NOTE: Before purchasing, check with your instructor to ensure you select the correct ISBN. This ISBN is for the paperback PhysioEx Lab Manual and does NOT include access to the PhysioEx 10.0 website. The Lab Manual for PhysioEx (TM) 10.0 Laboratory Simulations in Physiology features 12 Exercises that contain 63 easy-to-use laboratory simulation activities to complement or replace wet labs, including those that are expensive or time-consuming to perform in class. PhysioEx allows students to repeat labs as often as they like, perform experiments without harming live animals, and conduct experiments that are difficult to perform in a wet lab environment because of time, cost, or safety concerns. 3 ways students can access the PhysioEx 10.0 website: By purchasing a Mastering A&P title that includes PhysioEx 10.0 -- the most common way students access the PhysioEx 10.0 website. By purchasing instant online access to PhysioEx 10.0 Premium Website (ISBN: 9780136447672 / 0136447678) at www.physioex.com. By purchasing the PhysioEx 10 Lab Manual package (ISBN: 9780136643746 / 0136643744) that includes an access code to the PhysioEx 10.0 website.

RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.

From the 40th annual conference of the International Society on Oxygen Transport to Tissue (ISOTT), held in Bruges, Belgium in August 2012, this volume covers aspects of clinical applications, muscle oxygenation, cancer, measurement technologies, oxygen transport modelling and Near-Infrared Spectroscopy (NIRS), cell metabolism and brain oxygenation. Each topic was presented by one or two invited speakers, and a series of contributed talks.

Spanning biological, mathematical, computational, and engineering sciences, computational biofluiddynamics addresses a diverse family of problems involving fluid flow inside and around living organisms, organs, tissue, biological cells, and other biological materials. Computational Hydrodynamics of Capsules and Biological Cells provides a comprehensive, rigorous, and current introduction to the fundamental concepts, mathematical formulation, alternative approaches, and predictions of this evolving field. In the first several chapters on boundary-element, boundary-integral, and immersed-boundary methods, the book covers the flow-induced deformation of idealized two-dimensional red blood cells in Stokes flow, capsules with spherical unstressed shapes based on direct and variational formulations, and cellular flow in domains with complex geometry. It also presents simulations of microscopic hemodynamics and hemorheology as well as results on the deformation of capsules and cells in dilute and dense suspensions. The book then describes a discrete membrane model where a surface network of viscoelastic links emulates the spectrin network of the cytoskeleton, before presenting a novel two-dimensional model of red and white blood cell motion. The final chapter discusses the numerical simulation of platelet motion near a wall representing injured tissue. This volume provides a roadmap to the current state of the art in computational cellular mechanics and biofluiddynamics. It also indicates areas for further work on mathematical formulation and numerical implementation and identifies physiological problems that need to be addressed in future research. MATLAB (R) code and other data are available at http://dehesa.freeshell.org/CC2

Advances in Insect Physiology is committed to publishing eclectic volumes containing comprehensive and in-depth reviews on all aspects of insect physiology. First published in 1963, these volumes are an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect biochemists. This latest volume now has a new four-color laminated cover.
In 1999, the Institute for Scientific Information released figures showing that Advances in Insect Physiology has an Impct Factor of 4.5, placing it second in the highly competitive category of Entomology.
Key Features
*NEW (and improved) cover!!!!
* Comprehensive reviews, written by experts
Key Features of the Series:
*first vol published in 1963.
* Adv Insect Physio ranked 2nd in Entomolgy list (acc to ISI data released in 1999) with an Impact factor of 4.5

Multidisciplinary Anatomy & Physiology textbook for Health Professionals! This title will enable the reader to take an informed interest in the patient's or client's condition, and in the planning of total patient care or complementary therapy treatments. It is relevant to students studying anatomy and physiology at a basic level - nursing, complementary therapies, sport therapy, physiotherapy and occupational therapy. A systems approach is presented in an accessible way accompanied by clear illustrations. It is written in an easy to read style explaining otherwise complicated topics.

Store-operated Ca2+ entry (SOCE) serves to control essential functions throughout the human body and represents a novel and attractive target for therapeutic intervention. This book provides an extensive overview of the role of SOCE pathways in Molecular Physiology and Cell Biology, as well as their clinical significance. (Patho)physiological principles and emerging therapeutic strategies are delineated in a way that is valuable both for the education of graduate students in advanced Cell Biology/Molecular Physiology and for the promotion of innovative research and developments in the clinical/therapeutic fields. A comprehensive, clear and elaborate representation of current concepts is provided, including a pathophysiological section arranged in a tissue/organ/system-oriented manner. The book is intended for basic researchers specializing in cell signaling, ion transport, or pharmacology, as well as biomedical scientists and clinicians with a focus on immunology, neurology or cardiology.

Focusing on assessment through therapist-driven protocols, this valuable tool provides an overview of the assessment process and fundamentals needed for success. It offers discussion of the top five treatment protocols: oxygen, hyperinflation , bronchial hygiene and bronchodilator therapies, as well as mechanical ventilation. Using a case study approach, students learn to manage an entire case from beginning to end. Each time they assess the patient, they use the SOAP format: Subjective, Objective, Assessment, and Plan reasoning, giving them practice in documenting history and developing care plans.

Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.

The Laboratory Computer: A Practical Guide for Physiologists and Neuroscientists introduces the reader to both the basic principles and the actual practice of recording physiological signals using the computer.
It describes the basic operation of the computer, the types of transducers used to measure physical quantities such as temperature and pressure, how these signals are amplified and converted into digital form, and the mathematical analysis techniques that can then be applied. It is aimed at the physiologist or neuroscientist using modern computer data acquisition systems in the laboratory, providing both an understanding of how such systems work and a guide to their purchase and implementation.
Written by an expert in the field, the book presents:
-The key facts and concepts that are vital for the effective use of computer data acquisition systems;
-A unique overview of the commonly available laboratory hardware and software, including both commercial and free software;
-A practical guide to designing one's own or choosing commercial data acquisition hardware and software.

This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.

This book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011. The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract. The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE.

Anesthetics produce a reversible state of unconsciousness accompanied by ante- grade amnesia. This remarkable phenomenon brings great relief to surgical patients and wonder to clinicians and scientists. To date, we do not fully understand the mechanisms by which anesthetics ablate conscious sensation and memory. We are, however, making progress. This book presents original results as well as overviews of the current state of knowledge of the problem. It is authored by investigators who know the ?eld well; their research at a number of levels has contributed substantially to our c- rent understanding of anesthetic modulation of memory and consciousness. Most of the contributors were presenters at two workshops organized by Dr. Pearce and Dr. Hudetz at the 40th Annual Winter Conference on Brain Research, held at Snowmass Village, Colorado, from January 27 through February 2, 2007. One workshop focused on anesthetic modulation of consciousness and another on an- thetic modulation of memory. Seven of the chapters are based on material presented at these symposia - appropriately updated with new relevant ?ndings. This infor- tion is supplemented by chapters on anesthesia and sleep, computational analysis of the state of anesthesia, and the clinical phenomenon of "anesthesia awareness," a topic that has recently received much public attention. With these three additional contributions, the book thus includes 10 chapters.

This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs.
* The revised fourth edition contains approximately 50% new material
* Includes information on all the latest drugs

From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here we give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here

Gert Ter Horst and a panel of recognized experts illuminate the complexities and importance of heart-brain and brain-heart interactions in human health. These distinguished authorities critically review what is known about autonomic control of the heart, hypothalamo-pituitary- adrenal modulation, heart pain, modulation by humoral factors, and the relationship between cognitive/neuropsychiatric disorders and heart disease. Highly relevant and up-to-date, The Nervous System and the Heart offers the first comprehensive treatment of the important mutual interactions of the heart and the brain. By integrating specialist knowledge in cardiology with that from neuroscience, this important book constitutes a brilliant guide to today's novel approaches to neural control of the heart and consequent reduction of cardiovascular mortality.

Sunao Tawara's epoch-making work on the excitation conduction system of the mammalian heart paved the way for the advancement of modern cardiology in the 20th century. Even today, more than 90 years after the publication of the German monograph "Das Reizleitungssystem des Saugetierherzen", his precise account of the conduction system from the atrioventricular node through the His-Purkinje system to the ordinary ventricular muscle fibers retains all of its original actuality.This English edition of Tawara's monograph will serve as an invaluable reference for both basic and clinical cardiological research in the years ahead.

Considerable evidence exists that visual sensory information is analyzed simultaneously along two or more independent pathways. In the past two decades, researchers have extensively used the concept of parallel visual channels as a framework to direct their explorations of human vision. More recently, basic and clinical scientists have found such a dichotomy applicable to the way we organize our knowledge of visual development, higher order perception, and visual disorders, to name just a few. This volume attempts to provide a forum for gathering these different perspectives.

When we walk, drive a car, or fly an airplane, visual motion is used to control and guide our movement. Optic flow describes the characteristic pattern of visual motion that arises in these situations. This book is the first to take an in-depth look at the neuronal processing strategies that underlie the brain's ability to analyze and use optic flow for the control of self-motion. It does so in a variety of species which use optic flow in different behavioral contexts. The spectrum ranges from flying insects to birds, higher mammals and man. The contributions cover physiological and behavioral studies as well as computational models. Neuronal Processing of Optic Flow provides an authoritative and comprehensive overview of the current state of research on this topic written by a group of authors who have made essential contributions to shaping this field of research over the last ten years.
Key Features
* Provides the first detailed overview of the analysis of complex visual motion patterns in the brain
* Includes physiological, behavioral, and computational aspects of optic flow processing
* Highlights similarities and differences between different animal species and behavioral tasks
* Covers human patients with visual motion deficits
* Enhances the reader's understanding with many illustrations

Cardiac ion channels and mechanisms for protection against atrial fibrillation. Intrinsically photosensitive retinal ganglion cells. Quantifying and modeling the temperature-dependent gating of TRP channels.

The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.
Key Features
* Covers all aspects of the aging skeleton in one comprehensive volume
* Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass
* Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton
* Reviews current therapeutic approaches and methods
* Written by internationally renowned authors and edited by leaders in the field
* Is the only book available on this subject

Well known experts in the field of Chronobiology from around the world, provide an integrative view of the state of the art of circadian biology. At present, genetic and epigenetic interaction of regulatory pathways among circadian oscillators, metabolic networks, cellular differentiation and neuronal communication are subject of intense scrutiny. The book is organized in three sections: The first includes selected examples of the circadian systems of crustaceans, insects, fish, birds and mammals. The second is a detailed view of the physiological mechanisms underlying the circadian clocks in mammals. Finally, in the third section some examples of the relevance of circadian biology and circadian misalignment to health and disease are provided including nutrition and metabolism, obesity, cancer, cardiovascular and pulmonary diseases, Huntington and affective diseases. This section concludes with a brief review on gene therapy and its potential use as a therapeutic tool to correct "clock genes" pathologies. This book is aimed at all those interested in contemporary aspects of physiology, biochemistry and molecular biology applied to the study and characterization of timing systems.. It could be used as an initial approach to this field, but it also provides updated information for those already familiar with the fascinating field of Chronobiology.

Systems and Signal Processing of Capnography as a Diagnostic Tool for Asthma Assessment provides a comprehensive overview of groundbreaking tools and techniques for the diagnosis and monitoring of asthma. Sections cover an introduction to the human respiratory system and the pathophysiology of asthma before analyzing current assessment concepts, tools and techniques. The book describes spirometry and the peak flow meter as existing tools in assessing asthma along with their limitations. In addition, a detailed description of capnography as a new approach is included with various studies conducted on its analysis. Academicians and researchers in biomedical engineering, particularly in the course of biomedical signal processing and biomedical instrumentation will find the book useful.

Platelets are fragments of blood cells that occur in the blood of vertebrates and are associated with blood clotting. Scientists have made great strides in recent years in understanding what stimulates platelets to form blood clots at the molecular level and in developing drugs to inhibit platelet action. Their work has a direct effect on millions of people who deal with cardiovascular disease, strokes, surgery, physical trauma, and other conditions. While references to platelet function have been included in some large texts, there has not been a basic reference manual that researchers and clinicians can use in their daily work until now.
Platelet Protocols fills the need for a straightforward and comprehensive laboratory manual on current procedures for evaluating and analyzing platelet function and abnormalities. It is an easy-to-read, understandable resource which can be kept at the bench and referred to frequently by scientists, clinicians, and laboratory staff involved in platelet related areas. Topics range from the basics of anticoagulants to the latest developments in platelet testing.
Key Features
Includes:
* A basic introduction to platelet anatomy and physiology
* Testing procedures for new anti-platelet therapies
* Descriptions of platelet function abnormalities
* Therapeutic approaches to inhibition of platelet function
* Step-by-step methodologies with clear explanations
* Helpful appendixes of recipes, instructions, sources of reagents, and more

It has been over 40 years since the original report by Salmon and Daughaday demon strating that the ability of GH to stimulate sulfation of cartilage was mediated by a "sulfation factor. " In the ensuing decades, it has become apparent that this "sulfation factor activity" encompasses a complex system ofligands (IGFs), receptors, and carrier proteins that are, in tum, responsible for a wide array of cellular actions. The IGF system has been demonstrated to be critically involved in both intrauterine and postnatal growth, and to have important implications in cancer biology as well, owing to the ability of the IGFs to function in endocrine, paracrine, and autocrine modes and given the wide distri bution of IGFs in virtually every organ system. The contributions to The /GF System reflect the wide span of interest in the IGF system and its implications for normal and abnormal growth and metabolism. The chapters have been divided into four broad sections: I. Molecular biology of the IGF system; II. Bio logical actions of the IGFs; III. IGF physiology; and IV. Clinical aspects of the IGFs. We have made every effort to highlight the major contemporary themes in IGF biology, but as is inevitable in such a fast-moving field, perspectives will continue to change as new information is accumulated."