Although longitudinal social network data are increasingly collected, there are few guides on how to navigate the range of available tools for longitudinal network analysis. The applied social scientist is left to wonder: Which model is most appropriate for my data? How should I get started with this modeling strategy? And how do I know if my model is any good? This book answers these questions. Author Scott Duxbury assumes that the reader is familiar with network measurement, description, and notation, and is versed in regression analysis, but is likely unfamiliar with statistical network methods. The goal of the book is to guide readers towards choosing, applying, assessing, and interpreting a longitudinal network model, and each chapter is organized with a specific data structure or research question in mind. A companion website includes data and R code to replicate the examples in the book.

A compelling defense of hormone replacement therapy, exposing the faulty science behind its fall from prominence and empowering women to make informed decisions about their health. For years, hormone replacement therapy (HRT) was hailed as a miracle. Study after study showed that HRT, if initiated at the onset of menopause, could ease symptoms ranging from hot flashes to memory loss; reduce the risk of heart disease, Alzheimer's, osteoporosis, and some cancers; and even extend a woman's overall life expectancy. But when a large study by the Women's Health Initiative announced results showing an uptick in breast cancer among women taking HRT, the winds shifted abruptly, and HRT, officially deemed a carcinogen, was abandoned. Now, sixteen years after HRT was left for dead, Dr. Bluming, a medical oncologist, and Dr. Tavris, a social psychologist, track its strange history and present a compelling case for its resurrection. They investigate what led the public -- and much of the medical establishment -- to accept the Women's Health Initiative's often exaggerated claims, while also providing a fuller picture of the science that supports HRT. A sobering and revelatory read, Estrogen Matters sets the record straight on this beneficial treatment and provides an empowering path to wellness for women everywhere.

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Although the use of new health technologies in healthcare and medicine is generally seen as beneficial, there has been little analysis of the impact of such technologies on people's lives and understandings of health and illness. This ground-breaking book explores how new technologies not only provide hope for cure and well-being, but also introduce new ethical dilemmas and raise questions about the 'natural' body. Focusing on the ways new health technologies intervene into our lives and affect our ideas about normalcy, the body and identity, Medical Technologies and the Life World explores: how new health technologies are understood by lay people and patients how the outcomes of these technologies are communicated in various clinical settings how these technologies can alter our notions of health and illness and create 'new illness'. Written by authors with differing backgrounds in phenomenology, social psychology, social anthropology, communication studies and the nursing sciences, this sensational text is essential reading for students and academics of medical sociology, health and allied studies, and anyone with an interest in new health technologies.

Although the use of new health technologies in healthcare and medicine is generally seen as beneficial, there has been little analysis of the impact of such technologies on people's lives and understandings of health and illness. This ground-breaking book explores how new technologies not only provide hope for cure and well-being, but also introduce new ethical dilemmas and raise questions about the 'natural' body. Focusing on the ways new health technologies intervene into our lives and affect our ideas about normalcy, the body and identity, Medical Technologies and the Life World explores: how new health technologies are understood by lay people and patients how the outcomes of these technologies are communicated in various clinical settings how these technologies can alter our notions of health and illness and create 'new illness'. Written by authors with differing backgrounds in phenomenology, social psychology, social anthropology, communication studies and the nursing sciences, this sensational text is essential reading for students and academics of medical sociology, health and allied studies, and anyone with an interest in new health technologies.

Laboratory animals, including dogs, play an important role in biomedical research and medical advances. Dogs have a long history of use in research and have contributed enormously to the health and welfare of both humans and animals. The humane care and management of these animals is a fundamental component of their use in medical research.

The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources. The book offers guidance on performing a detailed physical examination, including necessary veterinary supplies, clinical signs of illness, clinical conditions, and reference tables of widely used veterinary drugs. It discusses the human-animal bond or the relationship between people and animals and its significance and importance to the quality of research, the health of the animals, and the emotional health of staff caring for or working with animals. It also examines anesthetic and surgical procedures that include pre-, intra-, and post-anesthesia/operative monitoring. The Laboratory Canine contains reference charts for monitoring patients through post-operative recovery and reference tables for anesthetics and analgesics.

Because dogs are a highly visible species in the eyes of the public and regulators, it is important that individuals working with laboratory canines have the proper training and experience. This valuable resource is ideal for those charged with the care and use of canines in a research setting.

The long-awaited third edition of Doing Qualitative Research by Benjamin F. Crabtree and William L. Miller is out! Co-create your own inspired research stories with this reader-friendly text on qualitative methods, design, and analysis. Written for both students and researchers with little to no qualitative experience, as well as investigators looking to expand and refine their expertise, this clear and concise book will quickly get readers up to speed doing truly excellent qualitative research. The first four chapters of the book set the stage by contextualizing qualitative research within the overall traditions of research, focusing on the history of qualitative research, the importance of collaboration, reflexivity, and finding the appropriate method for your research question. Each part then addresses a different stage of the research process, from data collection, data analysis and interpretation, and refocusing on the bigger picture once your research is complete. Unique chapters cover case study research, intervention studies, and participatory research. The authors use their experiences and knowledge to provide both personal and published research stories to contextualize qualitative concepts. Many of the examples demonstrate the use of qualitative methods within a mixed-methods approach. Each chapter concludes with open-ended questions to further reader contemplation and to spark discussions with classmates and colleagues. With an abundance of clinical research examples featuring a variety of qualitative methods, Doing Qualitative Research encourages researchers to learn by doing and actively experiment with the tools and concepts presented throughout the book.

This book is an accessible, contemporary, and comprehensive guide to the concepts and practice of evaluation. Authors Gail Vallance Barrington and Beverly Triana-Tremain integrate new approaches and concerns, and classic frameworks with practical tools that readers can use to design evaluation studies. They show how evaluators measure whether the planned and implemented interventions or services are achieving their goals and objectives, while focusing on the questions most important to the community and organizations in which the evaluation takes place. The book stresses the role of critical and evaluative thinking, as well as self-reflection, and demonstrates the importance of context and equity in today's turbulent environment, offering a new stance for evaluators to support global as well as local issues.

Learn how to better clinically serve risky adolescentsfrom the clients themselves! Clinical and Research Uses of an Adolescent Mental Health Intake Questionnaire: What Kids Need to Talk About explores the research on adolescent behavior culled from the answers to a clinician-designed intake questionnaire given to adolescent clients asking how they view their own risks, what they worry about, and what they wish to talk about. Respected authorities discuss the enlightening findings and present ways to reshape services, taking into account customer preference, risk and worry, and youth development (YD) perspectives while presenting practical clinical strategies to engage at-risk adolescents in mental health treatment. Clinical and Research Uses of an Adolescent Mental Health Intake Questionnaire: What Kids Need to Talk About provides conceptual models that practitioners and organizations can use to develop reflective practices and to understand better how to engage adolescent clients in treatment. The book includes three case studies that illustrate an organization's experience in developing ways for organizational learning, including the clinicians' own accounts of their experience in conducting practice-based research. Two chapters describe the development and the clinical uses of the intake questionnaire and offer guidelines for other practitioners to develop their own. The book discusses specific findings about adolescent risk, worries, and desire to talk across a wide range of psychosocial domains such as education and work, sex and sexuality, safety, substance abuse, and family and friends. Other research examines adolescent risk and vulnerability profiles of lesbians, gays, and bisexuals, as well as the impact of racism. Finally, the book builds upon this empirical analysis to address the clinical challenge of engaging risky adolescents in counseling. Clinical and Research Uses of an Adolescent Mental Health Intake Questionnaire: What Kids Need to Talk About analyzes: adolescent risks, worries, and coping adolescent help seeking and desire to talk in counseling youth development (YD) and adolescent vulnerability urban adolescents' health and mental health concerns effectively engaging adolescents in counseling collaborative strategies for clinicians and managers reflectivity and learning in human service organizations Clinical and Research Uses of an Adolescent Mental Health Intake Questionnaire: What Kids Need to Talk About presents essential information for social workers, mental health professionals who work with adolescents, adolescent researchers, pediatricians and adolescent medicine practitioners, teachers, students, and youth workers.

Clinical Chemistry: Principles, Techniques, and Correlations, Ninth Edition is the most student-friendly clinical chemistry text available today.

The Ninth Edition keeps students at the forefront of what continues to be one of the most rapidly advancing areas of laboratory medicine with clear explanations that balance analytic principles, techniques, and correlation of results with coverage of disease states.

The book not only demonstrates the how of clinical testing, but also the what, why, and when of testing correlations to help students develop the knowledge and interpretive and analytic skills they'll need in their future careers.

In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at: http://jmr.r-forge.r-project.org/

Offering an authoritative account of the relationship between literature and medicine between approximately 1800 and 1900, this volume brings together leading scholars in the field to provide a valuable overview of how two dynamic fields influenced and shaped each during a period of revolutionary change. During the nineteenth century, medicine was being redefined as a subject in which experimental methodologies could transform the healing art, and was simultaneously branching off into new specialisms and subdivisions. Questions addressed in this volume include the influence of physics on poetry, the role of medical professionalism in fiction, the cultural and literary representation of sanitation, and the interdisciplinary nature of controversy and negligence. Along with its sister publication, Literature and Medicine in the Eighteenth Century, this volume offers a major critical overview of the study of literature and medicine.

The revised Tomorrow's Doctors makes it clear that doctors need to be aware of their responsibilities as a scholar and scientist and it is therefore vital that students develop excellent critical thinking and research skills. Whilst there are many 'research skills' books, medical students frequently struggle with understanding the difference between the practices of research, audit, service evaluation, systematic and narrative reviews and when and how to apply them. This book addresses the kinds of questions novice investigators always ask and helps students utilise study designs, data collection tools and analysis effectively.

Clinical Trials and Tribulations evaluates the multiple layers of complexities around research management, also exploring current practices, challenges and future directions. The book provides answers to readers questions and problems through extensive use of real-world examples, case studies and lessons learned. Following an approach to provide pragmatic viewpoints as well as concepts and methodologies and its alignment with specific practices, the book explores paradigms between planning and conducting research in academia vs. healthcare vs. industry in the UK vs. Europe vs. America. It highlights practical solutions to real-world complex issues that have been documented by independent regulators. This will be an indispensable book for all staff working in clinical research within healthcare, academia and industry, as well as students intending to work in clinical trials.

Contents:
1. The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future 2. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism 3. Sample Preparation 4. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis 5. Quantitative Mass Spectronomy 6. Immunoassay in Bioanalysis 7. Phase I Metabolism 8. Phase II Enzymes 9. In vitro Techniques for Investigating Metabolism 10. Drug to Drug Interactions: an in vitro Approach 11. Clinical Impact of Drug Interactions 12. PreClinical Pharmacokinetics 13. Pharmacokinetic / Pharmacodynamic Modelling in PreClinical Drug Discovery 14. Toxicokinetics 15. Protein Binding in PlasmaA Case History of a Highly Protein Bound Drug 16. Metabolite Identification by Spectroscopy 17. Whole Body Autoradiography 18. Radiolabelled Studies in Man 19. Molecular Biology

Offering an encyclopedic introduction to research, this book shows you how to think about every stage of their project and equips you with the tools you need to understand different research processes. Packed with examples showing the diversity of research, this third edition provides hands-on guidance to help: Develop key academic skills like critical thinking, effective writing and building an argument Confidently interpret findings, assess arguments and understand the wider impact of their research Understand the challenges and opportunities involved in working with new types of data like social media and online data Supported by a dynamic new website with downloadable templates, case studies, dos and don'ts videos and more, this practical book prepares you for not just getting to grips with methodological concepts, but being ready to apply them.

**THE SUNDAY TIMES BESTSELLER | BBC RADIO 4 BOOK OF THE WEEK** Preventable tells the extraordinary story of COVID-19 and how global politics shape our health - from a world-leading expert and the pandemic's go-to science communicator Professor Devi Sridhar has risen to prominence for her vital roles in communicating science to the public and speaking truth to power. In Preventable she highlights lessons learned from outbreaks past and present in a narrative that traces the COVID-19 pandemic - including her personal experience as a scientist - and sets out a vision for how we can better protect ourselves from the inevitable health crises to come. In gripping and heartfelt prose, Sridhar exposes the varied realities of those affected (from the jailed doctor in Wuhan who sounded the alarm, and the bored passengers marooned on the Diamond Princess cruise ship, to the daily nightmares of exhausted healthcare workers), and puts you in the room with key decision makers at crucial moments (from over-confident heads of states and their hesitant scientific advisors, to the beleaguered leaders of global health organisations). Sridhar vibrantly conveys the twists and turns of a plot that saw: deadlier variants emerge (contrary to the predictions of social media pundits who argued it would mutate to a milder form); the Pyrrhic victory in many countries of the false narrative of health versus the economy (those countries which controlled the virus, like Taiwan and Denmark, had a steadier recovery); countries with weak health systems like Senegal and Vietnam fare better than countries like the US and UK (which were consistently ranked as the most prepared); and the quickest development of game-changing vaccines in history (and their unfair distribution). Combining science, politics, ethics and economics, this definitive book dissects the global structures that determine our fate, and reveals the deep-seated economic and social inequalities at their heart - it will challenge, outrage and inspire. 'A brutally compelling reminder that if voices like Devi's had been listened to, so many more could have lived' OWEN JONES 'One of the most brilliant scientists in the world who has been proven consistently right in this crisis' PIERS MORGAN 'Excellent . . . Fair, clear and compelling' NICOLA STURGEON 'Those who have found Professor Devi Sridhar's expertise and calm advice invaluable since the arrival of Covid-19 will be glad to know that she has written Preventable' RACHEL COOKE, Guardian, Non-fiction to look out for in 2022

Understanding the diagnostic methods necessary to identify bloodstream infections. In the clinical microbiology laboratory, blood is a critical diagnostic sample that, in the majority of cases is sterile (or is it?). However, when microbes gain access to and multiply in the bloodstream, it can result in life-threatening illness including sepsis. Mortality rates from bloodstream infection and sepsis range from 25% to 80%, killing millions of people annually. Blood cultures are a vital technology used in the microbiology laboratory to isolate and identify microbes and predict their response to antimicrobial therapy. The Dark Art of Blood Cultures, edited by Wm. Michael Dunne, Jr., and Carey-Ann D. Burnham, surveys the entire field of blood culture technology, providing valuable information about every phase of the process, from drawing samples to culture methods to processing positive cultures. The Dark Art of Blood Cultures is organized around several major topics.

Challenged by stringent regulations, vigorous competition, and liability lawsuits, medical device manufactures must develop safe, reliable, and cost-effective products, and managing and reducing risk is a vital element of reaching that goal. These guidelines focus on Failure Modes and Effects Analysis (FMEA) and its application throughout the life cycle of a medical device. It outlines the major U.S. and E.U. standards and regulations and provides a detailed yet easy-to-read overview of risk management and risk analysis methodologies, common FMEA pitfalls, and FMECA-Failure Mode, Effects, and Criticality Analysis.

Guidelines for Failure Modes and Effects Analysis for Medical Devices is written as a practical guide to achieving corporate consistency while dramatically cutting the time required for studies. It will help you prevent patient injuries, costly product recalls, and production department down-time.

Discover how the FMEA methodology can help your company achieve a more cost-effective manufacturing process by improving the quality and reliability of your products. This new FMEA manual from the experts at Dyadem is the ultimate resource for you and your colleagues to learn more about Failure Modes and Effects Analysis and then teach others at your facility. This comprehensive manual is sure to become a standard reference for engineering professionals.

A volume in the new Principles and Applications in Engineering series, Tissue Engineering provides an overview of the major physiologic systems of current interest to biomedical engineers: cardiovascular, endocrine, nervous, visual, auditory, gastrointestinal, and respiratory. It contains useful definitions, tables of basic physiologic data, and an introduction to the literature. Then, the book reviews the status of tissue engineering of specific organs, including bone marrow, skeletal muscle, and cartilage. Readers will acquire a good understanding of the engineering and cell biological fundamentals of tissue engineering and will develop ideas for further development of this emerging and important field.

Conceived and edited by Nigel Dent and Ramzan Visanji, Veterinary Clinical Trials form Concept to Completion is designed for both established practitioners and novices, offering alternative ways of conducting studies and ensuring that the studies are guided by Good Clinical Practices and are in compliance with regulations. Comprehensive in scope, it provides the scientific, biological, and regulatory background invaluable to teachers, researchers, and regulatory affairs staff, as well as those directly involved in clinical trials. The book covers: -Objectives of the clinical study -Control of the study -Conduct of the study -Regulation versus compliance -Factors for success -International harmonization activities -Roles of the investigator, the monitor, and the practicing veterinarian -Setting up GCP trials with particular animal species -SOPs, the generic protocol, and the study report -Contract research farms and multi-site studies -Auditing With contributions from experts in every area of veterinary trials, the text has been organized with everyday use in mind. The chapters can be read sequentially for a comprehensive view or individually for coverage of particular topics and issues as needed. Drawing directly from the in-the-trenches experience of the editors and chapter authors, the book is a guide to methods that ensure studies meet regulatory compliance and strategies that ensure avoidance of common pitfalls.

This volume explores developments in techniques in diagnostics, DNA sequencing, bioanalysis of immunoassays, and single-molecule detection. It promotes the measurement, identification, monitoring, analysis, and application of near-infrared spectroscopy (NIR) to medical and pharmaceutical advances. The text also considers noninvasive methods of NIR for successful, cost-effective, and prompt diagnoses of diseases.

Auto-immune disorders like Graves Disease, Hashimoto's Thyroiditis, Lupus, Coeliac and even Long-Covid, affect an estimated 300 million people worldwide. These disorders can be frustrating as they are difficult to diagnose, painful and often invisible. Now, with this simple yet powerful 5-step plan devised by Dr Akil Palanisamy, readers can learn to treat, tame and potentially reverse painful autoimmune conditions. In The T.I.G.E.R. Protocol, Dr Akil Palanisamy uses his training in Western medicine and complementary therapies to create an integrative approach to treat autoimmune diseases. Addressing five key elements - Toxins, Infections, Gut health, Eating right and Rest and balance - this approach has proved remarkably effective for both patients with full-blown disease and those who had been told they were on the path to autoimmunity. The foundation of this approach is the use of specific healing foods. Diet can be a powerful tool, but autoimmune diets that are typically recommended are often restrictive. Dr Akil's protocol expands the diet to be less draconian while maintaining clinical efficacy, potentially reversing the effects of years of suffering from disease and taking a person off the path to suffering in years to come. The protocol is split into easy-to-follow Phase 1 and Phase 2 diets, allowing you to eliminate the necessary food sensitivities in the short term and then reintroduce foods to achieve a more diverse and balanced diet. It also includes Dr Akil's top 10 healing foods for the microbiome - including mushrooms, artichokes and dark chocolate.