The opening chapter of The Essential Guide to Magnetic Resonance presents applications of Fluorine-19 Magnetic Resonance Imaging (19F MRI) in cancer research, tissue metabolomics, quantification of drug delivery, cellular tracking, tissue pH measurements and detection of 19F labeled cells. The authors review in vitro research applying 19F MRI and Magnetic Resonance Spectroscopy (MRS) to facilitate the synthesis, tracking and visualization of new fluorinated drug conjugates. 19F MRI also provides high contrast in vivo images due to the absence of an endogenous 19F signal, 100% natural abundance of 19F, and a chemical shift range of over 400 ppm. Afterwards, examples of current methods of magnetic resonance imaging (MRI) guided photodynamic therapy are presented. Recent development of MRI detectable nanoparticle constructs, magnetic resonance spectroscopy (MRS) sensors, gadolinium based photosensitizers and europium singlet oxygen probes are discussed. In addition, applications of Functional MRI using a blood oxygen dependent level (BOLD) MRI in monitoring photodynamic action are addressed, with the goal of informing researchers about the potential for using MRI guided photodynamic therapy and oxygen dosimetry. The applications of MRI within the sphere of pharmacy are analyzed; in particular, the use of MRI to track pharmaceuticals in vitro and in vivo noninvasively and monitoring their controlled-release. Functional MRI for noninvasive clinical brain imaging is explored as it is applied to studies of autism, schizophrenia, epilepsy Alzheimers disease, Parkinson's disease, traumatic brain injury and blood oxygenation-level dependent (BOLD) imaging of brain function. An overview of the scope of MRI as a diagnostic technique in neurology and in neurosurgery is also provided.

The knowledge of the morphofunctional features from the coronary microcirculation is essential for understanding its role in cardiac physiological work and in the pathogenesis of coronary microvascular dysfunction (CMD). The cardiovascular system comprises the heart and blood vessels, including arteries, veins, and capillaries, both systemic and pulmonary. Arterioles are the primary site of vascular resistance and have only one to two layers of smooth muscular walls. Chapter One will provide an overview of the coronary microcirculation, its functions and regulatory mechanisms. The importance of CMD will be summarised in the context of diverse clinic scenarios, considering its pathogenesis, assessment and therapeutic management. The purpose of Chapter Two is to understand the role of arteriolar endothelial dysfunction in CVDs and its underlying mechanisms. Chapter Three will explore the physiopathology, epidemiology, and the diagnosis and treatment of hypertensive retinopathy. Chapter Four reports on angiogenesis, a critical process for reproduction in mammals, which consists of arterioles and blood vessels formation from the existing ones.

This pocket reference guide covers the routine and special tests audiologists must conduct and interpret in their practices. Disorders such as nonorganic hearing loss, middle and inner ear disorders, and systemic disorders are covered with a separate chapter set aside for audiogram examples are covered in the middle section. The final chapter is devoted to medical referral decision-making criteria.The audiologist that has this handy guide in his or her pocket will have a valuable and quick reference for every day audiologic diagnosis and referral!Key features:*Concise and approachable outline format for quick reference*Small size for ease of portability*Over 75 figures and tables to enhance the content

A complete how-to guide for incorporating genomics into all applicable areas of clinical medicine Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. To be as clinically relevant as possible, the book intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support. Precision Medicine: A Guide to Genomics in Clinical Practice follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage. This organization allows healthcare providers to easily find the information relevant to their practice. Throughout, the authors highlight common pitfalls - technical and ethical - that might complicate the delivery of quality genomic healthcare. The book is enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement. If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practice belongs on your desk.

This book is written for the primary care clinician to help update knowledge of pediatric endocrinology (with an emphasis on diabetes) from both ancient and modern times. The current and future shortage of pediatric endocrinologists necessitates steady, rejuvenated information on diabetes and other endocrine disorders for primary care clinicians as they care for the child and adolescent with complex endocrine dilemmas and disorders. In view of this shortage and the rapidly increasing knowledge in pediatric diabetes as well as understanding indications for referral to pediatric endocrinologists in the 21st century, au courant assiduous information aimed at primary care clinicians in these areas becomes increasingly important.

Psoriasis is a common, non-infectious, chronic inflammatory skin disease characterised by distinctive erythematous plaques that multiply and scale over with silvery patches. Psoriasis can affect any cutaneous site and is frequently found on the extensor skin surface of elbows and knees, scalp and sacral regions. Psoriasis is also associated with systemic conditions, including psoriatic arthritis, Crohns disease and lymphoma. This book discusses the epidemiology, diagnosis and management strategies of psoriasis. Chapter One provides an overview of the challenging medical condition. Chapter Two discusses the possible factors raised by literature as main contributors to sleep disturbances and its correlation to psoriasis. Chapter Three gives an overview of the current results where blood plasma thermal changes have been detected by Differential Scanning Calorimetry (DSC) technique on psoriatic patients with different clinical stages, and monitored patients with no symptoms to patients with serious symptoms. Chapter Four discusses psoriasis treatment that targets the IL-23/Th17 axis. Chapter Five reviews natural health products for managing psoriasis.

Photodynamic therapy (PDT) is increasingly being used amongst health practitioners in combating a variety of diseases. This book reviews the current state of development of PDT, and also presents the foreseeable advancements of the field in the next decade. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find this book an invaluable source of information. Chapters are drawn from research discussed at the 10th International Symposium on Photodynamic Therapy and Photodiagnosis in Clinical Practice in Brixen and are written and edited by leaders in the field. Mirroring the philosophy of that meeting, this book contains an informative balance of the basic science and clinical applications of PDT. Following an introduction to PDT, its history, and how techniques have developed, chapters serve as a practical guide for practitioners, covering topics such as sensitizer dosage and light dosage, and examples of relevant studies. The text goes further to explore areas outside the medical field, such as the impact of PDT on society and the environment, and the economics of therapies. This book is dedicated to the memory of Professor Giulio Jori, an expert in this field, who sadly passed away on the 23rd December 2014.

In this issue an impressive group of contributors at the forefront of sedation research has been assembled to provide endoscopists and dedicated nursing personnel alike a comprehensive review of important topics in the field sedation and analgesia. A discussion on the pharmacology and agents used to provide moderate and deep sedation provides the basic framework that is a crucial element in determining the driving force behind the developments in sedation and analgesia. An evidence-based approach on the use of unsedated endoscopy is also provided. Other topics included the use of propofol, patient-controlled sedation and analgesia, extended physiologic monitoring, risk management, and quality assurance as they apply to the spectrum of sedation in the endoscopy suite. Sedation and analgesia in the pediatric patient is also addressed.

Chronic Lymphocytic Leukemia (CLL) is the most common leukemia in the western world, seen mostly in the elderly age-group and has a very variable clinical outcome. Traditionally considered an indolent, antigen inexperienced leukemia of slowly accumulating cells that do not die, researchers now acknowledge that CLL cells are highly proliferative, antigen experienced cells that have a high cell turnover and a subset show an aggressive clinical course. The onset of the disease is usually asymptomatic; only abnormalities in whole blood count such as leukocytosis with lymphocytosis are found. Nowadays, CLL is diagnosed more often at an early, asymptomatic stage due to more frequent routine blood tests. More advanced stages are characterized by lymphadenopathy, hepatomegaly/splenomegaly, recurrent infections, weakness, pallor and hemorrhagic diathesis, and general symptoms such as weight loss, fever and night sweats are observed. This book reviews the diagnosis, treatment options and prognosis of CLL.

This book discusses the diagnosis, treatment and management of liver disease. Chapter One reviews hepatic hydatidosis. Chapter Two explores the diagnosis, natural history, and management for patients with chronic hepatitis C (CHC). Chapter Three discusses scientific evidence that explains the relationship between metabolic syndrome, non- alcoholic fatty liver disease (NAFLD) and psoriasis and the treatment strategy for this co-morbid condition. Chapter Four examines the pathophysiology and treatment of liver cirrhosis. Chapter Five reviews surgical strategies to push up resection limits in liver disease and liver failure after surgery.

The topics covered in this issue, an update from what was first published in the Gastrointestinal Endoscopy Clinics in 2008, reflect the fact that NOTES is seeing a resurgence in popularity. Now, eight years later, there is more data to confirm safety, to look at the best options for using natural orifices, and to talk about optimal training scenarios. The Guest Editor has enlisted some of the top experts on NOTES to contribute articles devoted to Seminal Developments: SM Tunnel Technique; Peroral Endoscopic Myotomoy (POEM); Submucosal Tumor Endoscopic Resection; Endoscopic Full Thickness Resection; Submucosal Tunneling for NOTES Procedures Beyond Resection; Pyloromyotomy; New NOTES: Western Perspective; and Why Did the Old NOTES Fail: Lessons Learned that can Guide New NOTES Development.

Widely regarded as a standard clinical resource, this book helps practitioners think outside the mental health box and recognize when a client may need a medical evaluation. Part I provides an accessible overview of symptoms that can be observed in a standard mental status examination and may point to medical illness. Engaging case vignettes and interviewing pointers help readers hone their diagnostic skills. Part II presents concise facts--including basic medical information and physical and mental symptoms--on more than 60 diseases and syndromes. An easy-to-read chart in Part III cross-tabulates all of the disorders and symptoms for quick reference and comparison. New to This Edition *Reflects more than 15 years of advances in medical and mental health knowledge. *Updated throughout for DSM-5. *Additional medical disorders: celiac disease, traumatic brain injury, heavy-metal toxicity, and others. *Updated links to further reading on each health condition. Winner (First Place)--American Journal of Nursing Book of the Year Award, Psychiatric and Mental Health Nursing Category

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The ultimate case-based study guide based on the most popular annual resource in internal medicine-now updated CURRENT Medical Diagnosis and Treatment Study Guide facilitates your analysis of test cases and enhances your recall of internal medicine topics, making it invaluable preparation for any internal medicine examination. This study-enhancing resource covers over 30 core topics that encompass essentials, conditions, presentations, treatment approaches, and diseases seen by general practitioners in the inpatient and outpatient settings. The study guide utilizes content from CMDT to provide a case-based application that tests key concepts in clinical reasoning, clinical problem-solving, and recognition of essential clinical facts. The second edition of CURRENT Medical Diagnosis and Treatment Study Guide is extensively updated and examines the most fundamental issues you need to know to succeed on the clerkship shelf exam in Internal Medicine. The study guide includes an expanded format for a more formal and in-depth review and is perfect for instructors utilizing the main CMDT text. Features case-based coverage of 80 must-know diseases and disorders, from skin and hematologic disorders to infectious disorders For each topic, the study guide includes learning objectives; an expanded list of questions to prompt case analysis; a more detailed emphasis on signs and symptoms, lab findings, imaging studies, and medications; additional discussions on therapeutic procedures and outcomes; and full references

Acute myeloid leukemia (AML) is an aggressive bone marrow cancer associated with high morbidity and mortality and most commonly affects older patient populations. In this book, the clinical presentation of acute myeloid leukemia are presented. Other chapters present the differences in the outcomes of two subtypes of core binding factor (CBF) acute myeloid leukemia (AML); examine the occurrence of the Philadelphia chromosome in AML with core binding factor leukemia; and therapeutic options of older patients with AML.

From the potent properties of X rays evoked in Thomas Mann's Magic Mountain to the miniaturized surgical team of the classic science fiction film Fantastic Voyage, the possibility of peering into the inner reaches of the body has engaged the twentieth-century popular and scientific imagination. Drawing on examples that are international in scope, The Transparent Body examines the dissemination of medical images to a popular audience, advancing the argument that medical imaging technologies are the material embodiment of collective desires and fantasies--the most pervasive of which is the ideal of transparency itself. The Transparent Body traces the cultural context and wider social impact of such medical imaging practices as X ray and endoscopy, ultrasound imaging of fetuses, the filming and broadcasting of surgical operations, the creation of plastinated corpses for display as art objects, and the use of digitized cadavers in anatomical study. In the early twenty-first century, the interior of the body has become a pervasive cultural presence - as accessible to the public eye as to the physician's gaze. Jose van Dijck explores the multifaceted interactions between medical images and cultural ideologies that have brought about this situation. The Transparent Body unfolds the complexities involved in medical images and their making, illuminating their uses and meanings both within and outside of medicine. Van Dijck demonstrates the ways in which the ability to render the inner regions of the human body visible - and the proliferation of images of the body's interior in popular media - affect our view of corporeality and our understanding of health and disease. Written in an engaging style that brings thought-provoking cultural intersections vividly to life, The Transparent Body will be of special interest to those in media studies, cultural studies, science and technology studies, medical humanities, and the history of medicine.

Progressive multifocal leukoencephalopathy (PML) is a rare, disabling and potentially fatal brain infection of the central nervous system (CNS) caused by reactivation of the John Cunningham virus (JCV). The most important risk factor for PML is immunosuppression associated with HIV/AIDS or therapy. Approximately 60 to 80% of the adult population has JC antibodies, but PML is rarely diagnosed. The chapters in this book include research on the pathologic features of PML, the diagnosis, risk factors, pathogenesis, and management strategies.

Manual of Nursing Diagnosis, Thirteenth Edition outlines the major diagnoses listed by NANDA-I in order to help nurses and students create care plans for patients with any range of ailments. Updated and organized to meet the needs of both novices and expert diagnosticians, it includes sample admission assessment guides for critical care, the family, community, and individuals, including adults, infants, and children. Manual of Nursing Diagnosis, Thirteenth Edition is an easy-to-use quick reference that shows how to use diagnoses to guide questions and observations beyond the basic assessment. In addition, it helps nurses and students use diagnostic categories in other clinical activities, including critical paths and quality improvement. New to this edition are the latest NANDA-I changes, including more than 20 new nursing diagnoses, numerous revised nursing diagnoses, and several retired nursing diagnoses.

Studienarbeit aus dem Jahr 2013 im Fachbereich Medizin - Diagnostik, Note: 1,0, SRH Hochschule fur Gesundheit Gera, Sprache: Deutsch, Abstract: Der AVQI ermoglicht maschinelle Stimmfunktionsuntersuchungen nicht nur bei gehaltener Phonation, sondern auch in der gesprochenen Sprache. Er erscheint als vielversprechender Ansatz zu einer alltagsbezogeneren, objektiveren, absoluteren und verlasslicheren Messung organischer und funktioneller Stimmstorungen, wie auch zur Vereinheitlichung der Diagnostik in allen Stadien sprachtherapeutischer Intervention.

Essay aus dem Jahr 1994 im Fachbereich Medizin - Diagnostik, Note: "keine," -, Sprache: Deutsch, Anmerkungen: Die venose Thrombo-Embolie ist sehr haufig. Der Pathologe Prof. U.-N. Riede schrieb im "Taschenatlas der allgemeinen Pathologie" (Thieme, Stuttgart,1998)auf der Seite 410: "Lungenembolie. Vorkommen: 20 % aller Krankenhauspatienten." Die Diagnose der Lungenembolie ist sehr schwierig. Untersuchungen zeigen sehr haufiges Nicht-Erkennen der todlichen Gefahr. Vielleicht liegt das an einer falschen Sichtweise: Die Lungenembolie versteckt sich unter vielen Masken und totet ohne Vorwarnung. Diese Uberlegungen aus dem Jahre 1994 konnten eine neue, mathematische Sichtweise der komplexen Embolie bringen., Abstract: Mein Biochemielehrer starb als junger Gelehrter an einer Lungenembolie. Seit 1975 verfolgt mich das Problem der venosen Thrombose. In der Gottinger Universitatskinderklinik sah ich damals ein junges Madchen mit Schlaganfall, tiefer Beinvenenthrombose. In der Lungenfachklinik Lenglern uberraschte uns der Pathologe immer mit der Schreckensnachricht: "Todliche Lungenembolie." In der Herzchirurgie der Universitat Gottingen und der Bauchchirurgie des Krankenhauses Northeim zeigten sich immer wieder thrombo-embolische Komplikationen. Und auch in der Allgemeinpraxis wurde die Thrombo-Embolie zum Schrecken. Es stellte sich die Frage: Was kann man besser machen? Die Antwort kam aus Gottingen: Krankheit ist besser zu begreifen wenn man sie als mathematischen Korper versteht. Wir mussen weg von den falschen Vorstellungen und Fehldiagnosen hin zur Wahrheit, bevor der Pathologe sie uns zeigt. Diese Arbeit ist der Versuch, die Diagnose einer der haufigsten todlichen Krankheiten in Deutschland zu verbessern: Man muss neue Wege zur Pravention und Therapie suchen. Nicht neue Methoden oder neue Medikamente sind notig, sondern neues Denken Die Embolie ist ein hochkomplexes Krankheitsgeschehen, vergleichbar den komplizierten mathematischen Korpern, welche die Gottinger Mathe

Facharbeit (Schule) aus dem Jahr 2012 im Fachbereich Medizin - Diagnostik, Note: 1,5, - (Akademie fur Rehabilitationsberufe), Sprache: Deutsch, Abstract: Stellen Sie sich folgendes Szenario vor: Sie befinden sich in einem brennenden Krankenhaus. Sie haben nun die Wahl entweder einen Saugling oder 20 Embryonen in Petrischalen zu retten. Wie wurden Sie sich entscheiden?

Studienarbeit aus dem Jahr 2003 im Fachbereich Politik - Politische Systeme - Allgemeines und Vergleiche, Note: 2,0, Albert-Ludwigs-Universitat Freiburg, 20 Quellen im Literaturverzeichnis, Sprache: Deutsch, Abstract: Ziel der Arbeit soll es sein: 1. die Hauptunterschiede der Exekutiven und der Legislative der beiden Lander herauszuarbeiten und was diese fur den politischen Einfluss der jeweiligen Einrichtung (d.h. Staatsoberhaupt, Regierungschef, Parlament) bedeuten. 2. Es soll geklart werden, wohin unter welchen Umstanden sich die politische Entscheidungsgewalt verlagert. Zu Beginn der Arbeit sollen Frankreich und Deutschland einem bestimmtem Typ von Regierungssystem zugeordnet werden. Daraufhin folgt die Analyse der Exekutiven und Legislativen Deutschlands, wobei Aufgaben und Machtbefugnisse des Staatsoberhauptes, des Regierungschefs mit seiner Regierung sowie des Parlaments herausgearbeitet und miteinander in Bezug gesetzt werden. In selbiger Weise wird dann mit der Exekutiven und der Legislativen von Frankreich verfahren. Als dritte grossere Einheit steht ein direkter, zusammenfassender Vergleich an. Die Hauptunterschiede werden nun direkt gegenuber gestellt

Doktorarbeit / Dissertation aus dem Jahr 2011 im Fachbereich Medizin - Diagnostik, Note: 1,5, Georg-August-Universitat Gottingen, Sprache: Deutsch, Abstract: Hintergrund: Bei Patienten mit fortgeschrittenen Erkrankungen in der Palliativversorgung mussen beim Einsatz diagnostischer Massnahmen physische, psychosoziale (und finanzielle) Belastungen besonders sorgfaltig mit dem erhofften therapeutischen Nutzen abgewogen werden. Die Haufigkeit nicht-invasiver Diagnostik in der Palliativversorgung, die bevorzugten Methoden, Anwendungsprobleme und deren therapeutische Relevanz sind jedoch nicht bekannt. Methodik: Die Hospiz- und Palliativerhebung HOPE 2007 erfasste die Anwendung mikrobiologischer und bildgebender Diagnostik bei Palliativpatienten in Deutschland. Ferner wurden 70 Ultraschalluntersuchungen in der eigenen Palliativeinrichtung analysiert und abgeglichen. Bei 691 von insgesamt 3184 Patienten wurde das vorgegebene Modul zur Erfassung diagnostischer Massnahmen (DIA) genutzt. Ergebnisse: Die stationar behandelten Patienten mit DIA (86,1%) wiesen eine im Vergleich zum HOPE-Gesamtkollektiv vergleichbare Altersverteilung und Krankenhausaufenthaltsdauer auf. Bei diesen Patienten nahmen mikrobiologische Untersuchungen 26,1% aller dokumentierten Untersuchungen ein, bildgebende Verfahren 69,1%. Davon nahmen Sonografien mit 67,1% den grossten Anteil an bildgebenden Verfahren auf Palliativstationen ein, wahrend auf onkologischen Stationen eher Rontgenuntersuchungen, CT oder MRT zum Einsatz kamen. Nuklearmedizinische Verfahren wurden selten eingesetzt. In 80,8% der stationar erfassten Falle wurde der Einsatz bildgebender Verfahren als therapeutisch entscheidungsrelevant eingeschatzt. Transportprobleme und Schmerzen unter der Untersuchung waren die am haufigsten benannten Probleme. In der Auswertung eigener Ultraschalluntersuchungen wurden diese haufiger zur prognostischen Einschatzung, weniger mit direkter therapeutischer Konsequenz durchgefuhrt. Hier konnten Transport

Studienarbeit aus dem Jahr 2011 im Fachbereich Medizin - Diagnostik, Note: 1,0, Technische Universitat Dortmund (Institut fur Rehabilitationswissenschaften), Veranstaltung: Projekte zur Verbesserung der Menschen - Gentechnologie und Enhancement, Sprache: Deutsch, Anmerkungen: Rehabilitationspadagogik, Abstract: Pranatale Diagnostik ist zu einem festen Bestandteil der Schwangerenvorsorge in Deutschland und in vielen anderen westlichen Landern geworden. Schwangere Frauen werden nicht nur dahingehend untersucht, dass Komplikationen in der Schwangerschaft oder bei der Geburt fruhzeitig erkannt werden, sondern auch auf genetische Defekte oder Fehlbildungen, die das Ungeborene aufweisen kann. Gerade weil pranataldiagnostische Verfahren heute zur Alltagspraxis von Gynakologen und Geburtshelfern gehoren und zu Routineuntersuchungen fur schwangere Frauen geworden sind, ist es wichtig, sie auf ihre moralische Vertretbarkeit hin zu untersuchen. Ein zentraler Bezugspunkt in der folgenden Betrachtung soll dabei die Verbindung sein, die sich zwischen Befunden der Pranatalen Diagnostik und selektiven Schwangerschaftsabbruchen feststellen lasst. Zunachst sollen fundamentale Aspekte der Phanomene Pranatale Diagnostik" und Schwangerschaftsabbruch" dargelegt werden. Das Kapitel zur pranatalen Diagnostik geht auf einige haufig praktizierte Methoden vorgeburtlicher Diagnostik und die mit ihnen verbundenen Moglichkeiten und Risiken ein. Anschliessend werden die rechtlichen Rahmenbedingungen erlautert, die die Praxis der pranatalen Diagnostik bestimmen. Zum Phanomen Schwangerschaftsabbruch werden ebenfalls Moglichkeiten und Methoden sowie potentielle Risiken desselben thematisiert. Auch hier findet eine Darstellung der rechtlichen Hintergrunde statt, wobei unter anderem auf die Gesetzesanderung zur Abtreibungsregelung von 1995 eingegangen wird. Im zweiten Teil dieser Arbeit wird untersucht, inwiefern pranatale Diagnostik fur sich allein einen ethischen Problembereich darstellt od