This book analyzes several compliant contact force models within the context of multibody dynamics, while also revisiting the main issues associated with fundamental contact mechanics. In particular, it presents various contact force models, from linear to nonlinear, from purely elastic to dissipative, and describes their parameters. Addressing the different numerical methods and algorithms for contact problems in multibody systems, the book describes the gross motion of multibody systems by using a two-dimensional formulation based on the absolute coordinates and employs different contact models to represent contact-impact events. Results for selected planar multibody mechanical systems are presented and utilized to discuss the main assumptions and procedures adopted throughout this work. The material provided here indicates that the prediction of the dynamic behavior of mechanical systems involving contact-impact strongly depends on the choice of contact force model. In short, the book provides a comprehensive resource for the multibody dynamics community and beyond on modeling contact forces and the dynamics of mechanical systems undergoing contact-impact events.

Sedation is a necessary component of care for critically ill and injured individuals. Sedatives assist in coping with mechanical ventilation and other invasive devices, and help patients tolerate procedures and noxious stimuli in the intensive care unit. Sedatives are also useful in the control of agitation and delirium. In addition to fundamental humane reasons, calming patients with sedatives provides physiologic benefits, such as reducing oxygen consumption expended during restlessness, and prevents dislodgement of life-preserving tubes and catheters. When administering sedatives to manage critically ill patients, clinicians must be cognizant of the many complex issues surrounding their use. This issue, edited by Consulting Editor, Dr. Jan Foster, provides current updates in this area, including new guidelines and a focus on delirium.

This book provides an introduction to the biological background of heart functioning and analyzes the various materials and technologies used for the development of microfluidic systems dedicated to cell culture, with an emphasis on cardiac cells. The authors describe the characterization of microfluidic systems for cardiac cell culture and center their discussion of the use of stem cell stimulation based on four different types: electrical, biochemical, physical, and mechanical. This book is appropriate for researchers focused on on-chip technologies and heart studies, students in bioengineering and microengineering courses, and a variety of professionals, such as biotechnologists, biomedical engineers, and clinicians working in the cardiac diseases field.

Depression is the most common complication of childbirth and results in adverse health outcomes for both mother and child. It is vital, therefore, that health professionals be ready to help women who have depression, anxiety, or posttraumatic stress disorder in the perinatal period. Now in its third edition, Depression in New Mothers provides a comprehensive approach to treating postpartum depression in an easy-to-use format. It reviews the research and brings together the evidence-base for understanding the causes and for assessing the different treatment options, including those that are safe for breastfeeding mothers. It incorporates research from psychoneuroimmunology and includes chapters on: assessing depression mother-infant sleep traumatic birth experiences infant temperament, illness, and prematurity childhood abuse and partner violence psychotherapy complementary and integrative therapies community support for new mothers antidepressant medication suicide and infanticide. This most recent edition incorporates new research findings from around the world on risk factors, the use of antidepressants, the impact of breastfeeding, and complementary and integrative therapies as well as updated research into racial/ethnic minority differences. Rich with case illustrations and invaluable in treating mothers in need of help, this practical, evidence-based guide dispels the myths that hinder effective treatment and presents up-to-date information on the impact of maternal depression on the mother and their infants alike.

This book describes the development of three dimensional electroactive fibres using a novel coaxial wet-spinning approach from organic conductors in combination with non-conducting hydrogel polymers. This book also presents the characterization and evaluation of multiaxial biofibres in terms of mechanical, physical, electrochemical and biological properties, and explores their use in a diverse range of applications including implantable electrodes, drug delivery systems and energy-storage systems. In the first chapter, the author highlights the significance of engineering three dimensional fibres, introduces the involved hydrogels and organic conductors with emphasis on their biomedical application, and collects some of the previously established methods for fabrication of biofibres. In the second chapter, particular attention is given to the overall experimental fabrication methods and characterization analyses conducted in the work. Chapters three to five present the main findings of this work, in which readers will discover how novel hybrid hydrogel fibres with an inner core of chitosan and alginate were prepared and characterized, how graphene was incorporated into coaxial wet-spun biofibres, and how one-dimensional triaxial fibres were developed using a novel coaxial wet-spinning fibre production method and applied as potential battery devices. In the final chapter of this work, the author summarizes the main achievements of the work and outlines some recommendations for future research.

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

This book approaches the differential diagnosis and management of rare, hereditary cancer syndromes from a practical angle, addressing the issues pertinent to each tumour type as encountered by health professionals in their day-to-day practice. This book enables readers to correctly identify patients with rare cancer syndromes who would benefit from genetic counselling and testing, and provides the necessary knowledge for appropriate patient management and advising at-risk family members. It begins by describing recent advances in genetic testing for cancer-predisposing genes. Leading experts from Europe and Australia then offer detailed, up-to-date guidance on the diagnosis and management of a wide range of hereditary cancers. The concluding chapter examines the wider issues that are raised by genetic testing for rare cancer syndromes for patients, families and health professionals. This book is an invaluable source of information for all specialists involved in the care of such patients and their families.

A cardiac dysrhythmia is a disturbance in the cardiac rhythm which can be normal (e.g., sinus arrhythmia) or instantly lethal (e.g., sustained ventricular tachycardia). This issue of Critical Care Nursing Clinics of North America will provide state of the art diagnostic and treatment information for cardiac dysrhythmias as well as addressing how to achieve the most accurate diagnostic approach to interpreting an electrocardiogram, which is omnipresent in critical care and of critical importance in diagnosing arrhythmias. Articles in this issue are devoted to: The Normal Cardiac Conduction System; The Normal Electrocardiogram: Resting 12-lead and Continuous Cardiac Rhythm Strips; Premature Beats; Paroxysmal Supraventricular Tachycardia, Including the Special Type Called Wolff-Parkinson-White; Atrial Fibrillation, The Most Common Type of Supraventricular Arrhythmia; Ventricular Tachycardia and Its Disorganized Counterpart, Ventricular Fibrillation; Brady-Dysrhythmias, When Heart Rate Slows Myocardial Ischemia & Infarction and their Relationship to Dysrhythmias; Pharmacologically Induced Dysrhythmias; and Implantable Cardiac Devices and their Role in Dysrhythmias Management.

How do you care for ageing parents without destroying the family emotionally or financially? Author Dan Taylor has answered that question in The Parent Care SolutionT. Dan helps you to initiate the Six Conversations you must have with your parents to plan for their care. Using a unique Conversation Strategy he strips away the reluctance and the awkwardness that often surrounds this topic. Once the Six Conversations are completed he provides effective tools for organizing finances, making gifts, selling the family home, evaluating a care facility and selecting someone for the role of a The Parent Care SpecialistT. Dan has taken all the complexity around this subject and reduced it to a simple confidence producing set of conversations and actions.

This book describes efforts to improve subject-independent automated classification techniques using a better feature extraction method and a more efficient model of classification. It evaluates three popular saliency criteria for feature selection, showing that they share common limitations, including time-consuming and subjective manual de-facto standard practice, and that existing automated efforts have been predominantly used for subject dependent setting. It then proposes a novel approach for anomaly detection, demonstrating its effectiveness and accuracy for automated classification of biomedical data, and arguing its applicability to a wider range of unsupervised machine learning applications in subject-independent settings.

Untold stories of people with substance addictions who have recovered without formal treatment Despite the widely accepted view that formal treatment and twelve-step groups are essential for overcoming dependencies on alcohol and drugs, each year large numbers of former addicts quietly recover on their own, without any formal treatment or participation in self-help groups at all. Coming Clean explores the untold stories of untreated addicts who have recovered from a lifestyle of excessive and compulsive substance use without professional assistance. Based on 46 in-depth interviews with formerly addicted individuals, this controversial volume examines their reasons for avoiding treatment, the strategies they employed to break away from their dependencies, the circumstances that facilitated untreated recovery, and the implications of recovery without treatment for treatment professionals as well as for prevention and drug policy. Because of the pervasive belief that addiction is a disease requiring formal intervention, few training programs for physicians, social workers, psychologists, and other health professionals explore the phenomenon of natural recovery from addiction. Coming Clean offers insights for treatment professionals of how recovery without treatment can work and how candidates for this approach can be identified. A detailed appendix outlines specific strategies which will be of interest to addicted individuals themselves who wish to attempt the process of recovery without treatment.

Focussing on the key technologies in developing robots for a wide range of medical rehabilitation activities - which will include robotics basics, modelling and control, biomechanics modelling, rehabilitation strategies, robot assistance, clinical setup/implementation as well as neural and muscular interfaces for rehabilitation robot control - this book is split into two parts; a review of the current state of the art, and recent advances in robotics for medical rehabilitation. Both parts will include five sections for the five key areas in rehabilitation robotics: (i) the upper limb; (ii) lower limb for gait rehabilitation (iii) hand, finger and wrist; (iv) ankle for strains and sprains; and (v) the use of EEG and EMG to create interfaces between the neurological and muscular functions of the patients and the rehabilitation robots. Each chapter provides a description of the design of the device, the control system used, and the implementation and testing to show how it fulfils the needs of that specific area of rehabilitation. The book will detail new devices, some of which have never been published before in any journal or conference.

The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of resistance. The volume will then detail resistance to the most commonly used classes of tyrosine kinase inhibitors, and will focus specific chapters on resistance to BCR-ABL1, FLT3, angiokinase family members, and ALK inhibitors.

This invaluable text covers the successful management of dry eye conditions very succinctly and in a way relevant for the modern practitioner or student. Setting goals and treatment objectives, and brimming with sound practical advice, it adopts a clinical decision-making approach to the subject. Management and treatment options are prioritised and evidence-based. An essential pocket reference for all students and practitioners treating dry eye conditions including ophthalmologists, optometrists, dispensing opticians, ophthalmic nurses and all those involved in the management of these challenging conditions. Clear discussions explain how to set priorities and establish guidelines for treatment based on the patient's presenting symptoms. No other book presents a succinct, practical guide to treatment and successful management of dry eye. All factors that can cause dry eye conditions are addressed, looking beyond the most common contact lens complications to factors such as disease, the environment, and equipment worn by the patient. Clinically relevant approach makes this unique resource extremely useful in the patient-care setting. Practical advice outlines succinct methods for the most effective management of dry eye conditions. Comprehensive information is presented in a quick-reference, synoptic format that's convenient and easy-to-use. Well-referenced chapters present evidence-based information and point to original sources for further research and investigation. Both common and severe dry eye conditions are covered, prioritized so clinicians can see the treatment implications associated with each. Clear illustrations and line diagrams show key visual concepts and help readers see the real-world clinical applications.

In this book, Spreen and Risser present a comprehensive, critical review of available methods for the assessment of aphasia and related disorders in adults and children. The authors explore test instruments and approaches that have been used traditionally for the diagnosis of aphasia, ranging from bedside screening and ratings, to tests of specific aspects of language, and to comprehensive and psychometrically standardised aphasia batteries. Coverage of other methods reflects newer trends, including the areas of functional communication, testing of bilingual patients, psycholinguistic approaches, and pragmatic and discourse-related aspects of language in everyday life. The authors also examine the expansion of language assessment to individuals with non-aphasic neurological disorders, such as patients with traumatic brain injury, lesions of the right hemisphere, the healthy elderly, and individuals with dementia. Taking a flexible and empirical approach to the assessment process in their own clinical practice, Spreen and Risser review numerous test instruments and their source for professionals and students-in-training to choose from in their own use. The introductory chapters cover the history of aphasia assessment, a basic outline of subtypes of aphasia, both neuro-anatomically and psycholinguistically, and the basic psychometric requirements for assessment instruments. The final part discusses issues in general clinical practice, specifically questions of test selection and interpretation. The book is a thorough and practical resource for speech and language pathologists, neuropsychologists, and their students and trainees.

Almost one out of every three US children is overweight or obese, with minority youth at highest risk. There are limited efficacious pediatric obesity interventions available for clinicians, and successful weight loss trials for minority youth are rare. Even fewer interventions have been shown to significantly improve clinical health outcomes such as adiposity, blood pressure, and cholesterol level, and maintenance of behavior change over the long-term remains a challenge Translation I research in which "bench" findings are applied to the "bedside" is uncommon in the behavioral arena. Thus, advances in our understanding of fundamental human processes such as motivation, emotion, cognition, self-regulation, decision-making, stress, and social networks are not being optimally applied to our most pressing behavioral health problems. This issue of Pediatric Clinics will focus on promising behavioral treatments "in the pipeline" that have been translated from basic behavioral science and are the process of refinement and proof of concept testing.

Now in its fourteenth edition, this best-selling textbook has been honed over many years to provide a clear, straightforward introduction to the human body for students of nursing, allied health or biomedical and paramedical science. The book covers the core essentials of anatomy and physiology, including basic pathology and pathophysiology of important diseases and disorders. This new edition presents additional illustrations to enhance understanding of key concepts, including pathophysiology and diagnostics. Included for the first time is an introduction to surface anatomy, while other updating reflects current scientific knowledge and developments, including coronavirus. Enhanced learning features and an extensive online resource help you grasp all the important areas. Like millions of readers before you, you will treasure Ross & Wilson as a go-to resource that you will refer to time and again to support this critical aspect of your healthcare education. Clear and easy to read - suitable for students new to the area and anyone whose first language is not English Hundreds of stunning illustrations and images to make learning easy Helpful learning features such as Learning Outcomes boxes, colour coding and orientation icons to facilitate navigation Definitions of common prefixes, suffixes and roots, examples, glossary and an appendix of normal biological values Self-assessment activities in each chapter, including 'spot check' questions for each section and case studies with answers to develop understanding of key principles Accompanying website with animations, videos, audio-glossary and other self-assessment material Evolve Study Resources Online content offered with Ross & Wilson Anatomy and Physiology in Health and Illness 14th edition includes: New for this edition - a set of expert-narrated 3D videos summarizing key topics in the book, powered by Complete Anatomy: the world's most advanced 3D anatomy platform Over 120 animations clarifying underlying principles and make learning fun More than 1700 audio glossary entries Body Spectrum (c) online colouring and self-test software Self-assessment questions to help students test their knowledge

Eating and its Disorders features contributions by international experts in the field of eating disorders which represent an overview of the most current knowledge relating to the assessment, treatment, and future research directions of the study of eating-related disorders. * Presents the newest models and theories for use in the treatment of patients with eating disorders * Written specifically to fulfill the needs of clinical psychologists and therapists * Includes coverage of important service related issues for working with people with eating disorders * Features chapters from a global group of authors which highlight differing methods and perspectives that can be incorporated into clinical practice

Pharmacologic options have exploded in recent years, forcing updates and creation of guidelines for their use in a near-simultaneous manner. While some nurses may encounter these new medications at the bedside, drugs with little or no indications in specific arenas may remain unknown to the nurse practicing in a specialized area. This issue of Nursing Clinics of North America offers a broad review of current pharmacologic therapy. Bedside applications (e.g., electronic apps) offering real-time information and updates for clinicians will be highlighted throughout the issue.