White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.

Diabetes affects over 29 million United States citizens and is the 7th leading cause of death, accounting for 23.9 per 100,000. Proper nursing care of the patient with diabetes is critical to the patient's wellbeing. The treatment of diabetes has been changing rapidly. The articles in this issue cover statistics, pathophysiology, and the current treatment recommendations written in a very practical manor for the bedside or clinic nurse who is not up to date on the latest recommendations and is not an expert in diabetes management. Cecelia Leveque has assembled top authors to write aritcles on the following topics: Review of 2017 Diabetes Standards of Care; Management of Type 1 Diabetes; Management of Type 2 Diabetes; Non-insulin Diabetes Medications; Insulin therapy; Pre-Diabetes; Management of Lipids in Patients with Diabetes; Management of Hypertension in Patients with Diabetes; Insulin Pump Therapy; Hypoglycemia in Patients with Diabetes; Outpatient Diabetes Education; Chronic Kidney Disease in Patients with Diabetes; Management of Children with Diabetes; and Management of Diabetes in Rotating Shift Workers.

This unique book helps nurses identify and develop the personal qualities that go into "artful" nursing practice. Based on nurse stories that portray the art of nursing, the book guides students to analyse how each personal quality or concept is actualised in the story, understand the challenges to enactment of the concept, and then apply the concept experientially through group and individual exercises. The text illustrates and elaborates onthe forms of knowledge used by nurses and concepts central to the art of nursing such as care, spirituality, presence, compassion, self-care and advocacy.

Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries.

ODE/PDE Alpha-Synuclein Models for Parkinson's Disease discusses a mechanism for the evolution of Parkinson's Disease (PD) based on the dynamics of the protein a-synuclein, a monomer that has been implicated in this disease. Specifically, a-synuclein morphs and aggregates into a polymer that can interfere with functioning neurons and lead to neurodegenerative pathology. This book first demonstrates computer-based implementation of a prototype ODE/PDE model for the dynamics of the a-synuclein monomer and polymer, and then details the methodology for the numerical integration of ODE/PDE systems which can be applied to computer-based analyses of alternative models based on the reader's interest. This book facilitates immediate computer use for research without the necessity to first learn the basic concepts of numerical analysis for ODE/PDEs and programming algorithms

Dr. Phillips has assembled well-published authors on optimizing patient outcomes in those living with HIV and AIDS. The clinical reviews in this issue will provide nurses with the current clinical information they need to incorporate best practices into their patient care and manageement. Articles are devoted to the following topics: Exercise and Positive Living in HIV/AIDS; Managing Other Chronic Illnesses in PLWHAl; Nutritional Issues and Positive Living in HIV/AIDS; Spiritual Dimensions/Resilience; Positive Thinking in HIV/AIDS; Health Promotion in HIV/AIDS; Mental Health in HIV/AIDS; Promoting Cardiovascular Health in PLWHA; Pharmacological Considerations in HIV/AIDS; and Sleep Disturbances Associated with HIV/AIDS.

This issue of Sleep Medicine Clinics focuses on Sleep in Older Adults, with topics including: Sleep in Normal Aging; Insomnia in the Older Adult; Sleep Apnea in the Older Adult; Circadian Rhythm Sleep-Wake Disorders in the Older Adult; Restless Legs Syndrome; Periodic Limb Movement Disorder and Other Sleep Related Movement Disorders in the Older Adult; REM Sleep Behavior Disorder and Other Parasomnias in the Older Adult; Neurodegenerative Disorders and Sleep; Medical Conditions and Sleep in the Older Adult; Psychiatric Illness and Sleep in the Older Adult; Sleep and Cognition in the Older Adult; Sleep and Nocturia in the Older Adult; Sleep and Long Term Care; and Sleep in the Hospitalized Older Adult.

This treatment guide is based on selected disorders taken from the American Psychiatric Association DSM-IV Diagnostic Classifications. The disorders selected are treatable or responsive to brief therapy methods.
The therapist or student in training can use this book to identify the elements needed for formulating a treatment plan on disorders typically encountered in clinical practice. The approaches taken are based on cognitive behavioral principles and makes use of empirical findings. However, the case study format allows the reader to see how the assessment and treatment is implemented in a "real-life" patient, and not as a clinical abstraction distilled from research studies. Moreover, the treatment plan is outlined in a manner that makes reimbursement likely from managed care organizations and insurance companies. Effective Brief Therapies is useful as a reference for therapists and as a training guide for graduate students.
Key Features
* Case Descriptions
* Treatment Conceptualization
* Assessment Techniques
* Treatment Implementation Techniques
* Concurrent Diagnoses and Treatment
* Complications and Treatment Implications
* Dealing with Managed Care and Accountability
* Outcome and Follow-up
* Dealing with Recidivism

This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease

Global Air Pollution in Aging: Reading Smoke Signals is a complete reference connecting environmental pollution research to the human aging process. Since 1800, lifespans have more than doubled as infections declined and medicine improved. But the 20th century introduced a new global scourge of air pollution from fossil fuels with the potential to damage arteries, hearts and lungs that has been related to chronic exposure of air pollution from fossil fuels. Risk areas of study include childhood obesity, brain damage associated with air pollution, increased risk for autism in children and dementia in older adults. In humans and animals, air pollution stimulates chronic inflammation in different organs, and genetic vulnerability to air pollution is being recognized, particularly for carriers of the Alzheimer risk gene ApoE4.

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.

This book showcases the state of the art in the field of sensors and microsystems, revealing the impressive potential of novel methodologies and technologies. It covers a broad range of aspects, including: bio-, physical and chemical sensors, actuators, micro- and nano-structured materials, mechanisms of interaction and signal transduction, polymers and biomaterials, sensor electronics and instrumentation, analytical microsystems, recognition systems and signal analysis and sensor networks as well as manufacturing technologies, environmental, food, energy and biomedical applications. The book gathers a selection of papers presented at the AISEM Regional Workshop on Sensors and Microsystems, held in Portici (Naples), Italy in February 2020.

The most popular teaching text on laboratory data for pharmacy students and go-to reference for pharmacists in therapeutic practice. Now in its seventh edition, Basic Skills has been expanded and updated to cover new drugs, research, and therapeutic approaches. Written by 40 established clinicians and pharmacy faculty members and reviewed by additional experts, it is designed to make all information clear and quickly accessible. Minicases provide clinical scenarios for using tests and managing patients, and quickview charts throughout offer clear interpretations of lab results. The indispensable guide to interpreting clinical laboratory data. New to this edition: A new chapter on nutrition support Significant updates to all chapters Expanded chapters on Pharmacogenomics and Cardiology Additional section on Infectious Diseases covering Bacteria, and Fungi, Viruses and Mycobacteria Learning points conclude each chapter and highlight key concepts about the laboratory tests 25 chapters divided into three sections: Basic Concepts and Test Interpretations; System Disorders and Diagnostic Tests; and Tests for Special Populations Complex but critical skills are required for clinical pharmacists to effectively use lab data in screening for or diagnosing diseases and in monitoring the safety and effectiveness of treatment. As the only book of its kind specifically written for pharmacists by pharmacists, Basic Skills makes it easier to make accurate and critical decisions based on laboratory data.

Substance Use Disorders: Assessment and Treatment is a summary of everything a therapist should know about substance abuse in one easy-to-read comprehensive book. The book begins with a discussion of the pharmacology of specific drug classes (opioids, hallucinogens, etc.) and the epidemiology of abuse. It then presents psychological theories of substance abuse, the initiation and progression of substance abuse disorders, issues of prevention and early intervention, and screening and assessment for substance abuse (including specific tests for assessment) and discusses in detail the various treatment methodologies available. Two final chapters explore issues relevant to special populations and legal and ethical considerations, regarding issues such as confidentiality and coerced treatment.
Key Features
* A synthesis of the current research and clinical literature
* Includes strengths and weaknesses of commonly used psychometric assessment measures
* Presentation and review of a complete Psychosocial/Substance Use Assessment form
* Discussion of treatment settings and criteria for placement decisions
* Discussion of treatment alternatives and effectiveness of major pharmacological and psychotherapeutic approaches
* Discussion of factors leading to Relapse, and components of Relapse Prevention programs

Covering the full spectrum of rehabilitation after traumatic brain injury, this practical reference by Drs. Blessen C. Eapen and David X. Cifu presents best practices and considerations for numerous patient populations and their unique needs. In an easy-to-read, concise format, it covers the key information you need to guide your treatment plans and help patients relearn critical life skills and regain their independence. Covers neuroimaging, neurosurgical and critical care management, management of associated complications after TBI, pharmacotherapy, pain management, sports concussion, assistive technologies, and preparing patients for community reintegration. Discusses special populations, including pediatric, geriatric, and military and veteran patients. Consolidates today's available information and guidance in this challenging and diverse area into one convenient resource.