The maintenance of arterial blood pressure and the distribution of blood flow to the various organs of the body depends on the control of the pumping action of the heart and of the resistance of the vascular beds in the individual organs in accordance with their metabolic needs. These controls are achieved through the integrated actions of circulat ing hormones, humoral factors that are synthesized and released in the heart and blood vessels, and the autonomic nervous system. The heart, however, is not only the target for the direct and indirect actions of a number of hormones and humoral factors, it is also an endocrine organ in the traditional sense, synthesizing and secreting into the circulation chemical factors that act at distant sites. In this treatise, Hormones and the Heart in Health and Disease, we interpret "endocrinology" broadly and consider traditional hormones as well as autocoids that are secreted by the heart or that act on it. In this overview, the relevant chapters are indicated in parentheses. The discovery of atrial natriuretic peptide (ANP; atrial natriuretic factor, ANF) in the 1980s indicated that the heart does indeed function as an endocrine organ in the classic sense. ANP (Chapter I) is synthesized in the heart and secreted into the circulation for actions on the kidney, where it is a potent natriuretic agent, and on the vasculature, where it causes vasodilation. ANP can also affect myocardial contractility."

Quantitative ultrasound (QUS) of bone is a relatively recent research field. The research community is steadily growing, with interdisciplinary branches in acoustics, medical imaging, biomechanics, biomedical engineering, applied mathematics, bone biology and clinical sciences, resulting in significant achievements in new ultrasound technologies to measure bone, as well as models to elucidate the interaction and the propagation of ultrasonic wave in complex bone structures. Hundreds of articles published in specialists journals are accessible from the Web and from electronic libraries. However, no compilation and synthesis of the most recent and significant research exist. The only book on QUS of bone has been published in 1999 at a time when the propagation mechanisms of ultrasound in bone were still largely unknown and the technology was immature. The research community has now reached a critical size, special sessions are organized in major international meetings (e.g., at the World Congress of Biomechanics, the annual meetings of the Acoustical Society of America, International Bone Densitometry Workshop, etc...). Consequently, the time has come for a completely up to date, comprehensive review of the topic. The book will offer the most recent experimental results and theoretical concepts developed so far and is intended for researchers, graduate or undergraduate students, engineers, and clinicians who are involved in the field. The central part of the book covers the physics of ultrasound propagation in bone. Our goal is to give the reader an extensive view of the mathematical and numerical models as an aid to understand the QUS potential and the types of variables that can be determined by QUS in order to characterize bone strength. The propagation of sound in bone is still subject of intensive research. Different models have been proposed (for example, the Biot theory of poroealasticity and the theory of scattering have been used to describe wave propagation in cancellous bone, whereas propagation in cortical bone falls in the scope of guided waves theories). An extensive review of the models has not been published so far. We intend in this book to present in details the models that are used to solve the direct problem and strategies that are currently developed to address the inverse problem. This will include analytical theories and numerical approaches that have grown exponentially in recent years. Most recent experimental findings and technological developments will also be comprehensively reviewed.

The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.

The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control."

For fans of Gut by Giulia Enders Eating is the most pleasurable, gross, necessary, unspeakable biological process we undertake. But very few of us realise what strange wet miracles of science operate inside us after every meal - let alone have pondered the results (of the research). How have physicists made crisps crispier? What do laundry detergent and saliva have in common? Was self-styled 'nutritional economist' Horace Fletcher right to persuade millions of people that chewing a bite of shallot seven hundred times would yield double the vitamins? In her trademark, laugh-out-loud style, Mary Roach breaks bread with spit connoisseurs, beer and pet-food tasters, stomach slugs, potato crisp engineers, enema exorcists, rectum-examining prison guards, competitive hot dog eaters, Elvis' doctor, and many more as she investigates the beginning, and the end, of our food.

This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases. Within the story of the various chapters, the authors line out various malfunctions of the transportome and where they can be found at different stages of the metastatic cascade. The authors describe how the interactions between the tumor cells' transportome and the environment reinforce mesenchymal behaviour of cancer cells and contribute to their uncontrolled proliferation, migration, invasion, intra- and extravasation up to the formation of metastases. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.

This volume is a record of the proceedings of a festspiel held to honor Jozef F. Zwislocki for his outstanding contributions to science and to Syracuse University. His contributions to the knowledge of the hydromechanical, neurophysiological, and perceptual mechanisms of the auditory system are truly monumental. In addition, his contributions to the comprehension of the mammalian auditory system include not only landmark ideas, but also many of the experimental findings in psychoacoustics and peripheral auditory physiology that constitute the database which has provided a springboard for research in laboratories throughout the world. His efforts to link physics, biology, and psychophysics to create a basis for our understanding of the nervous system have had an influence that extends far beyond the science of acoustics.
Although the purpose of this conference was to recognize the many achievements of Professor Zwislocki, the spirit of the participants was to honor him in a manner that best characterized his lifetime dedication to research, that is, to report the results of their own work. Consequently, this volume is first and foremost a compilation of scientific papers in the area of sensory research. Some are reports of recent experiments and some present an overview of research efforts extending from the past up to ongoing work. His influence can be recognized in all of the contributions and some explicitly describe the ties between their own work and the germinal ideas planted by him. This volume, in reflecting the rapid progress being made in sensory science and written by those who are making it, is a fitting tribute to Zwislocki, who always stood at the forefront of his science.

The result of the first Appalachian Conference on neurodynamics, this volume focuses on processing in biological neural networks. How do brain processes become organized during decision making? That is, what are the neural antecedents that determine which course of action is to be pursued? Half of the contributions deal with modelling synapto-dendritic and neural ultrastructural processes; the remainder, with laboratory research findings, often cast in terms of the models. The interchanges at the conference and the ensuing publication also provide a foundation for further meetings. These will address how processes in different brain systems, coactive with the neural residues of experience and with sensory input, determine decisions.

There are many separate groups working in gut biology, and they feel that the gut is an excellent model for investigating general problems in differentiation, growth control, stem cell biology, and regeneration and adaptive responses. There is a pressing need to define the objectives of the next 5 to 10 years, and the meeting, Part III of the Gastroenterology Symposia Freiburg 1996 (Falk Symposium No. 94), held in Freiburg, Germany, October 25-26, brought together some of these groups with a view to identifying areas which are not being utilized and need to be exploited, such as transgenic and knockout approaches, retrovirus delivery systems, and model cell/tissue systems. The main themes of the book are gastrointestinal development and differentiation, gut stem cell biology, and the control of gut growth in normal and abnormal situations. Basic research findings are related to clinical situations, and the book will appeal not only to gut cell and molecular biologists, but also to gastroenterologists interested in the potential applications of these subject areas.

Employing a multidisciplinary approach to phospholipid research, this work catalogues the current knowledge of this class of molecules and details the general, chemical, physical and structural properties of phospholipid monolayers and bilayers. Phospholipid applications are also covered.

Carry the same authoritative, useful knowledge that readers of Guyton and Hall have come to trust - in an easily accessible, pocket format. Pocket Companion to Guyton and Hall Textbook of Medical Physiology, 14th Edition, echoes the structure and content of the world's foremost physiology textbook, making it ideal for a quick, portable review or entry point into complex topics. Grasp key information quickly thanks to concise, readable text. Benefit from updated content of the 14th edition of the bestselling text in a condensed synopsis format. Quickly locate more in-depth discussions inside the parent text with abundant cross-references and a parallel chapter organization. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This accessible work is the first in more than seventy-five years to discuss the many roles of adrenaline in regulating the "inner world" of the body. David S. Goldstein, an international authority and award-winning teacher, introduces new concepts concerning the nature of stress and distress across the body's regulatory systems. Discussing how the body's stress systems are coordinated, and how stress, by means of adrenaline, may affect the development, manifestations, and outcomes of chronic diseases, Goldstein challenges researchers and clinicians to use scientific integrative medicine to develop new ways to treat, prevent, and palliate disease.

Goldstein explains why a former attorney general with Parkinson disease has a tendency to faint, why young astronauts in excellent physical shape cannot stand up when reexposed to Earth's gravity, why professional football players can collapse and die of heat shock during summer training camp, and why baseball players spit so much.

Adrenaline and the Inner World is designed to supplement academic coursework in psychology, psychiatry, endocrinology, cardiology, complementary and alternative medicine, physiology, and biochemistry. It includes an extensive glossary.

The thoroughly revised edition of Vander's Human Physiology is an integrated package of textual and digital material that delivers basic and clinical content, real-life applications, and educational technologies. All these pieces come together to facilitate learning and enthusiasm for understanding the mechanisms of body function. Key focus areas include homeostasis, exercise, and human health. These and other areas of interest are elaborated upon, beginning with Chapter 1, where the key "General Principles of Physiology," an underlying theme in the book, is first introduced. Unifying themes, such as homeostasis, are explored throughout the book at all levels of system, organ, tissue, and cellular function-themes that are always related to pathophysiology through the use of compelling clinical case studies in all chapters, and a final chapter with several cases that integrate material across the entire book.

Probes developments and trends in research and clinical applications of vitamin E, discussing its chemistry and biochemistry and natural occurence in nuts, seeds, whole grains and vegetable and fish-liver oils. The book covers new findings on the role of vitamin E as a biological response modifier.

Measurement of Cardiac Deformations from MRI: Physical and Mathematical Models describes the latest imaging and imag analysis techniques that have been developed at leading centers for the visualization, analysis, and understanding of normal and abnormal cardiac motion with magnetic resonance imaging (MRI). The use of MRI in measuring cardiac motion is particularly important because MRI is non-invasive, and it is the only modality capable of imaging detailed intramural motion within the myocardium. Biomedical engineers, medical physicists, computer scientists, and physicians interested in learning about the latest advances in cardiovascular MRI should find this book to be a valuable educational resource. In particular, it is more tutorial in nature than most of the technical papers where the research was originally published. Practitioners and researchers working in the field of cardiovascular MRI will find the book to be filled with practical technical details and references to other work, enabling the implementation of existing methods and serving as a basis for further research in the area.

This volume introduces the concepts of income and optimal choice to the realms of brain activity and behavior regulation. It begins by developing the concept of the Income-Choice approach in the field of biological control systems, then deals with the problems of control of brain activity, and finally presents a model of behavior disturbance based on the idea that its cause is a definite and simple change in the income system of the organism. Other areas to which the proposed Income-Choice approach could be applied are also addressed including the origin of the epileptic aura and why it is a predictor of the imminent attack, the mechanism of the phenomena of "personality switching" in schizophrenics, and the possible connection between schizophrenic- like symptoms and epileptic status. Written nearly 20 years ago in Russia and now published in the West, this book will be of value to many professionals in related fields. This volume introduces the concepts of income and optimal choice to the realm of brain activity and behavior regulation. It begins by developing the concept of the Income-Choice approach in the field of biological control systems, then deals with the problems of control of brain activity, and finally presents a model of behavior disturbance based on the idea that its cause is a definite and simple change in the income system of the organism. Other areas to which the proposed Income-Choice approach could be applied are also addressed, including the origin of the epileptic aura and why it is a predictor of the would-be attack, the mechanism of the phenomena of "personality switching" in schizophrenics, and the possible connection between schizophrenic- like symptoms andepileptic status. Originally written nearly 20 years ago in Russia and now published for the first time in the West, this book will be of value to many professionals in related fields.

This third and final volume in the "Ion Transport in Tumor Biology" collection presents novel diagnostic and therapeutic approaches in cancer based on the exploitation of ion transport proteins. The authors critically examine several transportome members, particularly Na+, K+, Ca2+, and Cl- channels, as well as organic solute carriers regarding their suitability as therapeutic targets. Synergistic effects resulting from the combined use of classical cytostatics with ion transport-inhibiting drugs are pointed out, and the capability of bispecific antibodies to function as anticancer drugs is discussed. As readers will also learn, the use of ion channel inhibitors could improve the outcome of radiotherapy because the development of radio-resistance during radiotherapeutic treatment often correlates with increases in the expression levels and conductance of ion channels. The translational topics of this volume form a bridge between biochemical research and therapeutic application. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians in the cancer field.

From Natural Character to Moral Virtue in Aristotle discusses Aristotle's biological views about character and the importance of what he calls 'natural character traits' for the development of moral virtue as presented in his ethical treatises. The aim is to provide a new, comprehensive account of the physiological underpinnings of moral development and thereby to show, first, that Aristotle's ethical theories do not exhaust his views about character as has traditionally been assumed, and, second, that his treatment of natural character in the biological treatises provides the conceptual and ideological foundation for his views about habituation as developed in his ethics. Author Mariska Leunissen takes seriously Aristotle's-often ignored-claim that nature is one of the factors through which men become 'good and capable of fine deeds'. Part I ('The Physiology of Natural Character') analyzes, in three chapters, Aristotle's notion of natural character as it is developed in the biological treatises and its role in moral development, especially as it affects women and certain 'barbarians'-groups who are typically left out of accounts of Aristotle's ethics. Leunissen also discuss its relevance for our understanding of physiognomical ideas in Aristotle. Part II ('The Physiology of Moral Development) explores the psychophysical changes in body and soul one is required to undergo in the process of acquiring moral virtues. It includes a discussion of Aristotle's eugenic views, of his identification of habituation as a form of human perfection, and of his claims about the moral deficiencies of women that link them to his beliefs about their biological imperfections.

Essentials of Neuromodulation describes the application of neuromodulation for aesthetic purposes. Detailed for readers are all essential aspects of neuromodulation treatment, including how to best safeguard patients. This volume provides an increased anatomical understanding of the injection anatomy within the face in an effort to focus on standard of care and set an industry standard in cosmetic injectables. Given the highly specialized training required for this skill, it details the history as well as the mechanism of action for each FDA-approved neuromodulating drug on the market. Unique anatomical renderings by medical artist Kevin Cease provide accurate and detailed anatomy to correlate beautifully with the content. With before, during, and after photos of more than 20 models and written detailed descriptions, diagrams, tables, and charts, all types of learners with every style of learning will benefit from this one-of-a-kind book. This book is a stepping stone for in-depth knowledge into this specialty field and begin to set the standard for entrance into the practice of aesthetics.

A compilation of the proceedings of a conference held to honor Alvin M. Liberman for his outstanding contributions to research in speech perception, this volume deals with two closely related and controversial proposals for which Liberman and his colleagues at Haskins Laboratories have argued forcefully over the past 35 years. The first is that articulatory gestures are the units not only of speech production but also of speech perception; the second is that speech production and perception are not cognitive processes, but rather functions of a special mechanism. This book explores the implications of these proposals not only for speech production and speech perception, but for the neurophysiology of language, language acquisition, higher-level linguistic processing, the visual perception of phonetic gestures, the production and perception of sign language, the reading process, and learning to read. The contributors to this volume include linguists, psycholinguists, speech scientists, neurophysiologists, and ethologists. Liberman himself responds in the final chapter.

Presenting the work of researchers who are at the forefront of the study of memory mechanisms, this volume addresses a wide range of topics including: physiological and biophysical studies of synaptic plasticity, neural models of information storage and recall, functional and structural considerations of amnesia in brain-damaged patients, and behavioral studies of animal cognition and memory. The book's coverage of diverse approaches to memory mechanisms is intended to help dissolve the borders between behavioral psychology, cognitive neuropsychology, and neurophysiology.

Measured by any criteria, research in chronobiology in general and chronopharmacology in particular has expanded rapidly in recent years. This expansion has been paralleled by an increasing recognition by those outside the field of the relevance and significance of recent developments in chronobiology. Advances in two areas have been chiefly responsible. First, application of the full range of modern techniques in behavioral, neurochemical, and molecular biology have greatly improved our understanding of basic clock mechanisms. In several species the genetic basis of the circadian clock is being progressively delineated. A complete picture of the neurochemical and neuroanatomical structure of the mammalian clock is emerging and the complex pattern of control mechanisms involving endogenous clock mechan isms and photic and nonphotic zeitgebers is being built up as a result of behavioral studies. Secondly, in parallel with these exciting developments in basic science, clinical applications are being convincingly demonstrated in the general fields of pharmacology and medicine as well as in specific areas, e.g., jet lag, shiftwork maladaption syndrome, blindness, and cardiovascular system. It is therefore an opportune time to review progress in the field of chronopharmacology and to introduce some of the exciting developments and prospects to a readership beyond the confines of the chronobiological cognoscenti. This volume is therefore aimed primarily at the pharmacologist - whether basic, applied, or clinical-who is not a specialist in chronobiology."

The seventh "Oxford Conference" on Modeling and Control of Ventilation was held in the beautiful setting of Northem Ontario at the Grandview Inn in Hunstville. This meet- ing was called the Canadian Conference on Modeling and Control ofVentilation (CCMCV) to follow on LCMCV held in London, England, three years ago. The beautiful view over Fairy Lake greeted everyone in the moming and provided an ideal setting for many discus- sions about respiratory physiology and modeling. The Oxford Conferences began in 1971 when Dr. Richard Hercynski (a mathematical modeler with an interest in respiratory physiology) and Dr. Dan Cunningham (a respiratory physiologist with an interest in modeling) decided to organize a meeting "Modelling of a Biological Control System: Tbe Regulation of Breathing" in Oxford, England, in 1978. The meeting was a success, and it spawned aseries of meetings that have continued to today. A second conference was organized at Lake Arrowbead, Califomia, in 1982. After tbis, con- ferences were repeated at tbree-year intervals. My first Oxford Conference was at tbe abbey in Solignac, France, in 1985. Next, we met in tbe cabins overlooking Grand Lake, Colorado, in 1988. In 1991, we traveled to the training institute at the base ofMt. Fuji (or at least they tell us Mt. Fuji was out there--we never saw it because of a typhoon rolling through). Our last meeting was at Royal Holloway College (University of London) where we got to dine in a castle among artwork that required guards and an electronic security system.

MICHAEL S. GAZZANIGA The investigation of the human brain and mind involves a myriad of ap proaches. Cognitive neuroscience has grown out of the appreciation that these approaches have common goals that are separate from other goals in the neural sciences. By identifying cognition as the construct of interest, cognitive neuro science limits the scope of investigation to higher mental functions, while simultaneously tackling the greatest complexity of creation, the human mind. The chapters of this collection have their common thread in cognitive neuroscience. They attack the major cognitive processes using functional stud ies in humans. Indeed, functional measures of human sensation, perception, and cognition are the keystone of much of the neuroscience of cognitive sci ence, and event-related potentials (ERPs) represent a methodological "coming of age" in the study of the intricate temporal characteristics of cognition. Moreover, as the field of cognitive ERPs has matured, the very nature of physiology has undergone a significant revolution. It is no longer sufficient to describe the physiology of non-human primates; one must consider also the detailed knowledge of human brain function and cognition that is now available from functional studies in humans-including the electrophysiological studies in humans described here. Together with functional imaging of the human brain via positron emission tomography (PET) and functional magnetic resonance imaging (fMRI), ERPs fill our quiver with the arrows required to pierce more than the single neuron, but the networks of cognition."