The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

This volume reviews the drinking water treatments in which AOPs display a high application potential. Firstly it reveals the typical supply sources and limitations of conventional technologies and critically reviews natural organic matter characterization and removal techniques, focusing mainly on AOP treatments. It then explores using AOPs for simultaneous inactivation/disinfection of several types of microorganisms, including highly resistant Cryptosporidium protozoa. Lastly, it discusses relevant miscellaneous topics, like the most promising AOP solid catalysts, the regime change of Fenton-like processes toward continuous reactors, the application of chemometrics for process optimization, the impact on disinfection byproducts and the tracing of toxicity during AOP treatments. This work is a useful reference for researchers and students involved in water technologies, including analytical and environmental chemistry, chemical and environmental engineering, toxicology, biotechnology, and related fields. It is intended to encourage industrial and public-health scientists and decision-makers to accelerate the application of AOPs as technological alternatives for the improvement of drinking water treatment plants.

This book provides an overview of polyolefine production, including several recent breakthrough innovations in the fields of catalysis, process technology, and materials design. The industrial development of polymers is an extraordinary example of multidisciplinary cooperation, involving experts from different fields. An understanding of structure-property and processing relationships leads to the design of materials with innovative performance profiles. A comprehensive description of the connection between innovative material performance and multimodal polymer design, which incorporates both flexibility and constraints of multimodal processes and catalyst needs, is provided. This book provides a summary of the polymerization process, from the atomistic level to the macroscale, process components, including catalysts, and their influence on final polymer performance. This reference merges academic research and industrial knowledge to fill the gaps between academic research and industrial processes. * Connects innovative material performance to the flexibility of multimodal polymer design processes; * Provides a comprehensive description of the polymerization process from the atomic level to the macroscale; * Presents a polyhedric view of multimodal polymer production, including structure, property, and processing relationships, and the development of new materials.

This book covers current advances and practices in machining fibre-reinforced polymer composites under various conventional and nonconventional processes. It presents recent research and practices for effective and efficient machining of difficult-to-cut material, providing the technological 'know-how' on delamination-free of drilling, milling, trimming, and other cutting processes on fibre-reinforced polymer composites. It also guides the reader on the selection of optimum machining parameters, tool materials, as well as tool geometry. This book is of interest to academicians, students, researchers, practitioners, and industrialists working in aerospace, automotive, marine, and construction industries.

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

High Temperature Mechanical Behavior of Ceramic Composites provides an up-to-date comprehensive coverage of the mechanical behavior of ceramic matrix composites at elevated temperatures. Topics include both short-term behavior (strength, fracture toughness and R-curve behavior) and long-term behavior (creep, creep-fatigue, delayed failure and lifetime). Emphasis is on a review of fundamentals and on the mechanics and mechanisms underlying properties.
This is the first time that complete information of elevated temperature behavior of ceramic composites has ever been compacted together in a single volume. Of particular importance is that each chapter, written by internationally recognized experts, includes a substantial review component enabling the new material to be put in proper perspective.
Shanti Nair is Associate Professor at the Department of Mechanical Engineering at the University of Massachusetts at Amherst. Karl Jakus is Professor at the University of Massachusetts at Amherst.

This book volume provides complete and updated information on the applications of Design of Experiments (DoE) and related multivariate techniques at various stages of pharmaceutical product development. It discusses the applications of experimental designs that shall include oral, topical, transdermal, injectables preparations, and beyond for nanopharmaceutical product development, leading to dedicated case studies on various pharmaceutical experiments through illustrations, art-works, tables and figures. This book is a valuable guide for all academic and industrial researchers, pharmaceutical and biomedical scientists, undergraduate and postgraduate research scholars, pharmacists, biostatisticians, biotechnologists, formulations and process engineers, regulatory affairs and quality assurance personnel.

Plasticizer Databook contains data on selection of the most important plasticizers in use today. The selection includes 375 generic and commercial plasticizers. The generic plasticizers contain data for particular chemical compound from numerous sources and these generic plasticizer tables usually contain the most extensive information. The commercial plasticizers include only data given by plasticizer manufacturers. This allows comparison of properties of commercial plasticizers coming from different sources.

The databook was developed to contain data required in plasticizers application. Attempts have been made to include plasticizers used in various sectors of industry to provide information for all users and to help in finding new solutions. Plasticizers included in the book differ from solvents by boiling point, which is above 250oC, but some plasticizers are used as temporary plasticizers or are expected to react with other components of mixture. These substances will not meet the boiling temperature criterion but will still be included since they play role of plasticizers.
Based on the biggest plasticizer database ever published.

Includes 375 generic and commercial plasticizers.

Divided into sections for ease of use.

This comprehensive guide to fan-out wafer-level packaging (FOWLP) technology compares FOWLP with flip chip and fan-in wafer-level packaging. It presents the current knowledge on these key enabling technologies for FOWLP, and discusses several packaging technologies for future trends. The Taiwan Semiconductor Manufacturing Company (TSMC) employed their InFO (integrated fan-out) technology in A10, the application processor for Apple's iPhone, in 2016, generating great excitement about FOWLP technology throughout the semiconductor packaging community. For many practicing engineers and managers, as well as scientists and researchers, essential details of FOWLP - such as the temporary bonding and de-bonding of the carrier on a reconstituted wafer/panel, epoxy molding compound (EMC) dispensing, compression molding, Cu revealing, RDL fabrication, solder ball mounting, etc. - are not well understood. Intended to help readers learn the basics of problem-solving methods and understand the trade-offs inherent in making system-level decisions quickly, this book serves as a valuable reference guide for all those faced with the challenging problems created by the ever-increasing interest in FOWLP, helps to remove roadblocks, and accelerates the design, materials, process, and manufacturing development of key enabling technologies for FOWLP.

This book is based on selected papers from keynote and symposium sessions given at the 16th International Union of Food Science and Technology (IUFoST) World Congress, held in Foz do Iguacu, Brazil August, 2012. The theme of the Congress was the challenges faced by food science in both the developed and developing regions of the world. The symposia featured prominent world-renowned keynote and plenary speakers, young researchers, and the technical sessions covered the whole spectrum of basic and applied food science and technology, including consumer issues and education, diets and health, ethnic foods, and R&D.

This book provides an overview of current issues and challenges in the fashion industry and an update on data-driven artificial intelligence (AI) techniques and their potential implementation in response to those challenges. Each chapter starts off with an example of a data-driven AI technique on a particular sector of the fashion industry (design, manufacturing, supply or retailing), before moving on to illustrate its implementation in a real-world application

Processing of polymer nanocomposites usually requires special attention since the resultant structure-micro- and nano-level, is directly influenced by among other factors, polymer/nano-additive chemistry and the processing strategy. This book consolidates knowledge, from fundamental to product development, on polymer nanocomposites processing with special emphasis on the processing-structure-property-performance relationships in a wide range of polymer nanocomposites. Furthermore, this book focuses on emerging processing technologies such as electrospinning, which has very exciting applications ranging from medical to filtration. Additionally, the important role played by the nanoparticles in polymer blends structures has been illustrated in the current book, with special focus on fundamental aspects and properties of nanoparticles migration and interface crossing in immiscible polymer blend nanocomposites. This book introduces readers to nanomaterials and polymer nanocomposites processing. After defining nanoparticles and polymer nanocomposites and discussing environmental aspects, the second chapter focuses on the synthesis and functionalization of nanomaterials with applications in polymers. A brief overview on nanoclay and nanoclay-containing polymer nanocomposites is provided in third chapter. The fourth chapter provides an overview of the polymer nanocomposites structural elucidation techniques, such as X-ray diffraction and scattering, microscopy and spectroscopy, rheology. The fifth chapter is dedicated to the polymer nanocomposites processing technologies, among which electrospinning, which has very exciting applications ranging from medical to filtration. The last chapter provides an overview on how melt-processing strategy impact structure and mechanical properties of polymer nanocomposites by taking polypropylene-clay nanocomposite as a model system. The book is useful to undergraduate and postgraduate students (polymer engineering, materials science & engineering, chemical & process engineering), as well as research & development personnel, engineers, and material scientists.

In this first book on an additive group of growing importance, the authors review the commercial additives available on the market. The applications chapters provide you with a step by step description of techniques to select and incorporate these additives in various products.

Engineers and scientits involved in polymer processing need practical information about these additives, their applications, and proper and safe handling. Until now much of this information has been difficult to obtain because of commercial secrecy.

In recent years, the applications of fluoropolymer additives have expanded significantly, with even the meaning of fluoropolymer additives expanding from relatively the narrow definition of PTFE powder fillers to a wide variety of fluoropolymer elastomers, used as a processing aid for plastics processing such as extrusion, injection molding, and film blowing. The benefits of fluoropolymer additives used in plastics are the elimination of sharkskin defects, increases in process speed and output (up to 20%), the reduction of die build up, the reduction of gels and optical defects, etc.

In addition, fluropolymer additives are being increasingly used in inks, lubricants, and coatings. For example, in the coating industry fluoropolymer additives can increase the life cycle of exterior coatings due to their excellent weatherability and subsequently increase the time between recoats.

Fluoropolymer additives are becoming more widely used with key applications including

use as a polymer processing aid (increasing speed and reducing faults) and as an additive

to lubricants, inks and coatings. This book is the only practical guide available to the

selection and use of fluoropolymer additives, and will help readers to optimize existing

fluoropolymer applications and implement new ones.

Fluoropolymers are known as an area where detailed information is hard to come by. In

this book two former DuPont employees provide a wide range of industry sectors with the

essential practical information and data they need to realize the full benefits of

fluoropolymer additives.

Written for practicing engineers, Ebnesajjad and Morgan take a highly practical approach

to the subject, based on real-world experience and case studies."

CAMD or Computer Aided Molecular Design refers to the design of molecules with desirable properties. That is, through CAMD, one determines molecules that match a specified set of (target) properties. CAMD as a technique has a very large potential as in principle, all kinds of chemical, bio-chemical and material products can be designed through this technique.
This book mainly deals with macroscopic properties and therefore does not cover molecular design of large, complex chemicals such as drugs. While books have been written on computer aided molecular design relating to drugs and large complex chemicals, a book on systematic formulation of CAMD problems and solutions, with emphasis on theory and practice, which helps one to learn, understand and apply the technique is currently unavailable.
-This title brings together the theoretical aspects related to Computer Aided Molecular Design, the different techniques that have been developed and the different applications that have been reported.
-Contributing authors are among the leading researchers and users of CAMD
-First book available giving a systematic formulation of CAMD problems and solutions

This volume contains papers presented in the third international symposium titled Fatigue of Materials: Advances and Emergences in Understanding held during the Materials Science and Technology 2014 meeting. The book contains contributions from engineers, technologists, and scientists from academia, research laboratories, and industries. The papers are divided into six topical areas: Session 1: Aluminum Alloys Session 2: Ferrous Materials I Session 3: Ferrous Materials II Session 4: Composite Materials Session 5: Advanced Materials Session 6: Modeling The papers cover a broad spectrum of topics that represent the truly diverse nature of the subject of fatigue as it relates to the world of materials.

Significant progress has been made in advanced packaging in recent years. Several new packaging techniques have been developed and new packaging materials have been introduced. This book provides a comprehensive overview of the recent developments in this industry, particularly in the areas of microelectronics, optoelectronics, digital health, and bio-medical applications. The book discusses established techniques, as well as emerging technologies, in order to provide readers with the most up-to-date developments in advanced packaging.

This contributed volume presents an overview of concepts, methods, and applications used in several quantitative areas of drug research, development, and marketing. Chapters bring together the theories and applications of various disciplines, allowing readers to learn more about quantitative fields, and to better recognize the differences between them. Because it provides a thorough overview, this will serve as a self-contained resource for readers interested in the pharmaceutical industry, and the quantitative methods that serve as its foundation. Specific disciplines covered include: Biostatistics Pharmacometrics Genomics Bioinformatics Pharmacoepidemiology Commercial analytics Operational analytics Quantitative Methods in Pharmaceutical Research and Development is ideal for undergraduate students interested in learning about real-world applications of quantitative methods, and the potential career options open to them. It will also be of interest to experts working in these areas.

In the last 10 years organic dyes, traditionally used for coloring textiles and other materials, have become increasingly important in the hi-tech industries of electronics and optoelectronics. They can be used in optical data storage, new solar cells and biomedical sensors.
Functional Dyes discusses the synthesis of these new, high-value dyes and pigments as well as their applications and performance. The chapters are arranged so that the reader logically advances from the fundamental concepts to more practical aspects of the technology in which they are used.
In providing the reader with current information on functional dye chemistry, as well as important developments within the field, Functional Dyes is a valuable information source for dye and material chemists, researchers and graduates, who want a summary of the key advances in the field over the last 10 years and an authoritative view on future developments.
* Provides a broad introduction to the science technology of the functional dye application
* Reviews recent advances on synthesis and characteristics of the functional dyes and their applications
* Is a valuable information source for dye and material chemists and researchers

In Advanced ULSI interconnects - fundamentals and applications we bring a comprehensive description of copper-based interconnect technology for ultra-lar- scale integration (ULSI) technology for integrated circuit (IC) application. In- grated circuit technology is the base for all modern electronics systems. You can ?nd electronics systems today everywhere: from toys and home appliances to a- planes and space shuttles. Electronics systems form the hardware that together with software are the bases of the modern information society. The rapid growth and vast exploitation of modern electronics system create a strong demand for new and improved electronic circuits as demonstrated by the amazing progress in the ?eld of ULSI technology. This progress is well described by the famous "Moore's law" which states, in its most general form, that all the metrics that describe integrated circuit performance (e. g. , speed, number of devices, chip area) improve expon- tially as a function of time. For example, the number of components per chip d- bles every 18 months and the critical dimension on a chip has shrunk by 50% every 2 years on average in the last 30 years. This rapid growth in integrated circuits te- nology results in highly complex integrated circuits with an increasing number of interconnects on chips and between the chip and its package. The complexity of the interconnect network on chips involves an increasing number of metal lines per interconnect level, more interconnect levels, and at the same time a reduction in the interconnect line critical dimensions.