From the dawn of life itself, every being that has ever lived owes its existence to the cell.

The discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether.

Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better.

Available for the first time with Macmillan's new online learning tool, Achieve, Molecular Cell Biology remains the most authoritative and cutting-edge resource available for the cell biology course. The author team, consisting of world-class researchers and teachers, incorporates medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. Emphasis on experimental techniques that drive advances in biomedical sciences and introduce students to cutting edge research teach students the skills they need for their careers. Achieve, Macmillan's new online learning platform, supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. Featuring new digital resources to engage students and help them to master cell biology concepts, the pairing of a powerful new platform with outstanding biology content provides an unrivaled learning experience.

'David Christian's approach to understanding history can help all of us learn to prepare for the future' - Bill Gates A user's guide to the future: from the algorithms in DNA to why time is like a cocktail glass, interstellar migrations, transhumanism, the fate of the galaxy, and the last black hole... Every second of our lives - whether we're looking both ways before crossing the street, celebrating the birth of a baby, or moving to a new city - we must cope with an unknowable future. How do we do this? And how do we, like most living organisms, manage this impossible challenge quite well (at least most of the time)? David Christian, historian and bestselling author of Origin Story, is renowned for pioneering the emerging discipline of Big History, which surveys the whole of the past. But with Future Stories, he casts his sharp analytical eye forward, offering an introduction to the strange world of the future, and a guide to what we think we know about it at all scales, from the predictive mechanisms of single-celled organisms and tomato plants to the merging of colossal galaxies billions of years from now. Drawing together science, history and philosophy from a huge range of places and times, Christian explores how we prepare for uncertain futures, including the future of human evolution, artificial intelligence, interstellar travel, and more. By linking the study of the past much more closely to the study of the future, we can begin to imagine what the world will look like in the next hundred years and consider solutions to the biggest challenges facing us all.

'David Christian's approach to understanding history can help all of us learn to prepare for the future' - Bill Gates A user's guide to the future: from the algorithms in DNA to why time is like a cocktail glass, interstellar migrations, transhumanism, the fate of the galaxy, and the last black hole... Every second of our lives - whether we're looking both ways before crossing the street, celebrating the birth of a baby, or moving to a new city - we must cope with an unknowable future by telling stories about what will happen next. Where is the future, the place where we set those stories? Can we trust our future stories? And what sort of futures do they show us? David Christian, historian and bestselling author of Origin Story, is renowned for pioneering the emerging discipline of Big History, which surveys the whole of the past. But with Future Stories, he casts his sharp analytical eye forward, offering an introduction to the strange world of the future, and a guide to what we think we know about it at all scales, from the predictive mechanisms of single-celled organisms and tomato plants to the merging of colossal galaxies billions of years from now. Drawing together science, history and philosophy from a huge range of places and times, Christian explores how we prepare for uncertain futures, including the future of human evolution, artificial intelligence, interstellar travel, and more. By linking the study of the past much more closely to the study of the future, we can begin to imagine what the world will look like in the next hundred years and consider solutions to the biggest challenges facing us all.

Available for the first time with Macmillan's new online learning tool, Achieve, Molecular Cell Biology remains the most authoritative and cutting-edge resource available for the cell biology course. The author team, consisting of world-class researchers and teachers, incorporates medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. Emphasis on experimental techniques that drive advances in biomedical sciences and introduce students to cutting edge research teach students the skills they need for their careers. Achieve, Macmillan's new online learning platform, supports educators and students throughout the full range of instruction, including assets suitable for pre-class preparation, in-class active learning, and post-class study and assessment. Featuring new digital resources to engage students and help them to master cell biology concepts, the pairing of a powerful new platform with outstanding biology content provides an unrivalled learning experience.

For more than four decades, Molecular Biology of the Cell has distilled the vast amount of scientific knowledge to illuminate basic principles, enduring concepts, and cutting-edge research. The Seventh Edition has been extensively revised and updated with the latest research, and has been thoroughly vetted by experts and instructors. The classic companion text, The Problems Book, has been reimagined as the Digital Problems Book in Smartwork, an interactive digital assessment course with a wide selection of questions and automatic-grading functionality. The digital format with embedded animations and dynamic question types makes the Digital Problems Book in Smartwork easier to assign than ever before-for both in-person and online classes.

Encyclopedia of Cell Biology, Second Edition, a Six Volume Set, has established itself as a fundamental reference work, providing broad coverage of the field in four main sections (Molecular, Organizational, Functional, Translational and Pathological Aspects of Cell Biology). This second edition revisits and expands each section, with entries on topics not covered in the first edition, including Crispr. The whole work is updated, providing greater coverage of specialized cell function and translational applications, and putting greater emphasis on these topics in graduate/medical teaching. New overview chapters and subsections provide a simplified cell biology text that can be used by instructors. The new version includes a standard template for each chapter, making the content easier to navigate, as well as inserts and graphics which provide summaries of key points in each chapter.

**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEAR 2022** 'As big a topic as life itself; I'm not sure a writer could cover it better' The Times From the prize-winning author of The Emperor of All Maladies, The Song of the Cell tells the vivid, thrilling and suspenseful story of the fundamental unit of life. In the late 1600s, a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, look down their hand-made microscopes. What they see introduces a radical concept that alters both biology and medicine forever. It is the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves, are built from these compartments. Hooke christens them 'cells'. The discovery of cells announced the birth of a new kind of medicine. A hip fracture, a cardiac arrest, Alzheimer's, AIDS, lung cancer - all could be re-conceived as the results of cells, or a cellular ecosystem, functioning abnormally. And all could be treated by therapeutic manipulations of cells. This revolution in cell biology is still in progress: it represents one of the most significant advances in science and medicine. Both panoramic and intimate, this is Siddhartha Mukherjee's most spectacular book yet. 'Brilliant ... medical magic' Daily Telegraph

The threat of climate displacement looms large over a growing number of countries. Based on the more than six years of work by Displacement Solutions in ten climate-affected countries, academic work on displacement and climate adaptation, and the country-level efforts of civil society groups in several frontline countries, this report explores the key contention that land will be at the core of any major strategy aimed at preventing and resolving climate displacement. This innovative and timely volume coordinated and edited by the Founder of Displacement Solutions, Scott Leckie, examines a range of legal, policy and practical issues relating to the role of land in actively addressing the displacement consequences of climate change. It reveals the inevitable truth that climate displacement is already underway and being tackled in countries such as Bangladesh, Kiribati, Papua New Guinea, Solomon Islands, Tuvalu and the United States, and proposes a series of possible land solution tools that can be employed to protect the rights of people and communities everywhere should they be forced to flee the places they call home.

Written and illustrated with unsurpassed clarity, Molecular Biology: Principles and Practice introduces fundamental concepts while exposing students to how science is done. The authors convey the sense of joy and excitement that comes from scientific discovery, highlighting the work of researchers who have shaped-and who continue to shape-the field today. The second edition addresses recent discoveries and advances, corresponding to our ever-changing understanding of molecular biology. There are numerous new figures and photos, along with significantly updated figures in every chapter. There are also new end-of-chapter questions for every chapter and many new Unanswered Questions. This textbook is available with LaunchPad. LaunchPad combines an interactive ebook with high-quality multimedia content and ready-made assessment options, including Learning Curve adaptive quizzing. See 'Instructor Resources' and 'Student Resources' for further information.

Get Insight on the Function of Supercomplexes in Biological Systems Redox Proteins in Supercomplexes and Signalosomes is one of the first books to explore the key role played by redox proteins and their interaction network in a wide range of essential cellular processes in all domains of life. The book explains how the mitochondrial respiratory chain is dynamically organized in supercomplexes even under physiological conditions. It also addresses the impact of supercomplex assembly on mitochondrial morphology, physiology, and biogenesis to shed light on the molecular mechanisms of pathological situations, including aging. Discover the Connection between Bioenergetic Supercomplexes and Signalosomes Compiling state-of-the-art research from leading practitioners in the field, this book gives you guidance on dealing with these biological systems in your investigations. The book shows that supercomplexes and signalosomes provide the link between reductive and systems biology, which enables us to understand how the molecular properties of individual macromolecular components trigger cellular function.

Describes landmark experiments in cell biology and biochemistry Discusses the "How" and "Why" of historically important experiments Includes primary, original data and graphs Emphasizes biological techniques, which helps understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.

Discover everything you need to know about biology, with the simplest most visual guide to the science of life. How do vaccines work? What is special about stem cells? How did we evolve from bacteria? The science of life can be dauntingly complex, and it can be hard to separate "good" science from "bad", fundamental truths from the much-hyped breakthroughs reported in the media. With clear, easy-to-understand graphics and packed with fascinating facts, How Biology Works demystifies both the core biology that may have eluded us at school, and the cutting-edge life science that makes the news, answering the questions that spark our curiosity. With power to every page, this striking science book: - Is illustrated entirely by specially commissioned, boldly coloured, distinctive, flat, vector graphics that explain each topic clearly and engagingly. - Supports the curriculum up to GCSE, but also includes some higher-level topics and cutting-edge biology that makes the news. - Uses clear, distinctive, eye-catching graphics to make even complex biology easy to understand. -Offers a practical, no-nonsense approach to each subject. Building from life's fundamental ingredients, such as carbon and water, the book explains chemical processes in living cells, controlled by the ultimate biochemical, DNA. It shows how DNA is made of units called genes, which are shuffled in each generation of offspring, leading to variation and evolution. It covers topics from school biology, such as how plants work and how animals, including humans, work, and goes on to ecology and biotechnology. Beyond school science, however, it covers the background to the latest medical technology and biotechnology: how gene therapy works, what stem-cell research is achieving, and how our immune systems, boosted by vaccines, are in an arms race with ever-mutating viruses and other pathogens. At DK, we believe in the power of discovery. So why stop there? How Biology Works is part of DK's widely successful How Stuff Works series. Discover the inner workings of the mind with How the Brain Works, succeed in all things science with How Science Works and discover the cosmos like you've never known before with How Space Works. Whatever topic sparks your interests, there's a plethora of knowledge to discover!

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Few, if any, genes have had the same level of impact on the field of evolutionary-developmental biology (evo-devo) as the Hox genes. These genes are renowned for their roles in patterning the body plans and development of the animal kingdom. This is complemented by the distinctive organisation of these genes in the genome, with them frequently being found as clusters in which gene position is linked to when and where the individual genes are expressed, particularly during embryogenesis. This book provides the latest overviews of Hox gene organisation and function for major clades of animals from across the animal kingdom. With the rapidly increasing availability of high-quality whole genome sequences from an ever-expanding range of species, it is becoming increasingly evident that there is great diversity in the organisation of Hox genes. These great strides in genome sequencing are wedded to important developments in our ability to detect expression and disrupt gene function in species that are not traditionally genetically-amenable animals. These technical developments are integrated with wide taxon-sampling in this volume to provide new perspectives on the roles of Hox genes in understanding fundamental issues such as embryo patterning, mechanisms of gene regulation, homology, evolvability, evolutionary novelties, phylogeny, the role of gene and genome duplications in evolution, and ancestral states for major clades of animals. Key features Integrative overviews from major animal groups including, arthropods, vertebrates, echinoderms, mollusks and other spiralians. Perspectives gleaned from the latest genome sequence and gene expression data. Individual chapters written by world-leading experts in Hox genes and evo-devo in each animal group. Related Titles Scholtz, G., ed. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1) Mattick, J. & P. Amaral. RNA, The Epicenter of Genetic Information (ISBN 978-0-3675-6778-1) Bard, J. Evolution: The Origins and Mechanisms of Diversity (ISBN 978-0-3673-5701-6)

Research in the field of senescence has boomed recently due to the gradual realization that senescent cells are associated with a significant number of diseases. The genetic or pharmacological elimination of senescent cells can cause widespread benefits and improves outcomes for most of those diseases. Cellular Senescence in Diseases presents an updated review of the role of cellular senescence in multiple pathologies. Focus is given to those diseases where the implication of senescence has been more extensively documented, such as (cancer, lung and liver diseases, diabetes, Neurodegenerative diseases and others). The Editors recruited a group of worldwide experts in each individual pathology to review the role of cellular senescence in each one of them, aiming at identifying potential therapeutic pathways. The first two chapters provide an overview of the cellular senescence principles. Next, the chapters are divided into specific diseases. Cancer, including premalignant lesions (OIS), Advanced disease (TIS), and Metastasis are covered. The following condition covered is Lund diseases, including IPF, COPD, and Pulmonary Hypertension. Next Liver Diseases are covered, including Fibrosis and Cirrhosis, and Fatty liver disease. Next there is coverage for Kidney implications, including fibrosis and transplantation. Vascular diseases are covered next including infarction and hear fibrosis, and atherosclerosis. Both diabetes types 1 and 2 are covered next. Following chapters cover Obesity, Sarcopenia, and Bone and Cartilage disorders, respectively. Neurodegenerative diseases are covered next, focusing on Alzheimer and Parkinson. The next chapter discusses accumulation of senescent cell in tissues during aging. The two final chapters cover current developments and conclusions. Cellular Senescence in Diseases is designed for researchers and clinicians with a focus on the cellular mechanisms of diseases. All chapters cover current experimental therapeutic approaches to eliminate or cancel the pathological effects of senescent cells. Pharmaceutical scientists may also benefit from the contents of the book in the exploration of novel therapeutic opportunities.

Stem cell research is one of the fascinating areas of contemporary biology, but, as with many expanding fields of scientific inquiry, research on stem cells raises scientific questions as rapidly as it generates discoveries. Research on stem cell treatment continues to advance knowledge about how an organism develops from a single cell and how healthy cells replace damaged cells in adult organisms. The most important potential application of human stem cells is the generation of cells and tissues that could be used for cell-based therapies, especially oncology. The Faculty of Medicine, Universitas Sumatera Utara, collaborated with the center of excellence and innovation (Pusat Unggulan Inovasi /PUI). The Stem Cell center of the Universitas Sumatera Utara (USU) organized an International Conference. The International Stem Cell and Oncology Conference (ISCOC) 2017 was a comprehensive academic conference in the field of stem cell and oncology research and also tropical medicine and related scientific topics. We expect Stem Cell Oncology will benefit academics and practitioners in the field of health sciences in Indonesia. This is an Open Access ebook, and can be found on www.taylorfrancis.com.

The new edition of Gene Control has been updated to include significant advances in the roles of the epigenome and regulatory RNAs in gene regulation. The chapter structure remains the same: the first part consists of pairs of chapters that explain the mechanisms involved and how they regulate gene expression, and the second part deals with specific biological processes (including diseases) and how they are controlled by genes. Coverage of methodology has been strengthened by the inclusion more explanation and diagrams. The significant revision and updating will allow Gene Control to continue to be of value to students, scientists and clinicians interested in the topic of gene control.

From Nobel Prize winner Venki Ramakrishnan 'Beyond superb' Bill Bryson 'A wonderful book' Ian McEwan Everyone knows about DNA, the essence of our being, the molecule where our genes reside. But DNA by itself is useless without a machine to decode the genetic information it contains. The ribosome is that machine. Venki Ramakrishnan tells the story of the race to uncover its enormously complex structure, a fundamental breakthrough that resolves an ancient mystery of life itself.

Histochemistry and cytochemistry are important fields for studying the inner workings of cells and tissues of the body. While visualization techniques have been in use for many years, new methods of detection developed recently help researchers and practitioners better understand cell activity. Histochemical and Cytochemical Methods of Visualization describes the essential techniques that can be used for histochemical investigations in both light and transmission electron microscopy. The book begins by discussing techniques in light microscopy. It reviews classical methods of visualization, histochemical and histoenzymatic methods, and methods used to visualize cell proliferation and apoptosis. Next, the book examines the cytochemical methods used in electron microscopy with traditional techniques, as well as more specialized methods. The final section provides an overview of image analysis and describes how image processing methods can be used to extract vital information. A 16-page insert supplies color illustrations to enhance the text. Techniques will continue to adapt to the latest technological innovations, allowing more and more precise quantification of images. These developments are essential to the biological as well as the medical sciences. This manual is a critical resource for novice and experienced researchers, technicians, and students who need to visualize what happens in the cell, the molecules expressed, the main enzymatic activities, and the repercussions of the molecular activities upon the structure of the cells in the body.

Encyclopedia of Respiratory Medicine, Second Edition, Six Volume Set explores the key processes of lung diseases and their diagnosis and management. The book dissects the molecular and cellular biology, physiology and immunology that underpin normal lung function, along with the aberrations that occur in respiratory diseases, from common disorders such as asthma and COPD to rarer lung diseases such as cystic fibrosis, interstitial lung diseases and pulmonary hypertension. Written in at a time when the globe is in the grip of respiratory pandemic, lung disease has never been so prominent in the public and political conscious. This new edition will provide new researchers in respiratory medicine with a solid foundation in unfamiliar topics and will update more experienced researchers seeking to step outside their core areas of research to put their work into a broader context.

This important book traces the history of genetics and genomics policy in Britain. Detailing the scientific, political, and economic factors that have informed policy and the development of new health services, the book highlights the particular importance of the field of Public Health Genomics. Although focused primarily on events in Britain, the book reveals a number of globally applicable lessons. The authors explain how and why Public Health Genomics developed and the ways in which genetics and genomics have come to have a central place in many important health debates. Consideration of their ethical, social, and legal implications and ensuring that new services that are equitable, appropriate, and well-targeted will be central to effective health planning and policymaking in future. The book features: Interviews with leading individuals who were intimately involved in the development of genetics and genomics policy and Public Health Genomics Insights from experts who participated in a pair of 'witness seminars' Historical analysis exploiting a wide range of primary sources Written in a clear and accessible style, this book will be of interest to those involved in the research and practice of genetics, genomics, bioethics, and population health, but also to NHS staff, policymakers, politicians, and the public. It will also be valuable supplementary reading for students of the History of Medicine and Health, Public Health, and Biomedical Sciences.

Documents the confused early history of DNA, RNA and proteins - a transformative history of molecular biology like no other. Integrates the influences of biochemistry and genetics on the landscape of molecular biology. Chronicles the important discoveries, preconceptions and misconceptions that retarded or misdirected progress. Highlights major pioneers and contributors to molecular biology, with a focus on RNA and noncoding DNA. Summarizes the mounting evidence for the central roles of non-protein-coding RNA in cell and developmental biology. Provides a thought-provoking retrospective and forward-looking perspective for advanced students and professional researchers.

Author Prof Jim Lynch is widely known and very experienced, well-connected with wide international networks, and globally distinguished. He was awarded the UNESCO Prize in Microbiology and Einstein Medal and Distinguished Scientist of the US Department of Agriculture. His OUP textbook Soil Microbiology was a bestseller. Taps directly into the topical area of the COVID-19 pandemic and One Health. Affordable and accessible to a wide interdisciplinary audience.