Molecular Biomarkers in Cancer Detection and Monitoring of Therapeutics: Volume Two: Diagnostic and Therapeutic Applications discusses how molecular biomarkers are used to determine predisposition, facilitate detection, improve treatment and offer prevention guidelines for different cancers. It focuses on novel diagnostic techniques based on molecular biomarkers and their impact on treatment, covering different cancer types such as tumors in the nervous system, head and neck, oral and GI tractor, lung, breast, gastric system, leukemia and urogenital tract cancers. For each type, the book discusses the best diagnostic techniques and therapeutic approaches, thus helping readers easily identify the best solution for each case. This is a valuable resource for cancer researchers, oncologists, graduate students and other members of the biomedical field who are interested in the potential of biomarkers in cancer research.

Nuclear Medicine and Molecular Imaging offers complete coverage of this exciting and key area of biomedicine, seamlessly fusing the science behind nuclear medicine with the clinical aspects of diagnostic imaging. Beginning with sections on the physics related to nuclear medicine, radiation biology/safety, and instrumentation/quality control, it then covers radiochemistry and the development of new radionuclide therapy/tracers, and basic techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT). The focus then shifts to the clinical aspects, with sections on clinical/preclinical nuclear imaging (structured via organ system such as gastrointestinal, cardiovascular, pulmonary, etc.), as well as other in vivo molecular imaging techniques such as optical imaging, digital image analysis (radiomics), as well as the increasing use of artificial intelligence (AI) in diagnostics. No other publication provides such a complete overview of the field, with most choosing to focus either on physics or imaging. In most cases, preclinical/experimental imaging is treated separately from clinical imaging. Nuclear Medicine and Molecular Imaging brings it all together into a complete, 4-volume, foundational resource for researchers and medical professionals specializing in this exciting area.

Addressing the problem of how weight is regulated, how obesity is acquired, and how it is cured, Weight Regulation and Curing Acquired Obesity provides the mathematical basis of control system theory as applied to weight regulation. Unlike the majority of weight control literature which focuses on biochemistry, this innovative title discusses the biomechanical aspects of a dual closed loop system which mechanically senses meal volume and accumulated intraabdominal fat, where accurate sensation depends on the mechanical strength of the anterior abdominal wall. Presents a unified theory of weight regulation, explains the pathology of acquired obesity, and offers therapy directed to correct the underlying pathophysiology. Discusses surgical therapy directed to re-establish the strength of the anterior abdominal wall, reverse the pathology, and cure acquired obesity. Contains a chapter on future animal and human studies to support the neuromechanical hypothesis.

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development.

This revised edition will serve as a useful guide for midwives working both in rural and urban areas. The complete and concise text of the latest edition is fully revised and updated with more than 150 new entries and around 60 new figures. New appendices, including normal values in neonates and pediatric populations, antenatal assessment format, newborn assessment format, formulae for assessing growth parameters in children, etc. would be of immense help to midwives and medical professionals. The dictionary would definitely serve as a ready reference to the entire midwifery community. The latest edition is fully revised and updated with more than 150 new entries and around 60 new figures. Written to train midwives regarding basic terms used in medical science, particularly obstetrics, gynecology and midwifery. Language and elaboration has been made and simple to comprehend.

This is the second edition of the highly acclaimed classic physiotherapy textbook which has become the definitive guide for undergraduate students, junior physiotherapists and practitioners specialising in obstetrics, gynaecology and urogynaecology. The text has been extensively re-written and up-dated for the twenty-first century by a group of respected specialists in the field. Following in the footsteps of its very successful predecessor, Mantle and Polden's Physiotherapy in Obstetrics & Gynaecology 2E it is extensively referenced and copiously illustrated, and it documents in the most practical and relevant way the scientific and philosophical basis on which all good physiotherapeutic clinical intervention rests. Brimming with evidence based advice and practical tips, the book contains:A detailed anatomical description of the female reproductive, urinary and lower intestinal tracts together with associated structures. The physiology of reproduction, pregnancy, parturition, the puerperium as well as the menopause and beyond. A thorough reasoned account of the physiotherapist's role preconceptually, through the reproductive cycle, to the middle years and beyond Information on a wide range of gynaecological pathologies and relevant surgery Treatment of incontinence in much detail with separate chapters on both urinary and bowel dysfunctions. This comprehensive text will be essential reading for all those participating in the post registration university physiotherapy courses in women's health and continence. The editors, Jill Mantle, Jeanette Haslam and Sue Barton are internationally known as physiotherapists, academics, authors and researchers in this field. Amazingly thorough coverage of the physiotherapist's role in obstetrics and gynecology make this resource the definitive one of its kind. Information includes detailed anatomical descriptions of the female reproductive, urinary and lower intestinal tracts together with associated structures. Material on the physiology of reproduction, pregnancy, parturition, the puerperium, menopause, and more makes this text the definitive resource of its kind. Practical content features a reasoned account of the physiotherapist's role preconceptually, through the reproductive cycle, to the middle years and beyond. Comprehensive coverage includes a wide range of gynecological pathologies and relevant surgeries. Detailed coverage of treatment of incontinence provides helpful knowledge to any practitioner. Information has been updated to reflect modern practice and recent changes in the electrotherapy machines used in labor.

Statistical, Mapping and Digital Approaches in Healthcare addresses all health territories, starting from the analysis of geographical data (health data, population data, health data systems and environmental data), to new health areas (Health 3.0), i.e. digital health territories. Specific tools are used to question environmental changes, such as health statistics, mapping, mathematical models, optimization models and serious games.

Computerized machines can be found in many forms and all around us - in our pockets, and even sometimes in our body. For many of us, they are now essential elements of everyday life. When it comes to smartphones, connected objects, medical digital devices and e-health, these digital tools have proliferated in our environment, continually transforming our modes of social organization. They act as prostheses and orthotics that "enhance" our cognitive capacities and influence our inherent behaviors. Are digital tools that perpetually envelop the body and the spirit able to overwhelm the social order? Could our cognitive prosthetics lead to permanent, radical change to our society, which could become similar to a hive? This book explores this reflection, which is at the center of social research on digital tools.

Electronic Assistive Technology (EAT) is a subset of a wider range of products and services known as Assistive Technology (AT). AT is designed to support and enable people with disabilities, either acquired or congenital, to participate in activities with greater independence and safety. With a global aging population, it has an important role to play in enabling and supporting those with disability and their carers. Handbook of Electronic Assistive Technology discusses a range of commonly available or emerging electronic assistive technologies. It provides historical background, advice when assessing for these devices and references different models of provision. It includes both medical and engineering aspects of provision. It is anticipated that the book will support students, trainees, and newly qualified Assistive Technology Practitioners to develop their understanding of the field, by considering the variables that could potentially influence the decision-making process when assessing for and providing this equipment. It also provides a reference point for those already practicing in this field and offers coverage of a broader range of technologies than clinicians may be exposed to, in their daily work This is the first reference book to focus on a comprehensive set of electronic assistive technologies and discuss their clinical application.

Healthcare Data Analytics and Management help readers disseminate cutting-edge research that delivers insights into the analytic tools, opportunities, novel strategies, techniques and challenges for handling big data, data analytics and management in healthcare. As the rapidly expanding and heterogeneous nature of healthcare data poses challenges for big data analytics, this book targets researchers and bioengineers from areas of machine learning, data mining, data management, and healthcare providers, along with clinical researchers and physicians who are interested in the management and analysis of healthcare data.

Handbook of Biomechatronics provides an introduction to biomechatronic design as well as in-depth explanations of some of the most exciting and ground-breaking biomechatronic devices in the world today. Edited by Dr. Jacob Segil and written by a team of biomechatronics experts, the work begins with broad topics concerning biomechatronic design and components, followed by more detailed discussions of specific biomechatronic devices spanning many disciplines. This book is structured into three main parts: biomechatronic design, biomechatronic components, and biomechatronic devices. The biomechatronic design chapter discusses the history of biomechatronics, conceptual design theory, biomechatronic design methods, and design tools. The next section discusses the technologies involved in the following components: sensors, actuators, and control systems. The biomechatronic devices chapters contains distinct examples of biomechatronic devices spanning visual prostheses to brain-machine interfaces. Each chapter presents the development of these biomechatronic devices followed by an in-depth discussion of the current state of the art

Covering the full spectrum of treatment guidance for dance artists, musicians, and more, this practical title by Dr. Lauren E. Elson expertly explores the intersection of sports medicine and performing arts medicine. Ideal for practicing and trainee physiatrists and sports medicine physicians, it addresses a wide range of relevant topics including auditory symptoms in musicians; management of the dancer's foot and ankle, hip, and spine; return-to-dance or return-to-performance guidelines; and much more.

Drug Delivery Nanosystems for Biomedical Application reviews some of the most challenging nanosystems with different routes of delivery that are useful for specific drugs, from both efficacy and bioavailability points-of-view. The chapters explore how this area is developing, the present state of the field, and future developments, in particular, inorganic, metallic, polymeric, composite and lipid nanosystems and their possible evolution to clinical applications. The book is a valuable research reference for both researchers and industrial partners who are not only interested in learning about this area, but also want to gain insights on how to move towards translational research.

Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource.

Smart Nanoparticles for Biomedicine explores smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties. This important reference resource will be of great value to readers who want to learn more on how smart nanoparticles can be used to create more effective treatment solutions. Nanotechnology has enabled unprecedented control of the interactions between materials and biological entities, from the microscale, to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions, such as cell adhesion, mobility and differentiation, and in tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications.

Nanostructured Nonlinear Optical Materials: Formation and Fabrication covers the analysis of the formation, characterization and optical nonlinearities of various nanostructures using different methods. It addresses many areas of research in the field, including the modification of the surfaces of materials for the formation of various nanostructures, transmission electron microscopy and time-of-flight mass spectroscopy studies of ablated bulk and nanoparticle targets, the low-order nonlinearities of metal and semiconductor nanoparticles, the nonlinear refraction and nonlinear absorption of carbon-contained nanoparticles, and low- and high-order harmonic generation in nanoparticle-contained plasmas, amongst other topics. The book is an essential reference for all nanomaterials researchers in the fields of photonics, materials, physics, chemistry and nanotechnology.

Intelligent Data Sensing and Processing for Health and Well-being Applications uniquely combines full exploration of the latest technologies for sensor-collected intelligence with detailed coverage of real-case applications for healthcare and well-being at home and in the workplace. Forward-thinking in its approach, the book presents concepts and technologies needed for the implementation of today's mobile, pervasive and ubiquitous systems, and for tomorrow's IoT and cyber-physical systems. Users will find a detailed overview of the fundamental concepts of gathering, processing and analyzing data from devices disseminated in the environment, as well as the latest proposals for collecting, processing and abstraction of data-sets. In addition, the book addresses algorithms, methods and technologies for diagnosis and informed decision-making for healthcare and well-being. Topics include emotional interface with ambient intelligence and emerging applications in detection and diagnosis of neurological diseases. Finally, the book explores the trends and challenges in an array of areas, such as applications for intelligent monitoring in the workplace for well-being, acquiring data traffic in cities to improve the assistance of first aiders, and applications for supporting the elderly at home.

Design of Nanostructures for Versatile Therapeutic Applications focuses on antimicrobial, antioxidant and nutraceutical applications of nanostructured materials. Many books discuss these subjects, but not from a pharmaceutical point-of-view. This book covers novel approaches related to the modulation of microbial biofilms, antimicrobial therapy and encapsulate polyphenols as antioxidants. Written by an internationally diverse group of academics, this book is an important reference resource for researchers, both in biomaterials science and the pharmaceutical industry.

Electrofluidodynamic Technologies (EFDTs) for Biomaterials and Medical Devices: Principles and Advances focuses on the fundamentals of EFDTs - namely electrospinning, electrospraying and electrodynamic atomization - to develop active platforms made of synthetic or natural polymers for use in tissue engineering, restoration and therapeutic treatments. The first part of this book deals with main technological aspects of EFDTs, such as basic technologies and the role of process parameters. The second part addresses applications of EFDTs in biomedical fields, with chapters on their application in tissue engineering, molecular delivery and implantable devices. This book is a valuable resource for materials scientists, biomedical engineers and clinicians alike.

This issue will include articles on Prehabilitation; Building a survivorship program in cancer rehabilitation; Aerobic and resistive training: pragmatic integration in cancer rehabilitation; Alternative exercise traditions in cancer rehabilitation; Cancer treatment induced fibrosis: associated functional morbidity; Cancer-related fatigue: The master disabler; and many more!

Physical medicine and rehabilitation (PM&R) physicians across the country see injured runners every day. Running injuries may impact other areas of the body and PM&R physicians are trained to treat the body as a whole, as opposed to treating just the injury, they work to identify the true source of the problem and develop a training or rehabilitation program to solve it.

Nursing is an evolving profession that requires continued knowledge updates in formulating a foundation for practice. In order to promote patient safety and satisfaction, it is imperative that nurses monitor publications and increase their knowledge base. Each patient is different; each care management situation requires an individualized plan of care. These require the nurse to develop a personal framework for practice that continually develops from this information. This mandates an evolving knowledge base which this edition will supply for nurses who work to deliver care that is research based and protocol driven. This issue of Nursing Clinics will be both timely and relevant as it will combine two clearly important topics for nurses in care management, pathophysiological updates as well as research based protocols that are important to continuity of validated evidence based care delivery. This will give nurses across organizations the opportunity to see care from a perspective of patient wholeness and not truncate care in order to address total components. With care reimbursement dependent on outcomes, it is important for the nurse to see care as a continuum and not finite. This issue will give nurses this perspective.

Heart failure is the only cardiovascular disease that is increasing. The impact on the critical care environment and the health care system, as a whole, is significant from both a cost and burden to the system perspective. There are 6.5 million hospital days a year and nearly $40 billion dollars in yearly health care costs attributed to heart failure in the United States. There are more Medicare monies spent for diagnosing and treating heart failure than any other Diagnosis Related Group. There is a 24% hospital re-admission rate for this diagnosis which leads to financial implications for health care systems. The human cost is also significant. Less than half of Americans diagnosed with heart failure survive greater than 5 years. The ongoing health care needs and cost of this chronic disease takes a significant toll on patients' finances, time and quality of life. Over $2.9 billion dollars is spent annually on the pharmaceutical management of heart failure in the United States. This diagnosis is the leading cause of hospitalization for patients who are 65 years of age and older. Few health care providers in the critical care environment are not affected by heart failure on a routine basis. Caring for these patients and their families is both a challenging and yet a rewarding experience. This edition will provide critical care nurses with a comprehensive heart failure review which is essential in caring for this challenging population given the dynamic health and critical care environments.

Following their issue on Sleep and Psychiatry in Adults, Drs. John Herman and Max Hirshkowitz have assembled an expert panel of authors in the topic of Sleep and Psychiatry in Children. Articles include:Kleine-Levin Syndrome;Sleep in Patient with Obsessive Compulsive Disorder;ADHD and Sleep: Diagnosis and Treatment; Relations Between Sleep, Personality, Behavioral Problems, and School Performance in Adolescents;Anxiety Disorders and Sleep in Children and Adolescents;Emotional and Cognitive Impact;REM Sleep Behavior Disorder in Children, Melatonin Treatment in Children with Developmental Disabilities and more!

This issue of Physical Medicine & Rehabilitation Clinics will focus on stroke rehabilitation and will include articles such as: Mechanisms of stroke recovery, Insights from basic sciences, Stroke recovery and predictors of rehabilitation outcomes, Upper limb motor impairments, Post-stroke spasticity, Communication disorders and dysphagia, Neuropharmacology of Recovery, Robotic therapy, and many more.