This unique volume advances the literature on sleep and health by illuminating the impacts of family dynamics on individuals' quality and quantity of sleep. Its lifespan perspective extends across childhood, adolescence, adulthood and older age considering both phenomena of individual development and family system dynamics, particularly parent-child and marital relationships. It extends, as well, to the broader contexts of social disparities in sleep as a significant health behavior. Emerging concepts and practical innovations include ancestral roots of sleep in family contexts, sleep studies as a lens for understanding family health, and methodologies, particularly the use of actigraphy technology, for studying sleep patterns in individuals and families. This rich area of inquiry holds significant keys to understanding a vital human behavior and its critical role in physical, psychological, and relational health and wellbeing. Among the topics covered: * Sleep and development: familial and sociocultural considerations. * Relationship quality: implications for sleep quality and sleep disorders. * Couple dynamics and sleep quality in an international perspective. * Family influences on sleep: comparative and historical-evolutionary perspectives. * Sociodemographic, psychosocial, and contextual factors in children's sleep. * Dynamic interplay between sleep and family life: review and directions for future research. Family Contexts of Sleep and Health Across the Life Course will advance the work of researchers and students in the fields of population health, family demography and sociology, sleep research and medicine, human development, neuroscience, biobehavioral health, and social welfare, as well as that of policymakers and health and human services practitioners.

Intended for school psychologists, counselors, and social workers, teachers, and therapists who work with school systems, this book presents a philosophy and numerous practical strategies for handling behavioral problems presented by students.

Cell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area. Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, and metabolism of glycoconjugates.

This book describes novel hardware security and microfluidic biochip design methodologies to protect against tampering attacks in cyberphysical microfluidic biochips (CPMBs). It also provides a general overview of this nascent area of research, which will prove to be a vital resource for practitioners in the field.This book shows how hardware-based countermeasures and design innovations can be a simple and effective last line of defense, demonstrating that it is no longer justifiable to ignore security and trust in the design phase of biochips.

The application of nanotechnology within the medical sphere has had a significant influence on how diseases and conditions are treated and diagnosed. While many strides have been made, there is still continuous research on nanotechnology being performed in the field. Advancing Medicine through Nanotechnology and Nanomechanics Applications highlights emergent trends and empirical research on technological innovations in medicine and healthcare. Investigating the impact of nanotechnology and nanomechanics on the treatment of diseases, regenerative medicine, and drug delivery systems, this publication is a vital reference source for professionals, researchers, medical students, and engineering students.

This book presents not only the simultaneous combination of optical methods based on holographic principles for marker-free imaging, real-time trapping, identification and tracking of micro objects, but also the application of substantial low coherent light sources and non-diffractive beams. It first provides an overview of digital holographic microscopy (DHM) and holographic optical tweezers as well as non-diffracting beam types for minimal-invasive, real-time and marker-free imaging as well as manipulation of micro and nano objects. It then investigates the design concepts for the optical layout of holographic optical tweezers (HOTs) and their optimization using optical simulations and experimental methods. In a further part, the book characterizes the corresponding system modules that allow the addition of HOTs to commercial microscopes with regard to stability and diffraction efficiency. Further, based on experiments and microfluidic applications, it demonstrates the functionality of the combined setup, and discusses several types of non-diffracting beams and their application in optical manipulation. The book shows that holographic optical tweezers, including several non-diffracting beam types like Mathieu beams, combined parabolic and Airy beams, not only open up the possibility of generating efficient multiple dynamic traps for micro and nano particles with forces in the pico and nano newton range, but also the opportunity to exert optical torque with special beams like Bessel beams, which can facilitate the movement and rotation of particles by generating microfluidic flows. The last part discusses the potential use of a slightly modified DHM-HOT-system to explore the functionality of direct laser writing based on a two photon absorption process in a negative photoresist with a continuous wave laser

This book shows how to develop efficient quantitative methods to characterize neural data and extra information that reveals underlying dynamics and neurophysiological mechanisms. Written by active experts in the field, it contains an exchange of innovative ideas among researchers at both computational and experimental ends, as well as those at the interface. Authors discuss research challenges and new directions in emerging areas with two goals in mind: to collect recent advances in statistics, signal processing, modeling, and control methods in neuroscience; and to welcome and foster innovative or cross-disciplinary ideas along this line of research and discuss important research issues in neural data analysis. Making use of both tutorial and review materials, this book is written for neural, electrical, and biomedical engineers; computational neuroscientists; statisticians; computer scientists; and clinical engineers.

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells. This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and plant sciences.

This volume contributes to an emerging field that could be referred to as "plural spiritual care and chaplaincy". It's innovative approach brings together contributions from a broad range of contexts and religious traditions and includes empirical work and conceptual explorations. It helps to fill the gap between practices and developments related to plural spiritual care and chaplaincy in the scholarly discourse.

How do you care for ageing parents without destroying the family emotionally or financially? Author Dan Taylor has answered that question in The Parent Care SolutionT. Dan helps you to initiate the Six Conversations you must have with your parents to plan for their care. Using a unique Conversation Strategy he strips away the reluctance and the awkwardness that often surrounds this topic. Once the Six Conversations are completed he provides effective tools for organizing finances, making gifts, selling the family home, evaluating a care facility and selecting someone for the role of a The Parent Care SpecialistT. Dan has taken all the complexity around this subject and reduced it to a simple confidence producing set of conversations and actions.

This book examines statistical techniques that are critically important to Chemistry, Manufacturing, and Control (CMC) activities. Statistical methods are presented with a focus on applications unique to the CMC in the pharmaceutical industry. The target audience consists of statisticians and other scientists who are responsible for performing statistical analyses within a CMC environment. Basic statistical concepts are addressed in Chapter 2 followed by applications to specific topics related to development and manufacturing. The mathematical level assumes an elementary understanding of statistical methods. The ability to use Excel or statistical packages such as Minitab, JMP, SAS, or R will provide more value to the reader. The motivation for this book came from an American Association of Pharmaceutical Scientists (AAPS) short course on statistical methods applied to CMC applications presented by four of the authors. One of the course participants asked us for a good reference book, and the only book recommended was written over 20 years ago by Chow and Liu (1995). We agreed that a more recent book would serve a need in our industry. Since we began this project, an edited book has been published on the same topic by Zhang (2016). The chapters in Zhang discuss statistical methods for CMC as well as drug discovery and nonclinical development. We believe our book complements Zhang by providing more detailed statistical analyses and examples.

This book covers the state-of-the-art research on advanced high-resolution tomography, exploring its role in regenerative medicine. and also explores the 3D interactions between tissues, cells, and biomaterials. Various multidisciplinary paths in regenerative medicine are covered, including X-ray microtomography and its role in regenerative medicine, synchrotron radiation-based microtomography and phase contrast tomography, the challenge of the vascularization of regenerated tissues, lung and cartilage imaging, and more. This is an ideal book for biomedical engineers, biologists, physicists, clinicians, and students who want to pursue their studies in the field of regenerative medicine. This book also: Reviews in detail the algorithms and software used for the 3D exploration of regenerated tissue Covers the latest research on the use of X-ray microtomography for muscle diseases Details applications of synchrotron radiation tomography in orthopedics and dentistry

This book presents cutting-edge research on the use of physical and mathematical formalisms to model and quantitatively analyze biological phenomena ranging from microscopic to macroscopic systems. The systems discussed in this compilation cover protein folding pathways, gene regulation in prostate cancer, quorum sensing in bacteria to mathematical and physical descriptions to analyze anomalous diffusion in patchy environments and the physical mechanisms that drive active motion in large sets of particles, both fundamental descriptions that can be applied to different phenomena in biology. All chapters are written by well-known experts on their respective research fields with a vast amount of scientific discussion and references in order the interested reader can pursue a further reading. Given these features, we consider Quantitative Models for Microscopic to Macroscopic Biological Macromolecules and Tissues as an excellent and up-to-date resource and reference for advanced undergraduate students, graduate students and junior researchers interested in the latest developments at the intersection of physics, mathematics, molecular biology, and computational sciences. Such research field, without hesitation, is one of the most interesting, challenging and active of this century and the next.

This is a one-of-a-kind, all-inclusive reference guide for new Clinical Nurse Specialists entering the field as well as seasoned practitioners looking to update their knowledge. Disseminating a wealth of current professional practice guidance and practical information on reimbursement and certification, the second edition has been fully updated to reflect changes resulting from the Affordable Care Act and the APRN Consensus Model. Four new chapters address changes and emerging trends, expanding focus on independent practice, increasing demands on health care due to the growing population of older adults, and updated reimbursement/economic issues. This authoritative toolkit is organized in an easy-to-use, bullet-point format and includes numerous clinical examples, case scenarios, and personal anecdotes culled from the contributors' own professional experiences. New to the Second Edition: Fully revised and updated. Addresses CNS practice within Affordable Care Organizations. Describes CNS leadership role in system-level evidence-based practice initiatives. Covers documentation and communication of CNS activities aligning with strategic initiatives and CNS practice priorities. Discusses facilitating transitions of care to assure safety and quality. Addresses the CNS role in interprofessional education in clinical settings. Key Features: Presents crucial information on negotiating and securing a job. Provides advice on establishing credibility, prioritising, and finding a mentor. Contains guidelines on mentoring staff, leading groups, and precepting students. Addresses documenting and measuring clinical outcomes. Describes how to network with professional organisations and community agencies. Offers practical guidance on applying for reimbursement and pursuing certification and licensure.

Untold stories of people with substance addictions who have recovered without formal treatment Despite the widely accepted view that formal treatment and twelve-step groups are essential for overcoming dependencies on alcohol and drugs, each year large numbers of former addicts quietly recover on their own, without any formal treatment or participation in self-help groups at all. Coming Clean explores the untold stories of untreated addicts who have recovered from a lifestyle of excessive and compulsive substance use without professional assistance. Based on 46 in-depth interviews with formerly addicted individuals, this controversial volume examines their reasons for avoiding treatment, the strategies they employed to break away from their dependencies, the circumstances that facilitated untreated recovery, and the implications of recovery without treatment for treatment professionals as well as for prevention and drug policy. Because of the pervasive belief that addiction is a disease requiring formal intervention, few training programs for physicians, social workers, psychologists, and other health professionals explore the phenomenon of natural recovery from addiction. Coming Clean offers insights for treatment professionals of how recovery without treatment can work and how candidates for this approach can be identified. A detailed appendix outlines specific strategies which will be of interest to addicted individuals themselves who wish to attempt the process of recovery without treatment.

This book documents the state of the art in the field of ambient assisted living (AAL), highlighting the impressive potential of novel methodologies and technologies to enhance well-being and promote active ageing. The coverage is wide ranging, with sections on assistive devices, elderly people monitoring, home rehabilitation, ICT solutions for AAL, living with chronic conditions, robotic assistance for the elderly, sensing technologies for AAL, and smart housing. The book comprises a selection of the best papers presented at the 7th Italian Forum on Ambient Assisted Living (ForitAAL 2016), which was held in Pisa, Italy, in June 2016 and brought together end users, technology teams, and policy makers to develop a consensus on how to improve provision for elderly and impaired people. Readers will find that the expert contributions offer clear insights into the ways in which the most recent exciti ng advances may be expected to assist in addressing the needs of the elderly and those with chronic conditions.

Computational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.