"Molecular Genetics of Inherited Eye Disorders" provides an authoritative and up-to-date account of molecular genetic advances in a wide spectrum of genetic eye disorders, and forms the second volume in the Modern Genetics book series. The field has produced some dramatic and often unexpected findings in recent years ranging from the elegant unravelling of the molecular basis of colour vision defects to the subtle complexity of the retinoblastoma gene. The role of crystallins in congenital cataract and of the rhodopsin molecule in retinitis pigmentosa are discussed, illustrating the importance of the "candidate gene" approach to genetic eye disease. "Reverse genetic" approaches to the cloning of genes responsible for aniridia and choroideremia exemplify the power of the new genetic techniques and signal the start of the next experimental phase, in which the functional characterization of identified genes begins. Sections on albinism, retinitis pigmentosa and collagen disorders deal w

Orthopaedic Knowledge Update (R): Spine 6 is a digest of relevant advances and thinking from the most recent 5 years of orthopaedic and subspecialty literature, as well as core knowledge from previous years. This comprehensive resource covers all aspects of the spine in a single, convenient volume. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Eeric Truumees, MD, FAAOS and Heidi Prather, DO. Orthopaedic Knowledge Update (R): Spine 6 presents relevant, evidence-based information, discusses its practical application, and provides supporting annotated references, all tailored to the needs of today's practicing orthopaedic surgeons and trainees. Written, edited, and peer-reviewed by more than 90 interdisciplinary contributing authors, the book offers a complete guide to the diagnosis, treatment, and management of spinal injuries and disorders, supported by the latest evidence. Covers a wide range of topics related to the spine, focusing on proven and promising treatments and approaches for this complex area. Provides evidence-based information, reinforced by recent prospective and randomized studies, on biomechanics and surgical techniques, special problems, and controversial topics. Reflects an interdisciplinary approach to spine care with contributions from experts in orthopaedics, physical medicine and rehabilitation, anesthesia, radiology, neurology, neurosurgery, rheumatology, and internal medicine. Includes sections on Spine Anatomy and Biomechanics, Diagnostics in Spine Care, Medical Management of Spine Disorders, Surgical Management of Degenerative Spine Disorders, Spine Deformity, Trauma, Neoplastic and Inflammatory Conditions, and Special Populations in Spine Care, as well as a new chapter titled Perioperative Pain Management and Persistent Opioid Use Avoidance. Ideal for general orthopaedic surgeons specializing in the spine, as well as residents in training and those studying for boards and recertification examinations. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

Packed with superb illustrations, pearls, and pitfalls, Reconstructive Foot and Ankle Surgery: Management of Complications, 3rd Edition, delivers step-by-step guidance on essential elements of complex foot and ankle surgery. World-renowned surgeon Dr. Mark S. Myerson, along with expert co-author Dr. Anish R. Kadakia, provides detailed instruction on how to select the correct treatment for challenging disorders and manage complications after surgery. A highly templated, consistent format, abundant illustrations, and decades of real-life experience make this an easy-to-use resource for everyday practice as well as an authoritative reference for in-depth study. Includes "Complications Considered" boxes that help you avoid and manage commonly seen complications, as well as techniques, tips, and pitfalls boxes in every chapter. Features hundreds of high-quality x-ray images and full-color intraoperative photos throughout. Indicates corresponding surgical videos with clear and easy-to-spot call-outs within the text. Covers the most up-to-date techniques, new procedures, innovative approaches, and technological advances. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Are you looking for concise, practical answers to questions that are often left unanswered by traditional sports medicine references? Are you seeking brief, up-to-date, expert advice for common issues that can be encountered when working with athletes? Quick Questions in Ankle Sprains: Expert Advice in Sports Medicine provides a unique format of concise and to the point responses with clinical application, backed by the latest research on sports-related ankle sprains among athletes. Drs. Patrick O. McKeon and Erik A. Wikstrom and their contributors present 39 common clinical questions regarding the prevention, assessment, treatment, management, and rehabilitation of ankle sprains. Co-published with the National Athletic Trainers' Association, Quick Questions in Ankle Sprains: Expert Advice in Sports Medicine provides concise answers to 39 frequently asked clinical questions. Written in a conversational tone, the authors of the individual questions represent a variety of different backgrounds and are experts in their respective field. The variety of questions and brevity of responses will make this a book that is easy to read and reference at the point of care. Some sample sections and questions include: Risk and reduction of ankle sprains What effect does prophylactic bracing and/or taping have on reducing lateral ankle sprain risk? Diagnosis What are the most useful clinical tests to accurately diagnose syndesmotic and medial ankle sprains? Treatment and rehabilitation To what extent should I use manual therapies to treat ankle sprains and chronic ankle instability? Surgical considerations When should I refer my patient with an ankle problem to an orthopedic surgeon? Quick Questions in Ankle Sprains: Expert Advice in Sports Medicine is the perfect at-your-side resource for the athletic trainer, team physician, or sports medicine clinician looking for practical answers to sports-related ankle sprain questions. The concise and conversational tone allows the reader to readily apply the information into their everyday practice. Other books in the Series Include: Quick Questions in Heat-Related Illness and Hydration Quick Questions in Sports-Related Concussion Quick Questions in the Shoulder

When dozens of holes appeared in a patient's femur alongside his hip prosthesis, experts were baffled as such a phenomenon had never been seen before. Over the first four decades of total hip surgery, the severe bone destruction multiplied, crippling many thousands of patients. Eventually identified as "periprosthetic osteolysis," this devastating disease affected over 1 million patients and was the leading cause of failure in total hip surgery. While total hip surgery dramatically reversed severe arthritis of the hip, the same operation simultaneously created a relentless 'particle generator' in the body. Ironically, in the effort to do good, doctors were simultaneously doing major harm. Vanishing Bone: Conquering a Stealth Disease Caused by Total Hip Replacements takes readers on a detective adventure in contemporary medical science, from the identification of the cause of the disease through the complex process of affecting its cure. Dr. William H. Harris and his colleagues played an important role in solving the mystery of this disease, pointing to its molecular biology, recognizing the unusual wear of the prostheses, and ultimately developing a new material for use in the manufacture of hip implants. With more than 6 million people walking on this stable, low-wear material, the disease has been virtually eliminated among those with total hip replacements worldwide. Diseases are rarely observed, revealed, and eliminated in one lifetime. Vanishing Bone tells the captivating story of one such disease through an engaging account of scientific and medical innovation.

Highly Commended, BMA Medical Book Awards 2015 Orthopaedic Trauma: The Stanmore and Royal London Guide is a definitive and practical guide to musculoskeletal trauma surgery with an emphasis on the techniques employed and the reasoning behind them. Written with the needs of trainees in orthopaedic surgery in mind, this comprehensive book systematically covers all aspects of trauma of the upper limb, lower limb, and spine, with separate sections on paediatric trauma. Many chapters include detailed descriptions of the initial diagnosis and management of common injuries as well as the consent process, theatre set-up, and surgical approach required for operative treatment. The book also features sections on topics such as polytrauma, pelvic trauma, and resuscitation, enabling the reader to learn safe, evidence-based approaches. Information on complications, key references, viva and multiple-choice questions to test understanding of concepts covered are included in each chapter, allowing the book to be used both as a practical guide to the treatment of patients and as a preparation tool for postgraduate orthopaedic examinations. This book complements the successful titles Basic Orthopaedic Sciences: The Stanmore Guide and Operative Orthopaedics: The Stanmore Guide.

All books on the market which have been written on the subject of botulinum toxin therapy focus on treatment of hyperactive movement disorders, autonomic dysfunction (bladder, sweat and salivary glands) and some pain indications (migraine). Reference to pre-or post -surgical indications are brief and often out-dated. No book has information on dentistry or veterinary medicine. This book provides up-to-date information on botulinum toxin therapy in surgical fields. It is also the only book in the market that provides information on botulinum toxin therapy in dentistry and veterinary medicine, furnishing the latest information. Botulinum Toxin Treatment in Surgery, Dentistry, and Veterinary Medicine appeals to many disciplines including surgery, dentistry and veterinary medicines well as appealing to neurologists and internists.

A comprehensive review, Sports-Related Conditions of the Elbow: A Guide to Successful Return to Play is a valuable resource for orthopedic surgeons as well as athletic trainers, therapists, and primary care physicians who regularly deal with athletes. Edited by Drs. Anthony A. Romeo and Brandon J. Erickson, Sports-Related Conditions of the Elbow: A Guide to Successful Return to Play is the most thorough text regarding how to treat athletic elbow conditions. Chapters are broken down by specific conditions, including in-depth assessments of muscle, tendons, ligaments, bone, nerves, and more. With insight given by expert contributors, including several physicians for professional and collegiate teams, the text shares extensive knowledge from these experts for treating conditions of the elbow. Additionally, each chapter includes: Expert pearls and experiences in treating athletes with the mentioned pathologic condition A synopsis on diagnosis as well as treatment algorithms Technique videos that display physical exam maneuvers, how to critically assess various types of diagnostic imaging, and surgical techniques A rehabilitation section focusing on the best-available evidence to allow these athletes to return to sport as efficiently and safely as possible Video website access is included with purchase, providing additional audio-visual support to theories and principles discussed in each chapter by the world's leading experts. Sports-Related Conditions of the Elbow: A Guide to Successful Return to Play is a must-have text that focuses on best practices in sports medicine and covers a wide range of common and uncommon elbow conditions that athletes of all levels of play may encounter.

Musculoskeletal Imaging Volume 2 provides a comprehensive review of the subject matter commonly encountered by practicing radiologists and radiology residents in training. This volume includes succinct overviews of metabolic, infectious, and congenital diseases; internal derangement of joints; and arthography, and ultrasound. Part of the Rotations in Radiology series, this book offers a guided approach to imaging diagnosis with examples of all imaging modalities complimented by the basics of interpretation and technique and the nuances necessary to arrive at the best diagnosis. Each pathology is covered with a targeted discussion that reviews the definition, clinical features, anatomy and physiology, imaging techniques, differential diagnosis, clinical issues, key points, and further reading. This organization is ideal for trainees' use during specific rotations, for exam review, or as a quick refresher for the established musculoskeletal imager. It is a must-read for residents and practicing radiologists seeking a foundation for the essential knowledge base in musculoskeletal imaging. Musculoskeletal Imaging Volume 1 reviews trauma, arthritis, and tumor and tumor-like conditions.

This book brings together a cross-fertilization of ideas between human molecular genetics, developmental biology, tissue biology and the biochemistry of cell signalling pathways, in order to create new insights into the mechanisms of normal and abnormal skeletogenesis. This broad perspective is essential in order to understand the aetiology of genetic diseases affecting skeletal development at all levels from genotype to phenotype, i.e. from mutation to syndrome.
The book encompasses normal and abnormal skeletogenesis process by process, beginning with the signalling pathways that control early patterning events, then the molecular control of osteoblast, chondrocyte and osteoclast differentiation, joint formation and finally osteoclast activity. Each step takes into consideration the results of mouse gene cloning and knockout studies, human molecular genetics, and new mouse studies stimulated by the human information. Such an integrated approach is essential if this new understanding is to be applied for future therapeutic strategies.

Succinct and highly illustrated, the third edition of this handy pocket guide enables practitioners to successfully manage common minor injuries in children at the point of care. Each chapter has been updated to reflect changes to the treatment for the injury based on recent research and new guidelines. The new edition includes: the latest recommended guidelines and procedures, for instant access to key information generous use of colour, warning boxes, icons, clinical tips and practical advice to help the reader find information at a glance numerous illustrations help explain more difficult concepts detailed guidance on when to treat, how to treat, when to refer or when minor trauma is indicative of a more serious diagnosis. This concise evidence-based book remains an essential purchase for junior doctors, nurse practitioners and emergency care practitioners in the emergency department, minor injury centre or primary care facility. It is a touchstone for all those seeing children following minor injury or trauma.

This book provides a state-of-the-art look at the applied biomechanics of accidental injury and prevention. The editors, Drs. Narayan Yoganandan, Alan M. Nahum and John W. Melvin are recognized international leaders and researchers in injury biomechanics, prevention and trauma medicine. They have assembled renowned researchers as authors for 29 chapters to cover individual aspects of human injury assessment and prevention. This third edition is thoroughly revised and expanded with new chapters in different fields. Topics covered address automotive, aviation, military and other environments. Field data collection; injury coding/scaling; injury epidemiology; mechanisms of injury; human tolerance to injury; simulations using experimental, complex computational models (finite element modeling) and statistical processes; anthropomorphic test device design, development and validation for crashworthiness applications in topics cited above; and current regulations are covered. Risk functions and injury criteria for various body regions are included. Adult and pediatric populations are addressed. The exhaustive list of references in many areas along with the latest developments is valuable to all those involved or intend to pursue this important topic on human injury biomechanics and prevention. The expanded edition will interest a variety of scholars and professionals including physicians, biomedical researchers in many disciplines, basic scientists, attorneys and jurists involved in accidental injury cases and governmental bodies. It is hoped that this book will foster multidisciplinary collaborations by medical and engineering researchers and academicians and practicing physicians for injury assessment and prevention and stimulate more applied research, education and training in the field of accidental-injury causation and prevention.

The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.

Clinics in Developmental Medicine No. 160

Children with craniosynostosis are born with congenital deformities of the face and skull. In severe cases associated problems are common. The child who is not properly cared for can end up blind, deaf and with severe learning difficulties. In addition, they may be left with unacceptable facial deformities. Outside specialized craniofacial units, there is at present nowhere for those involved in primary or secondary care to go for help with the many practical problems that these children present. In this book, a distinguished team of editors have assembled experts in the field to introduce the non-craniofacial specialist to what can be achieved and how they can contribute to the child's welfare. It will be essential reading for paediatricians seeking practical information about the management of these disorders, and for specialists in neurosurgery, ENT, ophthalmology, plastic surgery, maxillo-facial surgery, orthodontics, psychology, genetics, anaesthesia, audiology and speech therapy.

Shoulder Instability in the Athlete: Management and Surgical Techniques for Optimized Return to Play is a groundbreaking text that covers all aspects of care for athletes with shoulder instability - from on-the-field management and treatment to successful return to play. Edited by Drs. Jonathan F. Dickens and Brett D. Owens and featuring the expertise of internationally recognized surgeons who specialize in shoulder instability in high-level athletes, Shoulder Instability in the Athlete is a unique collaboration applicable across a variety of professional areas. This will be the premiere reference for physicians, surgeons, therapists, trainers, and students involved in the care of athletes. Each chapter of Shoulder Instability in the Athlete reviews cutting-edge clinical and surgical techniques, as well as outcomes and return to play criteria. In-depth analysis of appropriate literature and outcomes specific to the athlete population are also presented. Important sections within the text include: Principles for the team physician Anterior instability Posterior instability Special topics in instability By focusing specifically on the unique and challenging dilemma of caring for the athlete with shoulder instability, Shoulder Instability in the Athlete will be a valuable reference for all health professionals who manage athletes.

Presenting a logical, comprehensive approach to the patient with a massive rotator cuff tear, this book begins with the pathoanatomy and diagnostic work-up for this common injury, including imaging. Both non-operative and operativetreatment options for massive tearsfollow, including arthroscopy, the use of biologics and patches, tendon transfers, and hemiarthroplasty and reverse total shoulder arthroplasty. A practical treatment algorithm for clinicians treating patients with massive rotator cuff tears is also included. Each chapter opens with pearls and pitfalls covering the main key points for quick reference. The overarching theme of this book is that patients with similar imaging findings may demonstrate very different clinical presentations, and the final treatment recommendation should be made based on their complaints and expectations. As such, it will be an excellent resource for orthopedic surgeons, sports medicine and shoulder physicians, physiatrists, physical medicine and rehab specialists, and occupational therapists."

Injuries to the hamstring and quadriceps muscles can occur in both low- and high-impact sports and as such are among the more common injuries incurred by athletes. Reviewing the relevant physiology, epidemiology, mechanisms, clinical presentation and treatment of these conditions, Hamstring and Quadriceps Injuries in Athletes covers all sports-related injuries of the thigh musculature in one place. Topics covered include mid substance injuries, acute proximal tendon avulsions and harvesting of hamstrings, as well as strains, contusions and ruptures of the quadriceps, including the use of biologic enhancing agents in healing. Chapters on rehabilitation and injury prevention present techniques to maximize recovery and minimize long-term impairment, speeding up return to play. It will be an often-used and reliable guide for sports medicine practitioners, orthopedists, physical therapists, primary care physicians, team physicians and trainers who treat the injured athlete.

The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.

This book covers the latest progress in the biology and manufacturing of orthopedic biomaterials, as well as key industry perspectives. Topics covered include the development of biomaterial-based medical products for orthopedic applications, anti-infection technologies for orthopedic implants, additive manufacturing of orthopedic implants, and more. This is an ideal book for graduate students, researchers and professionals working with orthopedic biomaterials and tissue engineering. This book also: Provides an industry perspective on technologies to prevent orthopedic implant related infection Thoroughly covers how to modulate innate inflammatory reactions in the application of orthopedic biomaterials Details the state-of-the-art research on 3D printed porous bone constructs

Now in one convenient volume, Atlas of Amputations and Limb Deficiencies: Surgical, Prosthetic, and Rehabilitation Principles, Fifth Edition, remains the definitive reference on the surgical and prosthetic management of acquired and congenital limb loss. Developed in partnership with the American Academy of Orthopaedic Surgeons (AAOS) and edited by Joseph Ivan Krajbich, MD, FRCS(C), Michael S. Pinzur, MD, FAAOS, COL Benjamin K. Potter, MD, FAAOS, FACS, and Phillip M. Stevens, MEd, CPO, FAAOP, it discusses the most recent advances and future developments in prosthetic technology with in-depth treatment and management recommendations for adult and pediatric conditions. With coverage of every aspect of this complex field from recognized experts in amputation surgery, rehabilitation, and prosthetics, it is an invaluable resource for surgeons, physicians, prosthetists, physiatrists, therapists, and all others with an interest in this field. Offers important content updates throughout, with 12new chapters covering: General Rehabilitation Principles and Strategies for the Upper Limb Amputee General Rehabilitation Principles and Strategies for the Lower Limb Amputee Advanced Nerve Management Techniques for Treatment and Prevention of Pain Congenital Limb Deficiencies Scientific, Technologic, Surgical, and Prosthetic Advances in Pediatric Limb Deficiency Gait Analysis in the Limb-Deficient Child Psychologic, Social, and Socioeconomic Aspects of Limb Deficiencies Role of Limb Lengthening in the Pediatric Amputee Traumatic Amputations of the Lower Extremity in Children and Adolescents Syme, Boyd, and Transtibial Amputation in Children: Surgical and Prosthetic Management Terminal Bone Overgrowth Athletic and Sports Programs for Limb-Deficient Children Features more than 1,500 illustrations, photographs, and images that provide insights into the wide variety of current high-tech surgical techniques and prosthetic solutions Provides decision support for amputation versus limb salvage, including treatment, management, and alternatives for all levels of limb loss Brings you and your treatment team up to date with the latest research and considerations regarding these significant surgical procedures and surrounding treatments Covers every aspect of the field: General Topics, Upper Limb, Lower Limb, Management Issues, and Pediatrics—in one easy-to-reference volume Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

This book focuses on cartilage defects and new mesenchymal stem cell-based treatments for their repair and regeneration. Early chapters provide a review of current etiological findings and repair methods of cartilage defects. The next chapters discuss fundamental concepts and features of MSCs, including their proliferation, differentiation, migration and immunomodulatory effects. The discussion also includes clinical applications of MSCs in cartilage tissues, especially with regards to various animal models, biomaterials and transferring techniques. Cartilage Regeneration focuses on the biology of MSCs and their possible applications in cartilage reconstruction, with the goal of bringing new insights into regenerative medicine. It will be essential reading for researchers and clinicians in stem cells, regenerative medicine, biomedical engineering and orthopedic surgery.

Utilizing a rapid-fire, two-column question and answer format, this is an ideal on-the-spot resource for senior medical students covering a wide range of both general and subspecialty orthopedic topics: anatomy, physiology, presentation and history, pathophysiology, differential diagnosis, physical examination, radiological evaluation, operative and non-operative treatment techniques, surgical complications, rehabilitation and more. With hundreds of high-yield questions and answer items, this quick reference covers orthopedic basics before moving on to detailed sections on the upper and lower extremity, axial skeleton, pediatric orthopedics, and systemic conditions. The straightforward Q&A format allows for either self-testing or quizzing with partners, whether practicing for a board review or studying up in one's spare time. While it can be read cover to cover for a general foundation of knowledge, it can also be referred to selectively before starting a new rotation or seeing a patient with a subspecialty attending. Useful as a companion text to Orthopedic Surgery Clerkship and Orthopedic Surgery Rotation, Essential Orthopedic Review is a handy, pocket-sized resource and review guide that can be used by senior medical students, nursing and PT students, primary care providers, and junior residents in orthopedics and sports medicine.