Taurine 4 - Taurine and Excitable Tissues (Hardcover, 2002 ed.)

Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the "setpoint" andcorresponds to values between 0.3-3M. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .

General

Imprint:	Kluwer Academic / Plenum Publishers
Country of origin:	United States
Series:	Advances in Experimental Medicine and Biology, 483
Release date:	2001
First published:	2001
Editors:	Laura Della Corte • Ryan J. Huxtable • Giampietro Sgaragli • Keith F. Tipton
Dimensions:	234 x 156 x 37mm (L x W x T)
Format:	Hardcover
Pages:	652
Edition:	2002 ed.
ISBN-13:	978-0-306-46447-8
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Physiology > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	0-306-46447-0
Barcode:	9780306464478

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