How can you tell a fake watch from a real one? Where are fakes made? What grades of quality can one find among so-called "replicas"? How can one buy a watch on the internet? How can one avoid fraudulent copies? These are just some of the questions to which any wristwatch enthusiast needs to find answers in an era when counterfeiting luxury products has become an industry in its own right. This book, of which the greater part is devoted to the most prestigious watch brands, provides readers with vital information on identifying fakes. It aims to ensure that buying a watch from a private individual, from a professional or on the internet (the global hub for the sale of fake watches) does not turn out to be a nightmare! Illustrated with over 500 photos, the differences between original and counterfeit models are exposed in detail (mechanisms, dials, bracelets, etc.). To our knowledge, no other work of this type has been published to date, doubtless due to the explosive nature of this fascinating topic.

Provides insight about application of natural fibers in polymer and composite manufacturing Covers fundamental concepts for the characterization of natural fiber composites Describes extraction process of natural fibers with comparison Includes comparative study of different polymer matrices Discusses diverse applications and scope for commercialization and entrepreneurship

This book is an implementation guide for creating a Lean Culture from the ground up while gaining buy-in from key stakeholders and being able to sustain the results. Everyone talks about implementing a Lean Culture, but only provides Lean Tools for the implementation. This book discusses implementing the entire system from three main aspects. It covers the people (structural and cultural), the operation system, and the tools. Also included is a full set of case studies to show real-life implementations as well. FEATURES: Discusses Leader Standard work for all employees Covers the escalation process for tiers and daily accountability Shows how to deal with a change of SOP's and standardization within an organization Presents exercises for Lean Tools Implementation Offers real-life case studies of implementing a Lean Culture while sustaining it Building a Sustainable Lean Culture: An Implementation Guide discusses Lean Leadership from a managerial standpoint and ensures the Lean journey succeeds through accountability, standardized work, and technological advances utilizing Lean Systems. Useful in manufacturing, services, IT, and healthcare, this book includes the implementation of empowering employees to want to build a Lean Culture.

Interior Provocations: History, Theory, and Practice of Autonomous Interiors addresses the broad cultural, historical, and theoretical implications of interiors beyond their conventionally defined architectural boundaries. With provocative contributions from leading and emerging historians, theorists, and design practitioners, the book is rooted in new scholarship that expands traditional relationships between architecture and interiors and that reflects the latest theoretical developments in the fields of interior design history and practice. This collection contains diverse case studies from the late eighteenth century to the twenty-first century including Alexander Pope's Memorial Garden, Design Indaba, and Robin Evans. It is an essential read for researchers, practitioners, and students of interior design at all levels.

This comprehensive book brings together experts from both the marine science and pharmacy disciplines to relay important aspects on the pharmaceutical and nutraceutical values of 175 species of bony and cartilaginous fishes as well as the uses of fish processing byproducts and wastes.Presented in an easy-to-read style, the volume provides precise identification of freshwater and marine fishes possessing pharmaceutical and nutraceutical compounds along with over 180 photographs. Aspects covered include biology, ecology, diagnostic features, and pharmaceutical and nutraceutical compounds along with their activities for each of the fish included. The book details the bioactive compounds, including fish muscle proteins, peptides, collagen and gelatin, fish oil, etc., from such species, as well as the bioactive peptides that are derived from various fish muscle proteins, which have various biological activities, including cardio protective, antihypertensive, anticancer, anti-diabetic, antibacterial, anticoagulant, anti-inflammatory, and antioxidant activities. Also discussed are the nutritional benefits of fish consumption, which are largely due to the presence of proteins, unsaturated essential fatty acids, minerals, and vitamins. The waste products obtained during fish processing are also a potential source of bioactive peptides that can be used as a source of nitrogen and amino acids, which have immunomodulatory, antibacterial, antitrombotic, and antihypertensive properties. This volume provides the information needed to tap into these vast pharmaceutical and nutraceutical benefits. Pharmaceuticals and Nutraceuticals from Fish and Fish Wastes will be of great use for students and researchers of disciplines such as pharmaceutical sciences, marine/fisheries sciences, marine microbiology, and marine biotechnology. It will also be a standard reference for libraries of colleges and universities and a guide for pharmaceutical companies involved in the development of new drugs from fishes and their wastes.

Gene delivery is a transport of genes of therapeutic values into the chromosomes of the cells or tissues which can be targeted to replace the faulty genes. In last two decades lot of research efforts are dedicated to gene delivery for therapeutic applications. Today gene therapy is promising approach in treatment of genetic diseases including mitochondrial related diseases like blindness, muscular dystrophy, cystic fibrosis, and some cancers. Gene Delivery Systems: Nano Delivery Technologies observes the exploration of nanotechnology for gene therapy and gene delivery. Written by prominent authors in the field, this book covers various aspects of gene delivery including challenges in delivering gene therapy, advances in genome editing, RNA-based gene therapy, Green nanoparticles for oligonucleotide delivery. Additional features include" Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing. Includes knowledge of the current application of CRISPR/Cas9 gene-editing technique; an approach that has recently been given the Noble Prize. Examines the development of mRNA vaccines for Covid -19 in challenging pandemic scenario Discusses siRNA, mRNA, and DNA plasmids.

The series is designed to meet the needs of students and lecturers of the National Certificate Vocational. To facilitate students' learning, the following features are used in the series: Content is written in easy-to-understand language, key terms are carefully explained, using everyday English, case studies show how to apply the theory in the work environment, the study skills sections help students make the most of their learning in class and prepare for the exams, there are many practice activities and questions with model answers at the back of the title, checklists assist students to make sure that they have covered all the skills and content in each chapter, and summaries at the end of each chapter are useful for exam revision. Lecturers using the series can teach with confidence because content is comprehensive, up-to-date, and meets all the curriculum requirements for the subject, outcomes and assessment standards are clearly identified, and assessment tasks and activities are aligned to the outcomes and assessment standards. Prescribing lecturers have access to comprehensive lecturer support material on CD including model answers to assessments in the textbook, additional assessments with model answers, rubrics for assessments, and general reference material on teaching outcomes-based education. The series is available for all programmes, all fundamental and compulsory subjects, and all elective and optional subjects.

The respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.

Gives basics of Fortran and Numerical Calculation. The book includes Fortran codes and also gives access to author's website. Summarizes history of Quantum Mechanics through the most important papers. Presents detailed mathematical basis of Quantum Mechanics and Quantum Chemistry. Includes proposed exercises and do-it-yourself activities.

This book looks at industry change patterns and innovations (such as artificial intelligence, machine learning, big data analysis, and blockchain support and efficiency technology) that are speeding up industrial transformation, industrial infrastructure, biodiversity, and productivity. This book focuses on real-world industrial applications and case studies to provide for a wider knowledge of intelligent manufacturing. It also offers insights into manufacturing, logistics, and supply chain, where systems have undergone an industrial transformation. It discusses current research of machine learning along with blockchain techniques that can fill the gap between research and industrial exposure. It goes on to cover the effects that the Fourth Industrial Revolution has on industrial infrastructures and looks at the current industry change patterns and innovations that are accelerating industrial transformation activities. Researchers, scholars, and students from different countries will appreciate this book for its real-world applications and knowledge acquisition. This book targets manufacturers, industry owners, product developers, scientists, logistics, and supply chain engineers. Focuses on real-world industrial applications and case studies to provide for a wider knowledge of intelligent manufacturing Offers insights into manufacturing, logistics, and supply chain where systems have undergone an industrial transformation Discusses current research of machine learning along with blockchain techniques that can fill the gap between research and industrial exposure Covers the effects that the 4th Industrial Revolution has on industrial infrastructures Looks at industry change patterns and innovations that are speeding up industrial transformation activities Om Prakash Jena is currently working as an associate professor in the Department of Computer Science, Ravenshaw University, Cuttack, Odisha, India. Sabyasachi Pramanik is an assistant professor in the Department of Computer Science and Engineering, Haldia Institute of Technology, India. Ahmed A. Elngar is an associate professor in the Faculty of Computers & Artificial Intelligence, Beni-Suef University, Egypt. He is also an associate professor in the College of Computer Information Technology, chair of the Scientific Innovation Research Group (SIRG), and director of the Technological and Informatics Studies Center (TISC), American University in the Emirates, United Arab Emirates.

*A focus on normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power. *Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trials *An investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effect *Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysis *Prior distribution of power and sample size *Extension of the basic approach to proof-of-concept trials with dual success criteria *Investigation of the connection between conditional and predictive power at an interim analysis and power and assurance *Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version.

Natural Substances for Cancer Prevention explores in detail how numerous investigations in chemical biology and molecular biology have established strong scientific evidence demonstrating how the properties of naturally occurring bioactive chemicals hamper all stages of cancers (from initiation to metastasis). Accordingly, important goals for cancer prevention are the modification of our dietary habits and an increase in the intake of more anticancer-related natural substances. More significantly, the bioactive chemicals presented in the functional foods should be readily available, inexpensive, non-toxic, and nutritional.

Ketogenic: The Science of Therapeutic Carbohydrate Restriction in Human Health presents the most up-to-date and evidence-based science and research available in the field of TCR, with the purpose of training medical and allied healthcare professionals on the effective therapeutic use of low-carbohydrate and ketogenic nutrition in clinical practice. This book explores the appropriate, safe, and effective use of TCR to improve patient outcomes in a broad range of chronic metabolic conditions and aims to promote health. Focused on lifestyle management, health support, and the treatment of diseases rooted in poor nutrition, Ketogenics: The Science of Therapeutic Carbohydrate Restriction in Human Health explores the role of food and lifestyle modification as medicine and is a valuable resource for nutritionists, dietitians, and medical professionals who provide diet-related counselling, as well as those researching or studying related areas.

Unique selling point: * Based on years of personal leadership and mentoring experience Core audience: * Emergency workers and business leaders are the primary market. Place in the market: * Will help people to navigate personal leadership issues in the post-COVID world

Freshwater Aquaculture - the study of breeding, rearing and commercialization of organisms, fish in particular, which inhabit in fresh water. Even though there remains some fragmentary information regarding the history of development of aquaculture in India but those seem to be far from being complete. In the present communication, the same has been given elaborately. The book concentrates on the culture technology of commercially important fresh water fishes. Various types of culture techniques including Aquaponics, Bioflocs, Recirculatory Aquaculture Systems (RAS) apart from the conventional Cage culture, Pen culture, Integration of fish culture with other crops viz. paddy, vegetables, dairy, piggery, poultry etc. have been dispensed in detail. Note: T&F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Calculations in Chemical Kinetics for Undergraduates aims to restore passion for problem solving and applied quantitative skills in undergraduate chemistry students. Avoiding complicated chemistry jargon and providing hints and step wise explanations in every calculation problem, students are able to overcome their fear of handling mathematically applied problems in physical chemistry. This solid foundation in their early studies will enable them to connect fundamental theoretical chemistry to real experimental applications as graduates. Additional Features Include: Contains quantitative problems from popular physical chemistry references. Provides step by step explanations are given in every calculation problem. Offers hints to certain problems as "points to note" to enable student comprehension. Includes solutions for all questions and exercises. This book is a great resource for undergraduate chemistry students however, the contents are rich and useful to even the graduate chemist that has passion for applied problems in physical chemistry of reaction Kinetics.

Calculations in Chemical Kinetics for Undergraduates aims to restore passion for problem solving and applied quantitative skills in undergraduate chemistry students. Avoiding complicated chemistry jargon and providing hints and step wise explanations in every calculation problem, students are able to overcome their fear of handling mathematically applied problems in physical chemistry. This solid foundation in their early studies will enable them to connect fundamental theoretical chemistry to real experimental applications as graduates. Additional Features Include: Contains quantitative problems from popular physical chemistry references. Provides step by step explanations are given in every calculation problem. Offers hints to certain problems as "points to note" to enable student comprehension. Includes solutions for all questions and exercises. This book is a great resource for undergraduate chemistry students however, the contents are rich and useful to even the graduate chemist that has passion for applied problems in physical chemistry of reaction Kinetics.

The Routledge International Handbook of Green Criminology was the first comprehensive and international anthology dedicated to green criminology. It presented green criminology to an international audience, described the state of the field, offered a description of a range of environmental issues of regional and global importance, and argued for continued criminological attention to environmental crimes and harms, setting an agenda for further study. In the six years since its publication, the field has continued to grow and thrive. This revised and expanded second edition of the Handbook reflects new methodological orientations, new locations of study such as Asia, Canada and South America, and new responses to environmental harms. While a number of the original chapters have been revised, the second edition offers a range of fresh chapters covering new and emerging areas of study, such as: conservation criminology, eco-feminism, environmental victimology, fracking, migration and eco-rights, and e-waste. This handbook continues to define and capture the field of green criminology and is essential reading for students and researchers engaged in green crime and environmental harm.

Since sterile filtration and purification steps are becoming more prevalent and critical within medicinal drug manufacturing, the third edition of Filtration and Purification in the Biopharmaceutical Industry greatly expands its focus with extensive new material on the critical role of purification and advances in filtration science and technology. It provides state-of-the-science information on all aspects of bioprocessing including the current methods, processes, technologies and equipment. It also covers industry standards and regulatory requirements for the pharmaceutical and biopharmaceutical industries. The book is an essential, comprehensive source for all involved in filtration and purification practices, training and compliance. It describes such technologies as viral retentive filters, membrane chromatography, downstream processing, cell harvesting, and sterile filtration. Features: Addresses recent biotechnology-related processes and advanced technologies such as viral retentive filters, membrane chromatography, downstream processing, cell harvesting, and sterile filtration of medium, buffer and end product Presents detailed updates on the latest FDA and EMA regulatory requirements involving filtration and purification practices, as well as discussions on best practises in filter integrity testing Describes current industry quality standards and validation requirements and provides guidance for compliance, not just from an end-user perspective, but also supplier requirement It discusses the advantages of single-use process technologies and the qualification needs Sterilizing grade filtration qualification and process validation is presented in detail to gain the understanding of the regulatory needs The book has been compilated by highly experienced contributors in the field of pharmaceutical and biopharmaceutical processing. Each specific topic has been thoroughly examined by a subject matter expert.

Biologics and Biosimilars: Drug Discovery and Clinical Applications is a systematic integration and evaluation of all aspects of biologics and biosimilars, encompassing research and development, clinical use, global regulation, and more. Biosimilars are biological therapeutic agents designed to imitate a reference biologic with high similarities in structure, efficacy, and safety, but also with potential clinical effective and cost-efficient options for the manufacturers, payers, clinicians, and patients. Most of the top-selling prescription drugs in the current market are biologics, which have revolutionized the treatment strategies and modalities for life-threatening and/or rare diseases. This book outlines the key processes and challenges in drug development, regulations, and clinical applications of biologics, biosimilars, and even interchangeable biosimilars. Global experts in the field discuss essential categories and prototype drugs of biologics and biosimilars in clinical practice such as allergenics, blood and blood components, cell treatment, gene therapy, recombinant therapeutic proteins or peptides, tissues, and vaccines. Additional features: Integrates the latest bench and bedside evidence of drug development and regulations of biologics and biosimilars Contains key study questions for each chapter to guide the readers, as well as drug charts for all therapeutic applications of biologics and biosimilars Presents detailed schematic illustrations to explain the drug development, clinical trials, regulations, and clinical applications of biologics and biosimilars This book is an invaluable tool for health care professional students, providers, and pharmaceutical and health care industries, as well as the public, providing readers with educational updates about the drug development and clinical affairs of biological medications and their similar drugs.

Covers key areas of heterojunction nanomaterials for easy understanding of students, researchers, and academicians to promote the research in this field Systematically summarizes synthetic strategies, physicochemical properties, photocatalytic mechanisms, and applications of heterojunction materials through high-quality illustrations and schematic diagrams and references accompanying each chapter Emphasizes the ongoing challenges and potential directions for future development of heterojunction photocatalysts

Climate change has emerged as the most pressing global challenge of the 21st century and it has a dramatic effect on natural ecosystems and environment. Intelligent mitigation strategies to minimise climate change impacts can result in advanced, novel technologies; healthier aquatic ecosystems and higher food security and well-being for humans. The book includes 45 Chapters by expert authors, covering (i) Hydrometeorology and hydrology, (ii) Natural hazards and disaster risk management, (iii) Aquaculture, (iv) Changing biodiversity scenarios, (v) Capture fisheries, (vi) Food and nutritional insecurity, (vii) Climate change and socio-economic scenarios, and allied areas. It is hoped that this volume will further our understanding and research achievements in the field of climate change and its consequences and facilitate the synthesis of information on how climate-related changes will influence oceans, marine and inland ecosystems, hydrological cycles, fisheries and aquaculture and coastal communities and will be immensely useful to planners, scientists, conservationists, environmentalists, academicians, students and all those who are directly or indirectly involved in the study of impact of climate change and mitigation measures Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Volatility of crude oil prices, depleting reservoirs and environmental concerns have stimulated worldwide research for alternative and sustainable sources of raw materials for chemicals and fuels. The idea of using single-carbon atom molecules as chemical building blocks is not new, and many such compounds have been techno-economically studied as raw materials for fuels. Nevertheless, unifying the scientific and technical issues under the topic of C1 chemistry is not as easy as it may appear. C1 Chemistry: Principles and Processes provides a comprehensive understanding of the chemical transformation from molecular to commercial plant scales and reviews the sources of C1 molecules, their conversion processes and the most recent achievements and research needs. This book: Describes the latest processes developments and introduces commercial technologies Covers a wide range of feedstocks, including greenhouse gases and organic wastes Details chemistry, thermodynamics, catalysis, kinetics and reactors for respective conversions Includes preparation and purification of C1 feedstocks, C1 molecule coupling reactions and process technologies for each C1 conversion reaction Considers environmental impacts and sustainability This book will be of interest to a wide range of researchers, academics, professionals and advanced students working in the chemical, environmental and energy sectors and offers readers insights into the challenges and opportunities in the active field of C1 chemistry.

This book introduces a powerful system that explains how to run a company with a focus on continuous improvement. The results are a satisfied customer base, evolving products and an increase in revenue and profits. These factors determine the success for any company because business transformation involves making fundamental changes in how business is conducted to cope with shifts in the market environment. This a comprehensive book for valuable guidance on framing strategy and overcoming challenges for successful and sustainable implementation of a lean production system, daily management system and lean accounting system in companies to empower the managers to serve their customers with timely delivery of quality products while maximizing profits and easing workloads. The main challenge is ensuring operations colleagues in different functions understand the link between their daily work and the profit and loss statement. In addition, it illustrates how finance personnel can assist the operations team and be a part of the transformation journey. This book is not meant to impart theoretical knowledge of the lean production system, daily management and lean accounting, as there are many books already available that focus on the methodology instead of the implementation. This book empowers people in each function of a company, irrespective of which level they work in the company, and shows them the way to operate on a daily basis to achieve the company's strategy while simultaneously fulfilling their career goals. The book lays out a brief history of the evolution of lean concepts with a focus on lean accounting. This book guides the successful implementation and sustenance of lean and kaizen tools and provides answers to the questions: Who should lead the lean and kaizen implementation in the company? Where should the lean and kaizen journey begin? Which lean and kaizen tools should be implemented first? How important is capacity for the company? How much current capacity is wasted and how much free capacity is available? Where exactly are the resources being wasted in the company? How can the company reduce waste to release capacity for more production? Why should the daily management system and lean accounting system be implemented simultaneously with the lean production system? Why must managers understand the monetary value of their daily activities? Is there an easy way of making a profit and loss statement that is understood at each level in the company? Why is one-day closing of accounts important and how can it be done?

An Oleoresin represents the true essence of spices enriched with volatile and non-volatile essential oil and resinous fractions. The oleoresin represents the wholesome flavor of the spice, a cumulative effect of the sensation of smell and taste. Therefore, it is designated as "true essence" of the spice and can replace spice powders in food products without altering the flavor profile. Our earth comprises a plethora of spices that have carved a niche in the global market in medicinal and health-related food products. These spices play a dual role as a food ingredient and a therapeutic agent preventing various diseases. This industry has acquired tremendous attention not only from consumers but also from scientific communities, and various food manufacturing organizations. Handbook of Oleoresins: Extraction, Characterization, and Applications is a snapshot of information on oleoresins-production, composition, properties, applications (medicinal & health properties), and more. It is designed to be a practical tool for the various professionals who develop and market spices and oleoresins Key Features: Contains comprehensive information on the major oleoresins of the world Dicusses the extraction and characterization of major spice oleoresins Covers the safety and toxicity of oleoresins Sheds light on relationship between oleoresins and health benefits The world is moving towards natural products. Spices lend color, taste, and flavor, and oleoresins are good source of antioxidants and have preservative as well as therapeutic power. Therefore it is important to understand and document the chemistry, characterization, properties and applications of oleoresins, as found in this handbook.