This volume in the "Methods in Enzymology" series comprehensively covers Cancer, Cardiovascular and the central nervous system of Nanomedicine. With an international board of authors, this volume is split into sections that cover subjects such as Diabetes and nanotechnology as potential therapy, Nanomedicines for inflammatory diseases, and Development and use of ceramide nanoliposomes in cancer.
Comprehensively covers cancer and the cardiovascular and central nervous systems of nanomedicineAn international board of authorsSplit into sections that cover subjects such as diabetes and nanotechnology as potential therapy, nanomedicines for inflammatory diseases, and the development and use of ceramide nanoliposomes in cancer

Although hip, knee and other orthopaedic implants are well-established prostheses, much remains to be understood about how these implants wear in use. This important book summarises the wealth of recent research in this area and its implications for implant and joint design.
After an introductory overview, the book reviews the causes and prevention of implant wear. Part one discusses fundamental issues such as tissue response to wear, the anatomy and biomechanics of hips and knees as well as the materials and design issues they raise for hip, knee and other types of orthopaedic implant. Part two considers wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints. It also covers surgical and other factors influencing wear as well as ways of detecting, analysing and predicting implant wear and failure.
With its distinguished editor and international team of contributors, Wear of orthopaedic implants and artificial joints is a standard reference for implant manufacturers, surgeons and those researching this important area.
Summarises the wealth of recent research into the wear of orthopaedic implants and artificial joints and discusses the implications for implant and joint designReviews the causes and prevention of implant wear, tissue response to wear, the anatomy and biomechanics of hips and knees and the materials and design issues they raise for orthopaedic implantsConsiders wear phenomena in a range of materials, including ultra-high molecular weight (UHMWPE), metal and ceramic joints

Developments in tissue engineered and regenerative medicine products summarizes recent developments in tissue engineering and regenerative medicine with an emphasis on commercialization and product development. Features of current cell therapy and tissue engineered products which have facilitated successful commercialization are emphasized and roadblocks to successful product development are also highlighted. Preclinical and clinical testing of tissue engineered and regenerative medicine products, regulatory, quality control, manufacturing issues, as well as generating and securing intellectual property and freedom to operate considerations are presented. This book represents a complete 'how-to' manual for the development of tissue engineered and regenerative medicine products from conceptualization to clinical trial to manufacturing.
Addresses practical considerations for the field of tissue engineering and regenerative medicine from the perspective of the biotechnology industryWritten as a manual for tissue engineering and regenerative medicine product development applicable to the US and EUIllustrates pathway integration of science and business required for successful product development

Wound repair is an important and growing sector of the medical industry with increasingly sophisticated biomaterials and strategies being developed to treat wounds. Advanced wound repair therapies provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic wounds.
Part one provides an introduction to chronic wounds, with chapters covering dysfunctional wound healing, scarring and scarless wound healing and monitoring of wounds. Part two covers biomaterial therapies for chronic wounds, including chapters on functional requirements of wound repair biomaterials, polymeric materials for wound dressings and interfacial phenomena in wound healing. In part three, molecular therapies for chronic wounds are discussed, with chapters on topics such as drug delivery, molecular and gene therapies and antimicrobial dressings. Part four focuses on biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair. Finally, part five covers physical stimulation therapies for chronic wounds, including electrical stimulation, negative pressure therapy and mechanical debriding devices.
With its distinguished editor and international team of contributors, Advanced wound repair therapies is an essential reference for researchers and materials scientists in the wound repair industry, as well as clinicians and those with an academic research interest in the subject.
Provides readers with up-to-date information on current and emerging biomaterials and advanced therapies concerned with healing surgical and chronic woundsChapters include the role of micro-organisms and biofilms in dysfunctional wound healing, tissue-biomaterial interaction and electrical stimulation for wound healingCovers biologically-derived and cell-based therapies for chronic wounds, including engineered tissues, biologically-derived scaffolds and stem cell therapies for wound repair

Bioactive materials play an increasingly important role in the biomaterials industry, and are used for a range of applications, including artificial organs, drug delivery systems, nanomedicine, and biosensors. Bioactive materials in medicine reviews the current status and ongoing development of bioactive materials for medical applications.
Following an introduction to bioactive materials in medicine, part one covers the process of designing bioactive materials, including chapters on molecular design, nanotechnology, and tissue engineering. Part two focuses on the different applications of bioactive materials in medicine, with chapters discussing applications in orthopaedics, in the circulatory system, and as antibacterials. The final chapters focus on the uses of these materials in gene therapy, plastic surgery and body reconstruction, and in drug delivery systems.
With its distinguished editors and international team of contributors, Bioactive materials in medicine is an essential reference for researchers and designers in industry, as well as those with an academic interest in the subject.
Discusses the current status and ongoing development of bioactive materials for medical applicationsExplores the process of designing bioactive materials, including molecular design, nanotechnology, and tissue engineeringAssesses different applications of bioactive materials in medicine featuring applications in orthopaedics, in the circulatory system, and as antibacterials

Respected leader in Critical Care Medicine, Phillip Dellinger has complied a top-notch range of articles on the subject of Sepsis. Topics include: "The History of Sepsis," "Molecular Biology of Sepsis," "Sepsis Induced Tissue Hypoperfusion," "Hemodynamic Monitoring in Sepsis," "Performance Improvement in Sepsis," and more

This issue will deal with "Heel Pathology" and focus on topics such as: Tarsal Tunnel; Calcaneal Osteomyelitis; Plantar Fasciitis; Exostoses of the Calcaneus; Systemic Disorders affecting the Heel; Sports Injuries of the Heel;Calcaneal Fractures.

This issue reviews the major areas of clinical interest in Dental Sleep: Sleep Bruxism; Oral Evaluation and Screening by the Dentist; the Neurologic Basis of Sleep Breathing Disorders; Sleep and Orofacial Pain; Cone Beam Imaging of the Airway; The Cervical Spine: Considerations and Treatment for Sleep Disordered Breathing; the Role of the Nasal Airway; Myofunctional Tongue Therapy for Speech Therapy; Ambulatory Testing by the Dentist for Oral Appliance Therapy; Exercises to Address Posture, the Cervical Spine and the Airway; Oral Appliance Therapy for Sleep Breathing; Surgical Therapy for Sleep Breathing Disorders; Sleep Disorders and Headache; and Anatomy of the Airway.? Every sleep specialist needs to be aware of how dental concerns can impact sleep behaviors and sleep disorders.

'Trease and Evans' is an encyclopedic reference work on pharmacognosy - the study of those natural substances, principally plants, that find a use in medicine. Its popularity and longevity stem from the book's balance between classical (crude and powdered drugs' characterization and examination) and modern (phytochemistry and pharmacology) aspects of this branch of science, as well as the editor's recognition in recent years of the growing importance of complementary medicines, including herbal, homeopathic and aromatherapy. No other book provides such a wealth of detail. A reservoir of knowledge in a field where there is a resurgence of interest - plants as a source of drugs are of growing interest both in complementary medicine fields and in the pharmaceutical industry in their search for new 'lead compounds'. Dr Evans has been associated with the book for over 20 years and is a recognised authority in all parts of the world where pharmacognosy is studied, his knowledge and grasp of the subject matter is unique. Meticulously referenced and kept up to date by the editor, new contributors brought in to cover new areas. New chapter on 'Neuroceuticals'. Addition of many new compounds recently added to British Pharmacopoeia as a result of European harmonisation. Considers development in legal control and standardisation of plant materials previously regarded as 'herbal medicines'. More on the study of safety and efficacy of Chinese and Asian drugs. Quality control issues updated in line with latest guidelines (BP 2007).

Among the most interesting fields in research are the emerging possibilities to interface the human brain directly with machines, e.g. with computers and robotic interfaces. The European Space Agency's Advanced Concept team as a multidisciplinary team from engineering, artificial intelligence, and neural engineering has been working on the cutting edge of exploring brain machine interfaces for application in space as solutions to limitations astronauts face in space, and this book for the first time presents the state-of-the-art-cohesively.
* A pioneering book for a pioneering field
* Presents the application of cutting-edge brain machine interface technologies and concepts to support astronauts in space
* Of great interest to space scientists, neuroscientists, and biomedical engineers alike

This book provides a foundation for understanding the fundamentals of biomedical informatics, which deals with the storage, retrieval, and use of biomedical data for biological problem solving and medical decision making. It covers the application of these principles to the three main biomedical domains of basic biology, clinical medicine, and public health. The author offers a coherent summary, focusing on the three core concept areas of biomedical data and knowledge representation, biomedical information access, biomedical decision making, and information and technology use in biomedical contexts.
* Develops principles and methods for representing biomedical data, using information in context and in decision making, and accessing information to assist the medical community in using data to its full potential
* Provides a series of principles for expressing biomedical data and ideas in a computable form to integrate biological, clinical, and public health applications
* Includes a discussion of user interfaces, interactive graphics, and knowledge resources and reference material on programming languages to provide medical informatics programmers with the technical tools to develop systems

This book is aimed primarily at occupational therapy undergraduate students, but will be of use to new practitioners working in the field of learning disability and other students studying topics related to learning disabilities. It meets perceived learning needs in line with theory and practice outcomes and provides an understanding of the current issues in health and social care for people with a learning disability. It provides a basis for further learning and the depth reflects present curricula demands and expectations in line with professional practice. There are also contributions and comments from service users with a learning disability. This book is aimed primarily at occupational therapy undergraduate students, but will be of use to new practitioners working in the field of learning disability and other students studying topics related to learning disabilities. It meets learning needs in line with theory and practice outcomes and provides an understanding of the current issues in health and social care for people with a learning disability. It provides a basis for further learning and the depth reflects present curricula demands and expectations in line with professional practice. There are also contributions and comments from service users with a learning disability. Informative text supported by reflective activities Reflects changes in service provision subsequent to "A Strategy for the 21st Century" Case scenarios and self assessment tasks Advises on further reading Offers occupational therapy focus on issues that are also relevant to other health professionals

This book presents the application of the model of cognitive behavioural intervention in the practice of physiotherapy and occupational therapy addressing a range of clinical problems with contributions from professionals who are specialists in their field. The purpose of the book is to increase knowledge and awareness of how CBT can be applied within a theoretical framework from which physiotherapists and occupational therapists work. The book explains the psychological model and provides a rationale for applying CBT as a tool to strengthen physiotherapy and occupational therapy interventions. By bringing new knowledge to the practice of physiotherapists and occupational therapists in regard to CBT approaches opens up new options in relation to the management of specific conditions such as chronic pain, anxiety, fibromyalgia and other specialist areas. Case studies are integral to this book, highlighting the application of CBT, outlining the strategies, and illustrating the outcomes and boundaries of treatment. This is not a book for experts in CBT: focusing on physiotherapy and occupational therapy professions, Donaghy and her co-authors link models of current practice with CBT interventions, giving parameters an integrated practice. . case studies . evidence-based . interdisciplinary approach . contributed to by renowned specialists in the field

Learning Strategies for Allied Health Students equips you for success with separate sections filled with strategies for making reading, writing, mathematics, and studying easier; a vocabulary chapter that introduces the medical and non-medical terms you need to know...with a glossary that summarizes these terms for you, at a glance; 15 reading selections - one for each chapter - that let you practice using the skills you've learned; exercises from current allied health textbooks to give you hands-on practice with the kinds of assignments you'll encounter at school. An answer key allows you to check your work; and much, much more! Learning Strategies for Allied Health Students is the only book that's written specifically with your needs in mind. Clear and easy to read, it's your best way to prepare for the challenges you'll face in school...and in the workplace!

A first in Midwifery publishing! No other book advises midwives on the special needs of mothers with disabilities. Although an increasing number of women with disabilities are having children, the needs of this minority group are not always being effectively met. Disability in Pregnancy and Childbirth provides essential practical information to healthcare professionals working with this group. The first book on maternity care for women with additional or alternative needs A practical resource for all working with pregnant women and mothers Reflects the lived experiences of women with disabilities Written by experts in the field Holistic content Looks at professional attitudes as well as the woman's needs

Liu's Labour Ward Manual has for many years been the standard work for all personnel working on the labour ward. It gives instruction on the best application of technical procedures employed in the labour ward whilst promoting the ethos that the labouring mother and the unborn child must be the prime focus of attention. Offers a one-stop guide to all aspects of labour and birth in a hospital environment Covers everything from admittance procedures through to emergency drills and multiple births User-friendly layout with clear diagrams provide easy access to information Panel of international specialists ensure contemporary and representative content Incorporation of latest NICE and RCOG Guidelines as well as those of CNST New section on Emergency Drills Expanded segment on mental health

Modelling and Control in Biomedical Systems (including Biological Systems) was held in Reims, France, 20-22 August 2006. This Symposium was organised by the University of Reims Champagne Ardenne and the Societe de l Electricite, de l Electronique et des TIC (SEE).
The Symposium attracted practitioners in engineering, information technology, mathematics, medicine and biology, and other related disciplines, with authors from 24 countries. Besides the abstracts of the four plenary lectures, this volume contains the 92 papers that were presented by their authors at the Symposium
The papers included two invited keynote presentations given by internationally prominent and well-recognised research leaders: Claudio Cobelli, whose talk is titled "Dynamic modelling in diabetes: from whole body to genes"; and Irving J. Bigio, whose talk is titled "Elastic scattering spectroscopy for non-invasive detection of cancer." Two prestigious industrial speakers were also invited to give keynote presentations: Terry O'Brien from LIDCO, whose talk is titled "LIDCO: From the laboratory to protocolized goal directed therapy"; and Lorenzo Quinzio of Philips, whose talk is titled "Clinical decision support in monitoring and information systems."
* A valuable source of information on the state-of- the-art in Modelling and Control in Biomedical Systems
* Including abstracts of four plenary lectures, and 92 papers presented by their authors"

"I still have the confidence of that whole period. And I think that will stay with me for the rest of my life. Definitely a great sense of triumph really. It's incredible." Being a midwife today requires not only good clinical skills but also a broad understanding of the social and emotional changes a woman goes through before and after birth. The New Midwifery Second Edition looks at combining scientific knowledge with the more intangible skills needed in sensitive communication to provide the best possible care for the mother and her family. "There was a kind of silence in the relationship, a stillness which was very important. And we'd done all the talking in the build up. So the talking was done. I felt confident that she [the midwife] knew where I was coming from and vice versa. It was like we'd done all our dress rehearsal - what if, what if. And on the day there was nothing left to say really. So it just felt very calm, and I think that was the most important thing." The second edition of this celebrated text explores vividly the various skills and approaches that lead to successful midwifery practice and uses care stories to bring these to life. Building on a thorough grounding of theory and research evidence, The New Midwifery will enable all midwives to practise with a more effective range of skills and, as these real-life quotes from mothers bear out, provide unique professional support before, during and after birth. "I think we had a really good relationship actually. It was more of a friend relationship, but a friend you could trust in - a professional friend you could rely on." Provides a refreshingly new approach to key areas of midwifery practice in a way that brings practice to life. Illustrates and supports the fundamental changes currently taking place in midwifery around the world. Builds on the most up-to-date, evidence-based research to suggest guidelines for best practices. Explores the impact of parenthood and offers strategies for effectively supporting individuals during this period of transition. Includes "care stories" - case studies that highlight positive midwifery care and successful childbirth experiences. Offers contrasting stories from around the world, illustrating how maternity care in industrialized society differs from that in a non-industrial or third world environment. Provides up-to-date research and reference material.

This book is unique, because no other psychiatric/mental health nursing text has ever brought together 'opposing' or contrasting views of the same issue, and subsequently invited two seperate chapters to be written in order to articulate the different perspectives in the debate. Further, no book has then followed up such a wide and thorough discussion by inviting a third party to offer commentary. The purpose of this book is to present a range of key issues that psychiatric/mental health nurses face. They are practice, policy, research and education related issues. The purpose then is to present the most complete, balanced arguments possible in order to inform, educate, and stimulate psychiatric/mental health nurses. Furthermore the purpose of the book is to make psychiatric/mental health nurses more aware of the, often, uncertain nature of much of psychiatric/mental health nursing practice and knowledge. Psychiatric/mental health nursing is not characterised by 'black and white', easily delineated issues, and is perhaps characterised by various 'shades of grey'. Indeed, it is often stated as axiomatic that psychiatric/mental health nurses can be described as a 'broad church'. Consequently, the purpose of this book is to help psychiatric/mental health nurses appreciate this broad church, be able to understand the various 'shades of grey', be able to understand that, often, there are differing views, inconclusive arguments and contentious debates and for this to influence their clinical practice. As the international range of contributors illustrates, these debates (to a greater or lesser extent) are issues and debates that psychiatric/mental health nurses face the world over; these are matters of real international importance and significance. These issues have been touched upon, and to a limited extent, debated at psychiatric/mental health nursing conferences and, to an even lesser extent, within some psychiatric/mental health nursing journals. Thus, they are real issues that many nurses are facing, talking about and trying to resolve.key debates are presented with arguments from opposing viewpoints, followed by a third-party commentary, to give readers the necessary information to form their own view written by a range of international authors from different countries across three continents one of the first psychiatric/mental health nursing books to explore the pedagogical value of debate

Haematological oncology is a rapidly advancing and exciting field of medicine. This is the first British textbook addressing haematological oncology written specifically for nurses. The book is intended for qualified nurses working with, or having an interest in, haematological malignancies and will also be useful to student nurses and those undertaking specialist courses. The second edition of this successful text has been fully revised and updated throughout in line with recent developments in clinical practice. There are seven new chapters and expanded sections on bone marrow transplant, the immune system and palliative care. Comprehensive coverage of nursing issues in hematological malignancies providing everything a newcomer will need to know Addresses the role of chemotherapy, radiotherapy, and blood marrow transplant treatments in haematological oncology to enable effective management of patients Discusses pertinent daily issues for practicing nurses including oral care, nausea and vomiting, nutrition, infection control, social and psychological issues Reflection points provide an active reading experience and illuminate ideas and issues within the text Six new chapters: Research Priorities; Leadership Issues for Specialist Nurses; Fatigue; Adolescent Issues; Addressing the Needs of Families; Immune Modulators and Novel Therapies Expanded information on bone marrow transplant, the immune system and palliative care Improved design and layout New expert contributors to provide the latest information on their field

Comprehensive Disability Management articulates current disability management knowledge and provides insight into new concepts. Practitioners of disability management come from many diverse health and health related professions such as nursing, psychology, occupational therapy, etc. Disability management is an emerging profession without adequate reference materials. As professionals, disability management practitioners have a significant impact on the financial and human costs of disability. Most major corporations have the need for a disability management program and therefore require individuals with skills to perform these functions. The financial costs of disability in corporations are one of the key target areas that require attention. The human costs of disability are also dramatic and efforts need to be made to reduce the impact of disabilities on individuals. The book documents proven techniques in disability management for practitioners in the field. It introduces the first theoretical model in this developing profession and provides practical examples on how to implement and manage an effective disability management program. The approach commences with an overview and the history of disability management as a developing practice area. The authors establish a theoretical base for disability management to guide the activities of practitioners in the field. They then translate the theory into action paradigms and address important issues around the disability management process including role definitions and discussions on key components. The disability management process, including claim initiation, claims management, return to work and rehabilitation, will be discussed. The important aspects of data analysis and quality assurance in program evaluation for this field are also considered. The book addresses the core aspects of disability management knowledge, skills and capabilities and reviews in detail the factors that influence the ability to effectively perform disability management in today's workplaces. It also looks at the interaction of the workplace organization. Formulates the business case for disability management in an organization, helping the reader understand how disability management fits into the overall functioning of a corporation. Presents a theoretical model that recognizes the influence of multiple issues on a disability outcome. Reviews proven disability management techniques for ensuring evidence-based best practice treatments.

Maintaining quality of life in an ageing population is one of the great challenges of the 21st Century. This book and collection of illustrated CD lectures summarises how this challenge is being met by multi-disciplinary developments of specialty biomaterials, devices, artificial organs and in-vitro growth of human cells as tissue engineered constructs.
Biomaterials, Artificial Organs and Tissue Engineering is intended for use as a textbook in a one semester course for upper level BS, MS and Meng students. The 25 chapters are organized in five parts: Part one provides an introduction to living and man-made materials for the non-specialist; Part two is an overview of clinical applications of various biomaterials and devices; Part three summarises the bioengineering principles, materials and designs used in artificial organs; Part four presents the concepts, cell techniques, scaffold materials and applications of tissue engineering; Part five provides an overview of the complex socio-economic factors involved in technology based healthcare, including regulatory controls, technology transfer processes and ethical issues. Each chapter is supplemented with illustrated Power Point lectures and study questions in an easy to use CD to aid the reader in self-paced instruction.
Comprehensive introduction to living and man-made materialsLooks at clinical applications of various biomaterials and devicesBioengineering principles, materials and designs used in artificial organs are summarised

This publication aims to be a user-friendly resource for supervisors to develop their practice grounded in current theory and evidence. The publication extends beyond past notions of student supervision to include supervision of professionals in their work place and the emergent importance of professional mentoring for ongoing professional development. The publication is written from the perspective of a broad range of health science practitioners, including audiology, dietetics, nursing, occupational therapy, pharmacy, physiotherapy, podiatry, prosthetics and orthotics, radiography, and speech-language pathology. Acknowledging that health science professionals work in busy and often stressful environments, there is a deliberate intention to present complex theoretical material in a simple and person-centred format. Such a presentation aims to assist the reader to more easily integrate the material into their practice. The user-friendly style as previously utilized in Best and Rose (1996) continues to receive extremely positive feedback from readers and course developers. Written by multidisciplinary experts with academic and research backgrounds who also possess extensive practical experience in a variety of professional health fields. Reader-friendly, engaging material is grounded in current theory and evidence. Three distinct but interrelated fields - clinical education, professional supervision, and mentoring - are addressed together in one book for the first time. Supervision of professionals in their workplace is covered, as well as professional mentoring for ongoing professional development. Presents complex theoretical material in an engaging, "person-centered" approach. Acknowledges the importance of psychological well-being with chapters on the self in supervision and finding meaning and preventing burnout.