A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scientific and clinical perspectives.

The disciplines of cognitive neuroscience, development, and psychopathology are complementary in the study of human perception and attention, even though each discipline emerges from a decidedly different and sometimes incompatible worldview. The meeting of researchers across these disciplines results in a fruitful cross-fertilization that ultimately leads to better science within each discipline and a joint scientific endeavor that is greater than the sum of its parts.
Cognitive Neuroscience, Development, and Psychopathology: Typical and Atypical Developmental Trajectories of Attention unites scholars sharing common interests in the development of attention and related areas of functioning with different perspectives and methodologies. The volume does not impose a single framework for discussing the relevant issues, but rather the authors highlight the importance of their own approaches to the study of the typical and atypical development of attention. Drs. Burack, Enns, and Fox have organized the chapters into three sections: Atypical Environments, Threat, and the Development of Individual Differences in Attention; The Organization of the Development of Attention in Typical and Atypical Processing; and The Case of Orienting Attention in Developing an Integrated Science. Discussion topics include cognitive bias modification, attention and the development of anxiety disorders, deficient anchoring, reflexive and abnormal social orienting in autism, and social attention. This volume is a unique and critical resource for researchers in communication disorders, developmental and cognitive psychology, human development, neuroscience, and educational and counseling psychology.

Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

This book provides a comprehensive look at nonhuman primate social inequalities as models for health differences associated with socioeconomic status in humans. The benefit of the socially-housed monkey model is that it provides the complexity of hierarchical structure and rank affiliation, i.e. both negative and positive aspects of social status. At the same time, nonhuman primates are more amenable to controlled experiments and more invasive studies that can be used in human beings to examine the effects of low status on brain development, neuroendocrine function, immunity, and eating behavior. Because all of these biological and behavioral substrates form the underpinnings of human illness, and are likely shared among primates, the nonhuman primate model can significantly advance our understanding of the best interventions in humans.

This book offers a self-study program on how mathematics, computer science and science can be profitably and seamlessly intertwined. This book focuses on two variable ODE models, both linear and nonlinear, and highlights theoretical and computational tools using MATLAB to explain their solutions. It also shows how to solve cable models using separation of variables and the Fourier Series.

This volume provides comprehensive procedures for analyzing the extracellular matrix in native, injured, and engineered neural tissues. Divided into four parts, each focusing on different aspects of the extracellular matrix and the nervous system, Extracellular Matrix covers methods to analyze native tissue, in vitro models for investigating cell-extracellular matrix interactions in a variety of contexts, protocols to investigate the role of the extracellular matrix in nervous system injury, degeneration, and regeneration, as well as therapeutics and engineered systems. Each chapter is written by leading experts and presents established protocols in a concise format, encompassing current technologies as well as methods developed over years of research. Beginning with an introduction to the method, chapters continue with a listing of the materials and equipment, step-by-step protocols, and a Notes section with troubleshooting tips, supplemental details and alternative approaches, as well as a list of references for further information. As part of the practical and convenient Neuromethods series, Extracellular Matrix serves as an invaluable aid for researchers studying this vital area of neuroscience.

This issue of International Review of Neurobiology is split over 2 volumes, bringing together cutting-edge research on Bioinformatics of Behavior. The 2 volumes review current knowledge and understanding, provide a starting point for researchers and practitioners entering the field, and build a platform for further research and discovery.
Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered
All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one tocover the vascular aspects of CNS trauma.The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters. "

This book is devoted to the issue of how we can learn to live together in the face of division and conflict. It is dedicated to the life and work of a remarkable human being, Dr Epimenidis Haidemenakis, scientist, statesman, visionary leader, President Emeritus of the International S.T.E.P.S. Foundation and founding father of The Olympiads of the Mind (OM). The monograph consists of a collection of papers presented at the 8th and 9th Olympiads of the Mind held in Washington, DC and Chania, Crete respectively. Distinguished international scholars, government and corporate representatives, leading researchers and academics from multiple disciplines and Nobel Laureates Leon Lederman (Physics, 1988), Martin Perl (Physics, 1995) and Yuan T. Lee (Chemistry, 1986) address a broad range of issues all with the aim of improving the human condition and achieving cooperation among the people of the world. The topics include the environment, sustainability and security; diversity and how to achieve integration and peace among people in a fractured world; the important role of brain research; how to overcome poverty and inequality; how to enhance creativity and improve education at all levels; and how new technologies and tools can be used for common benefit. The culmination of the book is a call to action, to join what one might call the "OM Movement"-bringing the best minds in the world together to create solutions to world issues so that we can all live together in harmony.

This book is devoted to the welfare of invertebrates, which make up 99% of animal species on earth. Addressing animal welfare, we do not often think of invertebrates; in fact we seldom consider them to be deserving of welfare evaluation. And yet we should. Welfare is a broad concern for any animal that we house, control or utilize - and we utilize invertebrates a lot. The Authors start with an emphasis on the values of non-vertebrate animals and discuss the need for a book on the present topic. The following chapters focus on specific taxa, tackling questions that are most appropriate to each one. What is pain in crustaceans, and how might we prevent it? How do we ensure that octopuses are not bored? What do bees need to thrive, pollinate our plants and give us honey? Since invertebrates have distinct personalities and some social animals have group personalities, how do we consider this? And, as in the European Union's application of welfare consideration to cephalopods, how do the practical regulatory issues play out? We have previously relegated invertebrates to the category 'things' and did not worry about their treatment. New research suggest that some invertebrates such as cephalopods and crustaceans can have pain and suffering, might also have consciousness and awareness. Also, good welfare is going to mean different things to spiders, bees, corals, etc. This book is taking animal welfare in a very different direction. Academics and students of animal welfare science, those who keep invertebrates for scientific research or in service to the goals of humans, as well as philosophers will find this work thought-provoking, instructive and informative.

Discussed in this book is the association between speech and movements, especially those of the preferred hand. Both are skilled motor activities that appear to depend upon a similar neural organization that is available in the left hemisphere of the brain. The nature of this association of the cerebral control of speech and skilled manual performance is discussed in four sections: 1. Motor control and speech examines speech as a motor activity; 2. Language and gesture examines the correspondence between spoken language and manual gesture; 3. Motor performance and aphasia examines the motor impairments associated with aphasias; 4. Interactions of speech and manual performance examines the interactions that occur between concurrent verbal and manual activities.

Visualization of chemicals in tissues has seen incredible advances in the past several years. Visualization Techniques: From Immunohistochemistry to Magnetic Resonance Imaging provides practical advice from experts in the field as well as an excellent overview of some of the most important recent advances in visualization. This timely volume explores topics from immunohistochemistry for multiple neurochemicals, detecting expression levels of neurochemicals, following cellular processes and ionic movement, identifying polysynaptic pathways subserving physiological responses to identifying functional changes in vivo. Written for the popular Neuromethods series, this work includes the kind of detailed description and implementation advice that is crucial for getting optimal results in the lab. Meticulous and concise, Visualization Techniques: From Immunohistochemistry to Magnetic Resonance Imaging will prove invaluable for scientists seeking to gain a greater understanding of the practical skills, strengths, and pitfalls that these wonderful and exciting visualization techniques provide.

This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

This volume assembles the leading aggression researchers both at the preclinical and clinical level. They review the current state of knowledge about neural mechanisms of aggressive behavior and point to the need for innovative methodologies to further our understanding of this greatly understudied set of behaviors.

This book is a comprehensive review of the neuropsychology of emotion and the neural mechanisms underlying emotional processing. It is divided into four sections, preceded by an introductin summarizing each chapter and presenting future research directions. Sections include: Background and General Techniques, Theoretical Perspectives, Emotional Disorders, and Clinical Implications. The book draws on studies using behavioural paradigms, the brain lesion method, neurologic and psychiatric disorders, and neuroimaging.

The misfolding and aggregation of specific proteins is an early and obligatory event in many of the age-related neurodegenerative diseases of humans. The initial cause of this pathogenic cascade and the means whereby disease spreads through the nervous system, remain uncertain. A recent surge of research, first instigated by pathologic similarities between prion disease and Alzheimer s disease, increasingly implicates the conversion of disease-specific proteins into an aggregate-prone b-sheet-rich state as the prime mover of the neurodegenerative process. This prion-like corruptive protein templating or seeding now characterizes such clinically and etiologically diverse neurological disorders as Alzheimers disease, Parkinson s disease, Huntington s disease, amyotrophic lateral sclerosis, and frontotemporal lobar degeneration. Understanding the misfolding, aggregation, trafficking and pathogenicity of the affected proteins could therefore reveal universal pathomechanistic principles for some of the most devastating and intractable human brain disorders. It is time to accept that the prion concept is no longer confined to prionoses but is a promising concept for the understanding and treatment of a remarkable variety of diseases that afflict primarily our aging society. "

Various aspects, including diagnosis, therapy, and prognosis, of two brain tumors (meningioma and schwannoma) , of brain tumors are discussed in this volume. Insights on the understanding of molecular pathways involved in brain tumor biology are explained. For example, the role of E-cadherin gene instability, carbonic anhydrase 11, urokinase plasminogen activator, and Wnt signaling is discussed in detail. Such information will lead to the development of effective aniicancer drugs. The role of molecular genetics and epigenetic mechanisms in schwannomas is explained. Also, is explained the role of cyclin D1 in vestibular schwannoma. The determination of subtypes of meningiomas using perfusion magnetic resonance imaging is explained. Diagnosis of incidentally discovered meningioma and cystic papillary meningioma is also included. Diagnosis of facial nerve schwannoma, vestibular schwannoma, and intermediate nerve schwannoma is explained. Treatments for atypical meningioma, oncocytic meneingioma, intracranial meningioma, and cavernous are presented. Therapeutic methods such as neurosurgery, Gamma knife radiosurgery, and adjuvant radiation for this cancer are included. Large number of other treatments, including radiosurgery, retrosigmoidal craniotomy, and immunotherapy, for vestibular schwannoma patients are detailed.

This volume aims to connect current ideas and concepts about GI disorders with the search for novel therapeutics. Towards this goal, authors provide a timely state-of-the-art overview of the GI tract in health and disease, current treatment approaches and ongoing developments in drug discovery, and their potential for the better treatment of patients with GI disorders.

Posited by Professor Leon Chua at UC Berkeley more than 40 years ago, memristors, a nonlinear element in electrical circuitry, are set to revolutionize computing technology. Finally discovered by scientists at Hewlett-Packard in 2008, memristors generate huge interest because they can facilitate nanoscale, real-time computer learning, as well as due to their potential of serving as instant memories. This edited volume bottles some of the excitement about memristors, providing a state-of-the-art overview of neuromorphic memristor theory, as well as its technological and practical aspects. Based on work presented to specialist memristor seminars organized by the editors, the volume takes readers from a general introduction the fundamental concepts involved, to specialized analysis of computational modeling, hardware, and applications. The latter include the ground-breaking potential of memristors in facilitating hybrid wetware-hardware technologies for in-vitro experiments. The book evinces, and devotes space to the discussion of, the socially transformative potential of memristors, which could be as pervasive as was the invention of the silicon chip: machines that learn in the style of brains, are a computational Holy Grail. With contributions from key players in a fast-moving field, this edited volume is the first to cover memristors in the depth needed to trigger the further advances that surely lie around the corner.

This volume of Progress in Brain Research provides a synthetic source of information about state-of-the-art research that has important implications for the evolution of the brain and cognition in primates, including humans. This topic requires input from a variety of fields that are developing at an unprecedented pace: genetics, developmental neurobiology, comparative and functional neuroanatomy (at gross and microanatomical levels), quantitative neurobiology related to scaling factors that constrain brain organization and evolution, primate palaeontology (including paleoneurology), paleo-anthropology, comparative psychology, and behavioural evolutionary biology.

Written by internationally-renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

Written by internationally renowned scientists, this timely volume will be of wide interest to students, scholars, science journalists, and a variety of experts who are interested in keeping track of the discoveries that are rapidly emerging about the evolution of the brain and cognition.

'Wise, timely and eloquent... A joy to read.' Guardian What does it mean to be well? Is it something in our body? Or, is it rather something subjective - something of the mind? In this profound collection of clinical stories, eminent psychiatrist Dr Alastair Santhouse draws on his experience of treating thousands of hospital patients to show how our emotions are inextricably linked to our physical wellbeing. Our minds shape the way we understand and react to symptoms that we develop, dictate the treatments we receive, and influence whether they work. They even influence whether we develop symptoms at all. Written with brutal honesty, deep compassion, and a wry sense of humour, Head First examines difficult cases that illuminate some of our most puzzling and controversial medical issues-from the tragedy of suicide, to the stigma surrounding obesity, to the ongoing misery of chronic fatigue. Ultimately he finds that our medical model has failed us by promoting specialization and overlooking perhaps the single most important component of our health: our state of mind.

There are more than 100 billion brain cells in our heads, and every single one represents a fragment of thought and feeling. And yet each cell is a mystery of beauty, with branching, intricate patterns like shattered glass. Richard Wingate has been scrutinizing them for decades, yet he is still moved when he looks at one through a microscope and traces their shape by hand. With absorbing lyricism and clarity, Wingate shows how each type of cell possesses its own personality and history, illustrating a milestone of scientific discovery and exploring the stories of pioneering scientists like Ramon y Cajal and Francis Crick, and capturing their own fascinating shapes and patterns. Discover the ethereal world of the brain with this elegant little book - and find out how we all think and feel.