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Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General

Comparative Medicine - Disorders Linking Humans with Their Animals (Hardcover, 1st ed. 2017): Erika Jensen-Jarolim Comparative Medicine - Disorders Linking Humans with Their Animals (Hardcover, 1st ed. 2017)
Erika Jensen-Jarolim
R5,003 Discovery Miles 50 030 Ships in 12 - 17 working days

This book highlights the most significant diseases for humans and their dogs, cats and horses. The examples discussed, which include allergies, osteoporosis, cancer and many more, illustrate that humans and their companion animals may in fact develop similar diseases. The reader - whether expert or interested lay - can thus directly compare between human and animal patients. The animal patient thereby represents a natural disease model, which besides the experimental models, is urgently needed to improve the therapeutic options for both humans and animals.

Metallomics - Recent Analytical Techniques and Applications (Hardcover, 1st ed. 2017): Yasumitsu Ogra, Takafumi Hirata Metallomics - Recent Analytical Techniques and Applications (Hardcover, 1st ed. 2017)
Yasumitsu Ogra, Takafumi Hirata
R6,336 Discovery Miles 63 360 Ships in 12 - 17 working days

This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

Regenerative Medicine: Laboratory to Clinic (Hardcover, 1st ed. 2017): Asok Mukhopadhyay Regenerative Medicine: Laboratory to Clinic (Hardcover, 1st ed. 2017)
Asok Mukhopadhyay
R7,020 Discovery Miles 70 200 Ships in 12 - 17 working days

This book discusses the two different cellular approaches that are pursued in regenerative medicine: cell therapy and tissue engineering. It examines in detail the therapeutic application of hematopoietic stem cells in marrow regeneration, multi-potent mesenchymal stem cells (MSCs), also referred to as mesenchymal stromal cells. The interest in MSCs can be seen in more than 150 clinical trials, some of which have progressed to Phase III, despite the cells' limited differentiation potential. The book also explores how embryonic stem (ES) cells, being pluripotent in nature, can resolve some of the problems associated with adult stem cells, yet entail other challenges like risks of teratoma formation and immune rejection. A separate chapter deals with the role of noncoding RNAs in neuronal commitment of induced pluripotent stem (iPS) cells. Chapters like "Cord blood banking in India and the global scenario"; "3D bioprinting of tissue" and others will make this book an extremely interesting read for all students, researchers and clinicians working in the area of regenerative medicine/stem cells. The book is broadly divided into two parts, the first of which is devoted to basic information on stem cells, and the second of which addresses potential clinical applications in the areas of hematology, cardiology, orthopedic and immune suppression, etc.

The Cadherin Superfamily - Key Regulators of Animal Development and Physiology (Hardcover, 1st ed. 2016): Shintaro T. Suzuki,... The Cadherin Superfamily - Key Regulators of Animal Development and Physiology (Hardcover, 1st ed. 2016)
Shintaro T. Suzuki, Shinji Hirano
R5,634 Discovery Miles 56 340 Ships in 12 - 17 working days

This book presents an overview of the entire field of cadherin research and provides the current basic concept of cadherins. Cadherins have been widely accepted as key regulators of animal development and physiological functions, and it also has become clear that they play essential roles in various human diseases. With contributions by leading scientists, the book covers various aspects of the cadherin superfamily including the history of cadherin research, basic properties of classical cadherins as well as non-classical cadherins, cadherin-associated proteins, and the roles of cadherins in health and diseases. In addition, the book presents some contradictory results and important unanswered questions, and the authors propose their working hypotheses or future directions, to inspire future studies. This volume enables graduate students and young researchers to learn the basics and gain a comprehensive image of the cadherin superfamily, and experts in the field will easily find various topics of interest in relevant areas of study. Additionally, a list of cadherin-related diseases is included for quick reference to cadherins in human diseases.

Principles of Osteoimmunology - Molecular Mechanisms and Clinical Applications (Hardcover, 2nd ed. 2016): Peter Pietschmann Principles of Osteoimmunology - Molecular Mechanisms and Clinical Applications (Hardcover, 2nd ed. 2016)
Peter Pietschmann
R5,441 Discovery Miles 54 410 Ships in 12 - 17 working days

This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.

Chronomics and Continuous Ambulatory Blood Pressure Monitoring - Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring... Chronomics and Continuous Ambulatory Blood Pressure Monitoring - Vascular Chronomics: From 7-Day/24-Hour to Lifelong Monitoring (Hardcover, 1st ed. 2016)
Kuniaki Otsuka, Germaine Cornelissen, Franz Halberg
R5,943 Discovery Miles 59 430 Ships in 10 - 15 working days

This fascinating volume applies the concept of chronomics to the medical treatment of hypertension. It starts with the recent updates on chronomics, the analytic techniques, and their application to community-based assessments. The authors advocate the use of 7-day/24-h records of blood pressure, which is effective for finding masked hypertension, masked morning surge, and other rhythm abnormalities. Most organisms, from cyanobacteria to mammals, are known to use the circadian mechanism. However, our body systems also demonstrate circaseptan (roughly weekly), circannual (roughly yearly), and even longer rhythms. Chronomics monitors the physiological data and then analyzes the superimposed rhythms, isolating the cycles mathematically to determine how organisms and their environment interact. It is the study of interactions among time structures (chronomes) in and around us.

The Vital Nerves - A Practical Guide for Physical Therapists (Paperback): John Gibbons The Vital Nerves - A Practical Guide for Physical Therapists (Paperback)
John Gibbons
R655 R609 Discovery Miles 6 090 Save R46 (7%) Ships in 12 - 17 working days

A must-have book for understanding one of the most fundamental areas of physical therapy: the nervous system and its relationship to musculoskeletal pain. Osteopath, lecturer and author John Gibbons offers an accessible introduction to the peripheral nervous system (PNS). Alongside real case studies and guidelines for hands-on work with clients and patients, The Vital Nerves demystifies and makes accessible everything from how to diagnose nerve conditions to understanding how our cells communicate. Gibbons provides critical insights into the structure and functions of the PNS; the body's response to stimuli and how it knows what to do; the sympathetic and parasympathetic nervous systems; understanding the stress response; and how reflex testing can aid in diagnosing conditions like Multiple Sclerosis, Parkinson's Disease, and paresthesias. The Vital Nerves addresses practical, common considerations like how to: Assess the nervous system using a patella (reflex) hammer, myotome (muscle) testing and dermatome (sensory) testing Determine whether pain in the posterior part of the thigh is caused by the sciatic nerve, piriformis or simply a hamstring strain Decide at what level a disc may have herniated Differentiate between upper and lower motor neurone disorders Know what to do with the findings of your neurological assessment and the circumstances under which to refer patients for more specialist care. The Vital Nerves is a comprehensive, must-have roadmap to the functional anatomy of the nervous system. Enriched with anatomical drawings and detailed explanations, it explains neurological testing, common neuropathies, and differential diagnoses, and is an indispensable resource for physical therapists and bodyworkers.

Computational Hydrodynamics of Capsules and Biological Cells (Paperback): Constantine Pozrikidis Computational Hydrodynamics of Capsules and Biological Cells (Paperback)
Constantine Pozrikidis
R1,867 Discovery Miles 18 670 Ships in 12 - 17 working days

Spanning biological, mathematical, computational, and engineering sciences, computational biofluiddynamics addresses a diverse family of problems involving fluid flow inside and around living organisms, organs, tissue, biological cells, and other biological materials. Computational Hydrodynamics of Capsules and Biological Cells provides a comprehensive, rigorous, and current introduction to the fundamental concepts, mathematical formulation, alternative approaches, and predictions of this evolving field. In the first several chapters on boundary-element, boundary-integral, and immersed-boundary methods, the book covers the flow-induced deformation of idealized two-dimensional red blood cells in Stokes flow, capsules with spherical unstressed shapes based on direct and variational formulations, and cellular flow in domains with complex geometry. It also presents simulations of microscopic hemodynamics and hemorheology as well as results on the deformation of capsules and cells in dilute and dense suspensions. The book then describes a discrete membrane model where a surface network of viscoelastic links emulates the spectrin network of the cytoskeleton, before presenting a novel two-dimensional model of red and white blood cell motion. The final chapter discusses the numerical simulation of platelet motion near a wall representing injured tissue. This volume provides a roadmap to the current state of the art in computational cellular mechanics and biofluiddynamics. It also indicates areas for further work on mathematical formulation and numerical implementation and identifies physiological problems that need to be addressed in future research. MATLAB (R) code and other data are available at http://dehesa.freeshell.org/CC2

Eureka: Physiology, second edition (Paperback, 2nd Revised edition): Jake Mann Eureka: Physiology, second edition (Paperback, 2nd Revised edition)
Jake Mann; Contributions by David Marples
R1,000 Discovery Miles 10 000 Ships in 12 - 17 working days

Eureka: Physiology 2e provides everything a student needs to succeed in the subject, prepare for their clinical placements and pass their exams. Logical book structure to aid the learning process: The book starts with a First principles chapter which clearly explains key concepts and the mechanisms of physiology. The subsequent systems-based chapters, including neuromuscular, cardiovascular, respiratory, renal, endocrine, and gastrointestinal systems, describe the physiological processes which underpin normal function. The book concludes with a final Applied physiology chapter showing how the body responds to stress, exercise, high altitude and massive blood loss. Key features, to help learn the subject and link it to real world medicine: an engaging and authoritative style - with everything you need in one place realistic clinical cases - these show how skilled clinicians work through a presentation, and put disease and biomedical principles into context extensive range of photographs - superb photos show clinical presentations and exactly how to demonstrate related clinical signs starter questions - stimulating questions and answers to test your knowledge and highlight the level of detail you need study boxes - these highlight tips, tricks and key learning points Featuring insightful clinical cases, extensive illustrations and photographs, self-assessment questions and answers, and a wealth of other learning tools, Eureka: Physiology 2e will equip you with the core knowledge and skills you need for your exams and clinical placements!

Loose Leaf for Human Biology (Loose-leaf, 17th ed.): Sylvia Mader, Michael Windelspecht Loose Leaf for Human Biology (Loose-leaf, 17th ed.)
Sylvia Mader, Michael Windelspecht
R5,248 Discovery Miles 52 480 Ships in 10 - 15 working days
Molecular Exercise Physiology - An Introduction (Paperback, 2nd edition): Adam Sharples, James Morton, Henning Wackerhage Molecular Exercise Physiology - An Introduction (Paperback, 2nd edition)
Adam Sharples, James Morton, Henning Wackerhage
R1,807 Discovery Miles 18 070 Ships in 9 - 15 working days

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

Access to Higher Education - Anatomy and Physiology (Paperback, International Edition): Lin Shaw Access to Higher Education - Anatomy and Physiology (Paperback, International Edition)
Lin Shaw
R1,304 R1,166 Discovery Miles 11 660 Save R138 (11%) Ships in 10 - 15 working days

Written for the UK's Access to Higher Education program, yet universally accessible, Access to HE: Anatomy and Physiology provides an easy-to-understand text with diagrams and straightforward notes explaining the human body's structure and systems. The broader issues of progress in disease control and the links between stress and health are also examined in this textbook. This vital introductory source will benefit students entering the health profession.

Arterial Chemoreceptors - New Directions and Translational Perspectives (Hardcover, 1st ed. 2018): Estelle B. Gauda, Maria... Arterial Chemoreceptors - New Directions and Translational Perspectives (Hardcover, 1st ed. 2018)
Estelle B. Gauda, Maria Emilia Monteiro, Nanduri Prabhakar, Christopher Wyatt, Harold D. Schultz
R5,692 Discovery Miles 56 920 Ships in 10 - 15 working days

This volume contains reviews and brief research articles from participants attending the International Society for Arterial Chemoreception meeting, to be held in the USA (July 2017). Each article contains original data and represents up-to-date information concerning the carotid body and oxygen sensing in health and disease. This volume is a required text for all researchers in the field of arterial chemoreception and will provide a valuable reference source for years to come.

Cartilage - Volume 3: Repair Strategies and Regeneration (Hardcover, 1st ed. 2017): Susanne Grassel, Attila Aszodi Cartilage - Volume 3: Repair Strategies and Regeneration (Hardcover, 1st ed. 2017)
Susanne Grassel, Attila Aszodi
R5,473 Discovery Miles 54 730 Ships in 10 - 15 working days

In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.

Pocket Anatomy & Physiology (Spiral bound, 4th Revised edition): Shirley A. Jones, F A Davis Pocket Anatomy & Physiology (Spiral bound, 4th Revised edition)
Shirley A. Jones, F A Davis
R1,160 Discovery Miles 11 600 Ships in 12 - 17 working days

Access all of the A&P information you need - whenever and wherever you need it! In class or in practice, all of the A & P information you need is at fingertips in this handy, easy-to-understand pocket guide. Crystal-clear, full-color illustrations with concise labels put all the need-to-know A&P information at your fingertips. Whether you're looking for a cross section of the spinal cord or lateral view of the arteries of the head and neck, or any other perspective on the human body, you'll find it here. A brief description introduces each body system. Crystal-clear presentation makes the illustrations pop from the pages. Precise labels accurately identify every structure. Unique anatomical views - like the cross section of the hand - highlight every detail in full color. Every page tells you the orientation of every figure - no more guessing at what you're viewing. Easy-to-reference tables summarize all of the relevant physiology. New To This Edition: New, Revised & Updated! New illustrations and new topics in every tab to provide complete coverage that's even more relevant to the study of A&P today Body Structure-anatomical position and regional terms Cells, Tissues, and the Integumentary System-the plasma membrane, rough endoplasmic reticulum, Golgi apparatus, diffusion, and mitosis Human Microbiome-the human microbiome, the gut microbiome, bacteria, microbes, viruses, and diet-driven disease Skeletal System-the plasma membrane, rough endoplasmic reticulum, Golgi apparatus, diffusion, mitosis, and common types of fracturesMuscular System-the neuromuscular junction Nervous System-simple reflex arcs, nerve impulse, and sensory and motor neurons of the spinal cord The Senses-cutaneous senses and referred painEndocrine System-endocrine gland stimuli Circulatory System-hematocrit, reticulocytes, and monocytes, and nervous regulation of the heart New table: Complete blood count

Headache and Migraine in Practice (Paperback): Mansoureh Togha, Elham Jafari, Hossein Ansari, Samaneh Haghighi, Seyed Ehsan... Headache and Migraine in Practice (Paperback)
Mansoureh Togha, Elham Jafari, Hossein Ansari, Samaneh Haghighi, Seyed Ehsan Mohammadianinejad
R4,070 Discovery Miles 40 700 Ships in 12 - 17 working days

Headache and Migraine in Practice provides practical and precise approaches to the headaches and facial pains commonly encountered in hospitals and clinics. The book pays specific attention to the clinical features of headaches to present treatment solutions, while also recommending ICHD3 differential diagnoses based on diagnostic criteria. Topics covered were developed by colleagues with expertise in Neurology, Nutrition, Psychiatry, Physical Medicine, and Sports Medicine, thus providing a collaborative authorship that adds interdisciplinary value. Sections cover the diagnosis and treatment of various types of headaches in children, the elderly and women during different periods of pregnancy, lactation and hormone-related stages. This book is recommended for general practitioners, internists, neurologists, headache nurse specialists, and all others who would like to contribute to better diagnoses and more effective treatment plans for patients with headaches and facial pains.

Lahita's Systemic Lupus Erythematosus (Hardcover, 6th edition): Robert G. Lahita Lahita's Systemic Lupus Erythematosus (Hardcover, 6th edition)
Robert G. Lahita
R6,108 Discovery Miles 61 080 Ships in 12 - 17 working days

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries.

Understanding Pathophysiology (Paperback, 7th edition): Sue E. Huether, Kathryn L McCance Understanding Pathophysiology (Paperback, 7th edition)
Sue E. Huether, Kathryn L McCance
R4,526 Discovery Miles 45 260 Ships in 10 - 15 working days

Make difficult pathophysiology concepts come to life! Filled with vibrant illustrations, simplified language, and detailed online content Understanding Pathophysiology, 7th Edition delivers the most accurate information on treatments, manifestations, and mechanisms of disease across the lifespan. This new edition is fully revised and includes coverage of rare diseases and epigenetics to you with a thorough understanding of conditions affecting the human body. Plus, with over 30 new 3D animations on the companion Evolve site, quick check boxes at the end of each chapter, and disease progression algorithms, this text helps you engage with the fundamental knowledge you need to succeed in nursing school and in practice. Student resources include animations, review questions, answers to the Quick Check boxes (featured in the text), chapter summary reviews, and case study with answers for select chapters. Algorithms throughout the text clarify disease progression. Did You Know boxes highlight new developments in biologic research, diagnostic studies, preventive care, treatments, and more. Quick Check boxes tests your retention of important chapter concepts. Risk Factor boxes alert you to important safety considerations associated with specific diseases. Summary Review sections provide fast, efficient review of chapter content. Geriatric Considerations boxes and Pediatric Considerations boxes highlight key considerations for these demographics in relevant chapters. Consistent presentation helps you to better distinguish pathophysiology, clinical manifestations, and evaluation and treatment for each disease. Glossary of approximately 1,000 terms familiarizes you with the most difficult or important terminology related to pathophysiology. NEW! Chapters on Alterations in Immunity and Obesity and Disorders of Nutrition feature the latest coverage of these hot topics. NEW! Additional coverage of rare diseases and epigenetics gives you a comprehensive understanding of conditions and cell growths that affect the human body. NEW! Streamlined content and illustrations ensures content is at an appropriate level for undergraduate students. NEW! More than 1000 illustrations in the text and 30+ new 3D animations on companion Evolve site bring difficult concepts to life for a new perspective on disease processes.

Human Biochemistry (Hardcover, 2nd edition): Gerald Litwack Human Biochemistry (Hardcover, 2nd edition)
Gerald Litwack
R3,708 Discovery Miles 37 080 Ships in 12 - 17 working days

Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers.

Tinnitus and Stress - An Interdisciplinary Companion for Healthcare Professionals (Hardcover, 1st ed. 2017): Agnieszka J.... Tinnitus and Stress - An Interdisciplinary Companion for Healthcare Professionals (Hardcover, 1st ed. 2017)
Agnieszka J. Szczepek, Birgit Mazurek
R2,660 Discovery Miles 26 600 Ships in 10 - 15 working days

This book provides up-to-date scientific information on the pathways by which psychosocial stress can affect the auditory system and describes current approaches to the management of patients with stress-related tinnitus. The latest evidence is presented on aspects such as the role of stress hormones in auditory function, the effects of allostatic load, circadian sensitivity to auditory trauma, and the association between stress-related biomarkers and tinnitus. The clinically oriented chapters discuss psychometric instruments of value in the tinnitus clinic and present stress-related tinnitus treatment protocols and outcome measures. It is widely acknowledged that the tinnitus percept acts as a stressor. However, it is also now evident that psychosocial stress can play a causative role in tinnitus and that the impact varies according to the level, duration, and quality of the stress. Assessment of the types and levels of stress in tinnitus patients before, during, and after treatment is therefore very important. Healthcare professionals attending tinnitus patients will benefit from the information that this book provides on the relationship between tinnitus and stress and from the practical guidance that it offers.

Calcium Entry Pathways in Non-excitable Cells (Hardcover, 1st ed. 2016): Juan A. Rosado Calcium Entry Pathways in Non-excitable Cells (Hardcover, 1st ed. 2016)
Juan A. Rosado
R5,707 Discovery Miles 57 070 Ships in 12 - 17 working days

Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channels as the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.

Male Infertility: Understanding, Causes and Treatment (Hardcover, 1st ed. 2017): Rajender Singh, Kiran Singh Male Infertility: Understanding, Causes and Treatment (Hardcover, 1st ed. 2017)
Rajender Singh, Kiran Singh
R6,441 R5,685 Discovery Miles 56 850 Save R756 (12%) Ships in 12 - 17 working days

This book covers the latest research on male infertility. The topics discussed range from understanding the genetic basis of infertility, to its causes and treatment. Since infertility is also of great interest to the general public, the book also includes a detailed description of what infertility is and how one can understand the different types. Given the complex etiology of infertility, the book includes a number of chapters defining the known and probable causes of male infertility. Providing detailed information suitable for patients and clinicians alike, it also features a separate section on treatment, the ultimate goal.

Organelle Contact Sites - From Molecular Mechanism to Disease (Hardcover, 1st ed. 2017): Mitsuo Tagaya, Thomas Simmen Organelle Contact Sites - From Molecular Mechanism to Disease (Hardcover, 1st ed. 2017)
Mitsuo Tagaya, Thomas Simmen
R6,252 Discovery Miles 62 520 Ships in 12 - 17 working days

This book provides the first comprehensive coverage of the quickly evolving research field of membrane contact sites (MCS). A total of 16 chapters explain their organization and role and unveil the significance of MCS for various diseases. MCS, the intracellular structures where organellar membranes come in close contact with one another, mediate the exchange of proteins, lipids, and ions. Via these functions, MCS are critical for the survival and the growth of the cell. Owing to that central role in the functioning of cells, MCS dysfunctions lead to important defects of human physiology, influence viral and bacterial infection, and cause disease such as inflammation, type II diabetes, neurodegenerative disorders, and cancer. To approach such a multifaceted topic, this volume assembles a series of chapters dealing with the full array of research about MCS and their respective roles for diseases. Most chapters also introduce the history and the state of the art of MCS research, which will initiate discussion points for the respective types of MCS for years to come. This work will appeal to all cell biologists as well as researchers on diseases that are impacted by MCS dysfunction. Additionally, it will stimulate graduate students and postdocs who will energize, drive, and develop the research field in the near future.

Lipoxygenases in Inflammation (Hardcover, 1st ed. 2016): Dieter Steinhilber Lipoxygenases in Inflammation (Hardcover, 1st ed. 2016)
Dieter Steinhilber
R4,749 R3,688 Discovery Miles 36 880 Save R1,061 (22%) Ships in 12 - 17 working days

Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.

Heat Shock Factor (Hardcover, 1st ed. 2016): Akira Nakai Heat Shock Factor (Hardcover, 1st ed. 2016)
Akira Nakai
R4,440 Discovery Miles 44 400 Ships in 10 - 15 working days

This book presents a large amount of information related to the heat shock response and heat shock factor (HSF), describes core observations about molecular mechanisms and pathophysiological roles, and provides fundamental concepts on the basis of information from diverse aspects. This adaptive response to high temperature or protein misfolding is a fundamental mechanism to maintain the capacity of protein homeostasis, or proteostasis, and is evolutionally conserved among all living organisms, including bacteria and humans, on the earth. Furthermore, physiological and pathological roles of HSF have been extensively studied in fruit fly, worm, and mouse models. It has been revealed that HSF plays roles in development of the brain, reproductive and sensory organs, and in ageing, inflammation, and circadian rhythm. Analysis of the mechanisms have uncovered that HSF exerts a wide range of effects on gene expression and epigenetic status on the whole genome. Moreover, loss or gain of HSF function is also closely related to protein-misfolding diseases including neurodegenerative diseases, psychiatric diseases, heart diseases, and cancers. Therefore, HSF is now thought to be a promising therapeutic target for treatment of these refractory diseases. For undergraduate students, this is a highly understandable source of information on heart shock response and HSF, covering the basis of HSF biology, the physiological role of HSF, and disease associated with HSF function. This book not only serves as a guide to the heat shock response and HSF for students and young researchers in other fields, but also is a cornerstone for future work in the field related to the heat shock response and HSF.

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