Pediatric arrhythmias present numerous challenges to pediatric cardiologists and other practitioners who see pediatric patients, including pediatricians, family physicians, emergency physicians, residents, fellows, and other clinicians. Arrhythmias in Children: A Case-Based Approach features practical methods for diagnosing and treating arrhythmias in these patients across all settings. Nearly three dozen real-world scenarios are presented, followed by a discussion of the diagnosis, clinical thinking process involved, treatment options, expected outcomes, and how to manage anticipated and unanticipated outcomes. These practical, realistic cases provide a unique and engaging way of approaching these challenging patient scenarios. Uses a case-based approach for a full spectrum of pediatric arrythmias in the newborn, child, pre-teen, and teenager. Presents history and physical, differential diagnoses, tests to order, and practical plans of action. Includes a section on arrythmias in special circumstances. Models clinical thinking skills for a wide number of real-world patient situations. Reviews pertinent clinical guidelines, treatment, and follow up.

Synapse Development and Maturation, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. The book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the synaptogenesis and developmental sequences in the maturation of intrinsic and synapse-driven patterns.

An AGI Brain for a Robot is the first and only book to give a detailed account and practical demonstration of an Artificial General Intelligence (AGI). The brain is to be implemented in fast parallel hardware and embodied in the head of a robot moving in the real world. Associative learning is shown to be a powerful technique for novelty seeking, language learning, and planning. This book is for neuroscientists, robot designers, psychologists, philosophers and anyone curious about the evolution of the human brain and its specialized functions. The overarching message of this book is that an AGI, as the brain of a robot, is within our grasp and would work like our own brains. The featured brain, called PP, is not a computer program. Instead, PP is a collection of networks of associations built from J. A. Fodor's modules and the author's groups. The associations are acquired by intimate interaction between PP in its robot body and the real world. Simulations of PP in one of two robots in a simple world demonstrate PP learning from the second robot, which is under human control. "Both Professor Daniel C. Dennett and Professor Michael A. Arbib independently likened the book 'An AGI Brain for a Robot' to Valentino Braitenberg's 1984 book 'Vehicles: Experiments in Synthetic Psychology'." Daniel C. Dennett, Professor of Philosophy and Director of Center for Cognitive Studies, Tufts University. Author of "From Bacteria to Bach and Back: The Evolution of Minds." "Michael Arbib, a long time expert in brain modeling, observed that sometimes a small book can catch the interest of readers where a large book can overwhelm and turn them away. He noted, in particular, the success of Valentino Braitenberg's 'Vehicles' (for which he wrote the foreword). At a time of explosive interest in AI, he suggests that PP and its antics may be just the right way to ease a larger audience into thinking about the technicalities of creating general artificial intelligence." Michael A Arbib, Professor Emeritus of Computer Science, Biomedical Engineering, Biological Sciences and Psychology, University of Southern California. Author of "How the Brain Got Language". "Robots seem to increasingly invade our lives, to the point that sometimes seems threatening and other-worldly. In this small book, John Andreae shows some of the basic principles of robotics in ways that are entertaining and easily understood, and touch on some of the basic questions of how the mind works." Michael C. Corballis, Professor of Psychology, University of Auckland. Author of "The Recursive Mind". "A little book that punches far beyond its weight." Nicholas Humphrey, Emeritus Professor of Psychology, London School of Economics. Author of "Soul Dust: The Magic of Consciousness". "A bold and rich approach to one of the major challenges for neuroscience, robotics and philosophy. Who will take up Andreae's challenge and implement his model?" Matthew Cobb, Professor of Zoology, University of Manchester. Author of "The Idea of the Brain". "Here is a book that could change the direction of research into artificial general intelligence in a very productive and profitable way. It describes a radical new theory of the brain that goes some way towards answering many difficult questions concerning learning, planning, language, and even consciousness. Almost incredibly, the theory is operational, and expressed in a form that could-and should-inspire future, novel, research in AI that transcends existing paradigms." Ian H. Witten, Professor of Computer Science, Waikato University. Author with Eibe Frank of "Data Mining: Practical Machine Learning Tools and Techniques".

Anti-aging products are undergoing exceptional growth in the cosmetics industry far beyond that of general cosmetics. This book is the only available text that assembles the key pieces developers need to produce new breakthroughs for a growing market that demands quicker and more effective results. It also focuses much needed attention on the biochemical and clinical differences between Caucasian and other skin types.
Beginning with detailed descriptions of the forces driving the anti-aging market, this unique book provides readers with all the tools necessary to further research, develop, market, and sell novel products. Recent discoveries on the molecular level and novel methods of skin aging assessment are detailed as well as the state of the rapidly changing global regulatory environment. The formulation approaches of major cosmetics companies are presented as are their techniques for measuring skin aging in vitro and in vivo, both on the molecular and clinical levels.
Provides philosophical perspective on the growth of the anti-aging market
Covers skin types beyond Caucasian
Provides key pieces for developing and selling new breakthrough products
Includes technology from major cosmetic companies such as Chanel, Avon, Estee lauder and others"

Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and current concepts pertinent to their neurobehavioral genetics. Discussing their natural behavior, motor function, learning and memory, this book focuses on the fry and adult zebrafish, featuring a comprehensive account of modern genetic and neural methods adapted to, or specifically developed for, Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish are presented, as is a section on bioinformatics and "big-data" related questions.

The heart is invested with a complex, intertwining network of blood and lymphatic vessels which, respectively, provide the cardiac tissue with oxygen and nutrients and eliminate excess fluid from the interstitium. The coronary blood vessels have been the focus of much investigation in the past few decades. On the other hand, the literature regarding the cardiac lymphatic vessels remains sparse, despite their important role in maintaining normal heart function. With this in mind, a better understanding of the cardiac lymphatic network and its ability to regulate fluid homeostasis within the heart could give us insight into developing therapies for the alleviation of several cardiac pathological conditions.

Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements.

The Neuromodulation Casebook is a case-based volume for practical, hands-on decision-making using realistic case examples from the field of neuromodulation. It encompasses a variety of techniques and therapies, ranging from deep brain stimulation for a multitude of disorders, to spinal cord stimulation, peripheral nerve stimulation, cortical stimulation and cranial nerve stimulation, as well as non-invasive therapies and other implanted types of devices that interface with the nervous system. Allowing readers to better learn via case-based examples, this practical volume depicts real examples of decisions neuroscientists and neurosurgeons need to make every day from leaders in the field. This book serves as a companion text to the editor's previous titles Essential Neuromodulation and Innovative Neuromodulation for neuroscience, neural engineering and biomedical engineering courses.

Lymphatic Structure and Function in Health and Disease serves as a resource book on what has been learned about lymphatic structure, function and anatomy within different organ systems. This is the first book to bring together lymphatic medicine as a whole, with in-depth analysis of specific aspects of lymphatics in different vascular pathologies. This book is a useful tool for scientists, practicing clinicians and residents, in particular, those in vascular biology, neurology, cardiology and general medicine. Chapters discuss topics such as ontogeny and phylogeny of lymphatics, lymphatic pumping, CNS lymphatics, lymphatics in transplant and lymphatic reconstruction.

Theory of Endobiogeny, Volume 3: Advanced Concepts for Treatment of Complex Clinical Conditions explains complex and multi-factorial disorders and diseases using the theory of endobiogeny. It provides detailed applications of biological modeling, in-depth assessment into common disorders, an endobiogenic analysis, guidance on using biological modeling tools, and suggestions for treatment using standard of care treatments that also take into account diet, lifestyle and medicinal plants. This approach is an evolution in thinking from reductionism to holism, offering advice for symptomatic treatments that can be used in conjunction with a new way of thinking about diseases and disease management.

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases. By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.

The Science of Hormesis in Health and Longevity provides a comprehensive review of mild stress-induced physiological hormesis and its role in the maintenance and promotion of health. Coverage includes the underlying mechanisms of hormesis, including details of stress-response signaling, an enriched environment, positive challenges and dose-response mechanisms, amongst others. Research from top experts is presented to provide suggestions for developing novel therapeutic strategies, along with lifestyle interventions to promote health and homoeostasis. Researchers in aging and physiology, gerontologists, clinicians and medical students will find this a valuable addition for their work.

The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of "big data" readily available to clinicians for greater insight into the patient's state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond.

La Terapia del Momento Motivacional de Vida (Temomvi) se formulo para el manejo de disfunciones conductuales que amenazan con alterar o, en efecto, estan alterando el equilibrio vida-momento de la Persona, el grupo o la organizacion. En el mismo su autor hace acopio de ideas innovadoras incorporando conceptos nunca antes contemplados como parte de la terapia psicologica. Ademas, redefine y reconceptualiza los conceptos de normalidad, disfuncion y personalidad integrandolos en un paradigma en el cual se fusionan de forma sistematica y practica aspectos fenomenologicos, existenciales, psicodinamicos, cognitivos y de aprendizaje social. En Temomvi los conceptos de vida, mito de la felicidad, confusion vida-momento, movimiento rotacional-traslacional del ser y la existencia, sufrimiento en lay away, entre otros representan nuevas aportaciones a la prevencion y remision de las disfunciones conductuales y al desarrollo de un estilo de vida.

Molecular-Genetic and Statistical Techniques for Behavioral and Neural Research presents the most exciting molecular and recombinant DNA techniques used in the analysis of brain function and behavior, a critical piece of the puzzle for clinicians, scientists, course instructors and advanced undergraduate and graduate students. Chapters examine neuroinformatics, genetic and neurobehavioral databases and data mining, also providing an analysis of natural genetic variation and principles and applications of forward (mutagenesis) and reverse genetics (gene targeting). In addition, the book discusses gene expression and its role in brain function and behavior, along with ethical issues in the use of animals in genetics testing. Written and edited by leading international experts, this book provides a clear presentation of the frontiers of basic research as well as translationally relevant techniques that are used by neurobehavioral geneticists.

The face circulates through most things of this world: anything that has presence, that presents itself, that has a front, a surface, an appearance, an aspect, a reputation, or honor - anything that confronts, opposes, or defies - has a face. And the face is a front: from the back it is just a head, a radically different entity. In this exciting new book - and sadly his last before his untimely death - distinguished philosopher Marty Roth pursues considerations of the human face in art, literature, philosophy, and other manifestations of human culture.

This issue of Cardiac Electrophysiology Clinics--edited by Drs. Amin Al-Ahmad, Raymond Yee, and Mark Link--will focus on Contemporary Issues in Patients with Implantable Devices. Topics include, but are not limited to: Management of Device infections; Device longevity; Inappropriate ICD therapies; ILR for cryptogenic stroke; ICD implantation without DFT testing; S-ICD; Lead extraction; Use of the WCD as a bridge to ICD; Important parameters for ICD selection; Leadless pacemakers; Management of perioperative anticoagulation for device implantation; HIS bundle pacing; Single coil ICD leads; Venous system interventions for device implantation; and Remote monitoring.

Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle acts as a bridge between physiology and physics by discussing the physiology and calcium signaling mechanism in cardiac and smooth muscle. By exploring the mechanism of the cyclic release of stored Ca^(2+) in the SR or ER, this book covers the cell communication system, including excitable cells, recognizing the most relevant mechanisms of cell communication. Serving as a bridge between physiology and physics, coverage spans the physiology and calcium signaling mechanism in cardiac and smooth muscle, offering insight to physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists.

A successful Wall Street trader turned neuroscientist reveals how risk taking and stress transform our body chemistry
Before he became a world-class scientist, John Coates ran a derivatives trading desk in New York City. He used the expression "the hour between dog and wolf" to refer to the moment of Jekyll-and-Hyde transformation traders passed through when under pressure. They became cocky and irrationally risk-seeking when on a winning streak, tentative and risk-averse when cowering from losses. In a series of groundbreaking experiments, Coates identified a feedback loop between testosterone and success--one that can cloud men's judgment in high-pressure decision-making. Coates demonstrates how our bodies produce the fabled gut feelings we so often rely on, how stress in the workplace can impair our judgment and even damage our health, and how sports science can help us toughen our bodies against the ravages of stress. Revealing the biology behind bubbles and crashes, "The Hour Between Dog and Wolf "sheds new and surprising light on issues that affect us all.

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

A Structure-Function Toolbox for Membrane Transporter and Channels, Volume 594, a new release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters in the updated serial include Cryo-EM on membrane proteins embedded in nanodics, Solid-Supported membrane-based electrophysiology on membrane transporters and channels, Saposin-lipoprotein scaffolds for structure determination of membrane transporters and channels, Single-molecule FRET on transporters, Dynamics of channels and transporters investigated by NMR, Structure-function studies on channels and transporters, and a section on MemStar, a new GFP-based expression and purification system for transporters and channels.

This book introduces readers to the latest exciting advances in human motion sensing and recognition, from the theoretical development of fuzzy approaches to their applications. The topics covered include human motion recognition in 2D and 3D, hand motion analysis with contact sensors, and vision-based view-invariant motion recognition, especially from the perspective of Fuzzy Qualitative techniques. With the rapid development of technologies in microelectronics, computers, networks, and robotics over the last decade, increasing attention has been focused on human motion sensing and recognition in many emerging and active disciplines where human motions need to be automatically tracked, analyzed or understood, such as smart surveillance, intelligent human-computer interaction, robot motion learning, and interactive gaming. Current challenges mainly stem from the dynamic environment, data multi-modality, uncertain sensory information, and real-time issues. These techniques are shown to effectively address the above challenges by bridging the gap between symbolic cognitive functions and numerical sensing & control tasks in intelligent systems. The book not only serves as a valuable reference source for researchers and professionals in the fields of computer vision and robotics, but will also benefit practitioners and graduates/postgraduates seeking advanced information on fuzzy techniques and their applications in motion analysis.