Validation of computer systems is the process that assures the formal assessment and report of quality and performance measures for all the life-cycle stages of software and system development, its implementation, qualification and acceptance, operation, modification, requalification, maintenance and retirement (PICS CSV PI 011-3). It is a process that demonstrates the compliance of computer systems functional and non-functional requirements, data integrity, regulated company procedures and safety requirements, industry standards, and applicable regulatory authority's requirements. Compliance is a state of being in adherence to application-related standards or conventions or regulations in laws and similar prescriptions. This book, which is relevant to the pharmaceutical and medical devices regulated operations, provides practical information to assist in the computer validation to production systems, while highlighting and efficiently integrating worldwide regulation into the subject. A practical approach is presented to increase efficiency and to ensure that the validation of computer systems is correctly achieved.

Develop the untapped possibilities of this potential tourist El Dorado Given its size, location, cultural attractions, and natural beauty, South America gets far less of the international tourist dollar than it deserves. This valuable book identifies and explores the major issues that influence and shape tourism in South America. Tourism in South America includes original empirical research into the image people have of this varied continent, the factors that draw people to visit South America, and the fears, lack of knowledge, and negative images that can keep tourists away.Tourism in South America examines current practices and suggests alternative models of development. Its informative discussions range from cultural tourism to sustainable tourism to developing human resources. The original empirical research in this volume offers unique insights, and reference notes are included.The reader will encounter varied points of view in Tourism in South America. You can expect to: view Australian travel industry perspectives on Latin American tourism explore the impact of tourism on the Argentina's Patagonian Coast examine the environmental tactics that Mexican and Jamaican hotel companies employ survey the recreation preferences of hikers in a Colombian National Park ponder the implications of performing traditional dances for modern tourists in the AmazonTour operators, hotel managers, local tourism boards, and others seeking the attention of tourists will profit from the new strategies and original research presented in Tourism in South America.

In his latest offering, John Davis tackles the "human" side of a lean initiative -- cultivating a lean culture and gaining employee buy-in. How managers deal with these issues will ultimately determine their success. Leading the Lean Initiative: Straight Talk on Cultivating Support and Buy-in shows you how to lead a lean effort and effectively manage change. It is a practical manual for the new manager. Though directed at plant managers, and specifically those new to their jobs, this book benefits anyone taking on a leadership role. Davis provides complete direction on the crucial first steps and advise on competently responding to the "unknown and unexpected." In addition the book covers how to: Gain the respect and active support of the workforce. Work effectively with unions and customers. Create a culture for change. Actively seek out key people in your organization. Diplomatically buck the system. Extend lean to the entire enterprise. Develop and effectively earmark your plan for operation. Cultivate a winning relationship with your boss. Deal with major setbacks in business conditions.Throughout the text, Davis weaves the story of Jim Warring, a plant manager who is new to the job, detailing his frustrations, challenges, and accomplishments, and how he handles the daily responsibilities of a plant manager. At the end of each chapter, Davis rates Warring on how he performed in his role as plant manager and as a leader of the plant's lean initiative by presenting "The Warring Scorecard." Davis points out where he succeeded, and where he made some serious mistakes. Leading the Lean Initiative: Straight Talk on Cultivating Support and Buy-in, is a valuable resource or all managers in any industry. This book will show you how to effectively lead in your organization and how to cultivate a cooperative environment.

This handbook seeks to facilitate the selection, design and operation of large-scale industrial crystallizers that process crystals with the proper size distribution, shape and purity sought - including cooling, evaporation, drowning-out reaction, melt, and related crystallization techniques. This new edition offers new results on direct-contact cooling crystallization. It lists the properties of over 170 organic and inorganic crystallization systems.

Develop the untapped possibilities of this potential tourist El Dorado Given its size, location, cultural attractions, and natural beauty, South America gets far less of the international tourist dollar than it deserves. This valuable book identifies and explores the major issues that influence and shape tourism in South America. Tourism in South America includes original empirical research into the image people have of this varied continent, the factors that draw people to visit South America, and the fears, lack of knowledge, and negative images that can keep tourists away. Tourism in South America examines current practices and suggests alternative models of development. Its informative discussions range from cultural tourism to sustainable tourism to developing human resources. The original empirical research in this volume offers unique insights, and reference notes are included. The reader will encounter varied points of view in Tourism in South America.You can expect to: view Australian travel industry perspectives on Latin American tourism explore the impact of tourism on the Argentina's Patagonian Coast examine the environmental tactics that Mexican and Jamaican hotel companies employ survey the recreation preferences of hikers in a Colombian National Park ponder the implications of performing traditional dances for modern tourists in the Amazon Tour operators, hotel managers, local tourism boards, and others seeking the attention of tourists will profit from the new strategies and original research presented in Tourism in South America.

There is hardly a technical library in the world in which the volumes of the Chemical Formulary (Volumes 1-34) do not occupy a prominent place. It does not duplicate any of the formulas included in previous volumes, but lists a wide array of modern and salable products from all branches of the chemical industries. An excellent reference for formulation problems. - CONTENTS - I. Introduction - II. Adhesives - III. Beverages and Foods - IV. Cosmetics - V. Coatings - VI. Detergents - VII. Drugs - VIII. Metal Treatments - IX. Polishes - X. Elastomers, Polymers and Resins - XI. Miscellaneous - Appendix - Index - PREFACE - Chemistry, as taught in our schools and colleges, concerns chiefly synthesis, analysis, and engineering-and properly so. It is part of the right foundation for the education of the chemist. Many a chemist entering an Industry soon finds that most of the products manufactured by his concern are not synthetic or definite complex compounds, but are mixtures, blends, or highly complex compounds of which he knows little or nothing. The literature in this field, if any, may be meager, scattered, or obsolete. Even chemists with years of experience In one or more Industries spend conslderable time and effort in acquainting themselves with any new field which they may enter. Consulting chemists similarly have to solve problems brought to them from industries foreign to them. There was a definite need for an up-to-date compilation of formulae for chemical compounding and treatment. Since the fields to be covered are many and varied, an editorial board of chemists and engineers engaged in many industries was formed. Many publications, laboratories, manufacturing firms, and Individuals have been consulted to obtain the latest and best information. It is felt that the formulas given in this volume will save chemists and allied workers much time and effort.

Applies an inductive experimental approach to recognize, control, and resolve the variables that effect the wine-making process and the qual ity of the final product{focusing on the grape variety-yeast interacti on controversy. Contains over 300 original drawings, photographs, and photomicrographs-unavailable in any other source-that illustrate the d iagnostic morphology of wine yeast and bacteria used to track wine spo ilage and related problems. Promotes a better understanding of the bio technological phenomena in the wine-making process in which yeast enzy mology plays a key role with plant physiology.

Preparing Participants for Intergenerational Interaction: Training for Success examines established intergenerational programs and provides the training methods necessary for activity directors or practitioners to start a similar program. This book contains exercises that will help you train colleagues and volunteers for these specific programs and includes criteria for activity evaluations. Preparing Participants for Intergenerational Interaction will help you implement programs that enable older adults to build friendships, pass down their skills and knowledge to adolescents, and provide youths with positive role models.Discussing the factors that often limit the interaction of older adults with youths, this text stresses the importance of conveying information and history to younger generations. You will learn why the exchange between different generations is crucial to society and to the improvement of the community in which you live. Preparing Participants for Intergenerational Interaction provides you with proven suggestions and methods that will make your program successful, including: examining Howe-To Industries, a program that teaches entrepreneurial skills to youths through older adults focusing on activities between older adults and youths that address aging sensitivity and racial and ethnic understanding defining the roles of a mentor, including teacher, trainer, developer of talent, and counselor increasing support and understanding in your community by defining target markets and selling the project to the public describing the aspects of group dynamics and how group decisionmaking methods are used to assess the success of the program and its volunteers understanding the community where participants live in order to address issues important to them, such as poverty and other social problems Containing sample handouts, self-evaluations, and detailed lessons for different types of programs, this book offers you guidelines that apply to participants that have a variety of needs within different communities. Preparing Participants for Intergenerational Interaction: Training for Success will enable you to help older adults remain an active and essential part of these communities by teaching youths valuable life skills they may not receive from anyone else.

Why are some work partnerships exceptional while most are not? How can we establish and sustain an enhanced level of cohesion, connection, and collaboration in the most important work relationship, the one between a manager and team? What could remedy the high levels of isolation and anxiety so many feel at work these days? Silver and Franz explore the concept of 'meaningful partnership' in the workplace. They present meaningful partnership as a mindset where both leaders and their teams are fully committed to ensuring the support and success of the other. Then, they describe a model called ERTAP, which stands for Empathy, Respect, Trust, Alignment, and Partnership, which is the foundation for meaningful partnership. Finally, they detail a practical yet transformative relationship-building process referred to as the Workplace Covenant. This enables leaders and teams to create mutual commitments with obligatory weight that help them to feel accountable for the success of the relationship and each other. The book includes real client stories that illustrate the dimensions of partnership and the Workplace Covenant process. Silver and Franz also outline other work relationships that can benefit from meaningful partnership, pitfalls to avoid, relevant research, and insights derived from years of consulting experience. This book is a must-read for leaders interested in a better working relationship with their team; for teams who have critical work partnerships with other teams; for individuals who work closely with other individuals and need an exceptional 1:1 partnership; and finally for third-party experts in HR or continuous improvement who are seeking a new powerful way to help clients feel supported and be more successful.

Reliable methods to predict membrane scaling and fouling are important tools in the control of these phenomena. This dissertation focuses on the development and application of methods to predict and prevent barium sulphate scaling and particulate fouling in membrane filtration systems.

This book contains a selection of papers presented at APME '99 ( Third International Symposium on Advanced Polymers via Macromolecular Engineering --- Colonial Williamsburg, VA, USA, July/August 1999).
The book focuses on the synthesis of targeted polymers with specific properties using macromolecular architecture. Various controlled polymerization techniques such as ionic, metathesis and recently developed 'living'/controlled polymerization and some of their combinations are covered.
Polymers with different topologies such as block and graft copolymers, hyper branched polymers, heteroarm polymers, dentrimers, segmented networks and supramolecular systems are presented with emphasis on the special characteristics that influence their amphiphilic, liquid crystalline, complexation, thermo- and photosensitive and catalytic properties. The uses of such macromolecular structures in various fields such as surface modifiers, catalysts and coating and biomedical applications are also discussed.

This monograph aims to give a comprehensive and detailed review of general results, which have been obtained in a special segment of the design and manufacture of pressure-sensitive products, known as formulation. For manufacturers of pressure-sensitive products and product components, formulation probably includes the main part of their proprietary know-how. The scientific basis of formulation, explaining the reasons behind certain mixing and processing technologies, is doubtless more important than a collection of compositional data and technical parameters. This volume collects technical and scientific materials concerning the most important theoretical and practical aspects of the formulation of pressure-sensitive adhesives.
Based on the author's industrial and scientific experience, this treatise constitutes a theoretical and practical state-of-the-art monograph on the formulation of pressure-sensitive products. It is a practical guide for those who want to study, manufacture or use pressure sensitive products or their components, as well as for suppliers of adhesives, elastomers, plastics and additives, or manufacturing equipment.
This book will be of value and interest to production and manufacturing managers, production engineers, materials scientists, chemists and new product specialists involved in the production or application of pressure-sensitive products.

Sage, the Genus Salvia is one of the most famous and used herbs in the world. This volume, containing over twenty chapters written by leading experts in the field, presents a comprehensive coverage on all aspects of Salvia. Topics covered include the presentation of the most known Salvia species (approximately 400 of them), the distribution of the genus, its chemotaxonomy, ecophysiology, cultivation technology and breeding methods, information on the extraction, isolation, characterisation and structure of a large number of bioactive components, the various pharmacological properties of the species, the share of Salvia products in aromatherapy and the natural cosmetics market, biotechnological techniques, and commercial aspects.

This comprehensive volume on Salvia should be of interest to everyone involved in medicinal and aromatic plant applications and research.

The Handbook of Pharmaceutical Controlled Release Technology reviews the design, fabrication, methodology, administration, and classifications of various drug delivery systems, including matrices, and membrane controlled reservoir, bioerodible, and pendant chain systems. Contains cutting-edge research on the controlled delivery of biomolecules! Discussing the advantages and limitations of controlled release systems, the Handbook of Pharmaceutical Controlled Release Technology -covers oral, transdermal, parenteral, and implantable delivery of drugs -discusses modification methods to achieve desired release kinetics -highlights constraints of system design for practical clinical application -analyzes diffusion equations and mathematical modeling -considers environmental acceptance and tissue compatibility of biopolymeric systems for biologically active agents -evaluates polymers as drug delivery carriers -describes peptide, protein, micro-, and nanoparticulate release systems -examines the cost, comfort, disease control, side effects, and patient compliance of numerous delivery systems and devices -and more!

Illnesses resulting from foodborne pathogens occur at least 6 million times each year and cause an estimated 9,000 deaths. For decades, food microbiologists have developed various effective methods of food protection. However, the constant development of multi-facet food processing technologies and the emergence of potent foodborne pathogens, compromised the efficacy of many antimicrobial interventions. Most technologies also fail to address the problem of bacterial debris remaining on the food surface. Furthermore, some bacteria have the ability to develop resistance to antimicrobial interventions. All such factors contribute to the continuously growing concern of keeping our food safe. Lactoferrin: Natural o Multifunctional o Antimicrobial presents the scientific background on use of this naturally occurring microbial blocking agent as an effective food antimicrobial intervention. THE SOURCE FOR APPLIED SCIENTIFIC INFORMATION ON LACTOFERRIN AS A NATURAL ANTIMICROBIAL INTERVENTION Lactoferrin: Natural o Multifunctional o Antimicrobial details microbial blocking technology to protect foods from harmful microbes. Recently, researchers at the Center for Antimicrobial Research, California State Polytechnic University at Pomona found that lactoferrin, when activated, functions as a potent antimicrobial intervention. It protects food by removing harmful bacteria from the surface, and by starving bacteria before they can multiply and produce harmful toxins and it also prevents bacteria from re-attaching to food surfaces. As a result this substance has potential to help the agribusiness and food industry supply safer food products to consumers. WHY LACTOFERRIN? Studied for 50 years, lactoferrin is known to have many beneficial biological properties as an integral component of the mammalian innate defense system. Lactoferrin is a broad-spectrum antimicrobial known to inhibit proliferation of bacteria, viruses, fungi, and parasites. Some of its current applications include: dietary supplement, ingredient in infant formula, and a medical treatment to boost the immune system. Because lactoferrin occurs naturally in milk products, it has a long track record of being safely consumed by humans. Convenient and affordable, lactoferrin could revolutionize the field of food antimicrobial science and technology and the way we protect ourselves from foodborne pathogens.

A handbook on polyolefins. This second edition includes new material on the structure, morphology and properties of polyolefin (PO) synthesis. It focuses on synthetic advances, the use of additives, special coverage of PO blends, composites and fibres, and surface treatments. It also addresses the problem of interfacial and superficial phenomena.

Consumer concerns play a critical role in dictating the direction of research and development in food protection. The rising demand for minimally processed foods, growing concerns about the use of synthetic preservatives, and suspected links between the overuse of antibiotics and multi-drug resistance in microbes has made food safety a global priority.

Natural Food Antimicrobial Systems focuses on advances in the technology of food safety. Numerous antimicrobial agents exist in animals and plants where they evolved as defense mechanisms. For example, the antimicrobial components of milk have been unraveled in recent years. The book covers how these components - such as lactoferrin - can be used as multifunctional food additives such as antioxidants and immuno-modulating agents.

The six sections cover lacto-antimicrobials, ovo-antimicrobials, phyto-antimicrobials, bacto-antimicrobials, acid-antimicrobials, and milieu-antimicrobials. Each chapter provides background and historical information, molecular properties, antimicrobial activity, biological advantage, applications, safety, tolerance, and efficacy, and biotechnology.

To satisfy the rapidly changing consumption patterns of the global market, the food processing industry continuously searches for new technologies in food science. Designed as a reference for academia and corporate R & D, Natural Food Antimicrobial Systems fills this need, offering in-depth information on emerging biotechnology, efficacy, and applications of natural food antimicrobial systems.

This book is a collection of papers presented at the 7th ISPE International Conference on Concurrent Engineering (CE): Research and Applications. The papers deal with different topics providing information on information modelling, CE in virtual environment, and standards in CE.

The emergence of the book was not merely an event of world historical importance, but the dawn of modernity. In this much praised work, Lucien Febvre and Henri-Jean Martin mesh together economic and technological history, sociology and anthropology, with the study of consciousness itself to root the development of printing in the changing social relations and ideological struggles of Western Europe. Now that the printed page may become a thing of the past, "The Coming of the Book" is more pertinent than ever.
The Verso World History Series This series provides attractive new editions of classic works of history, making landmark texts available to a new generation of readers. Covering a time-span stretching from Ancient Greece and Rome to the twentieth century, and with a global geographical range, the series will also include thematic volumes providing insights into such topics as the spread of print cultures and the history of money.

"Covers recent advances in polymer degradation and stabilization. Focuses on the basics of photo- and bio-degradability. Delineates special and general environmental parameters such as solar irradiation, temperature, and agrochemical exposure. Surveys plastic waste disposal strategies such as recycling, incineration, chemical recovery by pyrolysis, and source reduction."

This volume compiles information from physics, metallurgy, and mechanical and electrical engineering to epitomize the fundamental characteristics of flat rolling steel. Flat Rolling Fundamentals is drawn from in-depth analyses of metal properties and behaviors to technologies in application. The book provides a full characterization of steel, including structure, chemical composition, classifications, physical properties, deformation, and plasticity. The authors present different types of rolling mills and the defining physical analytical parameters.They also discuss the effects of hot rolling on steel and the role of lubrication and thermomechanical treatments to minimize these effects. This book presents qualitative and quantitative advances in cost-effective steel production.

Intended for forensic scientists and students of the discipline, Forensic Interpretation of Glass Evidence provides the practicing forensic scientist with the necessary statistical tools and methodology to introduce forensic glass evidence into the laboratory. With free software available for downloading at the author's Web site, scientists can apply their own data and draw conclusions using principles practiced in the text.
This book contains an introductory chapter on glass evidence procedures and analysis before covering topics such as classical approaches to handling glass evidence, the application of Bayesian statistics to forensic science, and the use of histograms.
By presenting both the physical and chemical examinations performed on glass along with a recommended interpretation, the author allows readers the luxury of having all reference materials contained within a single book. Useful for case-working forensic scientists, this book is ideal for students of forensic science at both the undergraduate and graduate levels, as well anyone currently working in the field.

The ancient Oriental dyestuff madder red was avidly sought by Europeans and finally cracked by the French in 1760, and it became the main crop in the Caspian Caucasus. The quest for Turkey Red spurred an avalanche of research that led to its chemical synthesis in 1870 and subsequently the collapse of the world-wide madder industry.

eBook available with sample pages: 0203400437

"Compiles nearly 400 fully assigned NMR spectra of approximately 300 polymers and polymer additives, representing all major clases of materials: polyolefins, styrenics, acrylates, methacrylates, vinyl polymers, elastomers, polyethers, polyesters, polymides, silicones, cellulosics, polyurethanes, plasticizers, and antioxidants."