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Books > Medicine > Other branches of medicine > Pathology

Kala Azar in South Asia - Current Status and Sustainable Challenges (Hardcover, 2nd ed. 2016): E. Noiri, T.K. Jha Kala Azar in South Asia - Current Status and Sustainable Challenges (Hardcover, 2nd ed. 2016)
E. Noiri, T.K. Jha
R4,416 Discovery Miles 44 160 Ships in 10 - 15 working days

Visceral leishmaniasis (VL), (also known as black fever or Kala-azar) is a life-threatening disease first reported from the Indian subcontinent. VL ranks as the world's second largest parasitic disease killer and is a neglected tropical disease. Most of those infected by this life-threatening disease are uneducated daily wagers working to support their families, and vectors easily disseminate the disease to their neighbors. Owing to recent involvement of stakeholders, the number of patients is decreasing, but eradication remains a distant goal. This second edition presents latest reports of visceral Leishmaniasis by specialists working at the forefront of the endemic areas in Indian subcontinent. It also introduces vaccine development and inhibitors to Trypanosomatidae; some of them describing feasibility studies in visceral Leishmaniasis for the first time. Recent progress of the Science and Technology Research Partnership for Sustainable Development (SATREPS) is also reviewed and the contents share this collaborative research from the forefront of endemic sites in Bangladesh. Widely covering basic, clinical, epidemiological and entomological aspects, this volume will be of great interest to dedicated researchers interested inLeishmaniasis and to experts of NTDs in global health. There is a tide in the affairs of men. Which, taken at the flood, leads on to fortune; Omitted, all the voyage of disease control is bound in shallows and in miseries. ~modified from Shakespeare ~

Pasteurella multocida - Molecular Biology, Toxins and Infection (Hardcover, 2012 ed.): Klaus Aktories, Joachim H.C. Orth, Ben... Pasteurella multocida - Molecular Biology, Toxins and Infection (Hardcover, 2012 ed.)
Klaus Aktories, Joachim H.C. Orth, Ben Adler
R4,340 Discovery Miles 43 400 Ships in 10 - 15 working days

This volume brings together contributions from experts in the field of Pasteurella research. Its covers areas such as comparative genomics, pathogenic mechanisms, bacterial proteomics, as well as a detailed description and analysis of PMT and its interaction with host tissues, cells, immune system, and signalling pathways.

Multiplex Biomarker Techniques - Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification (Hardcover,... Multiplex Biomarker Techniques - Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification (Hardcover, 1st ed. 2022)
Paul C. Guest
R5,195 Discovery Miles 51 950 Ships in 10 - 15 working days

This detailed volume explores the application of multiplex biomarker methods in the critical area of COVID-19 research through state-of-the-art technologies in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging. The book features a series of protocols from labs across the globe employing multiplex molecular approaches, which can be applied to accelerate progress in the research of SARS-CoV-2 and other infectious illnesses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification serves as a vital resource for researchers in the areas of virology, metabolic diseases, respiratory disorders, as well as to clinical scientists, physicians, pharmacologists, and the healthcare services.

Asphyxia and Drowning - An Atlas (Paperback): Jay Dix Asphyxia and Drowning - An Atlas (Paperback)
Jay Dix
R2,593 Discovery Miles 25 930 Ships in 12 - 19 working days

This third volume in the Forensic Pathology Atlases: Causes of Death Series provides an overview of the types, mechanisms, and physical findings associated with deaths involving asphyxia. Asphyxia and Drowning serves as a basic framework for an extensive pictorial representation of findings associated with these types of deaths. It helps the reader to gain a better understanding of the processes leading to asphyxiation, to recognize the associated physical findings, and better appreciate the difficulties in evaluating asphyxiation deaths.

Advances in Parasitology, Volume 120 (Hardcover): David Rollinson, Russell Stothard Advances in Parasitology, Volume 120 (Hardcover)
David Rollinson, Russell Stothard
R6,292 R5,263 Discovery Miles 52 630 Save R1,029 (16%) Ships in 12 - 19 working days

Advances in Parasitology, Volume 120, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history.

Microbial Foodborne Diseases - Mechanisms of Pathogenesis and Toxin Synthesis (Hardcover): Jeffrey W. Cary, John E. Linz,... Microbial Foodborne Diseases - Mechanisms of Pathogenesis and Toxin Synthesis (Hardcover)
Jeffrey W. Cary, John E. Linz, Deepak Bhatnagar
R8,882 Discovery Miles 88 820 Ships in 12 - 19 working days

Through the use of molecular and cellular biological techniques, numerous advances have been made in understanding the molecular basis of virulence mechanisms and toxin biosynthesis in organisms that contaminate food and feed. Microbial Foodborne Diseases: Mechanisms of Pathogenesis and Toxin Synthesis serves as an advanced text on these techniques, providing useful, up-to-date information by recognized authorities on the molecular mechanisms of pathogenesis and toxin production of some of the most important foodborne pathogens. This book focuses on the molecular and cellular processes that govern pathogenicity and toxin production in foodborne and waterborne pathogens - viral, bacterial, fungal, and protozoan. It also includes current information related to the association of each pathogen with particular foods and water, epidemiology, methods of early detection, toxicology, and economic impact of the pathogen. It not only serves as an excellent reference, it is also a valuable tool in the rational design of preventative controls and therapeutic approaches to the disease process.

Laboratory Organization. Automation (Hardcover, Reprint 2012): D.J. Vonderschmitt Laboratory Organization. Automation (Hardcover, Reprint 2012)
D.J. Vonderschmitt
R12,002 Discovery Miles 120 020 Ships in 12 - 19 working days
The Retroviridae (Hardcover, 1995 ed.): Jay A. Levy The Retroviridae (Hardcover, 1995 ed.)
Jay A. Levy
R6,149 Discovery Miles 61 490 Ships in 10 - 15 working days

depth overview of the retrovirus family. I have greatly enjoyed and learned from this experience. Each chapter is an excellent introduction to the topic covered and provides a good foundation for further work in the field. Jay A. Levy University of California School of Medicine San Francisco, California REFERENCES Brown, E. W., Yuhki, N., Packer, C., and O'Brien, S. J., 1994, A lion lentivirus related to feline immunodeficiency virus: Epidemiologic and phylogenetic aspects, ,. Viral. 68:5953-5968. Merza, M., Larsson, E., Steen, M., and Morein, B., 1994, Association of a retrovirus with a wasting condition in the Swedish moose, Virology 202:956-961. Contents Chapter 1 The Human Immunodeficiency Viruses Edward Barker, Susan W Barnett, Leonidas Stamatatos, and Jay A. Levy I. Introduction .................................................... 1 TI. Description of Agent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 A. Virus Structure .............................................. 2 B. Genetic Organization and Gene Function ...................... 2 TIL Transmission.................................................... 7 A. General Observations ........................................ 7 B. HIV Transmission by Blood and Blood Products ................ 8 C. HIV Transmission by Genital Fluids ........................... 10 D. HIV Transmission by Other Body Fluids ....................... 12 E. Mother-to-Child Transmission ................................ 12 IV. HIV Infection of the Cell . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 . . . . . . . . . . . . . A. Introduction ................................................. 13 B. HIV-Cell Interaction............ ............... .............. 15 C. CD4-Induced gp120 Conformational Changes .................. 16 D. Soluble CD4-Induced gp120-gp41 Dissociation..... ............ 16 E. gp120 Proteolytic Cleavage ................................... 17 F. pH-Independent Membrane Fusion ............................ 19 G. Transmission of HIV by Cell-to-Cell Fusion.................... 19 H. Additional Cell Surface Receptors for HIV ..................... 20 I. The Envelope Region and Cell Tropism ........ . . . . . . . . . . . . 21 . . . .

100 Cases in Clinical Pathology and Laboratory Medicine (Hardcover, 2nd edition): Eamon Shamil, Praful Ravi, Ashish Chandra 100 Cases in Clinical Pathology and Laboratory Medicine (Hardcover, 2nd edition)
Eamon Shamil, Praful Ravi, Ashish Chandra
R2,469 Discovery Miles 24 690 Ships in 9 - 17 working days

Key features: Succinct case studies presented in an easy-to-read format, listing patient history, examination and investigations Questions at the end of each case prompt readers to consider their options for diagnosis, investigation and management Answer pages then guide readers through the clinician's sequence of thoughts and actions Subsections include histopathology, laboratory medicine (chemical pathology and immunology), haematology and microbiology Illustrations, information boxes and key points summaries reinforce learning, ideal during exam revision A broad range of common conditions is covered, from acidosis to urinary tract infection, together with more unusual cases

Endotoxin in Health and Disease (Hardcover, illustrated edition): Helmut Brade Endotoxin in Health and Disease (Hardcover, illustrated edition)
Helmut Brade
R12,243 Discovery Miles 122 430 Ships in 12 - 19 working days

Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.

Bacillus (Hardcover, 1989 ed.): Colin R Harwood Bacillus (Hardcover, 1989 ed.)
Colin R Harwood
R5,828 Discovery Miles 58 280 Ships in 10 - 15 working days

The genus Bacillw; has a long history of importance, both from an economic point of view and as a source of experimental microorganisms. This volume critically reviews aspects of identification, molecular biology, and growth that are of impor tance for the current and anticipated future exploitation of members of this group. In addition, the volume includes a chapter on taxonomy, as the importance of good taxonomy is often not fully appreciated; on sporulation, since so many important products are produced concomitantly with this process and we are beginning to understand the mechanisms by which the process is controlled; and, finally, on the cell envelope, as we are only just beginning to appreciate the significance of dif ferences between the cell walls of gram-positive and gram-negative bacteria for productivity and processing. The commercial importance of Bacillus lies mainly in the area of enzyme pro duction for the food, drink, and detergent markets. Increasingly, however, the ability of Bacillus to secrete proteins, coupled with its regulatory acceptability, has resulted in strenuous efforts to develop species of Bacillus as hosts for the produc tion of value-added heterologous proteins. Difficulties have often been encoun tered, indicating a need to divert more resources to improving our understanding of the molecular biology of members of this grou p. Experience with Escherichia coli, a far from ideal organism from a commercial point of view, suggests that an in creased investment in Bacillus is likely ultimately to be productive."

Problems in Psychopathology (Hardcover): T.W. Mitchell Problems in Psychopathology (Hardcover)
T.W. Mitchell
R4,919 Discovery Miles 49 190 Ships in 12 - 19 working days

Routledge is now re-issuing this prestigious series of 204 volumes originally published between 1910 and 1965. The titles include works by key figures such asC.G. Jung, Sigmund Freud, Jean Piaget, Otto Rank, James Hillman, Erich Fromm, Karen Horney and Susan Isaacs. Each volume is available on its own, as part of a themed mini-set, or as part of a specially-priced 204-volume set. A brochure listing each title in the "International Library of Psychology" series is available upon request.

Molecular Virology - Molecular and Medical Aspects of Disease-Causing Viruses of Man and Animals (Hardcover, 1983 ed.): Yechiel... Molecular Virology - Molecular and Medical Aspects of Disease-Causing Viruses of Man and Animals (Hardcover, 1983 ed.)
Yechiel Becker
R3,079 Discovery Miles 30 790 Ships in 10 - 15 working days

This book was written during a period when the technologies of genetic engineering were being applied to the study of animal viruses and when the organization and function of individual virus genes were being elucidated. This book, which uses human and animal viruses as models, aims to under stand the developments in molecular virology during the last 20 years. Al though molecular virology could also be taught by means of bacteriophages or plant viruses, the advantage of using animal viruses is in their ability to cause human and animal diseases as well as to transform cells, a primary problem in medicine. For the sake of clarity and convenience, not all the individual contributors to the various aspects of molecular virology were cited in the text. Instead, the reader is referred to review articles or key papers that list the numerous excel lent publications that have contributed to clarification of the various molecular processes. Thus the end-of-chapter bibliographies will guide the reader to the publications in which the original contributing authors are quoted. References given under the heading Recommended Reading are intended to assist those interested in pursuing a given subject further. I hope that this book will fulfill the purpose for which it is designed, and I urge readers to contact me if errors are found or updating is required."

Beneficial Microorganisms in Medical and Health Applications (Hardcover, 1st ed. 2015): Min-Tze Liong Beneficial Microorganisms in Medical and Health Applications (Hardcover, 1st ed. 2015)
Min-Tze Liong
R4,151 R3,581 Discovery Miles 35 810 Save R570 (14%) Ships in 12 - 19 working days

This volume is devoted to the application of microorganisms in medical treatment and health protection. Topics discussed include the role of probiotics in immune modulation, in prevention of influenza, and in atopic dermatitis. Further chapters cover aspects such as the relation of the gut microbiome and stress, the immune system, the regulation of inflammation, the benefits of Bifidobacterium for infants, and bacteriocin in medical applications, as well as the use of in vitro models of the gastrointestinal tract, omics approaches for targeting microbial health potential and the production of hepatitis B vaccines. This volume will be of particular interest to scientists working in the fields of clinical medicine, applied microbiology, pharmacy and public health.

Analytical Microbiology Methods - Chromatography and Mass Spectrometry (Hardcover, 1990 ed.): A Fox, L. Larsson, S.L. Morgan,... Analytical Microbiology Methods - Chromatography and Mass Spectrometry (Hardcover, 1990 ed.)
A Fox, L. Larsson, S.L. Morgan, G. Odham
R4,515 Discovery Miles 45 150 Ships in 10 - 15 working days

The First International Symposium on the Interface between Analytical Chemistry and Microbiology: Applications of Chromatography and Mass Spectrometry was held June 1987 at the University of South Carolina, Columbia, SC, U.S.A. The purpose of the "Interface" meeting was to forge connections between analytical chemists and microbiologists that are using chromatography and mass spectrometry to solve common problems. The goals were admirably fulfilled. Nearly a hundred participants from seven European countries, Japan, and the United States participated in hearing twenty-three plenary talks and thirty-six submitted papers and posters. The papers and discussions displayed the breadth and depth of current research applications and revealed future directions. This book "Analytical Microbiology Methods: Chromatography and Mass Spectrometry" is loosely based on some of the presentations and discussions at the meeting. Each chapter describes specific methodology and applications in the context of the relevant scientific background. The present book continues the theme of an earlier book, "Gas Chromatography/Mass Spectrometry Applications in Microbiology," edited by G. Odham, L. Larsson, and P-A. Mardh, published by Plenum Press in 1984.

The Papillomaviruses (Hardcover, 2007 ed.): Robert Garcea, Daniel DiMaio The Papillomaviruses (Hardcover, 2007 ed.)
Robert Garcea, Daniel DiMaio
R4,439 Discovery Miles 44 390 Ships in 10 - 15 working days

This volume evaluates the carcinogenic risk to humans posed by infection with human papillomaviruses (HPVs). To date, more than 70 HPV types have been identified, of which over 15 have been reported in cervical cancer biopsies. Worldwide, cervical cancer is the second most common cancer in women. This book also considers the possible involvement of HPV infection in cancers at other sites of the human body.

G Proteins, Receptors, and Disease (Hardcover, 1998 ed.): Allen M. Spiegel G Proteins, Receptors, and Disease (Hardcover, 1998 ed.)
Allen M. Spiegel
R5,864 Discovery Miles 58 640 Ships in 10 - 15 working days

"Theoretically, one should obtain essentially the same clinical picture from failure of an end-organ to respond to a hormone as from a decreased production or absence of said hormone. " With these words, Fuller Albright began his now classic paper describing a novel disease, pseudo hypoparathyroidism (PHP), and a novel concept, hormone resis- tance as a cause of disease. Soon, other hormone resistance disorders such as nephrogenic diabetes insipidus (NDI) were recognized, and the concept was extended to resistance to other substances such as calcium ions in familial hypocalciuric hypercalcemia (FHH). Later, diseases characterized by excess rather than deficient hormone action such as McCune-Albright syndrome (MAS) and familial male precocious puberty (FMPP) were recognized to be caused by autonomous endocrine hyperfunction. Although many i!!vestigators provided careful and detailed descriptions of the clinical features of these and other related endocrine disorders, an understanding of pathogenesis proved elusive for many years. In just the past few years, we have gone from clinical description to a molecular understanding of these interesting disorders. This remarkable progress reflects a synthe- sis of three distinct, but now overlapping, areas of biomedical research: the aforemen- tioned recognition and careful clinical description of specific diseases, the elucidation of the basic mechanisms of signal transduction, and the application of the powerful tools of molecular biology and genetics. Fundamental studies on the mechanisms of hormone action by Rodbell and colleagues at NIH culminated in the discovery of a major signal transduction pathway involving heterotrimeric G proteins.

Flow Cytometry Basics for the Non-Expert (Hardcover, 1st ed. 2018): Christine Goetz, Christopher Hammerbeck, Jody Bonnevier Flow Cytometry Basics for the Non-Expert (Hardcover, 1st ed. 2018)
Christine Goetz, Christopher Hammerbeck, Jody Bonnevier
R2,198 R1,494 Discovery Miles 14 940 Save R704 (32%) Ships in 12 - 19 working days

This first edition volume demystifies the complex topic of flow cytometry by providing detailed explanations and nearly 120 figures to help novice flow cytometry users learn and understand the bedrock principles necessary to perform basic flow cytometry experiments correctly. The book divides the topic of flow cytometry into easy to understand sections and covers topics such as the physics behind flow cytometry, flow cytometry lingo, designing flow cytometry experiments and choosing appropriate fluorochromes, compensation, sample preparation and controls and ways to assess cellular function using a variety of flow cytometry assays. Written as a series of chapters whose concepts sequentially build off one another, using the list of materials contained within each section along with the readily reproducible laboratory protocols and tips on troubleshooting that are included, readers should be able to reproduce the data figures presented throughout the book on their way to mastering sound basic flow cytometry techniques. Easy to understand and comprehensive, Flow Cytometry Basics for the Non-Expert will be a valuable resource to novice flow cytometry users as well as experts in other biomedical research fields who need to familiarize themselves with a basic understanding of how to perform flow cytometry and interpret flow cytometry data. This book is written for both scientists and non-scientists in academia, government, biotechnology, and medicine.

Diagnostic Pathology: Forensic Autopsy (Hardcover, Annotated Ed): Mary Ann Sens, Rhome Hughes Diagnostic Pathology: Forensic Autopsy (Hardcover, Annotated Ed)
Mary Ann Sens, Rhome Hughes
R5,557 Discovery Miles 55 570 Ships in 12 - 19 working days

This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Specifically designed to assist hospital pathologists and assistants, forensic pathology fellows, pathology residents, and medical examiners, it provides a comprehensive, authoritative discussion of key topics in forensic autopsy. Richly illustrated and easy to use, Diagnostic Pathology: Forensic Autopsy is a one-stop reference on the performance of procedures in this challenging field, ideal as a day-to-day reference or as a reliable training resource. Provides expert guidance on accurate diagnoses of the findings and patterns encountered in the forensic autopsy, as well as cause of death procedures Covers key topics such as opioid and drug deaths, including new drugs and their toxicology; deaths and investigations in custody; infant and child deaths, including SIDS and overlaying; and infant and child neck trauma, including shaken baby syndrome Contains the necessary information to aid in the performance of both routine and complicated forensic autopsies Features hundreds of high-quality images throughout, including full-color illustrations and clinical and gross pathology photographs-all carefully annotated to highlight the most diagnostically significant factors Features a templated, highly formatted design; concise, bulleted text; key facts in each chapter; and an extensive index for easy reference Offers authoritative, readable coverage for those who need to learn and understand important aspects of forensic autopsy, including coroners, medico-legal death investigators, and legal investigators Includes the enhanced eBook version, which allows you to search all text, figures, and references on a variety of devices

Malaria Immunology - Targeting the Surface of Infected Erythrocytes (Hardcover, 1st ed. 2022): Anja Tatiana Ramstedt Jensen,... Malaria Immunology - Targeting the Surface of Infected Erythrocytes (Hardcover, 1st ed. 2022)
Anja Tatiana Ramstedt Jensen, Lars Hviid
R6,562 Discovery Miles 65 620 Ships in 10 - 15 working days

This volume covers a broad range of methods, technologies, and protocols on malaria. Chapters detail research on collecting parasites in the field, single molecule-level analyses of adhesive interactions, and focused studies aiming at disrupting the devastating disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Malaria Immunology: Targeting the Surface of Infected Erythrocytes aims to be a useful and practical guide to researches to help further their study in this field. Chapter Analysis of var gene transcription pattern using DBL -tags [Chapter 14] is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Green Products in Food Safety (Paperback): Bhanu Prakash, Jackline Freitas Brilhante De Sao Jose Green Products in Food Safety (Paperback)
Bhanu Prakash, Jackline Freitas Brilhante De Sao Jose
R4,175 Discovery Miles 41 750 Ships in 12 - 19 working days

Green Products in Food Safety explores the potential of green chemicals in the sustainable management of food biodeterioration agents while also addressing existing limitations of green products for their sustainable application. The book summarizes food loss by biodeterioration agent (bacteria, fungi, mycotoxin and insect pest), novel detection methods for hazardous food contaminants, different sources of green chemicals, their origin, extraction and characterization methods, and bioactivity of green products against biodeterioration agent with their molecular sites of action. The contents of the book cover the basic and translational aspects that will prove to be beneficial for food scientists, researchers, students and young professionals. In addition, the pharmacological properties, metabolic engineering of green chemical biosynthesis, role of mathematical modeling to design the novel synergistic formulation (Additive, adjuvant and synergistic effect), nanocarrier applications in the food system, elucidation of novel site of action, and toxicity prediction and ecological perception are also included to overcome the existing limitations.

Molecular and Cellular Biology of Phagocytosis (Hardcover, 1st ed. 2020): Maurice B. Hallett Molecular and Cellular Biology of Phagocytosis (Hardcover, 1st ed. 2020)
Maurice B. Hallett
R4,380 Discovery Miles 43 800 Ships in 10 - 15 working days

Phagocytosis is the engulfment of particulate matter by cells. It is a fundamental (and probably "primitive") cell biological process which is important in single celled organisms such as amoeba; multicellular animals including coelenterates; and in higher animals. In humans and other mammals, specialised immune cells (phagocytes) utilise phagocytosis in their crucial role of engulfing and destroying infecting microbes. Yet, surprisingly, the biophysics and biochemistry underlying the process has only become clear recently with the advent of genetic manipulation and advances in single cell imaging. In this volume, the aim is to bring together recent fundamental advances that give a clear picture of the underlying mechanism involved in phagocytosis. Not only is this an important topic in its own right, but a full understanding of the process will have a potential impact on human medicine, since as antibiotics become less effective in fight infection, researchers are looking at alternative approaches, including enhancing the "natural" immunity brought about by immune phagocytes. The aim is to provide a comprehensive volume on the topic, with separate chapters on identified recent advances, each written by the major contributors in each area. In addition, the volume will attempt to give a wider overview than is often the case in single author reviews, with an emphasis here on the cell biological understanding of phagocytosis using biophysical approaches alongside the biochemical and imaging approaches.

The Human Teratomas - Experimental and Clinical Biology (Hardcover, 1983 ed.): Ivan Damjanov, Barbara B. Knowles, Davor Solter The Human Teratomas - Experimental and Clinical Biology (Hardcover, 1983 ed.)
Ivan Damjanov, Barbara B. Knowles, Davor Solter
R5,628 Discovery Miles 56 280 Ships in 10 - 15 working days

Human teratocarcinoma has long held a fascination to the pathologist be- cause of the diversity of the seemingly benign differentiated tissues asso- ciated with the tumor. An understanding of this diversity came with the demonstration of the pluripotent nature of the embryonal carcinoma cell, the stem cell of the tumor, in experimental animals. Single cell clones of murine embryonal carcinomas were derived and the resultant cell lines injected into immunosuppressed hosts, where the embryonal carcinoma stem cell itself gave rise to the wealth of differentiated tissues seen in teratocarcinomas. It was also shown that teratocarcinomas could be pro- duced experimentally by transplantation of staged early mouse embryo to extrauterine sites; subsequent experiments suggested that the embryonal carcinoma stem cell was, in fact, comparable to a normal cell of the em- bryonic ectoderm. Many elegant experiments have since been built on this early work; murine embryonal carcinoma cells are providing the ex- perimental material for a first biochemical evaluation of the earliest dif- ferentiation events in mammalian embryogenesis. In this volume, we relate the beginnings of experimental research on human teratoma. The human embryonal carcinoma cells have been char- acterized and established in vitro, providing an experimental model to study the unique biology of these cells. Monoclonal antibodies, estab- lished from work with these in vitro cultures, provide cell surface probes that define populations of embryonal cells and their derivatives in tumor sections.

Beta-Lactam Resistance in Gram-Negative Bacteria - Threats and Challenges (Hardcover, 1st ed. 2022): Mohammad Shahid, Anuradha... Beta-Lactam Resistance in Gram-Negative Bacteria - Threats and Challenges (Hardcover, 1st ed. 2022)
Mohammad Shahid, Anuradha Singh, Hiba Sami
R4,148 Discovery Miles 41 480 Ships in 10 - 15 working days

This timely book discusses antimicrobial drug resistance, specifically, the resistance against the beta-lactam class of antibiotics by Gram-Negative bacteria. The book is broadly divided into five sections. The first section describes the underlying mechanisms of antimicrobial resistance in Gram-negative bacteria. It gives an insight into the beta-lactamases, their types, classification, inhibitors, etc. The second section delves deep into the genetic basis of resistance. It talks about transposons, integrons, insertion sequences associated with antibiotic-resistant genes. The next section describes phenotypic and molecular methods to detect beta-lactam resistance. The fourth section talks about the epidemiology and prevalence of beta-lactamases in the environment. The last section of the book describes the various therapeutic options to combat this growing public threat of antimicrobial resistance. It talks about the current reserve drugs, as well as the newer antibiotic agents that are in the pipeline. This book is essential for clinical practitioners, students, and researchers in basic and medical microbiology.

Tumor Microenvironment and Cellular Stress - Signaling, Metabolism, Imaging, and Therapeutic Targets (Hardcover, 2014 ed.):... Tumor Microenvironment and Cellular Stress - Signaling, Metabolism, Imaging, and Therapeutic Targets (Hardcover, 2014 ed.)
Constantinos Koumenis, Ester Hammond, Amato Giaccia
R6,723 Discovery Miles 67 230 Ships in 10 - 15 working days

The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

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