This issue focuses on Pelvic Pain. Article topics include: Pelvic Pain-an overview; Anatomy and Physiology of the Pelvic Floor; Office Examination of Neuromuscular Pelvic Pain; Diagnostic Studies for Neuromuscular Pelvic Pain; Pelvic Floor Myofascial Pain and Associated Disorders; Bony and Ligamentous Causes of Pelvic Pain; Coccydynia;Neurogenic Pelvic Pain; Urologic and Gynecologic Sources of Pelvic Pain; Physical Therapy for the Treatment of Pelvic Pain; and more!

Dr. O'Malley is a well-known nurse researcer in the area of Hemaotology, and she has assembled top experts to write about the most important hemtaologic issues in critical care. The issue has articles devoted to the following topics: Cord blood banking; Leukemia and Lymphomas; Sickle Cell; Anticoagulants; Aplastic anemia & MDS; Hereditary Hemochromatosis and Pernicious Anemia; Hemophilia; Blood book: cells, products, transfusion; Anemia; Multiple Myeloma; DIC; and The lived experience of anemia without a cause. Nurses will come away with the clinical information they need to improve patient outcomes in the critical care setting.

Top experts from Vanderbilt University School of Nursing have put together an excellent issue devoted to Geriatric Syndromes that will prepare the reader for treatment and patient care of geriatric patients. Top authors have written reviews in the following areas: Cognitive Issues; GI Disturbances; Urinary Incontinence; Frailty; Impaired Mobility and Functional Decline; Risk for Injury (Falls); Nutritional Risks; Pain Management; Polypharmacy Management; Impairments in Skin Integrity; and Sleep Disorders. Nurses will come away with a current view of the clinical management for these clinical issues in geriatric population.

This issue of Dental Clinics of North America focuses on Dental Materials, and is edited by Drs. Jack Ferracane, Luiz E. Bertassoni, and Carmem S. Pfeifer. Articles will include: Tooth: Its structure and properties; Dental light curing; Bioactive dental materials having remineralizing or antimicrobial characteristics; Materials for regenerating dental pulp and soft tissues; Dental adhesives; Polymer-based direct filling materials; Dental impression materials and techniques; Dental ceramics for restoration and metal-veneering; Dental cements for luting and bonding restorations; Bone augmentation materials; Dental implants, and more!

This issue of Clinics in Podiatric Medicine and Surgery, edited by Dr. Alan Ng, will cover Surgical Advances in Ankle Arthritis. Topics discussed in the article include, but are not limited to Conservative Treatments, Ankle Arthrodiastsis; Ankle Arthroscopy; Supramalleolar Osteotomies; Ankle OCD Repair; Innovative Techniques for Ankle OCD Repair; Open Ankle Arthrodesis; Arthroscopic Ankle Arthrodesis; Total Ankle Arthroplasty; and Surgical Complications of Ankle Joint Arthrodesis and Arthroplasty Procedures.

Numerous phenomenal advances have been made towards understanding the role of neurotransmitters in the pathophysiology of neurological disorders, and these have resulted in a large number of novel molecules with the potential to revolutionize the treatment and prevention of such disorders. This book provides a comprehensive and detailed explanation of brain neurotransmitters and their receptors and associated channels. It includes a basic introduction, and also discusses the functions and recent advances and their pharmacology, highlighting the role of various computer aided drug design (CADD) strategies for the development of therapeutic ligands to modulate these receptors/ion channels. Written in an easy-to-read style, it is intended for neuroscience and pharmaceutical students and researchers working in the area of brain neurotransmitters.

This issue of Sleep Medicine Clinics is edited by Dr.Ahmed BaHammam and focuses on Hypersomnia. Article topics include: Hypersomnia: neurobiological basis; Narcolepsy Immunogenetics: Where is the Evidence?; Genetic markers of sleepiness; Autonomic function instabilities in Narcolepsy; Epidemiology of Excessive Daytime Sleepiness; Evaluation of the sleepy patient: differential diagnosis; Subjective and objective assessment of hypersomnia; Sleepiness in Narcolepsy; Idiopathic hypersomnia; Sleep disordered breathing and excessive daytime sleepiness; Drug-induced excessive sleepiness; Kleine-Levin syndrome and recurrent hypersomnia; Behaviorally induced insufficient sleep syndrome: an underestimated cause of hypersomnia; Sleepiness in children; Sleepiness in Adolescents; Sleepiness in the elderly; Depression and Hypersomnia: a complex association; Neurodegenerative diseases and excessive sleepiness; Sleepiness and traffic safety; Pharmacological management of excessive daytime sleepiness; Non-pharmacological management of excessive daytime sleepiness.

This book explores the possible development of neurokinin-3 receptor (NK3R) antagonists with reduced environmental impact. Pharmaceuticals are used to cure diseases and to alleviate symptoms in humans and animals. However, the stable, bioactive substances excreted by patients have unfavorable effects on non-target species. To overcome these disadvantages of these highly stable, potent substances, drug design to turn off bioactivity after release into the environment is needed. The book describes the development of eco-friendly NK3R antagonists by introducing a labile functional moiety and substituting a scaffold. This resulted in a novel NK3R antagonist that oxidized into its inactive form when exposed to air. Further, the book presents an efficient and easily achievable synthetic method of creating triazolopiperazine scaffolds, as well as a structure-activity relationship study involving scaffold hopping for decomposable motifs, which led to a novel photodegradable NK3R antagonist. Demonstrating that it is possible to develop compounds that convert into their inactive forms under environmental conditions, this book is useful for anyone interested in therapeutic agents with reduced environmental impact.

This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.

Midwives are essential for healthy nations! This narrative 'herstory' uncovers some of the mysteries and challenges during the past 100 years that surrounded a beleaguered profession and its global organisation, the International Confederation of Midwives (ICM). It tells the story of the power that a unified force of strong women leading the ICM and its midwifery associations did for Safe Motherhood and empowering women throughout the world. Their efforts resulted in today's ICM being a vital standard-setting group for midwives and a respected advocate for the sexual and reproductive health and rights of adolescents and women, for healthy mothers and newborns, and, globally, for healthy nations.

Biomedical Texture Analysis: Fundamentals, Applications, Tools and Challenges describes the fundamentals and applications of biomedical texture analysis (BTA) for precision medicine. It defines what biomedical textures (BTs) are and why they require specific image analysis design approaches when compared to more classical computer vision applications. The fundamental properties of BTs are given to highlight key aspects of texture operator design, providing a foundation for biomedical engineers to build the next generation of biomedical texture operators. Examples of novel texture operators are described and their ability to characterize BTs are demonstrated in a variety of applications in radiology and digital histopathology. Recent open-source software frameworks which enable the extraction, exploration and analysis of 2D and 3D texture-based imaging biomarkers are also presented. This book provides a thorough background on texture analysis for graduate students and biomedical engineers from both industry and academia who have basic image processing knowledge. Medical doctors and biologists with no background in image processing will also find available methods and software tools for analyzing textures in medical images.

This book provides a pioneering approach to modeling the human diabetic patient using a software agent. It is based on two MASc (Master of Applied Science) theses: one looking at the evolution of the patient agent in time, and another looking the interaction of the patient agent with the healthcare system. It shows that the software agent evolves in a manner analogous to the human patient and exhibits typical attributes of the illness such as reacting to food consumption, medications, and activity. This agent model can be used in a number of different ways, including as a prototype for a specific human patient with the purpose of helping to identify when that patient's condition deviates from normal variations. The software agent can also be used to study the interaction between the human patient and the health care system. This book is of interest to anyone involved in the management of diabetic patients or in societal research into the management of diabetes. The diabetic patient agent was developed using the Ackerman model for diabetes, but this model can be easily adapted for any other model subject with the necessary physiological data to support that model.

A timely, relevant work, this encyclopedia provides a comprehensive examination of a full range of topics related to eating disorders and body image. The mortality rate associated with eating disorders is higher than that of any other psychiatric illness. What are the factors that influence abnormal perceptions of body image and trigger the deadly behaviors of food deprivation or uncontrollable gluttony? This indispensable resource thoroughly examines the complex subject of eating disorders, particularly the sociocultural, psychological, and nutritional aspects of eating disorders and body image. Eating Disorders: An Encyclopedia of Causes, Treatment, and Prevention explores the definitions, risk factors, symptoms, and health consequences of such illnesses as anorexia, bulimia, and binge eating. The author discusses the assessment and treatment of these conditions, and imparts health education strategies related to the "Dos and Don'ts" of awareness and prevention efforts. Additionally, she shares tips for recognizing symptoms and discusses where to seek help if a friend or family member is affected. Topics include flight attendants and body weight requirements, the impact of Virtual Reality, and media and sociocultural influences. Case illustrations of eating disorder concerns A timeline of the history of eating disorders Contributions from experts in cross-disciplinary fields Types of prevention programs and ways to promote positive body image

Biomaterials for Oral and Dental Tissue Engineering examines the combined impact of materials, advanced techniques and applications of engineered oral tissues. With a strong focus on hard and soft intraoral tissues, the book looks at how biomaterials can be manipulated and engineered to create functional oral tissue for use in restorative dentistry, periodontics, endodontics and prosthodontics. Covering the current knowledge of material production, evaluation, challenges, applications and future trends, this book is a valuable resource for materials scientists and researchers in academia and industry. The first set of chapters reviews a wide range of biomaterial classes for oral tissue engineering. Further topics include material characterization, modification, biocompatibility and biotoxicity. Part Two reviews strategies for biomaterial scaffold design, while chapters in parts three and four review soft and hard tissues.

Biomedical Composites, Second Edition, provides revised, expanded, and updated content suitable for those active in the biomaterials and bioengineering field. Three new chapters cover modeling of biocomposites, 3D printing of customized scaffolds, and constructs and regulatory issues. Chapters from the first edition have been revised in order to provide up-to-date, comprehensive coverage of developments in the field. Part One discusses the fundamentals of biocomposites, with Part Two detailing a wide range of applications of biocomposites. Chapters in Part Three discuss the biocompatibility, mechanical behavior, and failure of biocomposites, while the final section looks at the future for biocomposites. Professor Luigi Ambrosio is the Director of the Institute for Composite and Biomedical Materials, Italy. He is a renowned scientist with expertise in biomedical composites and has published over 150 papers in international scientific journals and books, 16 patents, and over 250 presentations at international and national conferences.

This volume is about ultra high-speed cameras, which enable us to see what we normally do not see. These are objects that are moving very fast, or that we just ignore. Ultra high-speed cameras invite us to a wonderland of microseconds. There Alice (the reader) meets a ultra high-speed rabbit (this volume) and travels together through this wonderland from the year 1887 to 2017. They go to the horse riding ground and see how a horse gallops. The rabbit takes her to a showroom where various cameras and illumination devices are presented. Then, he sends Alice into semiconductor labyrinths, wind tunnels, mechanical processing factories, and dangerous explosive fields. Sometimes Alice is large, and at other times she is very small. She sits even inside a car engine. She falls down together with a droplet. She enters a microbubble, is thrown out with a jet stream, and finds herself in a human body. Waking up from her dream, she sees children playing a game: "I see what you do not see, and this is....". Alice thinks: "The ultra high-speed rabbit showed me many things which I had never seen. Now I will go again to this wonderland, and try to find something new.

The third edition of this popular introductory textbook has been revised to provide a totally up-to-date and hands-on guide to the practical aspects of health promotion. Focusing on the range of skills needed to become an effective practitioner, it takes readers step-by-step through the different settings in which health promotion takes place and the various tools they might employ, including chapters on health promotion through the lifespan, one-to-one communication, working with groups, advocacy, social media, workplace settings and planning and management. As well as incorporating the most recent government policies and initiatives in public health, there is new and expanded material on issues such as community initiatives and alliances, social media, health literacy, understanding health behaviours, stress in the workplace and much more. Throughout the text there are activities to develop students' understanding and encourage reflective practice. Each chapter opens with a list of the central issues and learning objectives which are reinforced with real-life case studies. The key terms highlighted are clearly explained and checklists dispersed throughout the book, enabling practical application. The new edition of Practical Health Promotion will continue to be the ideal and indispensable guide for students at all levels. It will inspire anyone involved with health care to find practical ways of promoting change.

The Guest Editors have assembled expert authors to contribute current reviews devoted to critical care in pediatrics. The articles are devoted to Simulation and Impact on Code Sepsis; Cardiac Rapid Response Team/Modified Cardiac PEWS Development; Impact on Cardiopulmonary Arrest Events on Inpatient Cardiac Unit; Promoting Safety in Post-Tracheostomy Placement Patients in the Pediatric Intensive Care Unit Through Protocol; Innovation in Hospital-Acquired Pressure Ulcers Prevention in Neonatal Post-Cardiac Surgery Patients; Utilizing an Interactive Patient Care System in an Acute Care Pediatric Hospital Setting to Improve Patient Outcomes; Advances in Pediatric Pulmonary Artery Hypertension; and Creating a Safety Program in a Pediatric Intensive Care Unit or Assessing Pain in the Pediatric Intensive Care Patients to name a few. Readers will come away with information that is actionable in the pediatric ICU.

This issue of Clinics in Podiatric Medicine and Surgery focuses on Foot and Ankle Arthrodesis. Article topics include: Lesser Toe Arthrodesis; First Metatarsophalangeal Arthrodesis; Tarsometatarsal Arthrodesis for Lisfranc's Injuries;Subtalar Joint Arthrodesis for Elective and Post-Traumatic Foot and Ankle Deformity; Midfoot and Hindfoot Arthrodesis for Elective and Post-Traumatic Foot and Ankle Deformity; Internal and/or External Fixation for Ankle Arthrodesis; Tibiotalocalcaneal Arthrodesis; Management of Osteomyelitis, Bone Loss and Arthrodesis in the Diabetic Charcot Foot and Ankle; Free Flap Coverage for Revisional Foot and Ankle Procedures; and Current Orthobiologics for Elective Arthrodesis and Nonunions of the Foot and Ankle.