5-Hydroxytryptamine (5-HT)4 receptors and central nervous system function: An update.- Chemical teratogenesis in humans: Biochemical and molecular mechanisms.- Recent advances in potassium channel modulation.- Neuronal prostacyclin receptors.- Effects of NSAIDs on the kidney.- G protein coupled receptors as modules of interacting proteins: A family meeting.- Antifungal therapy, an everlasting battle.- Index - Sachverzeichnis - Table des matieres, vol. 49.- Index of titles - Verzeichnis der Titel - Index des titres vol. 1-49.- Author and paper index - Autoren- und Artikelindex - Index des auteurs et des articles, vol. 1-49.

Nanomedicine consists of the use of nanotechnology and nanobiotechnology in medicine. There have been extensive developments in the area of nanomedicine. The scope of this book is first to discuss the origin of nanomedicine. Following this, instead of a general overview of the whole area, 24 chapters on selected topics of important areas are described in detail. Authors are selected from around the world to give a representative and international view of the activities in the area of nanomedicine.

This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson's Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center. Cutting-edge and authoritative, Clinical Trials in Parkinson's Disease is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.

An unprecedented compilation of state-of-the-art advances in clinical research on diabetes and obesity by premier clinical scientists around the world. This volume critically reviews the limitations and strengths of today's major techniques in clinical diabetes research, and then reviews how those methods have been used to carry out cutting-edge studies of carbohydrate, lipid, and protein metabolism in the disease.

This invaluable volume serves as a guide to up-to-the-minute techniques for the discovery and evaluation of pharmacologically active compounds for therapeutic development. Focusing on practical applications, provided by expert practitioners from both industry and academic research laboratories, Advances in Drug Discovery Techniques covers rational drug design, high-throughput screening and genetic approaches to drug discovery. Moreover, chapters also focus on advances in the use of combinatorial chemistry and natural products, both of which support the chemical diversity for many drug screening programmes. Typical screening studies and their link to robotics and informatics are also presented in detail, together with an overview of current progress within antisense therapeutics. Overall, this book will be an excellent reference source for all individuals interested in making sense of the rapid changes in drug discovery that result from developments in molecular biology, robotics and informatics.

The discovery of the two inherited susceptibility genes BRCA1 and BRCA2 in the mid-1990s created the possibility of predictive genetic testing and led to the establishment of specific medical programmes for those at high risk of developing breast cancer in the UK, US and Europe. The book provides a coherent structure for examining the diversity of practices and discourses that surround developments linked to BRCA genetics, and to the evolving field of genetics more broadly. It will be of interest to students and scholars of anthropology, sociology, history of science, STS, public health and bioethics. Chapter 8 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9780415824064_oachapter8.pdf

Given the latest advances in cancer research, which includes basic research and its derived diagnostic, clinical, and therapeutic applications, the book New Trends in Cancer for the 21st Century is written by individuals such as molecular biologists, whose tasks are to decipher, after sequencing the human genome, those new genes and pathways involved in the carcinogenesis process; clinical and molecular pathologists, who apply these discoveries for the molecular diagnosis and characterization of the tumor; and clinical oncologists, who treat patients. Pharmacogenetics introduces new perspectives in the translational fields with the design of drugs against specific targets, which at this moment are in clinical trials phases. Several organizations such as the EORTC (European Organization for Research and Treatment of Cancer) and the OECI (Organization of European Cancer Institutes) and comprehensive cancer centers play a crucial role in focusing cancer research on all these areas.
This book achieves a state of the art in every field of cancer research and discusses the new perspectives that will open the future for cancer treatment (basic research, new technologies, new drugs, therapies...). For this reason, the book is intended for pathologists, clinicians, and biologists, as well as fellows and students of physiology and medicine.

"Advances in Cancer Research" provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.
Provides information on cancer research

Oustanding and original reviews

Suitable for researchers and students

This new edition explores and provides an update on the biology and pathogenesis of human cytomegalovirus infection. Modern techniques that are currently being utilized to investigate the molecular aspects of viral infection, as well as how these new research studies are leading to new approaches to mitigate disease, are also provided. Given the key role the virus plays in significant acute and chronic human disease in all stages of life, from newborns to seniors, the need for clear methodologies to further explore the biology of HCMV infection and mitigation strategies is readily apparent. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Human Cytomegaloviruses: Methods and Protocols, Second Edition serves as an ideal scientific reference for basic and clinical scientists and medical personnel on the modern understanding of the pathobiology of the virus, and the approaches, techniques, and models to study human cytomegalovirus infection and disease.

This series was founded in 1959, and its focus has shifted from medicinal chemistry to a much wider scope. It now encompasses all fields concerned with the development of therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drugs research. Invited authors write reviews on the following fields: biology, chemistry, biochemistry, physiology, immunology, pharmacy, toxicology, pharmacology, and clinical aspects. The books are linked by indexes in each volume, forming an almost encyclopaedic work.

Developments in the area of biomaterials, bionanotechnology, tissue engineering, and medical devices are becoming the core of health care. Almost all medical specialties involve the use of biomaterials, and research plays a key role in the development of new and improved treatment modalities. This volume focuses on several current trends in tissue engineering, remodelling and regeneration. Leading researchers describe the use of nanomaterials to create new functionalities when interfaced with biological molecules or structures. In addition to coverage of basic science and engineering aspects, a range of applications in bionanotechnology are presented, including diagnostic devices, contrast agents, analytical tools, physical therapy applications, and vehicles for targeted drug delivery. The use of polymers, alloys, and composites, or a combination of these, for biomaterials applications in orthopaedics is also explored. These contributions represent essential reading for the biomaterials and biomedical engineering communities, and can serve as instructional course lectures targeted at graduate and post-graduate students.

The last 10 years have seen a seismic shift in therapeutic product development and testing. In both the pharmaceutical (both small and large molecule) and medical device sectors, the vast majority of testing and evaluation of products is not performed within innovator companies, but rather has been outsourced to a growing universe of commercial organizations. The authors both have more than 30 years experience in this field, and both have worked within innovator companies, for CROs, and as consultants in the field. "Contract Research and Development Organizations: Their Role in Global Product Development" has been crafted by these authors to provide a how to guide for all aspects of working with CROs in selecting, working with and ensuring the best possible desirable outcome of having the R&D function, or substantial parts of it, outsourced. It uses as the exemplary case nonclinical safety assessment, biocompatibility and efficacy testing which are to be performed to select the best possible candidate compound, device or formulation and then moving the resulting regulated therapeutic medical product into and through the development process and to marketing approval. But also covered are the contract synthesis of drug substances and corresponding manufacture of biologics and manufacture of products, formulation development, clinical evaluation, regulatory and document preparation support, and use of consultants.

Included in the volume are an exhaustive listing of those CROs in the (drug and device) safety evaluation sector and their contact information and capabilities, and extensive similar listing for the other types of contract service providers. Also included are guidances on how to monitor ongoing work at contract facilities and audit check lists for GLP, GMP and GCP facilities. These listings are international in scope, and a specific chapter addresses working with some of the newer international CROs. "

Do statistics-heavy research papers give you a headache? Are you baffled by bias, confused by correlation, or flummoxed by F-tests? A Guide for the Statistically Perplexed is here to help This book is designed to assist students, clinicians, and researchers in becoming familiar with statistical and research techniques by covering the essentials of the topic and drawing attention to many common problem areas.

Inspired to write on this topic in reaction to mistakes he encountered in actual papers, David L. Streiner uses his trademark sense of humour and light-hearted style to explain complex statistical concepts in lucid, jargon-free language. Streiner delves into topics such as presenting data (or, conversely, how not to), statistical techniques, and more advanced procedures. To help readers detect problems with research design and interpretation, he details important 'CRAP' (convoluted reasoning or anti-intellectual pomposity) detectors for which they should watch out.

Even those with little or no background in statistics, measurement theory, or research will come out of A Guide for the Statistically Perplexed with a new understanding and appreciation of these topics.

"Community-Based Participatory Research (CBPR) has become the preferred model for conducting research in communities. Most scientists who conduct such research now recognize that working in partnership with the community is preferable, and more ethical, than conducting research on a community . As Surgeon General of the United States, I direct a number of programs aimed at encouraging Americans to avoid tobacco, engage in physical activity, consume more nutritious diets, and protect their health in other ways. We need more effective methods to persuade, motivate, and enable individuals and communities to adopt these healthier lifestyles, and it is through CBPR that we will be able to discover these methods." From the Foreword by Regina M. Benjamin, MD, MBA, U.S. Surgeon General

"The editors of this book bring together in one place both a description of epidemiological methods and a discussion of community-level issues. It is a volume that will prove useful to those who wish to conduct contemporary community-based research." - Praise for the First Edition from the Foreword David Satcher, Former Surgeon General of the United States

This second edition of a highly regarded textbook on the foundations of and strategies for achieving fertile community-based health care research has been completely revised and updated. It now includes new chapters on translating research into practice, evaluating research, and applying community-based participatory research (CBPR) principles to service, education, and evaluation. The book also updates a crucial chapter on the voices of community stakeholders and an important study of the ethical issues surrounding the Tuskegee Syphilis Study. Edited by renowned professors of community-based research, the text is distinguished by its how-to approach and focus on practical research methods.

The text discusses the unique challenges of conducting CBPR and addresses ways to build and sustain community partnerships. It explores ethical issues regarding health care research, includes input from community stakeholders, and describes national and international support for CBPR. Research methods covered include qualitative studies, surveys, and intervention trials. Applications of CBPR illustrate how to translate research into practice and community-based participatory approaches to service, education, and evaluation. The second edition includes new chapters on:

Building and sustaining researcher/community partnerships National and international investments in and support for CBPR Surveys and methods for conducting CBPR Translating research into practice Community-based participatory approaches to service, education, and evaluation

Lead by both children's rights perspectives and methodological arguments there is an increasing emphasis on children and young people's participation in health and social care research by researchers, policy makers and funding bodies - with many now considering the active involvement of children and young people a requirement. However, although increasingly important, there is little exploration of how to address and overcome the many challenges arising from their participation. Divided into five parts, this practical book begins by considering what research with young people is and why we should do it, before leading the reader into how to undertake it. The book then provides practical examples of action and finishes with reflections about the whole process. Bringing together a variety of experienced researchers, from a wide range of backgrounds in health and social care and including young people, the chapters provide insight for practical action, as well as critical and theoretical reflection. Involving Children and Young People in Health and Social Care Research includes issues on: Understanding the reasons and processes for involving children and young people in research Making sure that involvement is meaningful and not merely tokenistic Developing research methods that are commensurate with different ages and abilities Ensuring adequate training and preparation, for children, young people and adults to make involvement meaningful Power and relationships between young people researchers and adult researchers Sustaining young people's interest and motivation Addressing ethical issues that arise throughout the research journey Committed to partnership and participation throughout the entire process of the active involvement of children and young people in health and social care research, this text provides invaluable insights and is a resource for all those conducting research in and with children and young people.

The book provides a comprehensive examination of pancreatic cancer, integrating global insights with an African-focused perspective. Understanding Pancreatic Cancer: Global Strategies and African Perspectives is structured into five parts, each addressing key aspects of the disease, from epidemiology to future innovations in care. Part I (Chapters 1 and 2) explores the global and African contexts, highlighting disparities in prevalence, diagnosis, and healthcare infrastructure. Part II (Chapter 3) delves into the biological and molecular mechanisms of pancreatic cancer, including genetic mutations and emerging therapeutic targets. Part III (Chapters 4 and 5) focuses on precision medicine and early detection, discussing advances such as artificial intelligence (AI) and biomarker-driven approaches. Part IV (Chapters 6-8) covers treatment strategies, from conventional therapies to novel interventions like immunotherapy and targeted treatments. Finally, Part V (Chapters 9-11) emphasizes the importance of advocacy, research, and policy reforms, outlining strategies for improving patient outcomes and shaping the future of pancreatic cancer care.

By bridging scientific advancements with real-world challenges, this book serves as an essential resource for researchers, clinicians, and policymakers working to enhance pancreatic cancer diagnosis, treatment, and prevention—both in Africa and globally.

Key Features

• Examines pancreatic cancer worldwide, with a focus on Africa’s unique challenges and healthcare disparities.
• Explores molecular mechanisms, precision medicine, and AI-driven early detection.
• Covers surgery, chemotherapy, immunotherapy, and targeted therapies.
• Highlights research, healthcare policies, and strategies to improve patient care.

The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as "Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide. The salient features of this book are: * Systematic and simple approach * Emphasis on traditional and modern drug design strategies * Comprehensive coverage for the current advances in the drug design * Experimental section to ensure hands-on-experience Note: T& F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

The study of human reproduction has focused on reproductive 'success' and on the struggle to achieve this, rather than on the much more common experience of 'failure', or reproductive loss. Drawing on the latest research from The UK and Europe, The United States, Australia and Africa, this volume examines the experience of reproductive loss in its widest sense to include termination of pregnancy, miscarriage, stillbirth, perinatal and infant death, as well as - more broadly - the loss of desired normative experiences such as that associated with infertility, assisted reproduction and the medicalisation of 'high risk' pregnancy and birth. Exploring the commonalities, as well as issues of difference and diversity, Understanding Reproductive Loss presents international work from a variety of multi-disciplinary perspectives and will appeal to sociologists, anthropologists and other social scientists with interests in medicine, health, the body, death studies and gender.

This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

"Research Methods in Human Skeletal Biology" serves as the one location readers can go to not only learnhow to conduct research in general, but how research is specifically conducted within human skeletal biology. It outlines the current types of research being conducted within each sub-specialty of skeletal biology, and gives the reader the tools to set up a research project in skeletal biology. It also suggests several ideas for potential projects. Each chapter has an inclusive bibliography, which can serve as a good jumpstart for project references.
Provides a step-by-step guide to conducting research in human skeletal biologyCovers diverse topics (sexing, aging, stature and ancestry estimation) and new technologies (histology, medical imaging, and geometric morphometrics)Excellent accompaniment to existing forensic anthropology or osteology works"

This book provides an introduction to the principles of both cardiovascular epidemiology and molecular pathophysiology; as a unique aspect, it also outlines and discusses the molecular concepts underlying epidemiological observations. This second volume is focused on all aspects concerning "secondary risk factors" in terms of diseases associated with enhanced risk for cardiovascular events. The book promotes the use of interdisciplinary approaches in the field of preventive medicine based on recent advances in molecular and cellular pathophysiology. The book offers a valuable resource for researchers in basic biomedical fields and clinical scientists alike, as well as guidelines for novel avenues of research in both basic pathophysiology and cardiovascular therapy and prevention.

Although the subject of federally mandated Institutional Review Boards (IRBs) has been extensively debated, we actually do not know much about what takes place when they convene. The story of how IRBs work today is a story about their past as well as their present, and "Behind Closed Doors "is the first book to meld firsthand observations of IRB meetings with the history of how rules for the treatment of human subjects were formalized in the United States in the decades after World War II. Drawing on extensive archival sources, Laura Stark reconstructs the daily lives of scientists, lawyers, administrators, and research subjects working--and "warring"--on the campus of the National Institutes of Health, where they first wrote the rules for the treatment of human subjects. Stark argues that the model of group deliberation that gradually crystallized during this period reflected contemporary legal and medical conceptions of what it meant to be human, what political rights human subjects deserved, and which stakeholders were best suited to decide. She then explains how the historical contingencies that shaped rules for the treatment of human subjects in the postwar era guide decision making today--within hospitals, universities, health departments, and other institutions in the United States and across the globe. Meticulously researched and gracefully argued, "Behind Closed Doors" will be essential reading for sociologists and historians of science and medicine, as well as policy makers and IRB administrators.

The purpose of this book is to provide an overview of the biology of the planorbid snail Biomphalaria glabrata mainly as related to the snail 's role as a host of larval trematodes . This snail is of great importance in medical and economic zoology as a vector of important trematode (fluke) diseases in human and veterinary medicine and in wildlife biology. Moreover, this snail is a useful model for numerous basic studies in biology and chemistry. A book that provides modern coverage of diverse topics from the molecule to the community of this snail as related to larval trematode parasitism is not available. This book should appeal to a wide audience of biologists, ecologists, biochemists, malacologists, parasitologists, public health workers, epidemiologists, and graduate and advanced undergraduate students in biomedical and allied health sciences.

This book discusses the unique ion channels and transporters found within the epithelial tissues of various organs, including the kidney, intestine, pancreas and respiratory tract. Authors focus on demonstrating the crucial roles that each of these channels and transporters play in transepithelial ion and fluid transport across epithelia, as well as in maintaining homeostasis. It allows readers to gain an understanding of the fundamentals of ion transport, in terms of function, modelling, regulation, trafficking, structure and pharmacology. This is the second of three volumes highlighting the importance of epithelial ion channels and transporters in basic physiology and pathophysiology of human diseases. This volume focuses on a wide array of epithelial tissues and the use of organoids to study epithelial function. Furthermore, clinical researchers and basic scientists from various fields provide a medical perspective on the physiology of a number of tissues and organs of the body including the pancreas, intestine, sweat glands, mammary gland, inner ear epithelia, retinal pigment epithelia of the eye, choroid plexus, and the ectodermal epithelia in dental enamel formation. This volume aims to 'round out' the reader's journey from basic science to the laboratory bench and clinical management of molecular diseases, making Volume 2 a must-read for students and scientists in the field of physiology, as well as for clinicians.

The trial of the "German doctors" exposed atrocities of Nazi medical science and led to the Nuremberg Code governing human experimentation. In Japan, Unit 731 carried out hideous experiments on captured Chinese and downed American pilots. In the United States, stories linger of biological experimentation during the Korean War. This collection of essays looks at the dark medical research conducted during and after World War II. Contributors describe this research, how it was brought to light, and the rationalizations of those who perpetrated and benefited from it; look at the response to the revelations of this horrific research and its implications for present-day medicine and ethics; and offer lessons about human experimentation in an age of human embryo research and genetic engineering.