Micro-machining is an advanced manufacturing technique of growing importance, and adoption of micro-machining using electrochemical discharges (Micro-ECDM) has increased steadily in recent years. Among new developments is the interest of industry in Micro-ECDM. However, the potential of the technology is not being fully utilized and there is no comprehensive reference book available today covering it. Micromachining Using Electrochemical Discharge Phenomenon, Second Edition fills this gap. It is unique in its detailed coverage of all aspects of the Micro-ECDM process, as well as Spark Assisted Chemical Engraving (SACE). As such, it covers technologies such as chemical etching, micro-drilling, and other material removal mechanisms, high aspect ratio machining, design and construction of the machining apparatus, and a wide range of applications. The new edition compares Micro-ECDM and SACE with other micromachining technologies such as laser machining and traditional EDM. ECDM is used for machining of electrically non-conductive materials. Micro-ECDM/SACE is mainly applied to glass and the book focuses on glass, but the authors also present new results on other materials such as ceramics. In addition, techniques to modify material properties for the machining process are explained. The authors discuss machining strategies including the latest developments in micro-texturing of glass micro-channels and reports on developments in controlling and analysis aspects of machining. This book is a unique reference for engineers and industrial researchers involved in development, design and use of micromachining, chemical micro-drilling or chemical engraving techniques and equipment.

Pulp and paper mill industries are always associated with the disposal problem of highly contaminated sludge or bio-solids. The development of innovative systems to maximize recovery of useful materials and/or energy in a sustainable way has become necessary. The management of wastes, in particular of industrial waste, in an economically and environmentally acceptable manner is one of the most critical issues facing modern industry, mainly due to the increased difficulties in properly locating disposal works and complying with even more stringent environmental quality requirements imposed by legislation. This book presents a general Introduction on waste management in the pulp and paper industry and contains topics on the generation of waste in pulp and paper mills, waste composition, methods of sludge pre-treatment, processes and technologies for conversion of pulp and paper mill waste into valuable products, waste reduction techniques employed in the pulp and paper Industry worldwide and future trends.

This is the first book to deal with the innovative technologies in the field of textiles and clothing sustainability. It details a number of sustainable and innovative technologies and highlights their implications in the clothing sector. There are currently various measures to achieve sustainability in the textiles and the clothing industry, including innovations in the manufacturing stage, which is the crux of this book.

This volume gathers the latest advances, innovations and applications in the field of cable robots, as presented by leading international researchers and engineers at the 4th International Conference on Cable-Driven Parallel Robots (CableCon 2019), held in Krakow, Poland on June 30-July 4, 2019, as part of the 5th IFToMM World Congress. It covers the theory and applications of cable-driven parallel robots, including their classification, kinematics and singularity analysis, workspace, statics and dynamics, cable modeling and technologies, control and calibration, design methodologies, hardware development, experimental evaluation and prototypes, as well as application reports and new application concepts. The contributions, which were selected through a rigorous international peer-review process, share exciting ideas that will spur novel research directions and foster new multidisciplinary collaborations.

This book summarizes the author's lifetime achievements, offering new perspectives and approaches in the field of metal cutting theory and its applications. The topics discussed include Non-Euclidian Geometry of Cutting Tools, Non-free Cutting Mechanics and Non-Linear Machine Tool Dynamics, applying non-linear science/complexity to machining, and all the achievements and their practical significance have been theoretically proved and experimentally verified.

Part A: Heat and Mass Transfer in Helium II: A Brief History of Cryogenics; R.G. Scurlock. Applications of Helium II: A Liquid/Gas Phase Separator for HeI and HeII; P.J. Shirron, et al. Heat Transfer in Cryogenc Fluids; Heat Exchangers; Thermoacoustic Oscillations. Insulation. Applications of Superconductivity: Magnet Stability; Coil Protection. Applications of Superconductivity: Magnets and Other Devices. Applications of Superconductivity: Cryogenic Techniques. Refrigeration for Electronics. Refrigeration of Superconducting Systems. Part B: Compressors, Expanders, Pumps for Liquid Helium. Magnetic Refrigerators. Pulse Tube Refrigerators. Cryocoolers. Properties of Cryogenic Fluids. Cryogenic Applications: Transportation. Cryogenic Applications: Space Science and Technology. Cryogenic Applications: Equipment for Space. Cryogenic Instrumentation. Miscellaneous Cryogenic Techniques and Applications. 170 additional articles. Index.

Simulation of ODE/PDE Models with MATLAB(r), OCTAVE and SCILAB shows the reader how to exploit a fuller array of numerical methods for the analysis of complex scientific and engineering systems than is conventionally employed. The book is dedicated to numerical simulation of distributed parameter systems described by mixed systems of algebraic equations, ordinary differential equations (ODEs) and partial differential equations (PDEs). Special attention is paid to the numerical method of lines (MOL), a popular approach to the solution of time-dependent PDEs, which proceeds in two basic steps: spatial discretization and time integration.

Besides conventional finite-difference and element techniques, more advanced spatial-approximation methods are examined in some detail, including nonoscillatory schemes and adaptive-grid approaches. A MOL toolbox has been developed within MATLAB(r)/OCTAVE/SCILAB. In addition to a set of spatial approximations and time integrators, this toolbox includes a collection of application examples, in specific areas, which can serve as templates for developing new programs.

Simulation of ODE/PDE Models with MATLAB(r), OCTAVE and SCILAB provides a practical introduction to some advanced computational techniques for dynamic system simulation, supported by many worked examples in the text, and a collection of codes available for download from the book s page at www.springer.com. This text is suitable for self-study by practicing scientists and engineers and as a final-year undergraduate course or at the graduate level.

This edited volume examines metallurgical technologies and their place in society throughout the centuries. The authors discuss metal alloys and the use of raw mineral resources as well as fabrication of engineered alloys for a variety of applications. The applications covered in depth include financial, mining and smelting, bridges, armor, aircraft, and power generation. The authors detail the multiple levels and scales of impact that metallurgical advances have had and continue to have on society. They include case studies with guidance for future research design and innovation of metallic materials relevant to societal needs. Includes case studies written by industry professionals with guidance for future research design and innovation; Demonstrates metal materials design that reflects relevant societal needs; Covers a broad range of applied materials used in aircraft, armor, bridges, and power generation, among others.

This book covers all the steps in order to fabricate a lab-on-a-chip device starting from the idea, the design, simulation, fabrication and final evaluation. Additionally, it includes basic theory on microfluidics essential to understand how fluids behave at such reduced scale. Examples of successful histories of lab-on-a-chip systems that made an impact in fields like biomedicine and life sciences are also provided. This book also: * Provides readers with a unique approach and toolset for lab-on-a-chip development in terms of materials, fabrication techniques, and components * Discusses novel materials and techniques, such as paper-based devices and synthesis of chemical compounds on-chip * Covers the four key aspects of development: basic theory, design, fabrication, and testing * Provides readers with a comprehensive list of the most important journals, blogs, forums, and conferences where microfluidics and lab-on-a-chip news, methods, techniques and challenges are presented and discussed, as well as a list of companies providing design and simulation support, components, and/or developing lab-on-a-chip and microfluidic devices.

This book gives an overview of the physiology, health, safety and functional aspects of microorganisms present in food and fermented foods. A particular focus is on the health effects of probiotics and non-dairy functional foods. The book deals also with microbes that cause food spoilage and produce toxins, and the efficiency of edible biofilm in the protection of packaged foods. Several chapters are devoted to the occurrence of Listeria pathogens in various food sources. Further topics are fortified foods, the role of trace elements, and the preservation of food and extension of food shelf life by a variety of measures.

Proteins are the cell's workers, their messengers and overseers. In these roles, proteins specifically bind small molecules, nucleic acid and other protein partners. Cellular systems are closely regulated and biologically significant changes in populations of particular protein complexes correspond to very small variations of their thermodynamics or kinetics of reaction. Interfering with the interactions of proteins is the dominant strategy in the development of new pharmaceuticals. Protein Ligand Interactions: Methods and Applications, Second Edition provides a complete introduction to common and emerging procedures for characterizing the interactions of individual proteins. From the initial discovery of natural substrates or potential drug leads, to the detailed quantitative understanding of the mechanism of interaction, all stages of the research process are covered with a focus on those techniques that are, or are anticipated to become, widely accessible and performable with mainstream commercial instrumentation. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Protein Ligand Interactions: Methods and Applications, Second Edition serves as an ideal guide for researchers new to the field of biophysical characterization of protein interactions - whether they are beginning graduate students or experts in allied areas of molecular cell biology, microbiology, pharmacology, medicinal chemistry or structural biology.

Since the industrial revolution, chlorine remains an iconic molecule even though its production by the electrolysis of sodium chloride is extremely energy intensive. The rationale behind this book is to present useful and industrially relevant examples for alternatives to chlorine in synthesis. This multi-authored volume presents numerous contributions from an international spectrum of authors that demonstrate how to facilitate the development of industrially relevant and implementable breakthrough technologies. This volume will interest individuals working in organic synthesis in industry and academia who are working in Green Chemistry and Sustainable Technologies.

This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management. The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors. The editors have used a different perspective - that of normalizing abnormal physiological processes with pharmacological agents - to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.

This book introduces fundamental principles and practical application of techniques used in the scalable production of biopharmaceuticals with animal cell cultures. A broad spectrum of subjects relevant to biologics production and manufacturing are reviewed, including the generation of robust cell lines, a survey of functional genomics for a better understanding of cell lines and processes, as well as advances in regulatory compliant upstream and downstream development. The book is an essential reference for all those interested in translational animal cell-based pharmaceutical biotechnology.

This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products. Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulations Details the latest developments in instrumental analysis and controlled ice nucleation technology Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics Details an exhaustive update on quality-by-design and process analytical technology approaches, illustrated superbly by case studies and FDA perspective Provides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studies Provides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launch Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.

A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.

Quality Determinants In Coffee Production presents a comprehensive overview of the main determinants of coffee quality during processing. Authored by members of the Laboratory for Analysis and Research in Coffee at the Federal Institute of Espirito Santo, the chapters in this text explain how coffee quality can be affected through each step of the main processing methods. The first section explores the history of coffee processing, covering how the processes and techniques of sensorial analysis have developed. The second section covers the evolution of these techniques and how various complexities can affect their use, plus the statistical tools that are used to increase test accuracy. Another section focuses on the relationship between fruit microbiology and coffee quality, promoting an understanding of how yeasts, fungi and bacteria effect the quality of coffee during processing. Another section is dedicated to the biotechnological processes used in coffee production, including the applicability of induced and spontaneous routes from the manipulation of raw material, the relationship between wet processing and spontaneous fermentation and the construction of sensorial routes. A final section explores volatile coffee compounds and gas chromatography techniques, including chemical and sensory maps. The majority of the reference works published on coffee processing have a pragmatic approach covering production, harvesting, post-harvesting and marketing. This work goes beyond these subjects, covering the factors that impact quality and how they lead to either qualitative reduction or gains during processing. New technological and scientific indicators for the modification and the creation of sensory routes are extensively covered, as are the international protocols used in the sensorial analysis of coffee. With its broad approach, this text presents a multidisciplinary perspective connecting areas such as statistics, biochemistry, analytical chemistry and microbiology to the results of sensory analysis using different technologies and processes. A direct relationship between these factors is established in order to help researchers understand their combined effect on coffee quality during processing.

This book focuses on the assessment of different coal gasification technologies for the utilization of Russian coals with analyses of economically feasible process chains for preparation of marketable products from high-ash coals. The work presented is important in view of the general competitiveness that marks the future of coal in the world. As the cheapest form of fuel (in comparable terms) coal will undoubtedly be in demand resources in the world. The book consists of parts which include an overview about the major coal characteristics, detailed discussion of fundamental aspects of gasification technologies and gasifiers, an introduction into annex concepts, an overview about different technologies of syngas utilization, technical and economic assessment of several coal-to-liquid and coal-to-chemicals routes, and feasibility demonstration for selected process chains. This book is addressed to the management and engineers of Russian coal companies and scientific staff of Russian research institutions working in the field of coal utilization.

Detailed mathematical models are increasingly being used by companies to gain competitive advantage through such applications as model-based process design, control and optimization. Thus, building various types of high quality models for processing systems has become a key activity in Process Engineering. This activity involves the use of several methods and techniques including model solution techniques, nonlinear systems identification, model verification and validation, and optimal design of experiments just to name a few. In turn, several issues and open-ended problems arise within these methods, including, for instance, use of higher-order information in establishing parameter estimates, establishing metrics for model credibility, and extending experiment design to the dynamic situation.
The material covered in this book is aimed at allowing easier development and full use of detailed and high fidelity models. Potential applications of these techniques in all engineering disciplines are abundant, including applications in chemical kinetics and reaction mechanism elucidation, polymer reaction engineering, and physical properties estimation. On the academic side, the book will serve to generate research ideas.
- Contains wide coverage of statistical methods applied to process modelling
- Serves as a recent compilation of dynamic model building tools
- Presents several examples of applying advanced statistical and modelling methods to real process systems problems

Contains descriptions of more than 2,200 materials currently available to the adhesives industry. The book includes Suppliers' Addresses and a Trade Name Index. Projected 1995 adhesives sales are $12 billion, with steady growth and expansion into new areas.