This book comprehensively reviews the state-of-the-art strategies developed for protein-protein interaction (PPI) inhibitors, and highlights the success stories in new drug discovery and development. Consisting of two parts with twelve chapters, it demonstrates the design strategies and case studies of small molecule PPI inhibitors. The first part discusses various discovery strategies for small molecule PPI inhibitors, such as high throughput screening, hot spot-based design, computational approaches, and fragment-based design. The second part presents recent advances in small molecule inhibitors, focusing on clinical candidates and new PPI targets. This book has broad appeal and is of significant interest to the pharmaceutical science and medicinal chemistry communities.

Polymer photonics is an interdisciplinary field which demands excellence both in optics (photonics) and materials science (polymer). However, theses disciplines have developed independently, and therefore the demand for a comprehensive work featuring the fundamentals of photonic polymers is greater than ever. This volume focuses on Polymer Optical Fiber and their applications. The first part of the book introduces typical optical fibers according to their classifications of material, propagating mode, and structure. Optical properties, the high bandwidth POF and transmission loss are discussed, followed by an outline on the propagating mode characteristics and how they affect the performances of the fiber. The second part of the book reviews conventional materials of POFs and gives an overview on fabrication methods. This is followed by a survey of characterization methods. Based on the characteristics of optical communication systems, the last chapter will concentrate on the many advantages of POF in link and network design. Written by a top expert in the field, this is an invaluable resource for semiconductor physicists, materials scientists, polymer chemists, electrical engineers, and those working in the semiconductor industry.

This book provides a comprehensive review of industry 4.0 and its applications, discussing the history of industry evaluation, including industry 1.0, 2.0, 3.0 and 4.0, and the future structure of industry evaluation. It also examines the effects and impact of various technologies in industry and presents new interdisciplinary business models based on advanced technologies with the help of use cases. Lastly, it highlights the benefits of technological implementation in industry using examples of real-world applications, providing a robust and reliable technological conceptual framework and roadmap for decision-makers in all areas of industry involved transformation.

This book provides an indispensable reference guide to the sustainable control and treatment of biomass residues from a wide variety of agroindustrial sources, e.g. sugarcane, livestock, pulp & paper, food wastes, among others. Pursuing a structured and clear approach, the book opens with a general introduction to biomass, sustainability and environmental chemistry aspects, and on how the use of biomass as a renewable material ties into the UN's Sustainable Development Goals. The book subsequently presents analytical methods applied to different biomass types and their residues and reviews monitoring and treatment strategies in order to avoid pollution of the same. The book closes by describing the value chains, bioeconomy and circular economy for globally relevant agroindustrial biomass. The book is intended for researchers in academia and industry alike and shows how, in addition to sustainability criteria and life cycle assessments, integrating environmental chemistry aspects can contribute to a holistic approach, and unlock the economic potential of biomass in the age of circular economy and sustainable development.

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on "Sex and gender factors affecting metabolic homeostasis, diabetes and obesity" to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.

Although the Bioequivalence (BE) requirements in many global jurisdictions have much in common, differences in certain approaches and requirements such as definitions and terms, choice of comparator (reference) product, acceptance criteria, fasted and fed studies, single and multi-dose studies, biowaivers and products not intended for absorption into the systemic circulation (locally acting medicines and dosage forms), amongst others, provide food for thought that standardisation should be a high priority objective in order to result in a harmonized international process for the market approval of products using BE. An important objective of Bioequivalence Requirements in Various Global Jurisdictions is to attempt to gather the various BE requirements used in different global jurisdictions to provide a single source of relevant information. This information from, Brazil, Canada, China, European Union, India, Japan, MENA, Russia South Africa, the USA and WHO will be of value to drug manufacturers, regulatory agencies, pharmaceutical scientists and related health organizations and governments around the world in the quest to harmonize regulatory requirements for the market approval of generic products.

"Industrialution, the Experience Principles" is a 'how to book' for plant level management teams on what it takes to sustain a long lasting manufacturing operation in today's environment of global competition.

Author Dennis Lex has over 35 years of hands-on manufacturing experience in metal stamping, injection molding, electronic processing, steel making, casting, welding and industrial engineering. What is unique about this book versus other books on manufacturing is the author addresses all the popular subjects on manufacturing necessary to run a successful operation and how all the theories are interrelated. The author presents his concepts based on real manufacturing experience. His key conclusions are:

Plant level management has the ability control a plants future existence Time is the major resource problem The experience principles do not change with technology, mergers, , acquisitions, etc.

This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book's unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.

The food industry is now entering a transition age, as scientific advancements and technological innovations restructure what people eat and how people think about food. Food Tech Transitions provides a critical analysis of food technology and its impact, including the disruption potential of production and consumption logic, nutrition patterns, agronomic practices, and the human, environmental and animal ethics that are associated with technological change. This book is designed to integrate knowledge about food technology within the social sciences and a wider social perspective. Starting with an overview of the technological and ecological changes currently shaping the food industry and society at large, authors tackle recent advancements in food processing, preserving, distributing and meal creation through the lens of wider social issues. Section 1 provides an overview of the changes in the industry and its (often uneven) advancements, as well as related social, ecological and political issues. Section 2 addresses the more subtle sociological questions around production and consumption through case-studies. Section 3 embraces a more agronomic and wider agricultural perspective, questioning the suitability and adaptation of existing plants and resources for novel food technologies. Section 4 investigates nutrition-related issues stemming from altered dietary patterns. Finally, Section 5 addresses ethical questions related to food technology and the sustainability imperative in its tripartite form (social, environmental and economic). The editors have designed the book as an interdisciplinary tool for academics and policymakers working in the food sciences and agronomy, as well as other related disciplines.

This book provides an overview of the experimental characterization of materials and their numerical modeling, as well as the development of new computational methods for virtual design. Its 17 contributions are divided into four main sections: experiments and virtual design, composites, fractures and fatigue, and uncertainty quantification. The first section explores new experimental methods that can be used to more accurately characterize material behavior. Furthermore, it presents a combined experimental and numerical approach to optimizing the properties of a structure, as well as new developments in the field of computational methods for virtual design. In turn, the second section is dedicated to experimental and numerical investigations of composites, with a special focus on the modeling of failure modes and the optimization of these materials. Since fatigue also includes wear due to frictional contact and aging of elastomers, new numerical schemes in the field of crack modeling and fatigue prediction are also discussed. The input parameters of a classical numerical simulation represent mean values of actual observations, though certain deviations arise: to illustrate the uncertainties of parameters used in calculations, the book's final section presents new and efficient approaches to uncertainty quantification.

This reference guide brings together a wide range of essential data on the effects of weather and UV light exposure on plastics and elastomers, enabling engineers to make optimal material choices and design decisions. In both normal and extreme environments, outdoor use has a variety of effects on different plastics and elastomers, including discoloring and brittleness. The data is supported by explanations of real-world engineering applications. The data tables in this book are supported by examples of real-world applications, enabling engineers and scientists to select the right materials for a given situation, across a wide range of sectors including construction, packaging, signage, consumer (e.g. toys, outdoor furniture), automotiveand aerospace, defense, etc.

The third edition includes new text chapters that provide the fundamental knowledge required to make best use of the data. Author Larry McKeen has also added detailed descriptions of the effect of weathering on the most common polymer classes such as polyolefins, polyamides, polyesters, elastomers, fluoropolymers, biodegradable plastics, etc., making this book an invaluable design guide as well as an industry standard data source.
Essential data and practical guidance for engineers and scientists working with plastics in outdoor applications and products New introductory chapters on weathering processes and the effect of light and heat on plastics25% new data"

Providing a comprehensive overview of hot stamping (also known as 'press hardening'), this book examines all essential aspects of this innovative metal forming method, and explores its various uses. It investigates hot stamping from both technological and business perspectives, and outlines potential future developments. Individual chapters explore topics such as the history of hot stamping, the state of the art, materials and processes employed, and how hot stamping is currently being used in the automotive industry to create ultra-high-strength steel components. Drawing on experience and expertise gathered from academia and industry worldwide, the book offers an accessible resource for a broad readership including students, researchers, vehicle manufacturers and metal forming companies.

This monograph reports recent advances in production, chemistry, analysis, nutritional properties and commercial processing of canola and rapeseed. Recent developments in biotechnology of canola production and genetic alterations and improvements of seeds, recent methods of analysis and recent studies to upgrade the canola proteins are presented.

Rice is a vitally important staple food for almost half of the world's population. As the global population increases, the demands for rice are expected to remain high. Since the rice industry will remain sustainable for a long time, the production of rice by-products will remain high. Substantial evidence suggests that rice by-products such as rice husk, rice straw, broken rice, rice germ, rice bran, and brewers' rice may possess beneficial effects against oxidative stress and metabolic disorders. These beneficial effects have been linked to the phytochemicals present in rice by-products such as vitamin E, dietary fiber, -oryzanol, -aminobutyric acid (GABA), and phytosterols. Despite this evidence, the literature pertaining to rice by-products and its derived components has not well been compiled. To this end, Rice By-products: Phytochemicals and Food Products Application provides full coverage of issues pertaining to rice by-products, namely rice demands and rice by-products production, phytonutrients and antioxidant properties of rice by-products, potential health benefits, application in food products, and future prospects. By summarizing all the information in a lucid and comprehensive manner, authors provide a cohesive representation of the literature on the molecular mechanisms involved in the pharmacological effects of the bioactive components that present in rice by-products, as well as plausible means for the prevention of metabolic disorders for readers and allied stakeholders.

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry. The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods. The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader. The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors. One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995). We agreed that a more recent book would serve a need in our industry. Since we began this project, an edited book has been published on the same topic by Zhang (2016). The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development. We believe our book complements Zhang by providing more detailed statistical analyses and examples.

This text provides comprehensive coverage of fibers used in food formulations, starting with the understanding of their basic chemical structure and how they are present and organized in the cell wall structure, their physicochemical and functional properties, their impact on the digestive process and their role and preventive action against various chronic diseases including colon cancer. The book focuses on traditional and new fiber rich sources, incorporating an integrated approach in terms of the technological and engineering processes used to obtain and incorporate them in traditional foods, plus their characterization, extraction and modification. The study of processing conditions including the chemical, physical and enzymatic processes of fiber extraction and modification are also covered, including traditional and emerging processing technologies, plus the application of fibers in the development of new products and processes. Science and Technology of Fibers in Food Systems integrates knowledge of fibers from their basic structural and property aspects and the applications of these ingredients to extraction process analysis, modification and feasibility for use at the industry level. The chapters incorporate the physiological aspects related to the consumption of fiber for prevention of serious diseases.

Material processing techniques that employ severe plastic deformation have evolved over the past decade, producing metals, alloys and composites having extraordinary properties. Variants of SPD methods are now capable of creating monolithic materials with submicron and nanocrystalline grain sizes. The resulting novel properties of these materials has led to a growing scientific and commercial interest in them. They offer the promise of bulk nanocrystalline materials for structural applications, including nanocomposites of lightweight alloys with unprecedented strength. These materials may also enable the use of alternative metal shaping processes, such as high strain rate superplastic forming. Prospective applications for medical, automotive, aerospace and other industries are already under development.

This book focuses on the food safety challenges in the vegetable industry from primary production to consumption. It describes existing and innovative quantitative methods that could be applied to the vegetable industry for food safety and quality, and suggests ways in which such methods can be applied for risk assessment. Examples of application of food safety objectives and other risk metrics for microbial risk management in the vegetable industry are presented. The work also introduces readers to new preservation and packaging methods, advanced oxidative processes (AOPs) for disinfection, product shelf-life determination methods, and rapid analytic methods for quality assessment based on chemometrics applications, thus providing a quantitative basis for the most important aspects concerning safety and quality in the vegetable sector.

This book treats the theoretical fundamentals of adsorption technology for water treatment from a practical perspective. It presents all the basics needed for experimental adsorption studies as well as for process modeling and adsorber design. According to the increasing importance of micropollutants in the water cycle, particular attention is paid to their competitive adsorption in the presence of background organic matter. The current edition considers recent developments in adsorption theory and practice.

This book provides an overview of recycled polyesters, which are an important sustainable raw material in textile production. It discusses the manufacturing methods and the unique properties of recycled polyesters manufactured using the different methods. It also highlights the various test methods and identification mechanisms for recycled polyesters, which are very essential for ensuring the traceability and conformity of usage of recycled polyester in the final product.

This collection presents papers from a symposium on extraction of rare metals as well as rare extraction processing techniques used in metal production. Topics include the extraction and processing of elements like antimony, arsenic, gold, indium, palladium, platinum, rare earth metals including yttrium and neodymium, titanium, tungsten, and vanadium. Rare processing techniques are covered, including direct extraction processes for rare-earth recovery, biosorption of precious metals, fluorination behavior of uranium and zirconium mixture of fuel debris treatment, and recovery of valuable components of commodity metals such as zinc, nickel, and metals from slag.

This book describes a simplified approach to the modelling and process design of a fixed bed hybrid bioreactor for wastewater treatment. In this work a simplified model for hybrid bioreactor is developed to determine output parameters like exiting substrate concentration in bulk liquid, average substrate flux in the biofilm, effective and total biofilm thickness. The model is based on mass balance of both carbonaceous substrate and biomass under suspended and attached growth simultaneously along with substrate mass transport into the biofilm. The proposed model has also been validated with the results obtained from experimental study with municipal wastewater considering as a low strength wastewater with no inhibition. There is a flexibility of the proposed model making it a versatile one to find out the exiting substrate concentration both in hybrid bioreactor as well as in a completely mixed biofilm reactor (CMBR). The book caters to academics and practitioners working in the field of advanced wastewater treatment.

This book is a comprehensive collaboration on intelligent polymers and coatings for industrial applications by worldwide researchers and specialists. The authors cover the basis and fundamental aspects of intelligent polymers and coatings, challenges, and potential mechanisms and properties. They include recent and emerging industrial applications in medical, smart textile design, oil and gas, electronic, aerospace, and automobile industries as well as other applications including microsystems, sensors, and actuators, among others. The authors discuss the potential for future research in these areas for improvement and growth of marketable applications of intelligent polymers and coatings.