The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.

This groundbreaking new guide helps you logically associate and link symptoms to likely diagnoses/conditions-a critical skill for passing the USMLE Step 1 Despite the recent changes to the USMLE Step 1, it remains a very important exam for medical students. In order to navigate the vignette-based questions, students must be able to determine a diagnosis based on the vignette, then understand the science behind the diagnosis-a process called pattern recognition. This innovative guide will help you master pattern recognition-a crucial skill to develop in order to thrive throughout the medical school curriculum. Organized by symptom to reflect exactly what you'll see on test day, First Aid Clinical Pattern Recognition for the USMLE Step 1 provides overviews for more than 50 symptoms, discussing differential diagnosis and the principles that should inform your thinking about each symptom. Overviews are followed by Step 1-style vignettes for every potential diagnosis that may be included in the Step 1 exam. Then, each vignette is followed by the diagnosis-and competing diagnoses-along with explanations of why the patterns fit for the correct diagnosis. Guiding principles provide important information (such as which diagnoses are common, which are rare, which are acute, which are chronic, etc.) to enhance the way you think about each symptom. Each vignette contains classic history/physical exam and lab/test findings that would be observed in a typical presentation of the disease.

This book provides a comprehensive overview of the fundamentals of nanotoxicity modeling and its implications for the development of novel nanomedicines. It lays out the fundamentals of nanotoxicity modeling for an array of nanomaterial systems, ranging from carbon-based nanoparticles to noble metals, metal oxides, and quantum dots. The author illustrates how molecular (classical mechanics) and atomic (quantum mechanics) modeling approaches can be applied to bolster our understanding of many important aspects of this critical nanotoxicity issue. Each chapter is organized by types of nanomaterials for practicality, making this an ideal book for senior undergraduate students, graduate students, and researchers in nanotechnology, chemistry, physics, molecular biology, and computer science. It is also of interest to academic and industry professionals who work on nanodrug delivery and related biomedical applications, and aids readers in their biocompatibility assessment efforts in the coming age of nanotechnology. This book also provides a critical assessment of advanced molecular modeling and other computational techniques to nanosafety, and highlights current and future biomedical applications of nanoparticles in relation to nanosafety.

• Offers group facilitators the insight and tools to competently lead engaging and meaningful groups • Includes practical guidelines, detailed instructions, and diverse examples for facilitating both trauma-informed and trauma-focused groups in treatment, community, and organizational contexts • Chapters focus on various topics including safety, empowerment, social justice, and vicarious trauma

This contributed volume provides insights into multiple applications using microbes to promote productivity in agriculture, to produce biochemicals or to respond to challenges in biomedicine. It highlights the microbial production of nanocompounds with medical functionality alongside new anti-mycobacterial strategies, and introduces plant-growth-promoting Rhizobacteria as well as the correlation between biofilm formation and crop productivity. Further, the authors illustrate the green synthesis of biochemical compounds, such as hydroxamid acid or biosurfactants, using microbial and fungal enzymes. It inspires young researchers and experienced scientists in the field of microbiology to explore the combined use of green, white and red biotechnology for industrial purposes, which will be one of the central topics for future generations.

Diagnosing Borderline Personality Disorder (BPD) in young people has long been a tough call for clinicians, either for fear of stigmatizing the child or confusing the normal mood shifts of adolescence with pathology. Now, a recent upsurge in relevant research into early-onset BPD is inspiring the field to move beyond this hesitance toward a developmentally nuanced understanding of the disorder.

The "Handbook of Borderline Personality Disorder in Children and Adolescents" reflects the broad scope and empirical strengths of current research as well as promising advances in treatment. This comprehensive resource is authored by veteran and emerging names across disciplines, including developmental psychopathology, clinical psychology, child psychiatry, genetics and neuroscience in order to organize the field for an integrative future. Leading-edge topics range from the role of parenting in the development of BPD to trait-based versus symptom-based assessment approaches, from the life-course trajectory of BPD to the impact of the DSM-5 on diagnosis. And of particular interest are the data on youth modifications of widely used adult interventions, with session excerpts.

Key areas featured in the "Handbook"

The history of research on BPD in childhood and adolescence.Conceptualization and assessment issues.Etiology and core components of BPD.Developmental course and psychosocial correlates.Empirically supported treatment methods.Implications for future research, assessment and intervention.

The "Handbook of Borderline Personality Disorder in Children and Adolescents" is a breakthrough reference for researchers and clinicians in a wide range of disciplines, including child and school psychology and psychiatry, social work, psychotherapy and counseling, nursing management and research and personality and social psychology.

This book gathers state-of-the-art research in computational engineering and bioengineering to facilitate knowledge exchange between various scientific communities. Computational engineering (CE) is a relatively new discipline that addresses the development and application of computational models and simulations often coupled with high-performance computing to solve complex physical problems arising in engineering analysis and design in the context of natural phenomena. Bioengineering (BE) is an important aspect of computational biology, which aims to develop and use efficient algorithms, data structures, and visualization and communication tools to model biological systems. Today, engineering approaches are essential for biologists, enabling them to analyse complex physiological processes, as well as for the pharmaceutical industry to support drug discovery and development programmes.

The goal of this book is to provide, in a friendly and refreshing manner, both theoretical concepts and practical techniques for the important and exciting field of Artificial Intelligence that can be directly applied to real-world healthcare problems. Healthcare - the final frontier. Lately, it seems like Pandora opened the box and evil was released into the world. Fortunately, there was one thing left in the box: hope. In recent decades, hope has been increasingly represented by Intelligent Decision Support Systems. Their continuing mission: to explore strange new diseases, to seek out new treatments and drugs, and to intelligently manage healthcare resources and patients. Hence, this book is designed for all those who wish to learn how to explore, analyze and find new solutions for the most challenging domain of all time: healthcare.

Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn s disease, diabetes, multiple sclerosis, critical limb ischemia and many others.

MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies "in vitro. "In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable "in vitro "expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress.

The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

This book presents the latest cutting edge research, theoretical methods, and novel applications in the field of computational intelligence and computational biological approaches that are aiming to combat COVID-19. The book gives the technological key drivers behind using AI to find drugs that target the virus, shedding light on the structure of COVID-19, detecting the outbreak and spread of new diseases, spotting signs of a COVID-19 infection in medical images, monitoring how the virus and lockdown is affecting mental health, and forecasting how COVID-19 cases and deaths will spread across cities and why. Further, the book helps readers understand computational intelligence techniques combating COVID-19 in a simple and systematic way.

Validation is a successful way of communicating with older adults with Alzheimer's-type dementia and responding to their challenging behaviors. The Validation method helps reduce stress, enhance dignity, and increase happiness for both the elder and the caregiver. Since its inception in 1989, Validation has helped thousands of professional and family caregivers improve their relationships with residents and loved ones with dementia by acknowledging older adults' expressed feelings rather than focusing on disorientation and confusion. Professionals will learn how to: Build relationships with residents based on empathy and compassion Understand and deal with challenging behaviors Interpret nonverbal cues to promote better communication Implement Validation in your own care setting through the experiences shared by Authorized Validation Organizations around the world The Validation method is easy to learn, and positive results can be seen in both residents and caregivers. Residents express less anger and anxiety, decreasing the need for chemical and physical restraints. Residents communicate more freely and more often. Residents often move better and experience an improved sense of self-worth. Staff members express a greater sense of fulfillment at work and feel better prepared for handling difficult situations. Families visit more often. The Validation Breakthrough is an essential resource for professionals in all settings serving adults who may be confused and disoriented, including assisted living facilities, skilled nursing facilities, hospice, home health care, adult day services, and family care settings. NEW to this edition: Updated language and explanations for the Phases of Resolution Revised case studies reflecting contemporary settings and issues Restructured content for clarity and ease of use

Alternative medicine: Herbal drugs and their critical appraisal - Part II.- Virus population dynamics, fitness variations and the control of viral disease: an update.- Applications of yeast in drug discovery.- Sympathetic nervous system and experimental diabetes: role of adrenal medullary hormones.- From outer to inner space: Traveling along a scientific career from astrochemistry to drug research.- Index Vol. 57.- Index of titles, Vol. 1-57.- Author and paper index, Vol. 1-57.

The purpose of this text is to provide not only the science and current knowledge of pediatric pain management but a rationale for intervention. The book is ground-breaking in that it provides pearls for the recognition and management of multiple childhood chronic pain syndromes. Also, uncommon yet confounding issues such as pain management for epidermolysis bullosa are adequately addressed. Concerns unique to pediatric patients are reviewed. While there are no firm standards in pediatric chronic pain, a care plan is offered to help guide practitioners when possible. The book will consist of 24 chapters, many co-written by a physician and a psychologist. Chapter 1 covers the history of pediatric chronic pain, the advancement pediatric pain as a clinical subspecialty, development of pediatric pain clinics, and characterization of the common pain syndromes. Chapters 2-4 cover, respectively, the research on early pain exposure and neuroplasticity, theories on the common adolescent pain syndromes, and the demographics of chronic pain in children. Chapters 5-16 discuss approaches to assessment and intervention for specific pediatric and adolescent pain syndromes. Chapters 17-23 address interventional techniques such as therapeutic blocks, neurablation, implantable systems, physical therapy, complementary therapy, and pharmacology including opioid tolerance. The final chapter discusses the role of the nurse practitioner in pediatric chronic pain.

Written to satisfy a wide audience, from basic scientist to clinical researcher, this volume explores such varied concepts as: the influence of CBF in the pathotrajectory of TBI, modeling TBI as a means to understand underlying pathological states associated with brain injury victims, disrupted vasculature following head trauma and advanced imaging techniques, vasoreactive substances underlying disrupted blood flow, the role of age and sex on injury outcome, and the latest pre-clinical rationale for focusing on CBF and strategies to improve blood flow as a means to improve outcome in patients suffering the effects of TBI.

Fall-induced hip fracture is an epidemic health risk among elderly people. This book presents an image-based multilevel modeling approach to understanding the biomechanics involved in fall-induced hip fracture. By hierarchically integrating a body-level dynamics model, a femur-level finite element model, and a local bone failure model, the biomechanics approach is able to simulate all stages in sideways falls and to incorporate all biomechanical variables affecting hip fracture. This book is useful for clinicians to accurately evaluate fracture risk, for biomechanical engineers to virtually test hip protective devices, and for biomedical students to learn image-based biomechanical modeling techniques. This book also covers: Biomechanical viewing on bone composition, bone remodeling, and bone strength Bone imaging and information captured for constructing biomechanical models Bone mechanical testing and mechanical properties required for biomechanical modeling

This invaluable resource delineates procedures for development and use of stem cells in the laboratory and explores the potential for clinical applications. The text discusses mesenchymal stem cell isolation, isolation of adipose derived stem cells, new trends of induced pluripotent stem cells in disease treatment, cord blood banking, future directions of the discussed therapies and much more. The chapters are contributed by preeminent scientists in the field and present a comprehensive picture of stem cell processes, from development in the laboratory to effects and side-effects of clinical application. Stem Cell Processing and the other books in the Stem Cells in Clinical Applications series, edited by Dr. Phuc Van Pham, is essential reading for scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

This book provides a unified framework for various currently available mathematical models that are used to analyze progression and regression in cancer development, and to predict its dynamics with respect to therapeutic interventions. Accurate and reliable model representations of cancer dynamics are milestones in the field of cancer research. Mathematical modeling approaches are becoming increasingly common in cancer research, as these quantitative approaches can help to validate hypotheses concerning cancer dynamics and thus elucidate the complexly interlaced mechanisms involved. Even though the related conceptual and technical information is growing at an exponential rate, the application of said information and realization of useful healthcare devices are lagging behind. In order to remedy this discrepancy, more interdisciplinary research works and course curricula need to be introduced in academic, industrial, and clinical organizations alike. To that end, this book reformulates most of the existing mathematical models as special cases of a general model, allowing readers to easily get an overall idea of cancer dynamics and its modeling. Moreover, the book will help bridge the gap between biologists and engineers, as it brings together cancer dynamics, the main steps involved in mathematical modeling, and control strategies developed for cancer management. This also allows readers in both medical and engineering fields to compare and contrast all the therapy-based models developed to date using a single source, and to identify unexplored research directions.

This book provides an insight into recent technological trends and innovations in mobility solutions and platforms to improve mobility of visually impaired people. The authors' goal is to help to contribute to the social and societal inclusion of the visually impaired. The book's topics include, but are not limited to, obstacle detection systems, indoor and outdoor navigation, transportation sustainability systems, and hardware/devices to aid visually impaired people. The book has a strong focus on practical applications, tested in a real environment. Applications include city halls, municipalities, and companies that can keep up to date with recent trends in platforms, methodologies and technologies to promote urban mobility. Also discussed are broader realms including education, health, electronics, tourism, and transportation. Contributors include a variety of researchers and practitioners around the world. Features practical, tested applications of technological mobility solutions for visual impaired people; Presents topics such as obstacle detection systems, urban mobility, smart home services, and ambient assisted living; Includes a number of application examples in education, health, electronics, tourism, and transportation.

The most important writings on the psychoanalytic understandings and treatments of drug and vice addiction Drug abuse, alcoholism, compulsive gambling, and other destructive addictions plague our society. Theories of addiction locate its cause variously-in factors related to the substance, the addict's personality, or to the addict's environment. Arguments about effective treatment programs are fierce. Essential Papers on Addiction presents the most important writing and the various sides of the debate on the psychoanalytic understanding and treatment of addiction. Daniel Yalisove outlines the history of the treatment of addiction and introduces important psychoanalytic concepts used in understanding addicts. The book includes case studies which illustrate the course of addiction and presents the work of the most influential theorists in the field. Divided into eight sections focusing on historical work on addiction, psychoanalytic theories of addiction, transference and countertransference issues in treating addiction, psychoanalytic treatment for the addictions, psychoanalytic therapy and disease concepts, and psychiatric illness and addiction, this definitive volume includes contributions by the most experienced and renowned experts on the subject. Contributors include S. Freud, E. Glover, S. Rado, R. P. Knight, L. Wurmser, N. E. Zinberg, H. Krystal, D. Jacobs, R. Fine, J. Gustafson, C. L. Brown, M. L. Selzer, V. Davidson, J. Imhof, R. Hirsch, R. E. Terenzi, M. E. Chafetz, A. Silber, R. J. Rosenthal, E. M. Pattison, M. B. Sobell, L. C. Sobell, J. E. Zweben, E. Simmel, B. Brickman, E. J. Khantzian, R. D. Weiss, S. M. Mirin, A. T. McLellan, and H. J. Richards.

This edited volume collects the research results presented at the 14th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Tel Aviv, Israel, 2016. The topical focus includes, but is not limited to, cardiovascular fluid dynamics, computer modeling of tissue engineering, skin and spine biomechanics, as well as biomedical image analysis and processing. The target audience primarily comprises research experts in the field of bioengineering, but the book may also be beneficial for graduate students alike.