The international symposium CAR '89 (the third in a row), held in Berlin in June 1989, was again focused on the fundamental principles of applying Computer Assisted Radiology (CAR) in health care. The book contains all the presentations of the symposium and this provides an up-to-date, complete state-of-the-art-report of this interdisciplinary subject, in which physicians, engineers, physicists and computer scientists cooperate.

Over the years, interventional radiology has developed many effective and less invasive procedures. As the number and types of interven tions increase, radiologists are becoming more and more involved in clinical patient care. This includes pre-interventional patient workup, sophisticated medical therapy and monitoring during interventions, regular inpatient rounds and complete follow-up management. Therefore interventional radiologists are faced with a broad spectrum of clinical and pharmacological questions. Adjunctive medical therapy should increase the patient's comfort, should improve the success rates, and should further reduce the risks of the procedures. In order to fulfill our responsibility to the patients, a profound knowledge of certain drugs is indispensable. This in cludes, for example, sedatives, analgesics, cardiovascular drugs and agents to prevent infections, thromboembolic complications or restenoses. Moreover, a good monitoring system during complex procedures will increase the safety of radiological interventions. These topics and several more have been presented and discussed during an international symposium in Basel, Switzerland, in January 1992. It is the benefit of the authors, that all these results could be published shortly after the event. Connected with our thanks to all the co-workers the editors hope to find this publication assisting an increasing number of safe interventions.

As an addition to the European postgraduate training system for young neurosurgeons we began to publish in 1974 this series of Advances and Technical Standards in Neurosurgery which was later sponsored by the European Association of Neurosurgical Societies. This series was first discussed in 1972 at a combined meeting of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the series being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo Krayenbiihl. Thus were established the principles of European co operation which have been born from the European spirit, flourished in the European Association, and have throughout been associated with this serIes. The fact that the English language is well on the way to becoming the international medium at European scientific conferences is a great asset in terms of mutual understanding. Therefore we have decided to publish all contributions in English, regardless of the native language of the authors. All contributions are submitted to the entire editorial board before publication of any volume. Our series is not intended to compete with the publications of original scientific papers in other neurosurgical journals. Our intention is, rather, to present fields of neurosurgery and related areas in which important recent advances have been made. The contributions are written by spe cialists in the given fields and constitute the first part of each volume.

New imaging technology and more sophisticated image processing systems will have a profound effect on those areas of medicine which are concerned with imaging for diagnosis and therapy planning. Digitally formated data will form the basis of an increasing number of medical imaging modalities. Before the diagnostic imaging department of the future will largely be digital, many problems have still to be solved as regards image quality, costs, and ease of use. The computer and other information science derived methods will contribute towards solving many of the problems in these areas. It is widely expected that there will be an information science derived evolution in imaging for radiology and related departments. Computer assistance may be applied to image generation, e.g. CT, MRI, DR and DSR, storing and transferring of images, and viewing, analysing and interpreting of images. The application of computers to these activities (which characterise radiological departments), may be defined as Computer Assisted Radiology (CAR) . In the main, CAR will promote the transition from analog imaging systems to digital systems, integration of digital imaging modalities through Picture Archiving and Communication Systems (PACS') and the graduated employment of Medica~ Work Stations (MWS) for diagnosis and therapy planning. It will transfer geographically, organisationally and/or mentally isolate imaging activities towards fully integrated multi-imaging modality diagnostic departments. This development will have a considerable impact on patient management, on the medical profession and on the health care system.

This unique ultrasound atlas is dedicated entirely to pathology of the scrotal contents. The 357 illustrations constitute the major proportion of the book, each of them is accompanied by a labelled diagram and detailed description. The atlas covers the essential embryology and ultrasound anatomy, the principal clinical presentations encountered in practice by the clinician and radiologists, and the differential diagnosis of intrascrotal cysts and calcifications. For each chapter there is a short but precise text, supplemented by tables or decision-making algorithms followed by the relevant images.

Nous sommes entrA(c) dans une civilisation de l'image et du numA(c)rique. L'imagerie mA(c)dicale numA(c)rique offre au clinicien des outils nouveaux, riches de promesses, et en pleine A(c)volution. Or ces techniques ne peuvent se concevoir sans utilisation de l'informatique. Mais cette imagerie utilise une information complexe, volumineuse, non structurA(c)e, souvent multimA(c)dia. Elle pose donc A l'informaticien des problA]mes difficiles qu'il ne sait pas encore parfaitement rA(c)soudre. Par consA(c)quent, la recherche d'outils informatique adaptA(c)s et la determination de leur meilleur mode d'utilisation est un domaine riche de possibilitA(c) de collaboration entre mA(c)decins et informaticiens. La premiA]re confA(c)rence organisA(c)e dans le cadre des Entretiens de Lyon a permis A des informaticiens et A des mA(c)decins, ensemble, d'une part d'A(c)tudier les aspects informatiques des bases de donnA(c)es d'imagerie mA(c)dicale, d'autre part de rechercher comment faire A(c)voluer les systA]mes d'imagerie mA(c)dicale (PACS) vers une intA(c)gration dans des systA]mes d'information hospitaliers, d'autre part encore de dA(c)terminer par quelles techniques pourraient Aatre obtenues et mieux visualisA(c)es des images mA(c)dicales notamment tridimensionnelles, enfin d'A(c)tudier les systA]mes experts mA(c)dicaux et les problA]mes d'intelligence artificielle appliquA(c)e A la mA(c)decine.

There is a tradition behind the current radiologic examination of the small bowel. Many of the great names in gastrointestinal radiology have established their reputations on the basis of their work in the small bowel. This is an area which is assuming ever greater importance for radiologists as its mucosal surface continues to elude the endos copist. Moreover, it is an aspect of radiology which calls for the greatest technical and interpretative skill. It is a great pleasure to welcome the English language version of this beautiful work on Radiology of the Small Intestine. English speaking physicians are frequently not as familiar with the large body of work published in French as they should be. Tant pis ! Dr. Bret and his co-workers have been pioneers in the pursuit of excellence in gastrointestinal radiology. During all the years that I have been involved in this field, I have admired their work.

Clinical studies during the past 10 years have shown that PET is more sensitive than CT and MRI for the detection of many tumors. In many cases, however, for example in head and neck tumors, combination with radiological procedures is necessary. It may be speculated that PET should be the first study in a malignant tumor when metastatic spread is suspected. MRI and CT may then be restricted to those body areas which evince sites of increased glucose metabolism. Thus, a combination of metabolic and morphologic procedures will enhance tumor detection and change the therapeutic strategy. In this light, an atlas including PET, CT, MRI, and histology data seems desirable to combine metabolic and morphologic imaging. This book presents an overview of the available data which should be of great interest not only for specialists in radiology and nuclear medicine, but also for oncologists.

Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems provides an overview of the current modeling methods and applications enhancing interventional treatments and computer-aided surgery. A detailed description of the techniques behind image acquisition, processing and three-dimensional reconstruction are included. Techniques for the computational simulation of solid and fluid mechanics and structure interaction are also discussed, in addition to various cardiovascular and pulmonary applications. Engineers and researchers involved with image processing and computational modeling of human organ systems will find this a valuable reference.

A goldmine of theoretical insights and practical suggestions, Achieving Excellence in Medical Education, Second Edition explores the essential question facing medical educators and learners today: What is our vision of educational excellence, and what can we do to enhance our performance? Among the topics explored within this updated, engaging, informative, and thought-provoking text are: * Education's position as a priority of medical schools * Seminal educational insights from non-medical educators * Best practices of outstanding educators and learners * Promises and pitfalls of new educational technologies * Key resources for promoting excellence in medical education * Medical education's role in preparing future leaders * Leadership roles for medical schools in universities and society Reviews of the first edition: "This is an eloquent, quotable, and inspirational book that provides a template for "Achieving Excellence in Medical Education." - Journal of the American Medical Association "Gunderman is an accomplished educator, well known as a thoughtful and provocative teacher. . . I recommend his book to department chairs, clerkship and residency program directors, and education professionals who are shaping the future of medical education." - New England Journal of Medicine

This book constitutes the thoroughly refereed conference proceedings of the 6th International Symposium on Biomedical Simulation (ISBMS) which was held in Strasbourg, France, in October 2014. Biomedical modeling and simulation are at the center stage of worldwide efforts to understand and replicate the behavior and function of the human organism. Large scale initiatives such as the Physiome Project, Virtual Physiological Human and Blue Brain Project aim to develop advanced computational models that will facilitate the understanding of the integrative function of cells, organs, and organisms, with the ultimate goal of delivering truly personalized medicine. At the same time, progress in modeling, numerical techniques and haptics has enabled more complex and interactive simulations. The 27 revised full papers (including 16 regular and 11 short papers) were carefully selected from 45 submissions and cover topics such as training systems and haptics, physics-based registration, vascular modeling and simulation, image and simulation, modeling, surgical planning, analysis, characterization and validation.

This book offers a review of the normal histopathological anatomy, imaging techniques and diagnostic findings for a broad spectrum of clinical problems. It includes a classification of inflammatory syndromes previously described under several different terms. It is the first textbook to describe the imaging of all anterior chest wall disorders.

This book constitutes the refereed proceedings of the 6th International Workshop on Biomedical Image Registration, WBIR 2014, held in London, UK, in July 2014.

The 16 full papers and 8 poster papers included in this volume were carefully reviewed and selected from numerous submitted papers. The full papers are organized in the following topical sections: computational efficiency, model based regularisation, optimisation, reconstruction, interventional application and application specific measures of similarity.

Gastrointestinal bleeding is an age-old problem. The original description of g- trointestinalbleedingmayhavebeenfromGalenandhisworkconnectingdyspepsia andmelanoticstool. Thechangesinourmanagementofgastrointestinalbleeding overthecenturieshavebeendrivenbynaturalalterationsinthespectrumofdiseases, expanding our understanding of these diseases and the never ending advances in technologyandpharmacologythathaveoccurredrelativetoGIdiseases. Academic interestingastrointestinalbleedingpeakedinthelasthalfofthetwentiethcentury withtheexpandingroleofsurgery,thediscoveryofacid-basedpepticulcerthe- pies,andtheriseof?exibleendoscopyandculminatedinthedescriptionofh. pylori as a causative agent for ulcer disease. More recently there has been a decrease incidenceinbleedingdiseasesofthegutandthereforeadecreasinginterestinthe scholarlywritingaboutthesediseases. Therehasnotbeenamajortextbookwritten aboutgutbleedinginover10yearsandthereforetheintentionofthistextbookisto ?llthatvoidbyprovidingareviewofacomprehensiveapproachtouppergut,mid, andlowergutbleeding. CliniciansatDukeUniversitywhohaveacommoninterestinthegastrointes- naltracthavecollaboratedintheconstructionofthistext. Thisefforthasbrought together surgeons, gastroenterologists, and radiologists, to carefully chronicle the presentation, diagnosis, and management of modern day causes of gastrointes- nal bleeding. These co-authors concentrate on some of the latest innovations in the endoluminal and minimally invasive techniques that characterize the current approaches to these diseases. Emphasis has been placed on capsule endoscopy, double-balloon endoscopy, laparoscopic peptic ulcer surgery, and angiographic diagnosis and management techniques. The text has been written in such a way thatthereadercanquicklyreviewaspeci?ccauseofGIbleedingpriortomanaging ofsuchapatient. Weexpectthistextwillbeusedwiththesameimmediacyasthe diseasespresent. Wehopethatthistextprovidesafoundationforlearningformedicalstudents, interns,residents,andpractitionerswhoencounterthesecriticallyillanddif?cultto managepatients. Durham,NC,USA AuroraD. Pryor Durham,NC,USA TheodoreN. Pappas Durham,NC,USA MalcolmStanleyBranch v Acknowledgment TheeditorswouldliketothankMs. VirginiaCashforherhelpinthepreparation andcoordinationofthetext. vii Contents Part I Upper GI Bleeding Stabilization of Patients Presenting with Upper Gastrointestinal Bleeding. ..3 ErrolL. BushandMarkL. Shapiro Urgent Workup for Upper Gastrointestinal Bleeding...13 LorettaErhunmwunseeandSandhyaA. Lagoo-Deenadayalan Management of Esophageal Variceal Bleeding ...23 KekiBalsaraandLisaPickett Management of Dieulafoy's Lesions ...31 SerainaK. Faes,BrianR. Untch,ClaireEdwards,JohnTurner, MartinPoleski,andDouglasS. Tyler Management of Bleeding Peptic Ulcer Disease ...39 JamesC. PadussisandTheodoreN. Pappas Management of Unusual Sources of Upper GI Bleeding...65 ElisabethTracyandJanetTuttle-Newhall Mallory-Weiss Syndrome...79 JacobN. SchroderandMalcolmS. Branch Management of Bleeding Small Bowel Tumors...85 KeriE. LunsfordandAuroraD. Pryor Management of Bleeding from the Bile Duct ...103 CarlosE. MarroquinandBridgetM. Marroquin Management of Bleeding from the Pancreas...

Regular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting "physical health", but also for the central nervous system believed to promote "brain health". Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a "multimodal imaging" perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.

This is the first work to take a comprehensive look at the application of Magnetic Resonance (MR) techniques in the diagnosis, follow-up and therapy monitoring of dementing illnesses. The authors present an overview of MR findings in neurodegenerative and vascular disorders leading to dementia. In doing so, they also discuss other diseases that lead to cognitive and/or behavioural deterioration, such as infectious inflammatory disorders, toxic encephalopathies, inborn errors of metabolism of adult onset and post-traumatic, post-radiotherapy and post-chemotherapy conditions. This authoritative, well-written and richly illustrated reference work is indispensable for anybody working in the field.

Nuclear Medicine in Psychiatry showcases the combined expertise of renowned authors whose dedication to the investigation of psychiatric disease through nuclear medicine technology has achieved international recognition. Psychiatric disorders are discussed both from categorical and functional psychopathological viewpoint and the latest results in functional neuroimaging are detailed. Most chapters are written jointly by a psychiatrist and a nuclear medicine expert, and each contains a section "Clinical Aspects", to link research data with clinical routine. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the psychiatrist and the radiologist/nuclear medicine specialist to the interested general practitioner and cognitive psychologist.

This invaluable and well-presented text brings together previously fragmented or incompletely elucidated data on the impressive recent advances in orthopedic nuclear medicine. The book begins by acquainting the readers with various anatomic, physiologic, pathologic and technical concepts crucial to understanding orthopedic nuclear medicine and its utilization in clinical practice. Subsequent chapters detail the diagnosis of skeletal infections, trauma, vascular disorders, metabolic and neoplastic bone diseases, soft tissue calcifications and joint disorders. A separate section is devoted to the use of radionuclides in the treatment of bone and joint diseases. A unique feature of this richly illustrated volume is its comprehensive and clinically oriented approach. The book will prove invaluable to all with an interest in diagnostic and therapeutic orthopedics, including radiologists, orthopedists, rheumatologists, pediatricians, other clinicians and nuclear medicine professionals.

Using images and anatomic illustrations, "Rad Tech's Guide to MRI: Imaging Procedures, Patient Care, and Safety" provides the reader with a quick overview of MRI for quick reference and examination preparation. As part of the Rad Tech's Guide Series, this volume features an overview of anatomy, imaging tips, scanning procedures, and the latest information on protocols--all in the context of patient care and safety.

Each book in the Rad Tech's Guide Series covers the essential basics for those preparing for their certifying examinations and those already in practice.

Special Features include:
Materal based on the ARRT educational requirements
Quick-reference bullet format
Concise presentation

Peripheral and Cerebrovascular Intervention draws upon experts from diverse fields to provide readers with a comprehensive foundation for understanding and performing endovascular procedures-from the basic steps to the most current and advanced techniques. Individual chapters focus on primary intervention sites, including lower extremity, renal/mesenteric, subclavian/upper extremity, carotid/vertebral, intracranial and venous interventions. Additionally, chapters covering critical limb ischemia and abdominal and thoracic aortic aneurysms are included. By incorporating valuable clinical information, such as indications, contraindications, complications and discussions of surgical techniques and procedures, this book is a valuable resource for the busy practitioner and will be of interest to all interventional and general cardiologists, radiologists and neurologists; vascular surgeons; internists and residents and fellows.

A single source of information about pathologic lesions of the adrenal, the urinary tract, and the male genital system, minimizing the need to consult numerous texts of limited scope, this book contains gross photos and photomicrographs of virtually every pathologic entity, and variants of those entities. The book is lavishly illustrated with images accompanied by text that explains the visual images, highlighting key diagnostic features and providing brief but helpful discussions of the differential diagnosis. This book is designed for practicing pathologists and pathologists in training as well as urologists, GU radiologists, GU radiation oncologists, and GU medical oncologists.

This volume highlights the remarkable new developments in brain imaging, including those that apply magnetic resonance imaging (MRI) and Positron Emission Tomography (PET), that allow us to non invasively study the living human brain in health and in disease. These technological advances have allowed us to obtain new and powerful insights into the structure and function of the healthy brain as it develops across the life cycle, as well as the molecular make up of brain systems and circuits as they develop and change with age. New brain imaging technologies have also given us new insights into the causes of many common brain disorders, including ADHD, schizophrenia, depression and Alzheimer's disease, which collectively affect a large segment of the population. These new insights have major implications for understanding and treating these brain disorders, and are providing clinicians with the first ever set of biomarkers that can be used to guide diagnosis and monitor treatment effects. The advances in brain imaging over the last 20 years, summarized in this volume, represent a major advance in modern biomedical sciences.