0
Your cart

Your cart is empty

Browse All Departments
Price
  • R100 - R250 (18)
  • R250 - R500 (51)
  • R500+ (6,498)
  • -
Status
Format
Author / Contributor
Publisher

Books > Science & Mathematics > Biology, life sciences > Cellular biology > General

Suppression and Regulation of Immune Responses - Methods and Protocols, Volume II (Hardcover, 1st ed. 2016): Maria Cristina... Suppression and Regulation of Immune Responses - Methods and Protocols, Volume II (Hardcover, 1st ed. 2016)
Maria Cristina Cuturi, Ignacio Anegon
R4,590 R3,833 Discovery Miles 38 330 Save R757 (16%) Ships in 12 - 17 working days

This second volume expands upon the previous edition with new research and objectives in immunoregulation and immune tolerance. Chapters cover topics ranging from new molecular and cellular mechanisms of tolerance; generation and characterization of mice regulatory macrophages; recent advances in the treatment of immune-mediated inflammatory disorders; and novel mechanisms and therapeutic perspectives on food allergies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II is a great resource for current research and inspiration for new studies in immune tolerance.

The Actin Cytoskeleton (Hardcover, 1st ed. 2017): Brigitte M Jockusch The Actin Cytoskeleton (Hardcover, 1st ed. 2017)
Brigitte M Jockusch
R9,032 Discovery Miles 90 320 Ships in 10 - 15 working days

Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.

From Proteins to Proteomics - Basic Concepts, Techniques, and Applications (Hardcover): Sanjeeva Srivastava From Proteins to Proteomics - Basic Concepts, Techniques, and Applications (Hardcover)
Sanjeeva Srivastava
R3,467 Discovery Miles 34 670 Ships in 12 - 17 working days

Basics of proteins and proteomics techniques In-depth understanding of mass-spectrometry and quantitative proteomics An overview of interactomics and its application for translational research. Advancement in the field of proteomics and challenges in clinical applications.

Biomaterials for Musculoskeletal Regeneration - Applications (Hardcover, 1st ed. 2017): Bikramjit Basu, Sourabh Ghosh Biomaterials for Musculoskeletal Regeneration - Applications (Hardcover, 1st ed. 2017)
Bikramjit Basu, Sourabh Ghosh
R4,079 Discovery Miles 40 790 Ships in 10 - 15 working days

This book discusses a number of case studies to showcase the translation of research concepts to lab-scale materials development for biomedical applications. The book intends to motivate active researchers to develop new generation biomaterials. This book is meant for readers, who are already familiar with the broad area of biomaterials. The book introduces readers to the field of additive manufacturing of biomaterials and teaches them how to extend this innovative processing approach to a variety of biomaterials for musculoskeletal applications. It covers both in vitro and in vivo biocompatibility and toxicity assessment for a broad range of biomaterials in the context of bone tissue engineering. It works to sensitise researchers in the field of translational biomedical engineering on the importance of clinical trials and discusses the challenges ahead in this important field of research. This book will be useful to clinicians, professionals and researchers alike.

Cellular Patterns (Paperback): Antonio Siber, Primoz Ziherl Cellular Patterns (Paperback)
Antonio Siber, Primoz Ziherl
R1,420 Discovery Miles 14 200 Ships in 12 - 17 working days

The mechanics underlying the form and structure of biological tissues is being increasingly investigated and appreciated, with new results appearing at a fast pace. Cellular Patterns covers the salient elements of this thriving field of research in a textbook style, including both historic landmark results and recent achievements. By building on concepts such as packing, confinement, surface tension, and elastic instabilities, the book explains the structure and the shape of sheet-like and bulk tissues by adapting the mechanics of continuous media to living matter. It reviews experimental results and empirical laws, and wherever possible, it discusses more than a single theoretical interpretation of a given phenomenon. The in-depth treatment of technical details, the many boxes summarizing essential physical and biological ideas, and an extensive set of problems make this book suitable as a complementary textbook for a graduate course in biophysics and as a standalone reference for students and researchers in biophysics, bioengineering, and mathematical biology interested in the mechanics of tissue. Features: Provides an overview of patterns and shapes seen in animal tissues in addition to an interpretation of these structures in terms of physical forces and processes Contains detailed analysis and a critical comparison of mechanical models of cells, tissues, and morphogenetic movements Presents a visually rich style which is accessible to physicists and biologists alike

Motor Proteins and Molecular Motors (Paperback): Anatoly B. Kolomeisky Motor Proteins and Molecular Motors (Paperback)
Anatoly B. Kolomeisky
R1,407 Discovery Miles 14 070 Ships in 12 - 17 working days

A Unified Microscopic Approach to Analyzing Complex Processes in Molecular Motors Motor Proteins and Molecular Motors explores the mechanisms of cellular functioning associated with several specific enzymatic molecules called motor proteins. Motor proteins, also known as molecular motors, play important roles in living systems by supporting cellular transport and force generation via the transformation of chemical energy into mechanical work. The book presents established results, theoretical methods, and experimental observations related to biological molecular motors. It uses fundamental physical-chemical concepts and methods to develop a systematic theoretical framework for understanding motor protein dynamics. The author introduces the main ideas using simple arguments that avoid heavy mathematical derivations in favor of more intuitive physical understanding. Although the book assumes some rudimentary knowledge of cell biology, calculus, and basic ideas from chemistry and physics, it gives explanations and derivations for most results. Accessible to students and researchers in a wide range of scientific fields, this book provides a unified molecular picture for analyzing motor proteins. It connects major experimental facts on molecular motors to principal theoretical concepts consistent with the fundamental laws of chemistry and physics.

Ion and Molecule Transport in Lysosomes (Hardcover): Bruno Gasnier, Michael X. Zhu Ion and Molecule Transport in Lysosomes (Hardcover)
Bruno Gasnier, Michael X. Zhu
R3,922 Discovery Miles 39 220 Ships in 12 - 17 working days

Lysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research

The Kinesin Superfamily Handbook - Transporter, Creator, Destroyer (Hardcover): Claire T. Friel The Kinesin Superfamily Handbook - Transporter, Creator, Destroyer (Hardcover)
Claire T. Friel
R3,911 Discovery Miles 39 110 Ships in 12 - 17 working days

This book brings together current information on the families that make up the kinesin superfamily of molecular motors in one comprehensive text; an ideal reference for researchers looking to make comparisons between different families, for specific information on an individual family, or simply for an overview of the kinesin superfamily. Information is clearly structured and grouped according to individual families and organised in a standardised way, allowing the reader to easily search and retrieve information on this large superfamily of molecular motors and understand how its individual members carry out a diverse variety of cellular functions. Features: The first book dedicated to the entire kinesin superfamily Enables a fuller understanding of this family of proteins, which is becoming an increasing focus of research due to its involvement in diseases such as cancer, neuropathies and ciliopathies Written in a manner accessible to a range of researchers in the life and medical sciences, including biophysicists, biochemists and medical researchers. Chapter 4 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here. Chapter 11 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.here.

Biophysical Chemistry (Paperback): Dagmar Klostermeier, Markus G. Rudolph Biophysical Chemistry (Paperback)
Dagmar Klostermeier, Markus G. Rudolph
R1,705 Discovery Miles 17 050 Ships in 9 - 15 working days

Biophysical Chemistry explores the concepts of physical chemistry and molecular structure that underlie biochemical processes. Ideally suited for undergradate students and scientists with backgrounds in physics, chemistry or biology, it is also equally accessible to students and scientists in related fields as the book concisely describes the fundamental aspects of biophysical chemistry, and puts them into a biochemical context. The book is organized in four parts, covering thermodynamics, kinetics, molecular structure and stability, and biophysical methods. Cross-references within and between these parts emphasize common themes and highlight recurrent principles. End of chapter problems illustrate the main points explored and their relevance for biochemistry, enabling students to apply their knowledge and to transfer it to laboratory projects. Features: Connects principles of physical chemistry to biochemistry Emphasizes the role of organic reactions as tools for modification and manipulation of biomolecules Includes a comprehensive section on the theory of modern biophysical methods and their applications

Cellular Processes in Segmentation (Hardcover): Ariel Chipman Cellular Processes in Segmentation (Hardcover)
Ariel Chipman
R3,196 Discovery Miles 31 960 Ships in 12 - 17 working days

The evolution of segmentation is one of the central questions in evolutionary developmental biology. Indeed, it is one of the best case studies for the role of changes in development in the evolution of body plans. Segmented body plans are believed to have appeared several times in animal evolution, and to have contributed significantly to the evolutionary success of the taxa in which they are present. Because of the centrality of the subject, and the continuing interest in understanding segmentation, this book offers an often overlooked focus on the cellular aspects of the process of segmentation, providing an invaluable reference for students of evolutionary developmental biology at all levels. Key Features Explores the role that segmentation has played in the diversity of animals Documents the diverse cellular mechanisms by which segmentation develops Reviews the independent evolutionary origins of segmentation Provides insight into the general patterns of serial homology at the cellular level Related Titles Lynne Bianchi. Developmental Neurobiology (ISBN 978-0-8153-4482-7). Jonathan Bard. Principles of Evolution: Systems, Species, and the History of Life (ISBN 978-0-8153-4539-8). Gerhard Scholtz. Evolutionary Developmental Biology of Crustacea (ISBN 978-9-0580-9637-1). Dr. Ariel D. Chipman is Associate Professor in the Department of Ecology, Evolution & Behavior of the Silberman Institute of Life Sciences at The Hebrew University of Jerusalem. He is the author or co-author of dozens of peer reviewed scientific journal articles. His research focuses upon the evolution of animal body plans with a focus on arthropod segmentation, integrating comparative embryology, the fossil record and genome evolution.

New Techniques for Studying Biomembranes (Hardcover): Qiu-Xing Jiang New Techniques for Studying Biomembranes (Hardcover)
Qiu-Xing Jiang
R3,177 Discovery Miles 31 770 Ships in 12 - 17 working days

New Techniques for Studying Biomembranes describes some of the latest methods used to investigate the dynamic distribution of specific lipids in membranes and their effects on other membrane components. The contributors present important discoveries with respect to lipid analysis and lipid interactions with membrane proteins. Various methods, which have been used to study lipid bilayer structure and lipid organization in membranes, include both in vitro and in vivo membrane systems, and study membrane proteins in various membrane systems. Key Features: Reviews both in vivo and in vitro analytical technologies and methods for studying membrane structure and function Explores how lipid bilayers and membrane proteins interact Includes contributions from an international team of researchers actively studying membrane structure and function Identifies various diseases whose causes are related to membrane proteins Related Titles: Christopher R. Jacobs, Hayden Huang, and Ronald Y. Kwon. Introduction to Cell Mechanics and Mechanobiology (ISBN 978-0-8153-4425-4) Wendell Lim and Bruce Mayer. Cell Signaling: Principles and Mechanisms (ISBN 978-0-8153-4244-1) Stephen Rothman. Proteins Crossing Membranes: A Scientist's Memoir (978-0-3670-7449-4)

The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases (Hardcover, 1st ed. 2019): Kenneth V. Honn, Darryl C.... The Role of Bioactive Lipids in Cancer, Inflammation and Related Diseases (Hardcover, 1st ed. 2019)
Kenneth V. Honn, Darryl C. Zeldin
R3,671 Discovery Miles 36 710 Ships in 12 - 17 working days

The Organizing Committee of the 15th International Conference on Bioactive Lipids in Cancer, Inflammation and Related Diseases compiled a group of junior investigators to provide reviews on the topics they presented at the Puerto Vallarta Bioactive Lipids conference, as part of the book series, Advances in Experimental Medicine and Biology (AEMB). The book in this series will be titled Bioactive Lipids in Cancer, Inflammation and Related Diseases. Topics range from all classes of lipids including prostaglandins, resolvins, spingolipids, P450-derived lipids, endocannabanoids and phospholipids. The focus includes physiology, cell biology, and structural studies in organisms from bacteria to humans and how these studies addressed the role of lipids in various disease i.e. cancer, inflammation, diabetes, obesity, cardiovascular disease and others.

Yeast Membrane Transport (Hardcover, 1st ed. 2016): Jose Ramos, Hana Sychrova, Maik Kschischo Yeast Membrane Transport (Hardcover, 1st ed. 2016)
Jose Ramos, Hana Sychrova, Maik Kschischo
R4,471 Discovery Miles 44 710 Ships in 10 - 15 working days

This contributed volume reviews the recent progress in our understanding of membrane transport in yeast including both Saccharomyces cerevisiae and non-conventional yeasts. The articles provide a summary of the key transport processes and put these in a systems biology context of cellular regulation, signal reception and homeostasis. After a general introduction, readers will find review articles covering the mechanisms and regulation of transport for various substrates ranging from diverse nutrients to cations, water and protons. These articles are complemented by a chapter on extremophilic yeast, a chapter on the mathematical modelling of ion transport and two chapters on the role of transport in pathogenic yeasts and antifungal drug resistance. Each article provides both a general overview of the main transport characteristics of a specific substrate or group of substrates and the unique details that only an expert working in the field is able to transmit to the reader. Researchers and students of the topic will find this book to be a useful resource for membrane transport in yeast collecting information in one complete volume, which is otherwise scattered across many papers. This might also be interesting for scientists investigating other species in order to compare transport mechanisms with known functions in yeast with the cells on which they work.

Embryonic Stem Cell Protocols (Hardcover, 3rd ed. 2016): Kursad Turksen Embryonic Stem Cell Protocols (Hardcover, 3rd ed. 2016)
Kursad Turksen
R4,577 Discovery Miles 45 770 Ships in 10 - 15 working days

This extensive volume explores areas of intense activity related to the very early commitment of stem cells to particular lineages and the progression of differentiation to mature cell stages. Research on embryonic stem cells continues to move very quickly, thus the kinds of studies continue to expand and diversify, and methodologies are continuously being refined and improved, which this book reflects. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions on their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and fully updated, Embryonic Stem Cell Protocols, Third Edition serves as an ideal reference for researchers investigating this rich area of study.

Antibacterial Surfaces (Hardcover, 1st ed. 2015): Elena Ivanova, Russell Crawford Antibacterial Surfaces (Hardcover, 1st ed. 2015)
Elena Ivanova, Russell Crawford
R4,358 R3,601 Discovery Miles 36 010 Save R757 (17%) Ships in 12 - 17 working days

'Antibacterial Surfaces' covers the advances being made in the design of antibacterial surfaces, which have the ability to either prevent the initial attachment of bacterial cells, or kill any cells that come into contact with these surfaces. This book discusses the mechanisms associated with the attachment of bacteria to surfaces and the main strategies currently being employed to control the initial attachment processes. These strategies are expanded upon in the subsequent chapters, where the definition and description of antibacterial surfaces are clarified, as are the mechanisms that come into play when determining the effectiveness of an antibacterial surface. Subsequent chapters discuss a number of naturally occurring antibacterial surfaces, the methods currently being used for producing synthetic antibacterial surfaces, and the current and potential applications of such materials. This book will be of great interest to people who work with materials that need to remain free of bacterial films, from designing safer biomedical implants to the production of self-cleaning materials where the prevention of biofilm formation has significant economic advantages.

Cartilage Tissue Engineering - Methods and Protocols (Hardcover, 1st ed. 2015): Pauline M. Doran Cartilage Tissue Engineering - Methods and Protocols (Hardcover, 1st ed. 2015)
Pauline M. Doran
R3,893 Discovery Miles 38 930 Ships in 12 - 17 working days

This volume aims to describe clearly and in detail the key practical skills involved in cartilage tissue engineering. Methods are outlined for isolation and expansion of chondrocytes and stem cells; differentiation; synthesis and application of three-dimensional scaffolds; design and operation of bioreactors; in vivo testing of engineered constructs; and molecular and functional analysis of cartilage cells and tissues. Frequently used technologies are covered, as well as more recent advances in inspirational areas such as 'smart' biomaterial development, novel bioreactor design, -omics analysis, and genetic manipulation of matrix synthesis. The key procedures discussed either underpin the progress already achieved in cartilage tissue engineering or are indicative of the direction of future research in the area. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible step-by-step laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Cartilage Tissue Engineering: Methods and Protocols is a useful resource that informs the scientific community about the experimental work covering a broad range of objectives for cartilage synthesis and regeneration.

The Cell - A Visual Tour of the Building Block of Life (Hardcover): Jack Challoner The Cell - A Visual Tour of the Building Block of Life (Hardcover)
Jack Challoner
R1,105 R907 Discovery Miles 9 070 Save R198 (18%) Ships in 10 - 15 working days

The cell is the basic building block of life. In its 3.5 billion years on the planet, it has proven to be a powerhouse, spreading life first throughout the seas, then across land, developing the rich and complex diversity of life that populates the planet today. With The Cell: A Visual Tour of the Building Block of Life, Jack Challoner treats readers to a visually stunning tour of these remarkable molecular machines. Most of the living things we're familiar with--the plants in our gardens, the animals we eat--are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role--from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them. The book is an authoritative yet accessible account of what goes on inside every living cell--from building proteins and producing energy to making identical copies of themselves--and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch.

Stem Cells: Basics and Clinical Translation (Hardcover, 1st ed. 2015): Robert Chunhua Zhao Stem Cells: Basics and Clinical Translation (Hardcover, 1st ed. 2015)
Robert Chunhua Zhao
R5,712 Discovery Miles 57 120 Ships in 12 - 17 working days

This book provides a comprehensive review of the properties of various stem cell types, the mechanisms of their behaviors and their potential clinical application. Stem cells have a great capacity of self-renewal and differentiation. They represent new paradigms for disease treatment in the field of regenerative medicine since the day they were discovered. As stem cell research is complicated and making progress rapidly, it is important to have expertise in this field to share their views and perspectives. This book provides a wonderful platform for those who are interested in stem cells to learn from and communicate with experts. Particularly, it highlights the roles of stem cell based therapy for a variety of diseases. Furthermore, this book gives a detailed introduction to the great works related to stem cells in China. The readers could gain a profound knowledge of the state-of-art research done by scientists in the field of stem cells. Overall, this book will be a valuable reference resource for both experienced investigators pursuing stem cell research as well as those are just entering into this field. Dr. Robert Chunhua Zhao, a Cheung Kong Professor of Stem Cell Biology, is Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College (PUMC), Beijing, China. He is Director of the Center for Tissue Engineering, PUMC and Chief Scientist of the National Basic Research Program of China ("973 Program"). He also serves as Regional Editor of Stem Cells and Development.

Human Microanatomy - Cell Tissue and Organ Histology with Celebrity Medical Histories (Paperback): Stephen A. Stricker Human Microanatomy - Cell Tissue and Organ Histology with Celebrity Medical Histories (Paperback)
Stephen A. Stricker
R2,557 Discovery Miles 25 570 Ships in 12 - 17 working days

Human Microanatomy is a comprehensive histology text that analyzes human structure and function from the subcellular to organ level of organization. In addition to emphasizing medically relevant information, each chapter considers developmental and evolutionary aspects of microanatomy while also using celebrity medical histories to help provide real-world context for accompanying descriptions of normal histology. The book is richly illustrated with over 1400 full-color micrographs and drawings assembled into cohesive groupings with detailed captions to help elucidate key histological concepts. Text illustrations are further supplemented by hundreds of other light and electron micrographs available in a free digital atlas covering a broad spectrum of microanatomy. Each text chapter also includes a preview, pictorial summary, and self-study quiz to highlight and review essential elements of histology. By incorporating features like medical histories, biological correlates, and various study aids, Human Microanatomy provides an appealing and informative treatment of histology for readers who are interested in the structural bases of cell, tissue, and organ functioning. KEY FEATURES: Uses celebrity medical histories to help provide context for descriptions of normal histology Supplements medically relevant information with developmental and evolutionary correlates of microanatomy Contains 1400+ full-color micrographs and drawings that illustrate a wide range of histological features Offers free access to an ancillary online atlas with hundreds of additional light and electron micrographs Includes helpful study aids such as chapter previews, pictorial summaries, and self-study quizzes Presents a novel and comprehensive account of the structure and function of human cells, tissues, and organs

Tissue Engineering (Paperback): Bernhard Palsson, Jeffrey A. Hubbell, Robert Plonsey, Joseph D. Bronzino Tissue Engineering (Paperback)
Bernhard Palsson, Jeffrey A. Hubbell, Robert Plonsey, Joseph D. Bronzino
R1,787 Discovery Miles 17 870 Ships in 12 - 17 working days

A volume in the new Principles and Applications in Engineering series, Tissue Engineering provides an overview of the major physiologic systems of current interest to biomedical engineers: cardiovascular, endocrine, nervous, visual, auditory, gastrointestinal, and respiratory. It contains useful definitions, tables of basic physiologic data, and an introduction to the literature. Then, the book reviews the status of tissue engineering of specific organs, including bone marrow, skeletal muscle, and cartilage. Readers will acquire a good understanding of the engineering and cell biological fundamentals of tissue engineering and will develop ideas for further development of this emerging and important field.

Structural Biology of the Complement System (Paperback): Dimitrios Morikis, John D. Lambris Structural Biology of the Complement System (Paperback)
Dimitrios Morikis, John D. Lambris
R1,787 Discovery Miles 17 870 Ships in 12 - 17 working days

Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science. Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function. Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology. Structural Biology of the Complement System comes with downloadable resources containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.

Proteinase and Peptidase Inhibition - Recent Potential Targets for Drug Development (Paperback): H. John Smith, Claire Simons Proteinase and Peptidase Inhibition - Recent Potential Targets for Drug Development (Paperback)
H. John Smith, Claire Simons
R1,795 Discovery Miles 17 950 Ships in 12 - 17 working days

Cellular proteinases and their physiological role in normal and disease states have been the subject of great interest over recent decades. At present, specific protease inhibitors are exploited both as tools in unraveling the role of individual proteinases in particular cellular processes and for the development of chemotherapeutic agents for the treatment of various disorders. Proteinase and Peptidase Inhibition presents updated progress reports on the characterization of a wide range of cellular proteinases whose inhibitors may hold the key to the development of new drugs. Introductory chapters deal with the broad enzyme classes, inhibitor types and regulatory mechanisms governing proteinase activity. The target enzymes themselves, together with all aspects of their inhibition and inhibitor design, are comprehensively described. The classification of target enzymes by structural similarity, rather than by pharmacological effects, provides a new and coherent platform for understanding how inhibition of different targets can lead to the same therapeutic outcomes. This is a valuable reference book that will appeal to both academic and industrial researchers in the fields of medicinal chemistry, drug design and development, pharmacology, biochemistry, and molecular and cell biology.

DNA Methyltransferases - Role and Function (Hardcover, 1st ed. 2016): Albert Jeltsch, Renata Z. Jurkowska DNA Methyltransferases - Role and Function (Hardcover, 1st ed. 2016)
Albert Jeltsch, Renata Z. Jurkowska
R7,952 Discovery Miles 79 520 Ships in 12 - 17 working days

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Eosinophils in Allergy and Inflammation (Paperback): Gerald J. Gleich Eosinophils in Allergy and Inflammation (Paperback)
Gerald J. Gleich
R1,896 Discovery Miles 18 960 Ships in 12 - 17 working days

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

The Biophysics of Cell Membranes - Biological Consequences (Hardcover, 1st ed. 2017): Richard M. Epand, Jean-Marie Ruysschaert The Biophysics of Cell Membranes - Biological Consequences (Hardcover, 1st ed. 2017)
Richard M. Epand, Jean-Marie Ruysschaert
R5,014 Discovery Miles 50 140 Ships in 12 - 17 working days

This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.

Free Delivery
Pinterest Twitter Facebook Google+
You may like...
Transgenesis and Secondary Metabolism
Sumita Jha Hardcover R5,828 Discovery Miles 58 280
Understanding Cancer
Robin Hesketh Paperback R369 R302 Discovery Miles 3 020
Photodynamic Therapy in Veterinary…
Fabio Parra Sellera, Cristiane Lassalvia Nascimento, … Hardcover R5,546 Discovery Miles 55 460
The Song Of The Cell - The Story Of Life
Siddhartha Mukherjee Paperback R345 R270 Discovery Miles 2 700
The Neuropilins: Role and Function in…
Gera Neufeld, Ofra Kessler Hardcover R4,414 Discovery Miles 44 140
DNA Replication, Recombination, and…
Fumio Hanaoka, Kaoru Sugasawa Hardcover R5,787 Discovery Miles 57 870
The Song of the Cell - An Exploration of…
Siddhartha Mukherjee Hardcover R778 R638 Discovery Miles 6 380
Understanding Development
Alessandro Minelli Paperback R393 R325 Discovery Miles 3 250
Future Stories - A user's guide to the…
David Christian Paperback R350 R280 Discovery Miles 2 800
Molecular Biology of the Cell
Bruce Alberts, Rebecca Heald, … Hardcover R8,674 R6,485 Discovery Miles 64 850

 

Partners