This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.

Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

Advances in Materials Science and Implant Orthopedic Surgery brings together experts from major university hospitals, materials scientists specializing in bio-materials, and development engineers working for implant manufacturers to address such issues as: mechanisms of fixation; foreign-body immune response; generation and consequences of ionic and wear debris; materials selection, design and manufacturing schemes; and surgical techniques to maximize the safety and efficacy of the devices.

Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.

Rheumatoid arthritis (RA) is the most common and most severe form of inflammatory arthritis. The pathogenesis of RA has been the subject of intense research for several decades. The prevailing hypotheses have changed over the years, and have attempted to incorporate the most recent data. Although T cells represent an important component of the cells which infiltrate the joint synovium, their contribution at a late stage of the disease remains a matter of debate. The goal of this book is to outline the major arguments and data suggesting that T cells may, or may not, be central players in the pathogenesis of chronic RA. While each of the editors and authors has his/her own bias (as will be clear by reading the respective chapters), our hope is that the readers will enjoy a complete and balanced view of the critical questions and experiments. This is not just an intellectual exercise since the direction of future therapeutic interventions depends heavily on how one interprets the pathogenesis of RA and the contribution of T cells.

Osteoporosis - an insidious and crippling skeletal disease characterized by low bone mass, systemic deterioration of bone tissue, and increase in bone fragility and susceptibility to fracture - has now reached epidemic proportions among postmenopausal women. This excellent collection of recent articles by specialists from medicine, nursing, nutrition, exercise physiology, physical therapy, and demography addresses the many challenges of a disease that for too long has been dismissed as a normal part of aging.
The volume first presents compelling statistics on the incidence and personal, social, and financial impact of this often preventable and treatable disease. Personal portraits then give a face and voice to those behind the statistics who are forced to cope with bent and fragile bones that may give way suddenly and painfully. Finally, encouraging information is offered on recent diagnostic and treatment breakthroughs that enhance doctors' ability to prevent and detect osteoporosis and better manage its unwelcome consequences.
Written in an accessible manner, this highly informative reference work will be of great interest to all women, especially those diagnosed with osteoporosis and their loved ones.

Replacement of a failing hip joint or other defective organs in the human body by artificial 'spare parts' has significantly improved our quality of life. These spare parts have to meet a wide spectrum of mechanical, chemical and design requirements. In this book, the properties and selection of materials for such `spare parts' are deduced from case studies at the start of each chapter. Hard tissue replacements (joints, long bones, dental), soft tissue (heart valves) and tissue engineering are included. The chapters also detail the three generic classes of materials: alloys (including shape memory alloys), ceramics & glasses and polymers. Separate chapters are devoted to the toxicity of implants, the metals zirconium(-zirconium oxide), tantalum, niobium and metallic glasses, soluble metals and Rapid Prototyping techniques for the fabrication of custom made prostheses. The book concludes by a chapter on water as water is always 'there' and conditions the interaction between body and implant. Water is the very matrix of life on earth. A peculiarity of the book is its 'perspective view', meaning that the authors looked behind the present biomaterials' decor and included historical backgrounds (real and mythological), future developments, and the relation to nature (plants and geology).

Interest in bone densitometry methods has recently experienced a resurgence within the medical community. Physicians have become more interested than ever before in the diagnosis and treatment of degenerative diseases of bone such as osteoporosis. The public perception of osteoporosis and its prevention has been recently heightened. Because osteoporosis is widespread, especially in women, and leads to an increase in fractures in our population, many re searchers and clinicians are strongly motivated in their search for more sensi tive and accurate methods of diagnosis. This book was written for physicians, scientists, engineers, medical phy sicists, and others desiring an introduction or further understanding of this exciting field. Beginning with the early development of x-ray film methods for assessing bone status, the field has steadily grown throughout the years. Novel and interesting devices have been designed for the measurement of bone mass, bone density, cortical thickness, and other parameters of bone changes. Both qualitative and quantitative bone methods are described. The techniques include imaging devices such as CT and radiography as well as fixed point methods in which bone characteristics of a region of interest are analyzed."

Written and edited by world-renowned experts in the field, Benzel's Spine Surgery: Techniques, Complication Avoidance and Management, 5th Edition, provides expert, step-by-step guidance on the evaluation and management of disorders of the spine. This definitive, two-volume work explores the full spectrum of techniques used in spine surgery, giving you the tools you need to hone your skills and increase your knowledge in this challenging area. Clearly organized and extensively revised throughout, it features contributions from both neurosurgeons and orthopaedic surgeons to present a truly comprehensive approach to spine disease. Offers a thorough overview of the effective management of patients with spinal disorders, including fundamental principles, biomechanics, applied anatomy, instrumentation, pathophysiology of spinal disorders, surgical techniques, motion preservation strategies, non-surgical management, and complication avoidance and management, as well as controversies. Focuses on both pathophysiology and surgical treatment of spine disease, with an increased emphasis on minimally invasive surgery. Contains new features such as key points boxes at the beginning of chapters and algorithms to help streamline the decision making process. Covers today's hot topics in spine surgery, such as health economics, artificial intelligence, predictive analytics, new less invasive techniques including endoscopic spine surgery, and the future of spine surgery. Provides expert coverage of key topics including biomechanics of motion preservation techniques, spinal injuries in sports, biologics in spine fusion surgery, anterior sub-axial cervical fixation and fusion techniques, complex lumbosacropelvic fixation techniques, and many more. Features more than 1,500 high-quality illustrations, as well as new procedural videos on en bloc spondylectomy, minimally invasive endoscopic posterior cervical foraminotomy, cervical total disc replacement, minimally invasive lumbar decompression of stenosis, and more. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Basic research on osteoarthritis has been carried out mainly from the his tological and biochemical aspects of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical stress has been shown to be the principal factor in the initiation of osteoarthritis. Although the exact process by which mechanical stress leads to the total destruction of cartilage tissue remains unclear, several new research methods have enabled us to gain a deeper understanding of the process of degeneration. In October 1997, we organized an international symposium titled "Ad vances in Osteoarthritis" in Kobe, with the main topics being updated re search, diagnosis, and treatment of osteoarthritis. The proceedings of the symposium are presented here in five sections: (1) Mechanical stress and reactions of chondrocytes, such as intracellular ion changes, changes in the cytoskeleton, intracellular messenger systems, release of gas mediators, and changes in electromechanical properties of cartilage; (2) Functional diagnosis of osteoarthritis by MR imaging, and using calpain and collagenase III as new cartilage markers; (3) Treatment with a promising simple washout technique and IL-1RA and MMP antagonists; (4) Cartilage repair by new grafting tech niques; and (5) Problems following total joint replacement. We sincerely hope that the advanced knowledge provided in this volume of proceedings will be valuable to our readers.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize

This book creates a unique platform that covers main ankle pathologies specifically related with football. Experiences from professional players have been combined with evidence-based medical content from renowned experts in the field to present a comprehensive picture on ankle injuries in football. Worldwide, ankle injuries present a high burden for sports medicine physicians, physiotherapists, players and coaches in and around the football pitch. This book contains updated content for both medical and nonmedical individuals involved with football.

In this issue of Foot and Ankle Clinics, guest editor Dr. Manuel Monteagudo brings his considerable expertise to the topic of Managing Challenging Deformities with Arthrodesis of the Foot and Ankle. Arthrodesis is a common treatment option for joint pain that cannot be managed by other forms of treatment. In this issue, top experts explore arthrodesis as a way of managing severe deformities of the foot and ankle. Contains 12 practice-oriented topics including arthrodesis of the first tarsometatarsal joint in complex deformities; Lisfranc arthrodesis in posttraumatic chronic injuries; arthrodesis in the deformed Charcot foot; ankle (tibiotalar) arthrodesis for the crippled ankle; pantalar fusion; and more. Provides in-depth clinical reviews on managing challenging deformities with arthrodesis of the foot and ankle, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Bandscheibendegeneration.- 1 Klinische und bildgebende Diagnostik des lumbalen Bandscheibenvorfalls.- 2 Lumbaler Bandscheibenvorfall - Konservative oder operative Behandlung?.- 3 Prinzipien der konservativen Behandlung des Bandscheibenvorfalls.- 4 Prinzipien der operativen Behandlung des lumbalen Bandscheibenvorfalls.- 5 Langzeitergebnisse nach konventioneller lumbaler Diskotomie.- 6 Die lumbale Mikrodiskotomie - Indikation, operatives Procedere.- 7 Die Bandscheibenoperation im Lumbaibereich Ergebnisse einer klinischen Nachuntersuchung der perkutanen Laser-Diskusdekompression und der mikrochirurgischen Bandscheibenoperation.- 8 ALPD oder PN - die perkutane Nucleotomie nach Gary Onik Behandlungsergebnisse von 1987-.- 9 Postdiskotomie-Syndrom - Diagnostische Kriterien, morphologisches Korrelat, Therapieansatze.- 10 Kunstliche Bandscheibenimplantate im Bereich der lumbalen Wirbelsaule.- Stabilisierungstechniken der Wirbelsaule.- 11 Dorsale Stabilisierungen.- 12 Ventrale Instrumentationen.- 13 Intervertebrale Fusionen mit Cages.- 14 Endoskopische Zugange zur Brustwirbelsaule.- 15 Mikrochirurgische ventrale Fusionstechniken an der Lendenwirbelsaule.- 16 Computerassistierte Wirbelsaulenchirurgie.- 17 Wirbelsaulenoperationen im offenen.- Spezielle Indikationen.- 18 Frakturstabilisierung im HWS-Bereich.- 19 Traumatologie der thorakolumbalen Wirbelsaule.- 20 Die lumbale Spinalkanalstenose.- 21 Moeglichkeiten der operativen Behandlung kyphotischer Deformitaten der Brust- und Lendenwirbelsaule.- 22 Operative Therapie der thorakolumbalen Spondylodiscitis.- 23 Spondylolisthesis: Reposition und Fusion durch Posterior-only approach.

This book reviews current understanding of normal muscle tone and how it differs in spastic, thixotropic and hypotonic patients. The book contains practical advice on measuring the postural system and will be of interest to paediatricians and also to physiologists involved in investigating muscle tone.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Bones and joints are always under mechanical loading a key concept in understanding bone metabolism. Among the most common diseases of bones and joints in the elderly are osteoporosis and joint osteoarthritis. Dynamic changes in mechanical loading give rise to problems resulting in stenosis of the spinal column at the cervical, thoracic, and lumbar levels. Mechanical loading also accelerates joint destruction caused by inflammation from such conditions as chronic rheumatoid arthritis. An understanding of mechanical loading is essential therefore to clinicians, basic researchers, and engineers working with bones and joints. Providing up-to-date research and clinical findings, the contents of this volume are from the papers, symposia, and special lectures presented at the 12th Annual Meeting of the Orthopaedic Research Meeting of the Japanese Orthopaedic Association in Niigata, in October 1997.

Total joint arthroplasty has brought manifold benefits to patients suffering from joint diseases, but the durability of prostheses remain a persistent problem, often requiring correction through revision surgery. Among the issues remaining to be resolved are wear and periprosthetic osteolysis after total joint arthroplasty. Today's researchers are investigating the pathogenesis and reduction of osteolysis and wear, and practitioners and engineers are working together to develop new types of prostheses for total hip and knee arthroplasty. This book presents the work of eminent orthopedic surgeons, biomedical engineers, and other researchers who have devoted their efforts to the creation and implementation of more durable total joint prostheses. The latest information on new concepts and clinical trials is included, with chapters on ostcolysis, recent developments in metal-on-metal and ceramic-to-ceramic articulation, and future trends in total joint arthroplasty.

Cartilage Repair Strategies is a comprehensive update of the present state of cartilage repair and regeneration. The information in this volume addresses what methods are effective, what methods are safe, and what methods will lead to an alteration in the short history of articular cartilage injury repair. Contributors present examinations of a variety of topics including the structure and function of articular cartilage, the evaluation of cartilage repair techniques, and the latest cartilage sensitive imaging techniques. Several chapters anticipate new and emerging cartilage repair techniques - such as second generation ACI, resorbable scaffold-based repair, and arthroscopically performed cartilage transplantation - and include descriptions of the rationale and application of these procedures. Leading experts present updates on current and emerging methodologies, making Cartilage Repair Strategies a unique and essential reference.

Providing clinicians with a comprehensive, evidence-based summary of musculoskeletal health in pregnancy and postpartum, this is the first book of its kind to describe the physiologic changes, prevalence, etiology, diagnostic strategies, and effective treatments for the most common musculoskeletal clinical conditions encountered during this phase of life. Lumbopelvic pain, upper and lower extremity diagnoses, labor and delivery considerations, including the impact on the pelvic floor, and medical therapeutics will be discussed. Additionally, the importance and influence of exercise in pregnancy, the long-term implications of musculoskeletal health in pregnancy and current and future directions for research will be addressed. The childbearing period is a time of remarkable reproductive and musculoskeletal change, predisposing women to potential injury, pain, and resultant disability. Musculoskeletal Health in Pregnancy and Postpartum offers musculoskeletal medicine specialists, obstetricians and any clinicians involved in the care of pregnant or postpartum women the tools necessary to prepare for, treat and prevent these concurrent injuries during an already challenging time.

In Osteoporosis and Osteoarthritis expert investigators detail modern tools to enhance discovery in bone and cartilage biology and promote translational research in osteoporosis and osteoarthritis. New chapters describe methods to generate induced pluripotent stem cells, perform high-throughput chromatin analysis, assess loads on bone cells in vivo and in vitro, use state-of-the art imaging techniques to measure articular cartilage thickness and biochemical properties, and establish animal models of osteoarthritis and bone healing. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Osteoporosis and Osteoarthritis shares successful techniques that can be applied to the study of either disease.

In this issue of Foot and Ankle Clinics, guest editor Dr. Scott Ellis brings his considerable expertise to the topic of Managing Complications of Foot and Ankle Surgery. Top experts in the field cover key topics such as ankle and TTC fusion, complications from lesser toe surgery, ORIF ankle, navicular fracture, ankle instability, Achilles failed repair, and more. Contains 16 relevant, practice-oriented topics including hallux valgus and hallux rigidus; failed Lisfranc/midfoot arthritis/arthrodesis; flatfoot; persistent pain after hindfoot fusion; and more. Provides in-depth clinical reviews on managing complications of foot and ankle surgery, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue, guest editors bring their considerable expertise to this important topic. Provides in-depth reviews on the latest updates in the field, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

This book covers the basics of evoked spinal cord potentials

(SCPs) with reference to studies in animals. Many illustrations help the reader grasp the neurophysiological and neuropharmacological background of spinal cord functions. Case studies offer insight into monitoring and diagnosing spinal cord dysfunctions and spinal cord diseases. The book is intended for students in clinical neurophysiology, neurosurgery, neurology, orthopedics and neuroanesthesia.