Aquick reference to clinical information needed in Pediatric Intensive Care Units. The Manual makes extensive use of illustrations tables and boxes and provides up-to-date information on nursing interventions for the critically ill child. It also includes content on psychosocial issues, family needs and PICU instrumentation. Authored by an international expert in pediatric critical care who has incorporated the most up to-date policies, practices, and procedures into the text. Provides manageable summaries so that clinical information needed in PICU's can be quickly referenced. Contains more than 300 illustrations, tables, and boxes to aid in quick referencing of essential critical care information. Provides anatomy and physiology reviews to ensure complete understanding. Contains up-to-date information on nursing interventions that aids in the formulation of appropriate policy and accurate decision-making. Has many updated drug tables for the most current pharmacotherapy interventions. Includes content on psychosocial issues, family needs, and PICU instrumentation to prepare the nurse for the realities of working in a pediatric critical care unit. Features a chapter on burns to assist the pediatric critical care nurse in the care of a child with severe burns. Suggested resource lists provide a practical reference supplement for more detailed conditions.

White biotechnology, or industrial biotechnology as it is also known, refers to the use of living cells and/or their enzymes to create industrial products that are more easily degradable, require less energy, create less waste during production and sometimes perform better than products created using traditional chemical processes. Over the last decade considerable progress has been made in white biotechnology research, and further major scientific and technological breakthroughs are expected in the future. Fungi are ubiquitous in nature and have been sorted out from different habitats, including extreme environments (high temperature, low temperature, salinity and pH), and may be associated with plants (epiphytic, endophytic and rhizospheric). The fungal strains are beneficial as well as harmful for human beings. The beneficial fungal strains may play important roles in the agricultural, industrial, and medical sectors. The fungal strains and their products (enzymes, bioactive compounds, and secondary metabolites) are very useful for industry (e.g., the discovery of penicillin from Penicillium chrysogenum). This discovery was a milestone in the development of white biotechnology as the industrial production of penicillin and antibiotics using fungi moved industrial biotechnology into the modern era, transforming it into a global industrial technology. Since then, white biotechnology has steadily developed and now plays a key role in several industrial sectors, providing both high value nutraceutical and pharmaceutical products. The fungal strains and bioactive compounds also play an important role in environmental cleaning. This volume covers the latest developments and research in white biotechnology with a focus on diversity and enzymes.

Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.

Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 1 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care.

Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures.

This issue of Sleep Medicine Clinics focuses on Sleep in Older Adults, with topics including: Sleep in Normal Aging; Insomnia in the Older Adult; Sleep Apnea in the Older Adult; Circadian Rhythm Sleep-Wake Disorders in the Older Adult; Restless Legs Syndrome; Periodic Limb Movement Disorder and Other Sleep Related Movement Disorders in the Older Adult; REM Sleep Behavior Disorder and Other Parasomnias in the Older Adult; Neurodegenerative Disorders and Sleep; Medical Conditions and Sleep in the Older Adult; Psychiatric Illness and Sleep in the Older Adult; Sleep and Cognition in the Older Adult; Sleep and Nocturia in the Older Adult; Sleep and Long Term Care; and Sleep in the Hospitalized Older Adult.

This issue of Sleep Medicine Clinics is edited by Drs. Brown and Shahrokh Javaheri and focuses on Advanced PAP Therapies and Non-invasive Ventilation. Article topics include: Current Positive Airway Pressure Device Technology: What's in the "black box?"; Testing the Performance of Positive Airway Pressure Generators: From Bench to Bedside; Treatment of Obstructive Sleep Apnea: Choosing the Best PAP Device; Treatment of Obstructive Sleep Apnea: Choosing the Best Interface; Treatment of Obstructive Sleep Apnea: Achieving Adherence and Dealing with Complications; Treatment of Hyperventilatory Central Sleep Apnea: Idiopathic, CHF, Cerebrovascular Disease, and High Altitude; Disordered Breathing Due to Chronic Opioid Use: Diverse Manifestations and Their Management; Obesity Hypoventilation Syndrome: Choosing the Appropriate Treatment for a Heterogeneous Disorder; Positive Airway Pressure Treatment in the Patient with Ventilatory Failure due to Neuromuscular Disease; Non-invasive Ventilation in Acute Ventilatory Failure; Domiciliary Non-invasive Ventilation for Chronic Ventilatory Failure; The Future of Positive Airway Pressure Technology.

A comprehensive textbook providing a complete overview of the multifaceted nature of public health practice. It explores all aspects of public health from communities and wider society, child development and early relationships, inequalities in health, safeguarding, the rapidly changing nature of society and the significance of culture, equality and diversity. The book takes a life-span approach and makes direct links to the UK health and social care context and has been written for an interprofessional audience. It will be essential reading for health and social care students including nurses and midwives, allied health care professionals, social care workers, qualified health and social care practitioners and anyone who plays a role in understanding, promoting, and protecting public health. Key features: Comprehensive, wide-ranging coverage Addresses the realities of public health in a globalised world Applied to the UK four nation context but also considers the global dimension of public health practice

This book addresses a range of synthesis and characterization techniques that are critical for tailoring and broadening the various aspects of polymer gels, as well as the numerous advantages that polymer gel-based materials offer. It presents a comprehensive collection of chapters on the recent advances and developments in the science and fundamentals of both synthetic and natural polymer-based gels. Topics covered include: synthesis and structure of physically/chemically cross-linked polymer-gels/polymeric nanogels; gel formation through non-covalent cross-linking; molecular design and characterization; polysaccharide-based polymer gels: synthesis, characterization, and properties; modified polysaccharide gels: silica-based polymeric gels as platforms for the delivery of pharmaceuticals; gel-based approaches in genomic and proteomic sciences; emulgels in drug delivery; and organogels. The book provides a cutting-edge resource for researchers and scientists working in various fields involving polymers, biomaterials, bio-nanotechnology and functional materials.

Covering the full spectrum of rehabilitation after traumatic brain injury, this practical reference by Drs. Blessen C. Eapen and David X. Cifu presents best practices and considerations for numerous patient populations and their unique needs. In an easy-to-read, concise format, it covers the key information you need to guide your treatment plans and help patients relearn critical life skills and regain their independence. Covers neuroimaging, neurosurgical and critical care management, management of associated complications after TBI, pharmacotherapy, pain management, sports concussion, assistive technologies, and preparing patients for community reintegration. Discusses special populations, including pediatric, geriatric, and military and veteran patients. Consolidates today's available information and guidance in this challenging and diverse area into one convenient resource.

Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.

Advanced Perioperative Crisis Management is a high-yield, clinically-relevant resource for understanding the epidemiology, pathophysiology, assessment, and management of a wide variety of perioperative emergencies. Three introductory chapters review a critical thinking approach to the unstable or pulseless patient, crisis resource management principles to improve team performance and the importance of cognitive aids in adhering to guidelines during perioperative crises. The remaining sections cover six major areas of patient instability: cardiac, pulmonary, neurologic, metabolic/endocrine, and toxin-related disorders, and shock states, as well as specific emergencies for obstetrical and pediatric patients. Each chapter opens with a clinical case, followed by a discussion of the relevant evidence. Case-based learning discussion questions, which can be used for self-assessment or in the classroom, round out each chapter. Advanced Perioperative Crisis Management is an ideal resource for trainees, clinicians, and nurses who work in the perioperative arena, from the operating room to the postoperative surgical ward.

This volume focuses on smart medical and healthcare systems (modern intelligent systems for medicine and healthcare) and includes 31 papers presenting recent trends and innovations in medicine and healthcare, including biomedical engineering research and technologies; machine learning and labeling for biomedical visual data analysis and understanding; advanced ICT for medicine and healthcare; and healthcare support systems. Innovation in medicine and healthcare is an interdisciplinary research area, which combines advanced technologies and problem-solving skills with medical and biological science, and smart medical and healthcare systems can provide efficient and accurate solution to problems faced by healthcare and medical practitioners today by using advanced information communication techniques, computational intelligence, mathematics, robotics and other advanced technologies. Discussing the techniques developed in this area, which will have a significant effect on future medicine and healthcare, the book is a valuable resource for researchers, students, engineers, and professionals working in the fields of medical systems, medical technology, and intelligent systems.