This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering the full range of nonneoplastic and neoplastic conditions of the female genital tract, it incorporates the most recent scientific and technical knowledge in the field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Gynecological is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource. Covers all areas of gynecologic pathology, organized into six easy-to-reference anatomic Covers all areas of gynecologic pathology, organized into seven easy-to-reference anatomic sections: vulva, vagina, uterine cervix, uterine corpus, fallopian tube and broad ligament, ovary, and peritoneum Includes all frequently encountered conditions plus extensive coverage of uncommon entities, such as inflammatory diseases of the vulva, discussed by experts in dermatopathology Provides updated differential diagnoses and diagnostic pearls as well as extensive revisions based on the 2020 WHO Classification of Tumors: Female Genital Tumors, including staging issues and measurement standards Reflects important molecular updates in endometrial carcinoma classifications as well as updated classifications for squamous and glandular tumors for the lower genital tract, both in situ and invasive Updates ancillary techniques, newly encountered pitfalls, and advances in the molecular landscape of epithelial and mesenchymal tumors Features more than 2,500 superb images in print and online, including many new gross and microscopic images as well as diagnostically relevant immunohistochemical and molecular findings Includes an eBook version that enables you to access all text, figures, and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud

Originally published in 1938, this volume contains the text of the Rede Lecture for that year, delivered by Sir Patrick Laidlaw. This book will be of value to anyone with an interest in virology and the history of medicine.

Pancreatic ductal adenocarcinoma is the fourth leading cause of cancer death in the United States. Annually approximately 30,000 Americans are diagnosed with the disease and most will die from it within five years. P- creatic ductal adenocarcinoma is unique because of its late onset in age, high mortality, small tumor samples infiltrated with normal cells, and a lack of both early detection and effective therapies. Some of these characteristics have made studying this disease a challenge. Pancreatic cancer develops as a result of the accumulation of genetic alterations in cancer-causing genes, such as the oncogenes and the tumor-s- pressor genes. In the last decade, major progress has been made in identifying important oncogenes and tumor-suppressor genes for the disease. In Panc- atic Cancer: Methods and Protocols, we review the classical techniques that have contributed to the advances in pancreatic research and introduce new strategies that we hope will add to future breakthroughs in the field of cancer biology. Pancreatic Cancer: Methods and Protocols provides a broad range of protocols for molecular, cellular, pathological, and statistical analyses of s- radic and familial pancreatic cancer. It covers topics from in vitro cell c- tures to in vivo mouse models, DNA to protein manipulation, and mutation analyses to treatment development. We believe that our book will prove an invaluable source of proven protocols for those who are interested in either basic or translational research in pancreatic cancer.

This second edition updates the reader on the most common intrauterine transmitted viral infection, CMV. The history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed in detail. Further a section specifically dedicated to prevention measures is included to the new edition. The chapter on virus-host interaction for defense and transmission is elaborately updated.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Three times in the last century, influenza viruses have undergone major genetic changes resulting in global pandemics that had devastating effects. The most infamous pandemic was the "Spanish Flu" which affected up to 25% of the world population and is thought to have killed at least 40 million people. In 1997 and 2003, a new influenza A virus of H5N1 subtype emerged in Asia and was transmitted directly from birds to humans with lethal outcomes. Despite monumental efforts to contain them, the H5N1 viruses expanded their territory and caused a major outbreak in wild waterfowl in China in 2005. Despite extensive, coordinated efforts by various agencies and disciplines, both national and international, we are ill-equipped for a new influenza pandemic. In fact, it is highly unlikely that adequate supplies of vaccine for the H5N1 viruses will be prepared prior to the occurrence of the next pandemic. To combat the outbreaks that will undoubtedly occur in the near future, a better understandi

This book offers a summary and discussion of the advances of inflammation and infection in various cancers. The authors cover the classically known virus infections in cancer, novel roles of other pathogens (e.g. bacteria and fungi), as well as biomarkers for diagnosis and therapy. Further, the chapters highlight the progress of immune therapy, stem cells and the role of the microbiome in the pathophysiology of cancers. Readers will gain insights into complex microbial communities, that inhabit most external human surfaces and play a key role in health and disease. Perturbations of host-microbe interactions often lead to altered host responses that can promote cancer development. Thus, this book highlights emerging roles of the microbiome in pathogenesis of cancers and outcome of therapy. The focus is on mechanistic concepts that underlie the complex relationships between host and microbes. Approaches that can inhibit infection, suppress chronic inflammation and reverse the dysbiosis are discussed, as a means for restoring the balance between host and microbes. This comprehensive work will be beneficial to researchers and students interested in infectious diseases, microbiome, and cancer as well as clinicians and general physiologists.

This book on NeuroAIDS, a collection of chapters written by experts and specialists from around the world, provides a global perspective on HIV and NeuroAIDS in the field, clinic, and laboratory. The chapters address the comorbidity of HIV and other infectious agents, including Zika virus, Ebola, Chagas disease, TB and HCV. Also discussed are key topics, such as: * Molecular socioepidemiology * Global HIV and NeuroAIDS * Neuropathology * cART and blood-brain barrier penetration * HIV replicative oscillations * HIV and SIV evolution * Psychiatric comorbidities * Neurosyphilis * The examination of current and innovative models of translational research to translational effectiveness

Communicable Disease Epidemiology and Control Edited by Norman Noah King's College School of Medicine and Dentistry, London, UK, and Mary O'Mahony Public Health Laboratory Service, London, UK With the growing interest in communicable diseases and their control worldwide, largely due to new and re-emerging infections, there is a need for up-to-date information in this continually changing field. Timely and wide ranging, Communicable Disease: Epidemiology and Control addresses many of the contemporary issues and provides:
* Detailed and concise examination of management issues, such as commissioning and contracting, setting up an incident room, and legal aspects
* A practical approach
* An examination of a wide spectrum of issues in communicable diseases, including cholera, tuberculosis, Helicobacter pylori, and sexually transmitted diseases
This volume is an invaluable resource for microbiologists, epidemiologists and all professionals involved in public health.

Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.

This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.

This book intends to provide information about detection and health effects due to bacteria, fungi and viruses in indoor environments. The book will cover also information about preventive and protective measures to avoid health-hazardous. Case studies will be also addressed to enrich the book with the expertise of each invited author. The book also intends to fill a gap regarding information about all biologic agents, since most of the books available are dedicated to only one type of microorganisms. For various different biologic agents and metabolites this book will compile information about indoors presence, detection methods, exposure assessment and health effects. Several problems regarding the exposure of biologic agents will be presented through case studies, and also the implementation of preventive and protective measures to avoid/minimize exposure. Besides, all the book will focus on occupational health and/or public health point of view.

Readable, well-illustrated, and concise, Robbins and Kumar's Basic Pathology, 11th Edition, offers today's busy students a rich understanding of all essential pathology concepts from trusted names in the field. This updated edition thoroughly covers key pathologic processes and the time-honored tools of gross and microscopic analysis, while also retaining a strong emphasis on clinicopathologic correlations and the impact of molecular pathology on the practice of medicine. Outstanding artwork and schematic drawings, as well as a robust eBook experience with extensive additional features, make complex concepts easier to learn and retain. Includes fully updated clinical topics throughout. Features high-quality photomicrographs, gross photos, and radiologic images, as well as new artwork and over 150 new schematic diagrams that help summarize key or complex disease mechanisms. Contains a new Rapid Review section that uses bulleted summary boxes to deliver essential take-home messages and help you focus on the fundamentals. Includes tables of relevant laboratory tests for each chapter that link pathophysiology of disease and diagnostic testing. Highlights pathogenesis, morphology, and pathophysiologic content throughout. Features increased representation of diverse populations throughout the text, including clinical photographs of skin lesions in multiple skin types and a new section on the role of socially defined race in health disparities. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud-as well as access bonus content, including case studies, additional gross and microscopic figures, and more.

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus. This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.

This volume describes the most common laboratory procedures for isolation, identification and characterization of polioviruses used in clinical and research laboratories. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Poliovirus: Methods and Protocols aims to ensure successful results in the further study of this vital field.

This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

The chapters in this topical volume of Advances in Microbiology, Infectious Diseases and Public Health present exciting, insightful observations on emerging viral infections like influenza, Middle East respiratory syndrome, or mosquito-transmitted diseases, as well as the potential of social media in preventing and fighting infectious diseases. This rapidly developing field of study, which involves interdisciplinary and challenging research conducted in both industrialized and limited-resource countries, can yield vital information for the life and social sciences, for public health, and for healthcare in general. The aim of this volume is to contribute to the development of knowledge on emerging infections in the endless struggle between viruses and man. The chapters selected are not intended as a systematic collection of all emerging infections, but instead highlight recent discoveries and provide insights on today's hot topics. The book offers a valuable resource for all scientists working in the field of emerging viral infections and possible vaccines, as well as for laboratory and medical staff whose work involves preventing, controlling and combatting infectious diseases.

DNA Methods in Clinical Microbiology describes the novel DNA-based technology now used in the diagnosis and management of infectious diseases. It is a concise, yet readable, overview written primarily for clinicians, clinical microbiologists, medical students and undergraduates in medical and veterinary microbiology. The book has two primary aims. First, to explain the principles of these methods at the molecular' level. Second, to provide a clinical perspective by reporting results from actual DNA-based investigations on a range of specimens. Those approaching DNA methods for the first time are assisted by a brief rA(c)sumA(c) of the relevant features of nucleic acids (Chapter 2): this information is essential for an understanding of later chapters. Subsequent text covers detection, characterization and quantification of pathogens by a variety of methods - e.g., target amplification (PCR, LCR, NASBA, TMA and SDA), signal amplification (bDNA) and probe-based techniques; the chapter on typing describes nearly twenty named molecular methods, including spoligotyping and MLST. All chapters include an adequate range of current reference from which, if required, detailed protocols can be obtained. The diagrams are clear, and readers are assisted by a detailed index.

This book focuses on waterborne pathogens and significant diseases occurring along major rivers around the globe, including key examples like the Amazonas, Mekong River and Nile. Written by leading international experts, it offers unique insights into local riverine infection risks in times of global warming, and addressing these through advances in diagnosis, health management and the development of simple but effective control measures. It also sheds light on why former societies collapsed due to transmitted diseases during periods of climate change, droughts and floods, to help establish effective preventive measures for the future. The book appeals to a wide readership, from scientists in the field of parasitology, infectious diseases and epidemiology, to healthcare managers and general readers with an interest in pathogen spread along the largest rivers on earth. It particularly highlights past and current control mechanisms in times of global warming and assesses potential future health hazards.

This book presents a comprehensive and state-of the-art approach to vascular disease for the geriatric patient, focusing on vascular pathology and interventions but also on perioperative care, anesthetic care, functional outcomes and quality of life, as well as ethical considerations that impact decision making. The book addresses open and endovascular interventions in different vascular beds, as well as preoperative workup and optimization, anesthetic considerations, all aspects and expectations of the postoperative care and recovery and is the only book to include specialize in the intricacies of the care of the geriatric patients, the challenging recovery and neurocognitive changes, and ethical considerations for the end stage geriatric patient or in the setting of postoperative complications. Written by experts in the field, each section addresses patient selection, pre-operative considerations, technical conduct of the most common operations with open or endovascular options, and avoiding complications. A brief review of the existing literature addressing the particular topic follows in each section. With its concise yet comprehensive summary of the field, Vascular Disease in Older Adults is the ultimate resource for geriatricians, cardiologists, surgeons, anesthesiologists, and all physicians of who care for the aging patient with vascular disease.

The topic of this book, Collectins, is a family of proteins whose major function is in innate immunity, where Collectins act as pattern recognition receptors (PRRs). In general they recognize targets such as microbial surfaces and apoptotic cells, and once bound to a target, Collectins promote the clearance of microorganisms and damaged host tissue. New cell-surface proteins and glycoproteins, which act as Collectin receptors, are currently being identified. Some Collectins, particularly MBL, activate the complement system, which enhances the ability of antibodies to fight pathogens, via three MBL-associated proteases, the MASPs. Additionally, recent research has begun to show wider-ranging activities of Collectins, such as: * Their role in metabolism, and therefore their involvement in lifestyle diseases such as obesity and cardiovascular disease. * Their ability to modulate the adaptive immune response, as well as to recognize and trigger apoptosis of cancer cells, which makes them effective in the annihilation of cancer cells with multiple mutations. * The regulation of their expression by gonadal steroid hormones implicates them with critical roles in both male and female fertility. * Altered levels of Collectins have been associated with various autoimmune diseases. This book brings together current knowledge of the structure, functions and biological activities of Collectins, to describe their integral role in human health.

Herpesviruses, classified in the family Herpesviridae, are important human and animal pathogens that can cause primary, latent or recurrent infections and even cancer. The major interest in research on herpesviruses today focuses on understanding the organization of the DNA genome, as well as on characterizing the viral genes in regard to their control and function. Modern techniques have allowed the viral DNA to become a molecular tool in the study of gene function, since it is now possible to implant the DNA into eukaryotic cells. This book contains original studies on the structure and organization of the DNA of human and animal herpes viruses. The various chapters acquaint the reader with the organization of the viral DNA, the mRNA transcripts, the replicative intermediates of the viral DNA, defective DNA genomes and their mode of synthesis, analyses of the viral DNA sequences in transformed cells, and the relationship between the presence of viral DNA fragments in the cancer cells and the transformed state of the cells."

This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites. We also explore antibiotic therapy for control of infection, a baffling topic that lends itself to exalted interpretation.

This books comprises of 24 chapters by experts from developed and developing countries. The book cover Argentina, Australia, Bangladesh, Brazil, Canada, Fiji, France, India, Indonesia, Italy, Japan, Malaysia, Mexico, Papua New Guinea, South Africa, Taiwan, Thailand, the UK and England, USA, West Africa, and Zambia. FOREWORD by David J. Hunter, Emeritus Professor, Newcastle University, the UK.