Written by the authority on hypertrophic cardiomyopathy (HCM) and an HCM patient, and fully endorsed by the Hypertrophic Cardiomyopathy Association (HCMA), the leading advocacy and support organization, the 3rd Edition of this best-selling guide offers unparalleled insight into all aspects of living with and treating HCM.

Accessible and practical, A Guide to Hypertrophic Cardiomyopathy For Patients, Their Families and Interested Physicians 3rd Edition: Answers the most pressing questions posed by patients, their families, and non-specialistshealth professionals involved in their careCovers everything from what is HCM and initial diagnosis of this increasingly prevalentcondition to the latest treatment optionsReflects the first-ever HCM guidelines published by the American Heart Association in 2011

A firm grasp of the functions of living organisms is one of the most important prerequisites to pharmacy study. The long-awaited second edition of Essentials of Human Physiology presents concepts in physiology in a way that prepares students for their subsequent study of pathophysiology, pharmacology, and pharmacotherapeutics. Thoroughly revised and updated, this text maintains the clarity of the first edition, yet provides important new information to give students a solid grounding in some of the most important aspects of pharmacy. As with the first edition, the book begins with an overview of the fundamental aspects of cell membrane physiology with particular emphasis on nerve cell function. This is followed by a detailed discussion of the two major regulatory systems in the body: the nervous system and the endocrine system. The book then continues with in-depth presentations of the reproductive, muscular, cardiovascular, immune, respiratory, digestive, and renal systems. An important focus throughout the text is how tissue and organ function are regulated in order to maintain homeostasis. New in This Edition: * All 19 chapters updated and expanded * Revised and additional subsections of pharmacy applications * New sections on medical terms with pronunciations and definitions * New chapters on the reproductive and immune systems * Additional figures and tables to clarify information . This book was written by Laurie Kelly McCorry, a professor of physiology for eighteen years. Using simple, straightforward language, the text presents the science of physiology clearly so that undergraduate students will understand the relevance of these concepts as they relate to the practice of pharmacy. By studying and mastering the principles in this text, students will develop a secure foundation in human physiology so that they are better equipped to meet the challenges in their pharmacy career.

Combining topics from numerous applications in biomechanics, Applied Biomedical Engineering Mechanics demonstrates how to analyze physiological processes from an engineering perspective and apply the results to tertiary medical care. The book extends its discussion to the investigation of diagnostic and surgical procedures. It also presents guidelines for prostheses design and explains how to optimize performance in sports games such as soccer, baseball, and gymnastics.

Using a problem-based format, the book explains how to-

- Formulate diagnostic and interventional procedures, based on the analysis of physiological and organ system-based processes

- How human anatomical structures and physiological processes are designed for optimal functionality

- Develop orthopedic surgical approaches, using pre-surgical analysis

- Assess and promote fitness, and analyze sports games to maximize competency.

The world-class instruction presented within Applied Biomedical Engineering Mechanics clearly demonstrates how to quantify physiological processes in order to formulate solutions to various medical problems.

Medical students and faculty have long looked to Boron & Boulpaep's Medical Physiology for an unparalleled, comprehensive understanding of complex human physiology. By popular demand, the new Boron & Boulpaep Concise Medical Physiology offers Boron & Boulpaep's authoritative content in a condensed, entry-level presentation that is well-illustrated and student friendly. You'll find the same trusted quality and attention to detail as the parent text, with a logically organized format, clear, instructive figures, and online animations-all focused on the essential information you need to know for a solid introduction or a quick review. Takes a strong molecular and cellular approach that relates these concepts to human physiology and disease. Presents challenging material in a clear, concise, logically organized format to further facilitate understanding and retention. Features simplified, didactic illustrations that clearly depict complex concepts. Focuses on the essentials, making it ideal for programs and courses with limited hours for physiology coverage, or as a review companion to Boron & Boulpaep's Medical Physiology. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

report on the latest developments in the field with new information in basic as well as in clinical sciences, S"odium in Health Diseases," covers both the physiology of sodium balance and how it relates to disease. Expertly written, its concise text examines ATPase, transport and receptor systems, and sodium balance as it relates to sex hormones, genes, and body fluid. This text will also examine disease based on animal models, genetic disorders, and the influence of sodium on pulse pressure, isolated systolic hypertension, and its blood pressure sensitivity.

"Sodium in Health and Disease" will

- cover the newest data on sodium transport by the epithelial sodium channel or the impact of renal structure proteins on sodium transport

- discuss the latest developments in our understanding of the role of aldosterone and 11-beta-hydroxysteroid dehydrogenase in the regulation of sodium balance.

- present original observations on the role of salt in isolated systolic hypertension and in the development of arterial stiffness.

- give new data on renal sodium handling in women and in diabetes and the metabolic syndrome.

Important topics covered:

- the epithelial sodium channel

- renal structure proteins and sodium transport

- the 11-beta-hydroxysteroid dehydrogenase

- the Integrative regulation of sodium sodium

From one person to the next, optimal health is governed by a huge array of minor genetic differences. When modulated by a variety of food bioiactives, these differences result in changes in gene expression and subsequent phenotypic expression. Combining biomedical and social science with contributions from leaders in both fields, Personalized Nutrition: Principles and Applications illustrates molecular, physiological, epidemiological, and public health aspects with examples from major diseases and discusses the behavioral, ethical, and consumer perspectives that will influence a successful introduction of personalized nutrition. Divided into three sections, the book answers pertinent questions crucial to the mainstream acceptance of personalized nutrition: to what extent is this personal diet-and-health relationship practically valid? how can nutrition science demonstrate this? And what is the proposition of stakeholders in society, including the consumer? The book begins with an overview of the state-of-the-science in nutrigenomic technologies including transcriptomics, proteomics, and metabolomics. It covers the use of genomics technology for a better understanding of the molecular mechanisms involved in major diet-related chronic disorders such as chronic inflammation, cardiovascular disease, diabetes, cancer, and obesity. Section two compares the practices and opinions of scientists, food companies, consumers, competitive athletes, and health care providers on the subject of personalized nutrition. It reviews marketing potential, consumer attitudes, and the ethical issues surrounding personalized advice. The final section focuses on humanitarian concerns related to developingcountries and calls for international efforts to develop best practices, collaboration, and dataset sharing. The authors also consider ongoing innovations in food technology, nutrigenomics, and food delivery systems.

Originally published in 1990, Nobel Laureates in Medicine or Physiology is a biographical reference work about the recipients of Nobel Prizes in Medicine or Physiology from 1901-1989. Each article is written by an accomplished historian of medicine or science. The book is designed to be accessible to students and general readers as well as to specialists in medical science and history. Each article combines personal and scientific biography, and each has an extensive biography to guide further reading and research.

Known for its clear presentation style, single-author voice, and focus on content most relevant to clinical and pre-clinical students, Guyton and Hall Textbook of Medical Physiology, 14th Edition, employs a distinctive format to ensure maximum learning and retention of complex concepts. A larger font size emphasizes core information, while supporting information, including clinical examples, are detailed in smaller font and highlighted in pale blue - making it easy to quickly skim the essential text or pursue more in-depth study. This two-tone approach, along with other outstanding features, makes this bestselling text a favorite of students worldwide. Offers a clinically oriented perspective written with the clinical and preclinical student in mind, bridging basic physiology with pathophysiology. Focuses on core material and how the body maintains homeostasis to remain healthy, emphasizing the important principles that will aid in later clinical decision making. Presents information in short chapters using a concise, readable voice that facilitates learning and retention. Contains more than 1,200 full-color drawings and diagrams - all carefully crafted to make physiology easier to understand. Features expanded clinical coverage including obesity, metabolic and cardiovascular disorders, Alzheimer's disease, and other degenerative diseases. Includes online access to interactive figures, new audio of heart sounds, animations, self-assessment questions, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Historically, most of the research into carbohydrates as functional ingredients focused on the improvement of appearance, taste, mouth-feel, and stability. The growing interest in functional foods, however, is demanding a critical look at the beneficial nonnutritive effects of carbohydrates on human health. Furthermore, there is a need to establish definitive relations among the structure, physical property, and physiological function of these bioactive compounds. As more of the benefit and functional versatility of carbohydrates is revealed, it is clear that any future research and recommendation must be based on a solid synthesis of multidisciplinary findings including epidemiological, metabolic, and clinical nutritional data.

Through clinical and epidemiological studies, Functional Food Carbohydrates addresses the specific classes of carbohydrates that seem to exert health-enhancing effects. The text begins with in-depth treatments of the chemistry, physical properties, processing technology, safety and health benefits of a variety of carbohydrates including cereal beta-glucans, microbial polysaccharides, chitosan, arabinoxylans, resistant starch, and other polysaccharides of plant origin. The authors then discuss the physiological and metabolic effects that a variety of carbohydrates have on specific chronic diseases such as cancer, diabetes, cardiovascular disease, obesity, and various gastrointestinal disorders. The final chapters discuss the regulatory and technological aspects of using carbohydrates as functional foods. Specifically, the authors consider the safety and efficacy of pre-, pro-, and synbiotics, and the potential use of carbohydrates as delivery vehicles forother bioactive compounds.

With contributions from experts specializing in food chemistry and technology, as well as human nutrition and physiology, this text illuminates the link between the behavior of carbohydrate compounds and their beneficial end-result on human health.

Instant Notes in Human Physiology will be valuable to students in whatever context they are studying physiology. It explains fundamental concepts and the major physiological systems, showing how they are integrated, without overloading the reader with information. key selling features: Explains physiology in the light of advances in molecular biology and cellular biology. Shows how the major physiological systems are integrated. Approaches physiology from the view that the purpose of life is to reproduce.

The book is designed as an introduction to the scientific study of speech. No prior knowledge of phonetics is assumed. As far as mathematical knowlege is concerned, all that is assumed is a knowledge of simple arithmetic and as far as possible concepts are dealt with on an intuitive rather than mathematical level. The anatomical material is all fully explained and illustrated. The book is arranged in four parts. Part 1, Basic Principles, provides an introduction to established phonetic theory and to the principles of phonetic analysis and description, including phonetic transcription. Part 2, Acoustic Phonetics, considers the physical nature of speech sounds as they pass through the air between speaker and hearer. It includes sections on temporal measurement, fundamental frequency, spectra and spectrograms. Part 3, Auditory Phonetics, covers the anatomy of the ear and the perception of loudness, pitch and quality. The final part, Part 4, covers the articulatory production of speech, and shows how experimentaltechniques and tools can enhance our understanding of the complexities of speech production.
Though the audience for this book is mainly students and professors in the Speech Sciences, it will also be valuable to any students studying hearing science and acoustics. The book is well supported with figures, tables, and practice boxes with experiments.

All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling. Key selling features: Focuses on smooth muscles of different types Describes ion channel signaling mechanisms Reviews calcium and receptor signaling Includes novel, cutting-edge methodologies Summarizes studies of mice with genetically encoding sensors in smooth muscle Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf

The advances made in vascular biology in the last 25 years have considerably changed the perception that one could have of the endothelial cells. Once considered as a diffusion barrier preventing the access of the blood cells to the vascular matrix, the endothelium is now recognized as playing a major role in the control of blood fluidity, platelet aggregation, and vascular tone, but also in immunology, inflammation, angiogenesis, and for serving as a metabolizing and an endocrine organ.
-- from the preface
Cardiovascular diseases, so prevalent in the Western world during the twentieth century, could well become the scourge of the twenty-first century in emerging countries as well as the West. Endothelial dysfunction linked to an imbalance in the synthesis and/or release of contracting and relaxing factors is often evoked to explain the initiation of the cardiovascular pathology or its development and perpetuation. Two decades ago, when nitric oxide was demonstrated to mediate endothelium-dependent relaxations, the vascular world seemed convinced that nitric oxide was the ultimate and sole explanation for such relaxations. However not everyone agreed.
EDHF: The Complete Story is the work of two leading researchers who did not accept that simple conclusion, but instead continued to search, along with others, for a deeper understanding of the ways in which endothelial cells communicate with the underlying smooth muscle to signal it to hyperpolarize. Now with most, if not all, of those ways, uncovered, the authors offer this summary as way of bringing closure to the quest.
This monograph reports on the work of many researchers. It summarizes the significant recent discoveries concerning endothelium-dependent hyperpolarizations, which are likely to play a much more important role in cardiovascular physiology and pathology than was originally foreseen
Extensively illustrated with original diagrams and schematics that summarize the different steps of endothelium-dependent hyperpolarization, the text is designed for vascular biologists, and cardiologists, as well as graduate students looking to gain an understanding of the intimate functioning of the blood vessel wall.

Mitochondria produce the chemical energy necessary for eukaryotic cell functions; hence mitochondria are an essential component of health, playing roles in both disease and aging. More than 80 human diseases and syndromes are associated with mitochondrial dysfunction; this book focuses upon diseases linked to these ubiquitous organelles. Accumulation of mitochondrial DNA damage results in mitochondrial dysfunction through two main pathways. Mutation in mitochondrial DNA causes diseases such as Kearns-Sayre syndrome and Pearson syndrome. Mutation in chromosomal DNA causes diseases such as Parkinson's disease and schizophrenia. These and many other diseases are reviewed in this book. Key Features Presents the detailed structure of mitochondria, mitochondrial function, roles of oxidants and antioxidants in mitochondrial dysfunction. Includes summary of both causes and effects of these diseases. Discusses current and potential future therapies for mitochondrial dysfunction diseases Explores a wide variety of diseases caused by dysfunctional mitochondria.

Science is a force for good in the world-at least usually. But sometimes, when obsession gets the better of scientists, they twist a noble pursuit into something sinister. Under this spell, knowledge isn't everything, it's the only thing-no matter the cost. Bestselling author Sam Kean tells the true story of what happens when unfettered ambition pushes otherwise rational men and women to cross the line in the name of science, trampling ethical boundaries and often committing crimes in the process. The Icepick Surgeon masterfully guides the reader across two thousand years of history, beginning with Cleopatra's dark deeds in ancient Egypt. The book reveals the origins of much of modern science in the transatlantic slave trade of the 1700s, as well as Thomas Edison's mercenary support of the electric chair and the warped logic of the spies who infiltrated the Manhattan Project. But the sins of science aren't all safely buried in the past. Many of them, Kean reminds us, still affect us today. We can draw direct lines from the medical abuses of Tuskegee and Nazi Germany to current vaccine hesitancy, and connect icepick lobotomies from the 1950s to the contemporary failings of mental-health care. Kean even takes us into the future, when advanced computers and genetic engineering could unleash whole new ways to do one another wrong. Unflinching, and exhilarating to the last page, The Icepick Surgeon fuses the drama of scientific discovery with the illicit thrill of a true-crime tale. With his trademark wit and precision, Kean shows that, while science has done more good than harm in the world, rogue scientists do exist, and when we sacrifice morals for progress, we often end up with neither.

Very Short Introductions: Brilliant, Sharp, Inspiring Physiology is the science of life, and sets out to understand how living things work and what makes them distinct from the non-living. It considers how our bodies are supplied with energy, how they maintain their internal parameters, the ways in which we gather and process information, the ways we take action, and the creation of new generations. This Very Short Introduction explores the field of human physiology, considering how the body works, senses, reacts, and defends itself. As Jamie A. Davies shows, human life (and indeed, all life) is sustained by the interplay of a wide variety of physiological mechanisms and principles. He discusses the physiological experiments and research undertaken to understand these processes, and analyses the ethical issues involved. He also considers the evolution of the scientific field itself, showing how enhanced understandings of physiological knowledge can help inform medical research and care. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Exercise Physiology Laboratory Manual is a comprehensive resource for instructors and students interested in practical laboratory experiences related to the field of exercise physiology. This program can be used as both a standalone lab manual and/or as a complement to any exercise physiology textbook. Students will come away with thorough instruction on the measurement and evaluation of muscular strength, anaerobic and aerobic fitness, cardiovascular function, respiratory function, flexibility, and body composition.

Instant Notes in Sport and Exercise Physiology looks at the key topics in exercise physiology and examines how each of the physiological systems responds to acute and chronic exercise. As well as reviewing special topics such as nutrition, altitude, temperature, and ergogenic acids, it assesses the importance of exercise to health and quality of life and considers the importance of exercise to adults, children and the elderly.

This new study guide is a companion to the bestselling textbook Fundamentals of Anatomy and Physiology for Nursing and Healthcare Students, and is designed to help and support you with this subject area, by testing and consolidating your knowledge of anatomy and physiology. Jam-packed with tips, hints, activities and exercises, this workbook will guide you through the core areas of anatomy and physiology, and provide you with loads of help with your studies. Designed to support all styles of learning, Fundamentals of Anatomy and Physiology Workbook provides you with a wide range of activities including: * Clear illustrations for tracing, copying, shading and colouring in * Blank diagrams for labelling * Multiple choice questions * Fill in the gap exercises * Learning tips and hints * Crosswords * Word searches Also available: Fundamentals of Anatomy and Physiology for Nursing and Healthcare Students 2nd edition the bestselling textbook upon which this study guide is based.

Molecular Basis of Human Nutrition focuses mainly on human nutrition and emphasises its metabolic basis to reflect the increasing knowledge and research in these fields. It explains the biochemical functions of the essential nutrients and the physiological consequences of deficient and excessive intakes. These are described within the context of normal human diets and requirements for health. Although this book is about human nutrition, in some instances there are comparisons with and examples of other mammalian species to facilitate understanding of the principles being explained.
Molecular Basis of Human Nutrition is the only book to cover this particular subject and will prove very popular with both students and lecturers alike.

Orthopaedic procedures in elderly patients are challenging and costly. As the population ages these costs will continue to escalate. ORTHOPAEDIC ISSUES IN OSTEOPOROSIS weaves together theory and applications to provide the first reference available on the orthopaedic aspects of osteoporosis.

The focus on the management of patients who have had a fracture sets this book apart. Featuring extensive coverage of surgical management of osteoporotic fractures, it highlights the challenges of internal repair in osteoporotic bone. The chapters combine the basic and clinical essentials of osteoporosis with the latest orthopaedic findings in applied research and surgical treatment.

Fractures associated with osteoporosis account for the majority of the money spent on this condition. However, the orthpaedic treatment of osteoporotic bone is a formidable surgical problem, and one not covered explicitly in any book - until now. With over 300 tables, line drawings, equations, and macro or X-ray photographs, ORTHOPAEDIC ISSUES IN OSTEOPOROSIS is a long overdue resource.

About the Editor: Yuehuei H. (Huey) An, MD, graduated from the Harbin Medical University, Harbin, Northeast China in 1983 and was trained in orthopaedic surgery at the Beijing Ji Shui Tan Hospital (Residency), and in hand surgery at Sydney Hospital (Clinical Fellow), Australia. In 1991, Dr. An joined with Dr. Richard J. Friedman in the Department of Orthopaedic Surgery at the Medical University of South Carolina to establish the MUSC Orthopaedic Research Laboratory, which is now a multifunctional orthopaedic research center. Dr. An has published more than 100 scientific papers and book chapters and more than 100 abstracts and edited 6 books, including Animal Models in Orthopaedic Research (CRC Press 1999) and Mechanical Testing of Bone and the Bone-Implant Interface (CRC Press 2000). He is an active member of eight academic societies in the fields of orthopaedics, biomaterials, biomechanics, and tissue engineering.

Traumatic injuries of the spinal cord continue to be the most common cause of permanent paralysis in young adults in the United States. New information has emerged on the response of spinal neurons to injury of either the spinal cord or peripheral nerves demonstrating that dendrites of injured motoneurons take on characteristics of axons. These and other new developments have helped to promote an exciting new era in the study of spinal cord neurobiology.

Motor Neurobiology of the Spinal Cord provides a description of the recent conceptual and technical advances in the field. It provides a description of the new experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture. It covers topics ranging from genetics to kinematics and examines cells, tissues, or whole animals in species ranging from fish to humans that are normal, injured, or diseased.

By integrating data derived from many new approaches, you'll learn about how spinal cord circuits operate under a variety conditions and about new and exciting inroads being made in motor neurobiology of the spinal cord. Motor Neurobiology of the Spinal Cord elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease.

Contents:
1. Cell Membranes, Epithelial Barriers and Drug Absorption 2. Parenteral Drug Delivery 3. Drug Delivery to the Oral Cavity or Mouth 4. Oesophageal Transit 5. The Stomach 6. Drug Absorption from the Small Intestine 7. Drug Delivery to the Large Intestine and Rectum 8. Transdermal Drug Delivery 9. Nasal Drug Delivery 10. Pulmonary Drug Delivery 11. Ocular Drug Delivery 12. Vaginal and Intrauterine Drug Delivery.

The importance of measurements for the proper assessment of human locomotion is increasingly being recognized. The fields of application encompass both healthy and pathological locomotion as encountered in rehabilitation medicine, orthopedics, kinesiology, sports medicine, and the like.
Measurement of Human Locomotion provides an up-to-date description of the instrument systems used for measurement of: kinematics of human movement; kinetic quantities experienced by the human body in contact with the ground; and, myoelectric changes associated with locomotor activity.

Physical principles behind the operation of various measurement systems are emphasized, as well as signal processing issues that must be addressed in order to obtain and use quantitative measurement variables in biomechanics. The book explains how measurement data are acquired, processed and presented to the user in the environment of a modern, computer-based laboratory. The ultimate aim is to contribute to the processes of the diagnosis and treatment of locomotion disorders.

The purpose of Measurement of Human Locomotion is to provide a concise but comprehensive presentation of the systems used for the measurement of human locomotion, with a view to the assessment and diagnosis of the phenomenon.

Genetic Steroid Disorders, Second Edition targets adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologists. It is designed to assist these specialists in the diagnosis and treatment of steroid disorders. This revision includes a new chapter on "Gonadotropins, Obesity and Bone" and new research on non-invasive prenatal diagnosis with cell-free DNA. Chapters are thoroughly updated covering steroid disorders, the genetic bases for the disorder and case presentations, This definitive reference belongs in every medical library!