Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability.

Gellan Gum as a Biomedical Polymer details key topics and fundamental aspects of gellan gum and its biomedical applications in drug delivery, proteins and peptides delivery, cell delivery, tissue engineering, wound dressings and enzyme immobilizations in developing high quality products. Sections introduce gellan gum, its source, production and gelation mechanism, discuss biomedical materials, and provides ways it can be used for biomedical applications. The book also examines the used of gellan gum as pharmaceutical excipients for drug delivery. Future developments and challenges round out the book’s coverage. With contributions for an international group of experts, this book is a useful reference for scientists, researchers and those in industry engaged in biomedical product development using natural polysaccharides.

This issue will focus on traumatic brain injury and will include articles on the following: Pathophysiology of TBI; Acute Management of Moderate-Severe TBI; Disorder of Consciousness; Rehabilitation of Moderate-Severe TBI; Acute Diagnosis and Management of Concussion; Rehabilitation of Persistent Symptoms after Concussion Chronic Traumatic Encephalopathy; Unique Aspect of TBI in the Military and Veteran; and many more!

The Guest Editors have secured top experts in the area of palliative care to write current and clinically relevant articles. Articles in this issue are devoted to: Caring for LGBT Populations; Integrating Palliative Care into Primary Care; Pain Management in the Cognitively Impaired; Pain Management in the Client with Substance Use Disorder; Rituals at End of Life; Death Bed Phenomena; Family Care During End of Life; Palliative Wound Care; Pet-Assisted Therapy in Palliative Care; Palliative Sedation: State of the Science. Readers will come away with the updated information they need to provide state-of-the-art palliative care to their patients.

Foot and ankle arthroscopy involves the surgical evaluation and treatment of the foot and ankle for a variety of conditions. This issue will cover everything from Arthroscopic Anatomy, Arthroscopic Instrumentation, Imaging Aspects of Joint Pathology and Arthroscopic Techniques, Intra-articular Soft Tissue Pathology, to Subtalar Joint Arthroscopy, and many more exciting articles.

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Recovering Assemblages offers an exciting new insight into the policies and practices of recovery and drug use bridging critical drug studies and the sociology of health and illness. The book investigates lived experiences of young people in Azerbaijan and Germany during their personal recovery from alcohol and other drug use and shows the contingency of 'real' experiences. The sociomaterial and ontological analyses unfold the interrelation of practices, spaces, bodies, and affects in experiencing recovery both within and outside of various treatment facilities. The book will appeal to a range of scholars, postgraduates, and undergraduates engaged in critical, methodological, and empirical studies of recovery, drug use, and policy.

An accessible text which covers the essentials of anatomy and physiology required by a range of health professions. Anatomy & Physiology is the ideal introduction to the subject for student nurses, midwives, operating department practitioners, paramedics, physiotherapists, occupational therapists, trainee nursing associates, and other allied health professionals. Written in an engaging and accessible style, the book helps readers to: learn the language of anatomy and physiology by explaining new terms clearly in the text and in a comprehensive glossary understand the key anatomical structures and physiological functions appreciate what happens during disease, with boxes throughout to highlight the clinical relevance, and more detailed explanations of chronic conditions such as diabetes, hypertension, obesity, and cancer apply this knowledge in healthcare contexts Bonus online material The following material to accompany the book is provided free of charge online: four additional chapters to help readers extend their knowledge a variety of self-assessment questions for every chapter The clear, reader-friendly presentation will aid understanding of a subject which is often viewed as challenging but is essential throughout a healthcare career.

This handbook covers established and advanced techniques for biomarker analysis, such as guidelines and strategies for assay validation methods; different mathematical models that are necessary in contemporary drug discovery and development; and evaluation of new cytometry methods. Expertly curated by two practicing professionals in drug development and biotherapeutics, individual chapters are selected for novel and sound research; information is chosen based on its relevance to lab applications and clinical trials, such as the topic of selecting animal models for their relevancy to humans. The book is multifaceted, discussing the ethics and issues with biospecimens and providing an in-depth analysis to the differences between pre-clinical and clinical assay development. The book is an essential read for general readers who need an introduction to the history and background of biomarkers, and it also provides critical analyses of various new validation methods for practitioners and researchers.

Years of experience, level of qualification, modality delivered, supervision, personal therapy, and continuing professional development are not predictive of client outcomes in psychotherapy. Further, the outcomes of psychotherapy have not improved in over 40 years, despite the proliferation of new therapy modalities. Evidence Based Counselling & Psychotherapy for the 21st Century Practitioner answers how counselling and psychotherapy can be operationalised in the 21st century, dispelling long-held beliefs about how psychotherapy works. Discussing evidence-based practice in its various forms, the chapters provide an analysis of research used and the debate around the effectiveness of specific therapies, commonalities across therapies and the many evidence-based relationship variables that are said to contribute to effective psychotherapy. Client factors and the use of technology, deliberate practice, supervision, and a simulated client case demonstrate the application of the methods and ideas reviewed. Whether a novice psychotherapy trainee or a seasoned practitioner or supervisor, Evidence Based Counselling & Psychotherapy for the 21st Century Practitioner illustrates what an effective 21st century practitioner needs to know, do, and reflect on to improve the effectiveness of their psychotherapeutic work and client outcomes - of interest across the allied health and social care sectors where counselling and therapy interventions are used.

It astounds the western world that such a highly industrialized nation as the Netherlands, with all the resources of modern medicine and technology, has a marked preference for home birth assisted by midwives. Van der Mark examines Dutch attitudes and practices surrounding birth from a sociohistorical point of view, explaining the importance of ideological consensus, the private nature of the Dutch family, the high regard for comfort and well being, and the professional development of midwives as trained and licensed practitioners. This volume will be welcomed by those convinced of the value of low-intervention home birth, but it will also be of interest to practitioners who must rely on technological procedures to manage the birth process. Since the Dutch hold one of the world records of pregnancy outcome statistics, readers will be interested in the Dutch midwifery model described here by various contributors.

Jane Dwinell has written an important book using real-life scenarios to illustrate her unique philosophy of childbirth, one that can only inspire women to take greater control over how and where they give birth. From her vantage point as a birth attendant, Dwinell recounts the moving birth experiences of twenty different women. Thus the reader learns that there are no right or wrong ways to give birth. In fact, the author shows how satisfying it can be for women to exercise their own strength, power and choice in the birth process instead of yielding to unnecessary technological and medical interventions. Birth, she says, is a process of wellness, not illness. Hence, most women don't need medication to help them deal with normal birth pains if they have the proper empowering support during labor.

When women give birth in a comfortable setting of their choice, the medical wrongs against them, committed in hospitals in the name of safety and technology, are prevented. In the face of opposition from an entrenched segment of the medical establishment, Dwinell dares the view that hospital care should not be routine but should be given only with good reason and the women's permission. For pregnant women and their partners, "Birth StorieS" makes a convincing argument that under normal circumstances wach women's intuitive knowledge and individual resources can help her to labor and deliver successfully in her own way. Nurses, midwives, doctors, and birth educators will find it useful to realize that there are many ways to give birth . . . that it is important for the family to be together and make their own choices . . . and that pregnant women can have safe births without excessive medical intervention. This book can also serve as a guide for professionals who want to develop this type of birthing model within their own institution.

This volume reviews the state of the art in caring for patients dying in the ICU, focusing on both clinical aspects of managing pain and other symptoms, as well as ethical and societal issues that affect the standards of care recieved, The book also addresses the changing epidemiology of death in this setting related to managed care, practical skills needed to provide the highest quality of care to terminal patients, communicating with patients and families, the mechanics of withdrawing life supporting therapies, and the essential role of palliative care specialists in the ICU. The book briefly describes unique issues that arise when caring for patients with some of the more common diseases that preciptate death in the ICU. Contributors for the book were chosed because they have experience caring for patients in the ICU, and are also doing curent research to find ways to improve care for terminal patients in this setting.

Mechanical Testing of Orthopaedic Implants provides readers with a thorough overview of the fundamentals of orthopedic implants and various methods of mechanical testing. Historical aspects are presented, along with case studies that are particularly useful for readers.

This issue of Sleep Medicine Clinics focuses on Ambulatory Sleep Medicine. Article topics include: Diagnosis of Obstructive Sleep Apnea; Personalised medicine for Obstructive Sleep Apnea therapies: Are we there yet?, Cardiovascular risk of Obstructive Sleep Apnea; Motor Vehicle Accident risk related to Obstructive Sleep Apnea; Impact of Obstructive Sleep Apnea Syndrome on Neurocognitive function and impact of CPAP; CPAP therapy for Obstructive Sleep Apnea; Maximizing adherence including using novel IT based systems; Mandibular advancement splints; Surgical approaches to Obstructive Sleep Apnea; Consequences of Obstructive Sleep Apnea; and more!

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Provides recommendations by foremost scholars regarding best practices and future directions in LGBT aging. With its critical examination of contemporary issues facing lesbian, gay, bisexual, and transgender (LGBT) elders, this landmark Annual Review continues a nearly 40-year tradition of providing state-of-the-art knowledge, insight, and research on topics critical to gerontologists worldwide. The 37th volume addresses the cardinal changes occurring in the public policy arena—marriage rights, social security benefits, and other movements toward equality—as they pertain to LGBT elders, and focuses on a variety of key challenges affecting this population. Bringing together the work of highly respected researchers in health policy and psychosocial spheres pertinent to older LGBT adults, the Review also sets forth recommendations on best practices and discusses future directions for working with this population. Each chapter covers a specific issue affecting the older LGBT population and includes definitions of key concepts; a summary of current research; and a discussion of trends and future directions. The Review addresses such key topics as sexuality and sexual health, health and mental health disparities, caregiving, and service needs. It focuses on such critical issues for LGBT elders as social services, families and social supports, health and wellbeing for transgender and bisexual older adults, stigma for bisexual older adults, and special issues for older LGBT veterans and rural-dwelling elders. Also examined is the intersection of diverse characteristics such as gender, race, religion, disability, and sexual orientation. The book concludes with a discussion of programs and policies for older LGBT adults and offers concluding comments for professionals working with this population. Key Features: Provides an historical view of events, policy, and public opinion that have affected the lives of older LGBT cohorts Distils state-of-the-art research and data on such critical issues as sexuality, health and mental health disparities, caregiving, and service needs Considers the intersection of diverse characteristics such as gender, race, religion, disability, sexual orientation, and aging Discusses families and social supports, health and wellbeing for transsexual and bisexual older adults, LGBT veterans, and rural elders Examines future trends and changes in policy and programming to benefit older LGBTs .

This book analyzes several compliant contact force models within the context of multibody dynamics, while also revisiting the main issues associated with fundamental contact mechanics. In particular, it presents various contact force models, from linear to nonlinear, from purely elastic to dissipative, and describes their parameters. Addressing the different numerical methods and algorithms for contact problems in multibody systems, the book describes the gross motion of multibody systems by using a two-dimensional formulation based on the absolute coordinates and employs different contact models to represent contact-impact events. Results for selected planar multibody mechanical systems are presented and utilized to discuss the main assumptions and procedures adopted throughout this work. The material provided here indicates that the prediction of the dynamic behavior of mechanical systems involving contact-impact strongly depends on the choice of contact force model. In short, the book provides a comprehensive resource for the multibody dynamics community and beyond on modeling contact forces and the dynamics of mechanical systems undergoing contact-impact events.