anatomists, pathologists, and physiologists.

"Our Genes, Our Choices: How Genotype and Gene Interactions Affect Behavior" explains how the complexity of human behavior, including concepts of free will, derives from a relatively small number of genes, which direct neurodevelopmental sequence. Are people free to make choices, or do genes determine behavior? Paradoxically, the answer to both questions is "yes," because of neurogenetic individuality, a new theory with profound implications.

Author David Goldman uses judicial, political, medical, and ethical examples to illustrate that this lifelong process is guided by individual genotype, molecular and physiologic principles, as well as by randomness and environmental exposures, a combination of factors that we choose and do not choose.

Written in an authoritative yet accessible style, the book includes practical descriptions of the function of DNA, discusses the scientific and historical bases of genethics, and introduces topics of epigenetics and the predictive power of behavioral genetics.
Poses and resolves challenges to moral responsibility raised by modern genetics and neuroscienceAnalyzes the neurogenetic origins of human behavior and free will Written by one of the world's most influential neurogeneticists, founder of the Laboratory of Neurogenetics at the National Institutes of Health

This volume explores some of the most exciting recent advances in basic research on protein phosphorylation in health and disease and how this knowledge is leading to advances in the various fields.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

This book illustrates the significance and relevance of immunotherapy in modern-day therapeutics. Focusing on the application of immunotherapy in oncology, neurodegenerative and autoimmune diseases, it discusses the drug delivery systems, and pre-clinical and clinical methodologies for immunotherapy-based drugs. It also comprehensively reviews various aspects of immunotherapy, such as regulatory affairs, quality control, safety, and pharmacovigilance. Further, the book discusses the in vitro validation of therapeutic strategies prior to patient application and management of immunotherapy-related side effects and presents case studies demonstrating the design and development (pre-clinical to clinical) of immunotherapy for various diseases. It also describes various design considerations and the scale-up synthesis of immunotherapeutics and screening methods. Lastly, it explores the important aspect of cost-effectiveness and rational immunotherapy strategies.

The gene's eye view of life, proposed in Richard Dawkins acclaimed bestseller The Selfish Gene, sees living bodies as mere vehicles for the replication of genetic codes. But in The Music of Life, world renowned physiologist Denis Noble argues that, to truly understand life, we must look beyond the "selfish gene" to consider life on a much wider variety of levels.
Life, Noble asserts, is a kind of music, a symphonic interplay between genes, cells, organs, body, and environment. He weaves this musical metaphor throughout this personal and deeply lyrical work, illuminating ideas that might otherwise be daunting to non-scientists. In elegant prose, Noble sets out a cutting-edge alternative to the gene's eye view, offering a radical switch of perception in which genes are seen as prisoners and the organism itself is a complex system of many interacting levels. In his more expansive view, life emerges as a process, the ebb and flow of activity in an intricate web of connections. He introduces readers to the realm of systems biology, a field that has been growing in strength in the past decade. Noble, himself one of the founders of this field, argues modern systems biology may be the view we need to adopt to gain a deeper understanding of the nature of life.
Drawing on his experiences in his research on the heartbeat, and on evolutionary biology, development, medicine, philosophy, linguistics, and Chinese culture, Noble presents us with a profound and very modern reflection on the nature of life.

The previous two editions of the "Human Nervous System "have been the standard reference for the anatomy of the central and peripheral nervous system of the human. The work has attracted nearly 2,000 citations, demonstrating that it has a major influence in the field of neuroscience. The 3e is a complete and updated revision, with newchapters covering genes and anatomy, gene expression studies, and glia cells. The book continues to be an excellent companion to the "Atlas of the Human Brain," and a common nomenclature throughout the book is enforced. Physiological data, functional concepts, and correlates to the neuroanatomy of the major model systems (rat and mouse) as well as brain function round out the new edition.
Adopts standard nomenclature following the new scheme by Paxinos, Watson, and Puelles and aligned with the Mai et al. "Atlas of the Human Brain" (new edition in 2007)Full color throughout with many new and significantly enhanced illustrationsProvides essential reference information for users in conjunction with brain atlases for the identification of brain structures, the connectivity between different areas, and to evaluate data collected in anatomical, physiological, pharmacological, behavioral, and imaging studies"

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. This volume of "Methods in Ezymology" is split into 2 parts and comprehensively covers the subject.

In a clear and accessible presentation, Occupational Physiology focuses on important issues in the modern working world. Exploring major public health problems-such as musculoskeletal disorders and stress-this book explains connections between work, well-being, and health based on up-to-date research in the field. It provides useful methods for risk assessment and guidelines on arranging a good working life from the perspective of the working individual, the company, and society as a whole.

The book focuses on common, stressful situations in different professions. Reviewing bodily demands and reactions in eight selected common, but contrasting job types, the book explains relevant physiology in a novel way. Rather than being structured according to organs in the body, the book accepts the complex physiology of typical jobs and uses this as an entry. In addition to physiological facts, the book discusses risk factors for disorders and gives ideas on how to organize and design work and tasks so as to optimize health, work ability, and productivity.

Although many books cover physiology, they are based on a traditional anatomical structure (e.g., addressing the physiology of the cardiovascular system, the gastrointestinal system, and so forth) and require readers to synthesize this knowledge into real-life complex applications. Occupational Physiology is, instead, structured around a number of typical jobs and explains their physiologies, as complex as they may be. This approach, while still presenting the physiology needed to understand occupational life, demonstrates how to use this information in situations encountered in practice.

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

* This series provides a forum for discussion of new discoveries, approaches, and ideas * Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

"Progress in Molecular Biology and Translational Science" provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease.

* Contributions from leading scholars and industry experts * Reference guide for researchers involved in molecular biology and related fields

Adolescent Psychosis: Clinical and Scientific Perspectives discusses new methodologies and novel scientific findings, with a comprehensive orientation into phenomenology, nosology, diagnostics and the history of adolescent early-onset psychosis research. This volume informs on psychotic disorders in adults and discusses recent epidemiological studies, along with co-morbid aspects associated with other neurodevelopmental syndromes and somatic diseases. The book also provides suggestions for future research to bridge neuroscience and the clinic using a translational perspective, from the clinic to the genes and relevant phenotypes, biomarkers, etiological aspects and clinical outcome. Topics discussed bring together expert researchers in the field to represent different translational perspectives and future possibilities.

Close your eyes and ask yourself, 'what do I feel?' You might feel thirsty or tired. You might feel healthy and well or perhaps a little under the weather. Maybe you can feel that you are standing or that you are leaning over. You may also feel the world around you - the shape and texture of an apple in your hand, the feel of a chair you're sitting on. All these feelings have something in common, say psychologists and neuroscientists. They are all mental events, things that happen in the mind. But what if this is all wrong? What if it's not just the mind, but also the body itself that feels? And not merely physical sensations, but other feelings that seem to have nothing to do with bodies. Things like 'emotions' and 'intuitions' - joy or rage, anxiety or optimism, or the feeling of being hard done by or misunderstood? Drawing on the latest research and a range of classic and contemporary thought, How You Feel shows you that your brain and your body are two parts of a single system that creates your mind and mental life. You will discover that you don't have feelings, thoughts and emotions inside your body, you have them with your body. There can be no mind without the body. Psychology is no longer about the brain, or about 'mind and body', it is about the whole that is you.

This book focuses on the life and work of Nathan Zuntz (1847-1920), a German physiologist, who made significant contributions to high altitude physiology and aviation medicine.
He achieved fame for his invention of the Zuntz-Geppert respiratory apparatus in 1886 and the first treadmill (Laufband) in 1889. He also invented an X-ray apparatus to observe cardiac changes during exercise and constructed a climate chamber to study exercise under varying and sometimes extreme climates.
* Focuses on Zuntz's contribution to high altitude physiology and aviation medicine

Understanding how angiogenesis "works" and how to control it will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases. Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over angiogenesis. Diseases that are angiogenesis-dependent result when blood vessels either grow excessively or insufficiently. Understanding how angiogenesis "works" and how to control it, will have massive implications on the management, treatments, and ultimately the prevention of many common (and not so common) diseases.
Angiogenesis cuts across virtually every discipline. The Angiogenesis Foundation identified angiogenesis as a "common denominator" in our most serious diseases. Excessive angiogenesis occurs in diseases such as cancer, diabetic blindness, age-related macular degeneration, rheumatoid arthritis, psoriasis, and many other conditions. Insufficient angiogenesis occurs in diseases such as coronary artery disease, stroke, and delayed wound healing.

* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition.
* Provides the "builder's manual" for essential techniques. This is a one-stop shop that eliminates needless searching among untested techniques.
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Angiogenesis is the growth of new blood vessels and is an important natural process in the body. A healthy body maintains a perfect balance of angiogenesis modulators. In many serious disease states, however, the body loses control over antiogenesis. Diseases that are angiogensis-dependent result when blood vessels either grow excessively or insufficiently.
* Tried-and-tested techniques written by researchers that developed them, used them, and brought them to fruition
* Provides the "builder's manual" for essential techniques--a one-stop shop that eliminates needless searching among untested techniques
* Includes step-by-step methods for understanding the cell and molecular basis of wound healing, vascular integrin signaling, mechanical signaling in blood vessels, and vascular proteomics

Master Medicine: Physiology is brief and accessible, approached from the point of view of what you will need to know in order to understand the clinical work you will eventually be doing. It includes a wide range of self-assessment material, ideal for testing your understanding, and helping you to prepare for your exams. Concise synoptic (not telegraphic text). Appropriate self-assessment material. Only covers core, so student knows the whole book is essential. Includes key objectives. Contains simple and memorable diagrams for reproduction in exams. Ideal for learning as well as examination review, specifically trying to stimulate the student into assessing his/her own knowledge. The books in the series both complement other available major texts, but also contain enough material to stand in the own right. Provides examination practice. Part of co-ordinated series.

"Lecture Notes: Human Physiology "provides concise coverage of general physiology for medical students as well as students of biological sciences, sport science, pharmacology and nursing.

This fifth edition of the ever popular "Lecture Notes: Human Physiology" has been thoroughly revised and updated by a new international team of authors. The simple structure and systems-based approach remain, with a new clean layout for ease of reading and colour now incorporated to aid understanding.

"Lecture Notes: Human Physiology"
Provides more focus on pathophysiology for clinical relevance
Is the perfect introduction for medical and allied health care students
Now includes physiology of pain and increased coverage of heart and the vascular system
Includes a completely revised chapter on the nervous system.