Every year, around the world, between 250,000 and 500,000 people suffer a spinal cord injury (SCI). Those with an SCI are two to five times more likely to die prematurely than people without a spinal cord injury, with worse survival rates in low- and middle-income countries. Dynamic aerobic requires integrated physiologic responses across the musculoskeletal, cardiovascular, autonomic, pulmonary, thermoregulatory, and immunologic systems. Moreover, regular aerobic exercise beneficially impacts these same systems, reducing the risk for a range of diseases and maladies. This book will present comprehensive information on the unique physiologic effects of SCI and the potential role of exercise in treating and mitigating these effects. In addition, it will incorporate work from scientists across a number of disciplines and have contributors at multiple levels of investigation and across physiologic systems. Furthermore, SCI can be considered an accelerated form of aging due to the severely restricted physical inactivity imposed, usually at an early age. Therefore, the information presented may have a broader importance to the physiology of aging as it relates to inactivity. Lastly, the need for certain levels of regular aerobic exercise to engender adaptations beneficial to health is not altered by the burden of an SCI. Indeed, the amounts of exercise necessary may be even greater than the able-bodied due to 'passive' ambulation. This book will also address the potential health benefits for those with an SCI that can be realized if a sufficient exercise stimulus is provided.

The book demonstrates how Resilient Health Care principles can enable those on the frontline to work more effectively towards interdisciplinary care by gaining a deeper understanding of the boundaries that exist in everyday clinical settings. This is done by presenting a set of case studies, theoretical chapters and applications that relate experiences, bring forth ideas and illustrate practical solutions. The chapters address many different issues such as resolving conflict, overcoming barriers to patient-flow management, and building connections through negotiation. They represent a range of approaches, rather than a single way of solving the practical problems, and have been written to serve both a scientific and an andragogical purpose. Working Across Boundaries is primarily aimed at people who are directly involved in the running and improvement of health care systems, providing them with practical guidance. It will also be of direct interest to health care professionals in clinical and managerial positions as well as researchers. Presents the latest work of the lauded Resilient Health Care Net group, developing applications of Resilience Engineering to health care, furthering safety thinking and generating applicable solutions that will benefit patient safety worldwide Enables health care professionals to become aware of the boundaries that affect their work so that they are able to use their strengths and overcome their weaknesses Written from a Safety-II perspective, where the purpose is to make sure that as much as possible goes well and the focus therefore is on everyday work rather than on failures. There are at present no other books that adopt this perspective nor which go into the practical details Provides a concise presentation of the state of resilient health care as a science, in terms of major theoretical issues and practical methods and techniques on the overarching and important topics of boundary-crossing and integration of care settings

"Advances in Calcium Phosphate Biomaterials" presents a comprehensive, state-of-the-art review of the latest advances in developing calcium phosphate biomaterials and their applications in medicine. It covers the fundamental structures, synthesis methods, characterization methods, and the physical and chemical properties of calcium phosphate biomaterials, as well as the synthesis and properties of calcium phosphate-based biomaterials in regenerative medicine and their clinical applications. The book brings together these new concepts, mechanisms and methods in contributions by both young and veteran academics, clinicians, and researchers to forward the knowledge and expertise on calcium phosphate and related materials. Accordingly, the book not only covers the fundamentals but also open new avenues for meeting future challenges in research and clinical applications.

Besim Ben-Nissan is a Professor of Chemistry and Forensic Science at the University of Technology, Sydney, Australia"

The growing number of elder men providing hands-on care to loved ones, particularly spouses, undeniably represents a hidden segment of the home care population. With that in consideration, caregiving in communities of color, in particular, is increasing while numbers of informal (unpaid) caregivers are projected to triple by 2030. Despite statistics, studies on African-American men who care for other elders (such as spouses and parents) - indeed, "the hidden among the hidden" - are negligible. This text follows a study conducted by Helen Black, a research scientist focusing on aging, alongside John Groce and Charles Harmon, founders of Mature Africans Learning from Each Other (M.A.L.E.), in which they interviewed elderly African-American men in caregiver roles. As a whole, The Hidden Among the Hidden is unique in its study of caregiving in the areas of subject matter, methodology, and presentation of findings. The men whose attitudes and behaviors toward caregiving are recorded in this book share a wealth of knowledge for other caregivers, gerontologists, healthcare professionals, students, and the community in general.

This monograph will provide an in-depth mathematical treatment of modern multiple test procedures controlling the false discovery rate (FDR) and related error measures, particularly addressing applications to fields such as genetics, proteomics, neuroscience and general biology. The book will also include a detailed description how to implement these methods in practice. Moreover new developments focusing on non-standard assumptions are also included, especially multiple tests for discrete data. The book primarily addresses researchers and practitioners but will also be beneficial for graduate students.

Since the early 20th century, medical imaging has been dominated by monochrome imaging modalities such as x-ray, computed tomography, ultrasound, and magnetic resonance imaging. As a result, color information has been overlooked in medical image analysis applications. Recently, various medical imaging modalities that involve color information have been introduced. These include cervicography, dermoscopy, fundus photography, gastrointestinal endoscopy, microscopy, and wound photography. However, in comparison to monochrome images, the analysis of color images is a relatively unexplored area. The multivariate nature of color image data presents new challenges for researchers and practitioners as the numerous methods developed for monochrome images are often not directly applicable to multichannel images. The goal of this volume is to summarize the state-of-the-art in the utilization of color information in medical image analysis.

Desire and the Female Therapist is one of the first full-length explorations of erotic transference and countertransference from the point of view of the female therapist. Particular attention is given to the female therapist/male client relationship and to the effects of desire made visible in art objects in analytical forms of psychotherapy. Drawing on aesthetic and psychoanalytic theory, specifically Lacan and Jung, the book offers a significant new approach to desire in therapy. Richly illustrated, with pictures as well as clinical vignettes, this book follows on from Joy Schaverien's innovative previous work The Revealing Image. Written primarily for psychotherapists, art therapists and analysts, Desire and the Female Therapist will be essential reading for all therapists affected by erotic transference and countertransference in the course of clinical practice and all whose clients bring art works to therapy.

This volume analyzes recent technological breakthroughs in aiding children with autism spectrum disorder (ASD). Chapters offer practical guidance in such areas as assessment, treatment planning, and collaborative intervention. The book also presents findings on hardware and software innovations and emphasizes their effectiveness in clinical practices that are targeted to specific cognitive, social, academic and motor skill areas. In addition, it describes promising new deficit-reducing and skill-enhancing technologies on the horizon. Featured topics include: Developing and supporting the writing skills of individuals with ASD through assistive technologies. The ways in which visual organizers may support executive function, abstract language comprehension and social learning. Do-as-I'm-doing situations involving video modeling and autism. The use of technology to facilitate personal, social and vocational skills in youth with ASD. Evidence-based instruction for students with ASD. The use of mobile technology to support community engagement and independence. Technology and Treatment of Children with Autism Spectrum Disorder is an essential resource for clinicians and related professionals as well as researchers and graduate students across such disciplines as child and school psychology, rehabilitation medicine, educational technology, occupational therapy, speech pathology and social work.

This book explores various practices and policies related to ageing issues in India. It addresses ageing concerns from a theoretical and empirical viewpoint with in-depth analyses of existential dimensions of ageing. It provides deep insights into ageing in India by discussing demographics related to health and social differentials, gender concerns, retirement problems, epidemiological transition taking place in the country with rising problem of dementia and mental health problems. It consists of 23 chapters written by various established as well as upcoming scholars in the field. The authors cover a broad range of topics with regard to provisions for institutional care, geriatric practice and emerging issues of elder abuse. The book will appeal to professionals and to lay people getting interested in ageing India from a social, health, gender, economic, psychological and emotional aspects.

This book focuses on interdisciplinary research in the field of biomedical engineering and neuroscience. Biomedical engineering is a vast field, ranging from bioengineering to brain-computer interfaces. The book explores the system-level function and dysfunction of the nervous system from scientific and engineering perspectives. The initial sections introduce readers to the physiology of the brain, and to the biomedical tools needed for diagnostics and effective therapies for various neurodegenerative and regenerative disorders. In turn, the book summarizes the biomedical interventions that are used to understand the neural mechanisms underlying empathy disorders, and reviews recent advances in biomedical engineering for rehabilitation in connection with neurodevelopmental disorders and brain injuries. Lastly, the book discusses innovations in machine learning and artificial intelligence for computer-aided disease diagnosis and treatment, as well as applications of nanotechnology in therapeutic neurology.

There are at least four reasons why a sleep clinician should be familiar with rating scales that evaluate different facets of sleep. First, the use of scales facilitates a quick and accurate assessment of a complex clinical problem. In three or four minutes (the time to review ten standard scales), a clinician can come to a broad understanding of the patient in question. For example, a selection of scales might indicate that an individual is sleepy but not fatigued; lacking alertness with no insomnia; presenting with no symptoms of narcolepsy or restless legs but showing clear features of apnea; exhibiting depression and a history of significant alcohol problems. This information can be used to direct the consultation to those issues perceived as most relevant, and can even provide a springboard for explaining the benefits of certain treatment approaches or the potential corollaries of allowing the status quo to continue. Second, rating scales can provide a clinician with an enhanced vocabulary or language, improving his or her understanding of each patient. In the case of the sleep specialist, a scale can help him to distinguish fatigue from sleepiness in a patient, or elucidate the differences between sleepiness and alertness (which is not merely the inverse of the former). Sleep scales are developed by researchers and clinicians who have spent years in their field, carefully honing their preferred methods for assessing certain brain states or characteristic features of a condition. Thus, scales provide clinicians with a repertoire of questions, allowing them to draw upon the extensive experience of their colleagues when attempting to tease apart nuanced problems. Third, some scales are helpful for tracking a patient's progress. A particular patient may not remember how alert he felt on a series of different stimulant medications. Scale assessments administered periodically over the course of treatment provide an objective record of the intervention, allowing the clinician to examine and possibly reassess her approach to the patient. Finally, for individuals conducting a double-blind crossover trial or a straightforward clinical practice audit, those who are interested in research will find that their own clinics become a source of great discovery. Scales provide standardized measures that allow colleagues across cities and countries to coordinate their practices. They enable the replication of previous studies and facilitate the organization and dissemination of new research in a way that is accessible and rapid. As the emphasis placed on evidence-based care grows, a clinician's ability to assess his or her own practice and its relation to the wider medical community becomes invaluable. Scales make this kind of standardization possible, just as they enable the research efforts that help to formulate those standards. The majority of Rating Scales in Sleep and Sleep Disorders: 100 Scales for Clinical Practice is devoted to briefly discussing individual scales. When possible, an example of the scale is provided so that readers may gain a sense of the instrument's content. Groundbreaking and the first of its kind to conceptualize and organize the essential scales used in sleep medicine, Rating Scales in Sleep and Sleep Disorders: 100 Scales for Clinical Practice is an invaluable resource for all clinicians and researchers interested in sleep disorders."

This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move from real measured data to the model of the corresponding signals. This book proposes a generic framework for this procedure. It can be used as a guide for modelling impedance cardiography (ICG) and impedance respirography (IRG) signals, as well as for developing the corresponding bio-impedance signal simulator (BISS).

An edited volume describing the latest developments in approaching the problem of polymer sequence analysis, with special emphasis on the most relevant biopolymers (peptides and DNA) but not limited to them. The chapters will include peptide sequence analysis, DNA sequence analysis, analysis of biopolymers and nonpolymers, sequence alignment problems, and more.

This book describes medical applications of photochemistry. In the first part, a general introduction to photochemistry and related phototechnologies is provided. In the second part, photochemistry-based medical applications for diagnostics (biochips and bioimaging) and therapeutics (biomaterials for artificial organs, medical adhesives, dental materials, drug-delivery systems, tissue engineering, and photodynamic therapy) are described, with examples of recent research. The year 2015 is the International Year of Light and Light-Based Technologies. Light plays a vital role in our daily lives and is important in many interdisciplinary scientific fields in the twenty-first century. Light-based concepts have revolutionized medicine, including areas such as oncology, molecular biology, and surgery. Although photochemistry has contributed significantly to medicine directly and through photochemical fabrication of biomaterials, a book giving a comprehensive overview of recent progress has not been published until now. The aim of this book is to highlight the contributions of photochemistry in interdisciplinary fields of chemistry and medical engineering. This book will be useful for chemists who are interested in medical applications of photochemistry and engineers who are eager to learn the principles of photochemistry to enable its use in practical applications.

This book examines the most novel and state-of-the-art applications of biomaterials, with chapters that exemplify approaches with targeted drug delivery, diabetes, neurodegenerative diseases and cranioplasty implants. Expert contributors analyze biomaterials such as calcium phosphate, sol-gel and quenched glasses, metallic and polymer implants, bioactive glass, and polymer composites while also covering important areas such as the soft tissue replacement, apatites, bone regeneration and cell encapsulation. This book is appropriate for biomedical engineers, materials scientists, and clinicians who are seeking to implement the most advanced approaches and technologies with their patients.

I. Ojima * E. S. Zuniga * J. D. Seitz: Advances in the Use of Enantiopure -Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests.- I. Fernandez * Miguel A. Sierra: -Lactams from Fischer Carbene Complexes: Scope, Limitations, and Reaction Mechanism.- Bablee Mandal * Basudeb Basu: Synthesis of -Lactams Through Alkyne-Nitrone Cycloadditions.- T. T. Tidwell: Preparation of Bis- -Lactams by Ketene-Imine Cycloadditions.- Edward Turos: The Chemistry and Biology of N-Thiolated -Lactams.- Indrani Banik * Bimal K. Banik: Synthesis of -Lactams and Their Chemical Manipulations Via Microwave-Induced Reactions.

What is reflective practice and why is it important? How do I write my first reflection? Learn how to carry out reflective practice quickly and easily with this beginner's guide for nurses. Written for nursing students and registered nurses, this book helps build confidence in writing reflectively by using clear step-by-step guidance, insightful case studies, learning activities, and by addressing commonly asked questions from nurses and nursing students. The book has three sections; the first starts with a simple model to help students practice a first reflection and explains how to use reflection as part of assessed work at university. The second section focuses on reflecting in practice and finding the time to do it in busy work situations. The final section helps students to think more deeply about models and theories of reflection, to develop the skills they will need to pass the final year of their course. Essential reading for any nursing student new to reflective practice or registered nurse wanting to improve their reflective writing skills.

This book examines the interactional practices of nurse practitioners (NPs) and the delivery of health care in the US. The author takes a discourse analytic approach, examining the linguistic resources that NPs employ in their interactions with patients. These linguistic features are connected to the concept of professional competency with specific focus on the enactment of the patient-centered approach. Analytic focus is placed on how NPs address organizational responsibilities during medical visits with patients, the form and function of patient education, the use of indirect speech, and the role that small talk plays in health care encounters. The book explores the understudied professional field of nurse practitioners and examines their linguistic practices with an eye on crossing disciplinary boundaries, integrating research from linguistics, discourse analysis and health communication. It will appeal to those interested in medical discourse analysis and health communication, as well as applied linguistics scholars.

In recent years, there have been many exciting breakthroughs in the application of nanotechnology to medicine. In Characterization of Nanoparticles Intended for Drug Delivery, expert researchers explore the latest advances in the field, providing a set of basic methods for the characterization of nanomaterials for medical use. Chapters provide methods to characterize the physiochemical properties (size, aggregation, and surface chemistry) and in vitro immunological and biological characteristics of nanomaterials. Composed in the highly successful Methods in Molecular Biology(TM) series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and informative, Characterization of Nanoparticles Intended for Drug Delivery is an essential survey of methods that are crucial to the preclinical characterization of nanomedicines.