0
Your cart

Your cart is empty

Browse All Departments
Price
  • R100 - R250 (18)
  • R250 - R500 (51)
  • R500+ (6,514)
  • -
Status
Format
Author / Contributor
Publisher

Books > Science & Mathematics > Biology, life sciences > Cellular biology > General

Handbook of Cell Signaling (Hardcover, 2nd edition): Ralph A. Bradshaw, Edward A. Dennis Handbook of Cell Signaling (Hardcover, 2nd edition)
Ralph A. Bradshaw, Edward A. Dennis
R10,114 R9,118 Discovery Miles 91 180 Save R996 (10%) Ships in 12 - 17 working days

KEY FEATURES:
* Contains over 350 chapters of comprehensive coverage on cell signaling
* Includes discussion on topics from ligand/receptor interactions to organ/organism responses
* Provides user-friendly, well-illustrated, reputable content by experts in the field
DESCRIPTION:
Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors.

The Evolution of Multicellularity (Hardcover): Matthew D. Herron, Peter L. Conlin, William C. Ratcliff The Evolution of Multicellularity (Hardcover)
Matthew D. Herron, Peter L. Conlin, William C. Ratcliff
R5,555 Discovery Miles 55 550 Ships in 12 - 17 working days

Among the most important innovations in the history of life is the transition from single-celled organisms to more complex, multicellular organisms. Multicellularity has evolved repeatedly across the tree of life, resulting in the evolution of new kinds of organisms that collectively constitute a significant portion of Earth's biodiversity and have transformed the biosphere. This volume examines the origins and subsequent evolution of multicellularity, reviewing the types of multicellular groups that exist, their evolutionary relationships, the processes that led to their evolution, and the conceptual frameworks in which their evolution is understood. This important volume is intended to serve as a jumping-off point, stimulating further research by summarizing the topics that students and researchers of the evolution of multicellularity should be familiar with, and highlighting future research directions for the field.

Molecular Imaging - FRET Microscopy and Spectroscopy (Hardcover): Ammasi Periasamy, Richard Day Molecular Imaging - FRET Microscopy and Spectroscopy (Hardcover)
Ammasi Periasamy, Richard Day
R2,784 Discovery Miles 27 840 Ships in 12 - 17 working days

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

Transformer - The Deep Chemistry of Life and Death (Hardcover, Main): Nick Lane Transformer - The Deep Chemistry of Life and Death (Hardcover, Main)
Nick Lane
R662 R627 Discovery Miles 6 270 Save R35 (5%) Ships in 12 - 17 working days

'One of my favourite science writers' Bill Gates For decades, biology has been dominated by information - the power of genes. Yet in terms of information there is no difference between a living cell and one that died a moment ago. What really animates cells and sets them apart from non-living matter? This question goes back to the flawed geniuses and heroic origins of modern biology. The answer could turn our picture of life on Earth upside down. In Transformer, Nick Lane captures a scientific renaissance that is hiding in plain sight. At its core is a cycle of reactions that transforms inorganic molecules into the building blocks of life, and the reverse - the iconic Krebs cycle that sits at the heart of metabolism. This conflicted merry-go-round of energy and matter has long taunted true understanding. Nick Lane is in the vanguard of scientists now tracing its ramifications across the tree of life. To grasp the Krebs cycle is to fathom the deep coherence of biology. It connects the first photosynthetic bacteria with our own peculiar cells. It links the emergence of consciousness with the inevitability of death. And it puts the subtle differences between individuals in the same grand story as the rise of the living world itself. Life is at root a chemical phenomenon: this is its deep logic.

Molecular Exercise Physiology - An Introduction (Hardcover, 2nd edition): Adam Sharples, James Morton, Henning Wackerhage Molecular Exercise Physiology - An Introduction (Hardcover, 2nd edition)
Adam Sharples, James Morton, Henning Wackerhage
R4,112 Discovery Miles 41 120 Ships in 12 - 17 working days

Second edition of the only comprehensive and student-friendly introduction to molecular exercise physiology available 12 chapter structure around which a complete single-semester course can be built Explains the concepts of exercise physiology at a molecular level in clear, accessible language and relates them to real practical and applied outcomes Covers applications in both sport and health-related physical activity Includes new chapters on the molecular aspects of exercise and cancer, and exercise and metabolic and cardiovascular diseases Every chapter includes useful features such as learning objectives, summaries, structured guides to further reading, review questions, overviews of work by key researchers and box discussions of important contemporary debates

Evolution of Neurosensory Cells and Systems - Gene regulation and cellular networks and processes (Hardcover): Bernd Fritzsch,... Evolution of Neurosensory Cells and Systems - Gene regulation and cellular networks and processes (Hardcover)
Bernd Fritzsch, Karen Elliott
R4,075 Discovery Miles 40 750 Ships in 12 - 17 working days

This book is an overview of primary sensory maps of vertebrates, characterized by continuous and discrete properties. The eight primary sensory maps of vertebrates have unique features and use distinct molecular cues, cell cycle exit, and activity combinations during development, regeneration, and plasticity. As an introduction and overview, the book provides a short overview for all eight sensory senses and presents through evolution and gene regulatory networks, the molecular cues needed for sensory processing. Independent contributions are included for olfactory, vision, trigeminal, taste, vestibular, auditory, lateral line, and electroreception.

Handbook of Tumor Syndromes (Paperback): Dongyou Liu Handbook of Tumor Syndromes (Paperback)
Dongyou Liu
R1,444 Discovery Miles 14 440 Ships in 12 - 17 working days

Tumors/cancers are characterized by uncontrolled growths of abnormal cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs and systems. While about 75%-80% of tumors/cancers arise sporadically without a family connection, 20%-25% appear to be familial (including 10%-15% nonhereditary familial tumors [or familial tumors] and 5%-10% hereditary familial tumors [or hereditary tumors]). As nonhereditary and hereditary familial tumors often show both tumor-related and non-tumor-related (or syndromic) symptoms, they are referred to as tumor syndromes (or cancer susceptibility syndromes). In comparison with sporadic tumors/cancers, tumor syndromes (>300 described so far) tend to occur at a younger age, involve multiple organs and systems, produce multiple (often in a distinct spectrum) and bilateral lesions, form multiple hamartomatous, benign, or precursor lesions; locate in specific site(s), display unique syndromic features, and affect multiple members/generations of a family. This book provides state-of-art and authoritative coverage of nearly 100 tumor syndromes, with chapters presenting overviews of individual tumor syndromes in relation to their biology, epidemiology, pathogenesis, clinical features, diagnosis, treatment, and prognosis. Featuring contributions from oncologists, clinicians, and specialists, the book offers a reliable, comprehensive reference on tumor syndromes for scholars and students of medicine, dentistry, pharmacology, nursing, public health, and other biomedical disciplines. Key Features Reviews the biology, epidemiology, pathogenesis, and clinical features of tumor syndromes Contains up-to-date information on the diagnosis and treatment of tumor syndromes Includes expert coverage from leading oncologists and clinicians Related Titles J. R. McIntosh, Understanding Cancer: An Introduction to the Biology, Medicine, and Societal Implications of This Disease (ISBN 978-0-8153-4535-0) P. S. T. Shanmugam, Understanding Cancer Therapies (ISBN 978-1-1381-9815-9) J. M. Baehring and J. M. Piepmeier, eds., Brain Tumors: Practical Guide to Diagnosis and Treatment (ISBN 978-0-3673-9022-8) D. Liu, Tumors and Cancers: Endocrine Glands - Blood - Marrow - Lymph (ISBN 978-1-4987-2975-8) Dongyou Liu, PhD, has worked at several research and clinical laboratories in Australia and the United States for the past three decades, with a focus on molecular characterization of microbial pathogens and detection of human genetic disorders and tumors/cancers. He is the primary author of more than 50 original research and review articles in various peer-reviewed international journals, the contributor of 197 book chapters, and the editor of more than 10 books.

Dopamine - Endocrine and Oncogenic Functions (Paperback): Nira Ben-Jonathan Dopamine - Endocrine and Oncogenic Functions (Paperback)
Nira Ben-Jonathan
R1,385 Discovery Miles 13 850 Ships in 12 - 17 working days

Dopamine is a small molecule traditionally regarded as a brain-derived neuronal modulator implicated in many neurological and psychiatric disorders. Outside the brain, dopamine fulfills all the criteria of a circulating hormone which affects normal and abnormal functions of multiple organs and regulatory systems and is also involved in many aspects of cancer formation and progression. This book provides a much needed systematic account of dopamine as an endocrine and autocrine/paracrine hormone and fills a major gap in the overall understanding of the production, distribution and actions of this very important molecule. Key Features: Explores the many different faces of dopamine as autocrine, paracrine and endocrine molecule Documents the adverse effects of antipsychotics on dopamine functions Reviews the many ways dopamine affects the cardiovascular, renal and reproductive systems Provides updates on receptor oligomerization and signaling Examines the role of dopamine in tumorigenesis Related Titles Jones, S. ed. Dopamine - Glutamate Interactions in the Basal Ganglia (ISBN 978-0-3673-8197-4) Luo, L. Principles of Neurobiology (ISBN 978-0-8153-4494-0) Sidhu, A. et al., eds. Dopamine Receptors and Transporters (ISBN 978-0-8247-0854-2)

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases (Hardcover): Luis Maria Vaschetto CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases (Hardcover)
Luis Maria Vaschetto
R3,038 Discovery Miles 30 380 Ships in 12 - 17 working days

Provides the current state of the art of genome editing technologies used in basic and applied research. Bring the latest advances in CRISPR/Cas9 technologies for treating genetic diseases. Provides future prospects and directions for clinical research.

Ion and Molecule Transport in Lysosomes (Paperback): Bruno Gasnier, Michael X. Zhu Ion and Molecule Transport in Lysosomes (Paperback)
Bruno Gasnier, Michael X. Zhu
R1,417 Discovery Miles 14 170 Ships in 12 - 17 working days

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

The Kinesin Superfamily Handbook - Transporter, Creator, Destroyer (Paperback): Claire T. Friel The Kinesin Superfamily Handbook - Transporter, Creator, Destroyer (Paperback)
Claire T. Friel
R1,407 Discovery Miles 14 070 Ships in 12 - 17 working days

This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily. Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions. Features: The first book dedicated to the entire kinesin superfamily Enables a fuller understanding of this family of proteins, which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists and medical researchers. Chapter 4 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here. Chapter 11 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.

Organelle and Molecular Targeting (Hardcover): Lara Scheherazade Milane, Mansoor M. Amiji Organelle and Molecular Targeting (Hardcover)
Lara Scheherazade Milane, Mansoor M. Amiji
R6,018 Discovery Miles 60 180 Ships in 12 - 17 working days

We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.

Bioenergetics - A Bridge across Life and Universe (Hardcover): Davor Juretic Bioenergetics - A Bridge across Life and Universe (Hardcover)
Davor Juretic
R5,104 Discovery Miles 51 040 Ships in 12 - 17 working days

Stimulates readers to recognize holistic nature of cellular bioenergetics. Encourages interdisciplinary approach to bioenergetics. Changes paradigm from negative to positive meaning for entropy increase. Connects biological to thermodynamic evolution. Illustrates how beautiful structures contribute to evolution of universe.

Development and Reproduction in Humans and Animal Model Species (Hardcover, 2015 ed.): Werner a. Mueller, Monika Hassel, Maura... Development and Reproduction in Humans and Animal Model Species (Hardcover, 2015 ed.)
Werner a. Mueller, Monika Hassel, Maura Grealy
R2,726 R1,424 Discovery Miles 14 240 Save R1,302 (48%) Ships in 12 - 17 working days

This book describes human development including sexual reproduction and stem cell research with the development of model organisms that are accessible to genetic and experimental analysis in readily understandable texts and 315 multi-colored graphics. The introductory account of model organisms selected from the entire animal kingdom presents general principles, which are then outlined in subsequent chapters devoted to, for example, sexual development; genes controlling development and their contemporary molecular-analysis methods; production of clones and transgenic animals; development of the nervous and circulatory systems; regenerative medicine and ageing. Finally the evolution of developmental toolkits and novelties is discussed including the genetic basis of the enlargement of the human forebrain. Separate boxes are devoted to controversial questions such as the benefits and problems of prenatal diagnostics or the construction of ancient body plans.

Plant Growth Responses for Smart Agriculture - Prospects and Applications (Hardcover): T. Girija, Nandini K., Parvathi M S Plant Growth Responses for Smart Agriculture - Prospects and Applications (Hardcover)
T. Girija, Nandini K., Parvathi M S
R3,044 Discovery Miles 30 440 Ships in 12 - 17 working days

Plant Physiology is a dynamic science which goes on adding knowledge to already characterized basic processes in plants. The past decade has witnessed an unprecedented progress in biological sciences with the advent of innovative technologies viz. recombinant DNA techniques, omics approaches and advanced phenotyping platforms. These tools have helped to redefine many of the already accepted facts of plant life. The present publication will give an insight into the lesser known signals that can influence plant growth and development. Knowledge of plant physiological processes provides the base for research in cognate disciplines such as crop improvement, crop production and crop protection. With the impetus for clean cultivation, information provided in the book can motivate researchers in developing environment-friendly and non-chemical means of improving crop production and activate the innate ability of the plant to enhance their field performance. Note: T&F does not sell or distribute the hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka. This title is co-published with NIPA.

Today's Curiosity is Tomorrow's Cure - The Case for Basic Biomedical Research (Paperback): Steve Caplan Today's Curiosity is Tomorrow's Cure - The Case for Basic Biomedical Research (Paperback)
Steve Caplan
R1,031 Discovery Miles 10 310 Ships in 12 - 17 working days

Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Today's Curiosity is Tomorrow's Cure - The Case for Basic Biomedical Research (Hardcover): Steve Caplan Today's Curiosity is Tomorrow's Cure - The Case for Basic Biomedical Research (Hardcover)
Steve Caplan
R2,297 Discovery Miles 22 970 Ships in 12 - 17 working days

Basic curiosity-driven biomedical science has delivered many of today's most significant medical advances. This book provides clearly explained examples from recent biomedical history and includes convincing arguments for sustaining a robust portfolio of basic research. Intended as an engaging read, which will delight undergraduate and graduate students, as well as scientific researchers, it is full-throated advocacy of basic science. Illustrations and examples include the discoveries of penicillin and insulin, and the breakthrough elucidation of the genetic code. Providing both compelling rationale in support of basic science, and a fascinating look through the history of modern biomedical research, this book highlights with stirring examples why basic biomedical research is so important, and how so many key advances in medicine are derived from basic research. The book also offers a rationale for scientific inquiry and a broader understanding of the history of modern biomedical research missing from today's classrooms. Key Features 1) Provides clear explanations of great scientific discoveries 2) Illustrates connections between basic research findings and modern medicine 3) Includes compelling graphics/diagrams/illustrations 4) Accessible to the general public 5) Offers background for more specialized readers, including researchers as well as those with advanced degrees. Related Titles Staddon, J. Scientific Method: How Science Works, Fails to Work, and Pretends to Work (ISBN 978-1-1382-9536-0) Helliwell, J. R. Skills for Scientific Life (ISBN 978-1-4987-6875-7) MacRitchie, F. Scientific Research as a Career (ISBN 978-1-4398-6965-9)

Histidine Kinases in Signal Transduction (Hardcover): Masayori Inouye, Rinku Dutta Histidine Kinases in Signal Transduction (Hardcover)
Masayori Inouye, Rinku Dutta
R4,093 Discovery Miles 40 930 Ships in 12 - 17 working days

Living cells are constantly sensing environmental changes, and their abilities to sense these changes and adapt to them are essential for their survival. In bacteria, histidine kinases are the major sensors for these environmental stresses, enabling cells to adapt to new growth conditions.
Written by leading experts in the field, this book provides an up-to-date and comprehensive review on the structure and function of histidine kinases. It also provides extensive information on the physiological roles of histidine kinases in bacteria and eukaryotes.
An an essential reference for cell biologists, microbiologists, molecular biologists, and biochemists interested in signal transduction. Experimental biologists and pharmacologists studying signal transduction systems in living organisms will also find it a valuable research tool.
Key Features
* The first comprehensive book on the roles of histidine kinases in cells
* 23 in-depth chapters written by leading experts in the field
* Describes the most recent advances in the field of signal transduction

Guide to Yeast Genetics and Molecular and Cell Biology, Part B, Volume 350 (Paperback): Author Unknown Guide to Yeast Genetics and Molecular and Cell Biology, Part B, Volume 350 (Paperback)
Author Unknown
R4,066 Discovery Miles 40 660 Ships in 12 - 17 working days

This volume and its companion Volume 351 will supplement Volume 194 of MIE. The guides are specifically designed to meet the needs of graduate students and postdocs as well as researchers. Whether an established researcher or newcomer to the field, these volumes will contain all the up-to-date methods needed to study "Genes in Yeast." Procedures are included to enable newcomers to set up a yeast laboratory and to master basic manipulations. Relevant background and reference information will be given for proven procedures that can be used as a guide for developing protocols in a number of disciplines.

Centrosomes and Spindle Pole Bodies, Volume 67 (Paperback): Robert E. Palazzo, Trisha N. Davis Centrosomes and Spindle Pole Bodies, Volume 67 (Paperback)
Robert E. Palazzo, Trisha N. Davis
R3,778 Discovery Miles 37 780 Ships in 12 - 17 working days

Containing a comprehensive collection of convenient and quantitative methods for studying centrosomes, spindle pole bodies and related organelles, this text is a valuable resource for researchers and others interested in studying the role of these organelles in cell replication. Chapters outlining the role of these organelles in other cell functions are also included, and a wide variety of experimental systems for analyzing these organelles are presented. Detailed protocols for experiments are contained in each chapter for researchers to perform in their own labs. This volume outlines key methodologies used to analyze centrosomes and spindle pole bodies, their replication, and reproduction in the clear, well-illustrated style of the METHODS IN CELL BIOLOGY series.

Charnolophagy in Health and Disease - With Special Reference to Nanotheranostics (Hardcover): Sushil Sharma Charnolophagy in Health and Disease - With Special Reference to Nanotheranostics (Hardcover)
Sushil Sharma
R5,438 Discovery Miles 54 380 Ships in 12 - 17 working days

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.

Nonclassical Ion Channels in the Nervous System (Hardcover): Tian-Le Xu Nonclassical Ion Channels in the Nervous System (Hardcover)
Tian-Le Xu; Long-Jun Wu
R5,412 Discovery Miles 54 120 Ships in 12 - 17 working days

Ion channels generate bioelectricity. Recent findings have documented the biophysical properties, the structure, assembly and regulation, and function and dysfunction of nonclassical nervous system ion channels. This book reviews nonclassical ion channel research, ranging from the basic biology, structure, regulations to their functions not only in normal physiology but also neurological disorders, using a variety of cutting-edge techniques and novel animal models.

Genomes 5 (Hardcover, 5th edition): Terry A. Brown Genomes 5 (Hardcover, 5th edition)
Terry A. Brown
R4,699 Discovery Miles 46 990 Ships in 12 - 17 working days

Completely updated and rewritten, with 150 new figures Genomes from a wide variety of organisms included, from viruses to humans Techniques fully integrated into the text, including those investigating the genome, transcriptome, and proteome Coverage of expression, regulation, and evolution is on a genomic scale Short answer questions and in-depth problems at the end of each chapter Same structure as Genomes 3 but streamlined

Systems Biology of Cell Signaling - Recurring Themes and Quantitative Models (Paperback): James Ferrell Systems Biology of Cell Signaling - Recurring Themes and Quantitative Models (Paperback)
James Ferrell
R2,336 Discovery Miles 23 360 Ships in 9 - 15 working days

How can we understand the complexity of genes, RNAs, and proteins and the associated regulatory networks? One approach is to look for recurring types of dynamical behavior. Mathematical models prove to be useful, especially models coming from theories of biochemical reactions such as ordinary differential equation models. Clever, careful experiments test these models and their basis in specific theories. This textbook aims to provide advanced students with the tools and insights needed to carry out studies of signal transduction drawing on modeling, theory, and experimentation. Early chapters summarize the basic building blocks of signaling systems: binding/dissociation, synthesis/destruction, and activation/inactivation. Subsequent chapters introduce various basic circuit devices: amplifiers, stabilizers, pulse generators, switches, stochastic spike generators, and oscillators. All chapters consistently use approaches and concepts from chemical kinetics and nonlinear dynamics, including rate-balance analysis, phase plane analysis, nullclines, linear stability analysis, stable nodes, saddles, unstable nodes, stable and unstable spirals, and bifurcations. This textbook seeks to provide quantitatively inclined biologists and biologically inclined physicists with the tools and insights needed to apply modeling and theory to interesting biological processes. Key Features: * Full-color illustration program with diagrams to help illuminate the concepts * Enables the reader to apply modeling and theory to the biological processes * Further Reading for each chapter * High-quality figures available for instructors to download

Evolutionary Cell Processes in Primates - Genes, Skin, Energetics, Breathing, and Feeding, Volume II (Hardcover): M. Kathleen... Evolutionary Cell Processes in Primates - Genes, Skin, Energetics, Breathing, and Feeding, Volume II (Hardcover)
M. Kathleen Pitirri, Joan T. Richtsmeier
R3,189 Discovery Miles 31 890 Ships in 12 - 17 working days

Many complex traits define the primate condition, including behaviors as fundamental as locomotion and traits as scrutinized as the dentition, and their study reveals dramatic evolutionary change across the primates. Genetic modifications are at the basis of these changes, but transformation of genetic information into phenotypes occurs at the level of the cell, which is the focus of this book. Contributors summarize novel methodologies to analyze the collective behavior of cells in forming tissues and organs influencing physiological functions and anatomical features that enable behaviors. Our goal is to review current knowledge and encourage others to adopt evolutionary cell biology to aid in deciphering the genotype-phenotype map that underlies the diversification of primates, human variation, and human evolution. The contributors to this book utilize advances in genetic analysis and visualization of cells and tissues and merge evolutionary developmental biology with evolutionary cell biology to address questions central to understanding human and primate evolution. Key Features Explores mechanisms underlying trait development, distribution, variation, and evolution, especially with respect to pigmentation, dental formulae, the skeleton, energetics, and temperature-related morphological variation Documents the advantages for anthropologists to work at the level of cells, focusing on how genes provide instructions for cells to make structure and how environment affects the behavior of cells Illustrates the role cell biology plays in pelage growth and pigmentation, facial morphology, melanin production in pigmentation, dental development and tooth loss, and energy expenditure Describes novel methodologies and techniques to analyze environment- and temperature-related influences on phenotypes Demonstrates how significant changes in life history occur at the level of the cell Related Titles Bianchi, L. Developmental Neurobiology (ISBN 978-0-8153-4482-7) King, G. R. Primate Behavior and Human Origins (ISBN 978-1-138-85317-1) Rhys Evans, P. H. The Waterside Ape: An Alternate Account of Human Evolution (ISBN 978-0-367-14548-4)

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Future Stories - A user's guide to the…
David Christian Paperback R350 R280 Discovery Miles 2 800
Cellular Osmolytes - From Chaperoning…
Laishram Rajendrakumar Singh, Tanveer Ali Dar Hardcover R5,304 Discovery Miles 53 040
Mechanisms of Molecular Carcinogenesis…
Johannes Haybaeck Hardcover R5,491 Discovery Miles 54 910
Bioprobes - Biochemical Tools for…
Hiroyuki Osada Hardcover R4,408 Discovery Miles 44 080
Photodynamic Therapy in Veterinary…
Fabio Parra Sellera, Cristiane Lassalvia Nascimento, … Hardcover R5,546 Discovery Miles 55 460
The Song Of The Cell - The Story Of Life
Siddhartha Mukherjee Paperback R345 R270 Discovery Miles 2 700
Biological Adhesives
Andrew M Smith Hardcover R6,311 Discovery Miles 63 110
Molecular Cell Biology with Achieve Pack
Harvey Lodish, Arnold Berk, … Mixed media product R2,679 Discovery Miles 26 790
Chromosome Structure and Aberrations
Tariq Ahmad Bhat, Aijaz Ahmad Wani Hardcover R4,471 Discovery Miles 44 710
Molecular Biology of the Cell
Bruce Alberts, Rebecca Heald, … Hardcover R8,674 R6,485 Discovery Miles 64 850

 

Partners