This book discusses the role of oxidative stress in human reproduction with a focus on men's health. The physiological roles of reactive oxygen species (ROS) in male fertility are the focus in this book. This topic is important because oxidative stress is a result of the imbalance between ROS and antioxidants in the body which may lead to sperm damage (DNA or count), deformity, and eventually, male infertility. Therefore, for a better understanding of the molecular mechanisms related to male genotoxicity and its regulation in infertility, this book provides an up-to-date view on the impact of oxidative stress factors in male reproduction . The main aim of this book is to collect a series of research articles and reviews from a diverse group of scientists to share their research work on the role of ROS or oxidative stress in physiological and pathological states in relation to (in)fertility in the male. This book presents various state-of-the-art chapters of the recent progress in the field of cellular toxicology and clinical manifestations of various issues related to men's health and fertility. Topics include cell signaling, DNA damage and infertility, the pathophysiology of disease instigation and distribution, immune toxicity and prevention.

General Pathology covers the study of pathological or disease processes in general with particular reference to morphological changes. The book is designed for second- and third-year pathology students in the medical and paramedical fields. Topics covered include cell injury, death and necrosis, pigmentation, calcification, haemorrhage, shock and oedema.

The book provides detailed information on breast cancer and covers all the aspects of this rapidly spreading disease, such as applied anatomy and physiology, causative factors, various Investigations to reach a concise, definitive and complete diagnosis. The management of breast cancer involves multi-modality treatment and the book describes all the modalities in a very clear manner. It also discusses in a very lucid and practical way. the multi-prong treatment that the patient requires . Additionally, the book covers lesser-known areas of the subject like rehabilitation, management of lymphoedema, Extravasation of chemo-Infusion, organization of breast cancer management group, breast cancer awareness and patient education, follow up of the patient, and psychological support to these patients who have undergone mutilation of their organ. Edited by experts the chapters are contributed by renowned onco-sugeons from high volume and reputed centers in India such as, PGIMER, Chandigarh, AIIMS, New Delhi, and TMH, Mumbai among others. The book serves as a useful resource for surgeons, medical oncologists, radiotherapists, pathologists, radiologists and many other specialists interested in the field of breast cancer and actively working in this area. It is useful for practitioners and residents as well as for those who want to learn the different aspects of this disease.

The heart-wrenchingly honest and fascinating new book from forensic pathologist and bestselling author of UNNATURAL CAUSES, Dr Richard Shepherd A TIMES AND SUNDAY TIMES BOOK OF THE YEAR 'Each chapter is like a finely-crafted detective story . . . Shepherd writes beautifully, and despite its subject, the book is very funny in parts' DAILY TELEGRAPH 'Enlightening, strangely uplifting . . . Shepherd's final chapter on death itself is a meditation of great beauty and light which puts all the darkness of the previous pages into perspective' DAILY MAIL 'Deeply insightful. Unflinching' THE TIMES 'Fascinating' DAILY EXPRESS 'This book is about death, but in it I will take readers on a journey through life . . .' _________ Dr Richard Shepherd, Britain's top forensic pathologist, has spent a lifetime close to the dead. As a medical detective, each autopsy he carries out is its own unique investigation, uncovering the secrets not only of how a person died, but also of how they lived. Through twenty-four of his most intriguing, enlightening and never-before-told cases, Dr Shepherd shares autopsies that span the seven ages of human existence, and have taught him as much about the marvels of life as the inevitability of death. From old to young, from murder to misadventure, and from illness to accidental death, each of these bodies has something to reveal: about human development, about mortality, about its owner's life story, about justice and even about Shepherd himself. From the bestselling author of Unnatural Causes comes a powerful, moving and above all reassuring book about death as it touches our own lives - how to understand it, and, when our time comes (as it must), how to embrace it as the last great adventure. _________ 'He has the ability to examine himself and other people with the same forensic eye that he applies to corpses - one of the reasons why his books feel so life-enhancing' Daily Telegraph Praise for Dr Richard Shepherd 'Gripping, grimly fascinating, and I suspect I'll read it at least twice' Evening Standard 'A deeply mesmerising memoir of forensic pathology. Human and fascinating' Nigella Lawson 'An absolutely brilliant book. I really recommend it, I don't often say that but it's fascinating' Jeremy Vine, BBC Radio 2 'Puts the reader at his elbow as he wields the scalpel' Guardian 'Fascinating, gruesome yet engrossing' Richard and Judy, Daily Express 'Fascinating, insightful, candid, compassionate' Observer

Part of the in-depth and practical Pattern Recognition series, Practical Surgical Soft Tissue Pathology, 2nd Edition, helps you arrive at an accurate diagnosis by using a proven pattern-based approach. Leading diagnosticians guide you through the most common patterns seen in soft tissue pathology, applying appropriate immunohistochemistry and molecular testing, avoiding pitfalls, and making the best diagnosis. High-quality illustrations capture key morphologic patterns for a full range of common and rare tumor types, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. A consistent chapter organization by histologic pattern considers soft tissue tumors the way you approach them in daily practice, helping you arrive at a quick and accurate diagnosis. A user-friendly design color-codes patterns to specific entities, and key points are summarized in tables and text boxes, so you can quickly and easily find what you are looking for. Sweeping content updates keep you at the forefront of recent findings regarding all major neoplastic and non-neoplastic diseases of the soft tissues. Improved pattern call-outs are now linked directly within the chapter, reinforcing the patterns for more efficient and complete understanding. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.

This book provides the description of the granulomatous diseases of otorhinolaryngology, head and neck with their characteristic features, investigations and management. It includes wide variety of infective, idiopathic, neoplastic, hereditary, reactive and various other types of chronic granulomatous reaction in the ear, nose, throat and head neck region. Further, the description is supported with various illustrations including clinical photographs, radiological pictures of CT scan, MRI scan etc. Histopathological and microbiological images which show characteristics and differentiating features are also included to aid in the diagnosis of the diseases. Histopathological colored images with high magnification and immunohistochemistry images are provided for better illustrations. This book also elaborates the important medical and surgical management of the granulomatous diseases. Every chapter ends with the 'Essential features' of that particular granulomatous disease, and this will certainly help the post-grad students and clinicians to differentiate the diseases, early diagnosis and management of the patients with chronic granulomatous diseases.

Regional Network for Asian Schistosomiasis and Other Helminthic Zoonoses, Volume 105, the latest release in the Advances in Parasitology series, captures the journey of RNAS+ from its early beginnings, to its current state, marking its accomplishments and impacts in research. Sections in this updated volume include Milestones of networking and global engagements for the RNAS+, Priorities and outcomes of collaborative researches for the RNAS+, Needs and coordination mechanism for capacity building by the RNAS+, Translational research and contributions to country control, Multi-disciplinary integration of networking through the RNAS+, Impact assessment of RNAS+ outcomes, and more.

Both communicable and noncommunicable diseases of the respiratory system are an increasing healthcare problem despite medical advances. This book aims at unraveling the mechanisms and improving the treatment of pulmonary pathologies, ranging from such common conditions like influenza and related viral infections, functional lung dysfunction, to lung lesions and others. Chapters present late-breaking findings in the diagnostics, pharmacotherapy, and clinical evidence-based decision-making to provide results that can be used to improve healthcare and quality of life. Extending new knowledge and exploring recent medical advances, the book will hopefully help enrich research and clinical experience regarding important respiratory issues. The book is intended for general practitioners and all professionals engaged in the pulmonary field, from basic scientists to clinical investigators.

Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation is a valuable industrial resource that addresses complex, multi-factorial topics regarding farm, wild, companion animals, fish, and how the environment plays an important role in amplification and transmission of resistant bugs into the human food chain. Information of phenotypical and genotypical properties of each bacterial genus associated with antimicrobial resistance, transmission dynamics from different reservoirs (food animals, poultry, fishes) and control measures with alternative therapy, such as phytobiotics and nanomaterials are provided. Researchers, scientists and practitioners will find this an essential resource on the judicial use of antibiotics in animals and humans.

A follow-up to Emerging Issues and Controversies in Infectious Diseases, this volume provides a comprehensive review of topical issues in infectious diseases, highlighting the controversies related to the newest findings and recommendations. Coverage includes trends and debates in HIV research, community-acquired pneumonia, H. pylori, progress in Hepatitis C treatment paired with the lack of progress on Hepatitis B, and the effects of climate change on infectious disease epidemiology, among others. This is an essential resource for practicing and academic physicians, investigators, residents, and fellows focused on infectious diseases, infection control, public health, and global health.

Virus Entry, Volume 104, the latest release in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on plant virus cell-to-cell entry, plant virus entry via insect transmission, VSV/Rabies virus entry, Papovavirus entry, New approaches to study fusion proteins, Hantavirus receptors, Gamma Herpesvirus entry, and many other interesting topics.

This book offers a much-needed discussion on the targeting of biofilm-related infections. Chapters include discussions on the impact of biofilm on medical implants, industrial applications, as well as wound and tissue infections. It also offers discussions on regulatory management for industrial sectors and medical environments. Given that there continues to be a paucity of effective antimicrobial products, devices, and coatings in clinical and industrial use that effectively reduce rates of infection or biofilm-related problems, Targeting Biofilms in Translational Research, Device Development, and Industrial Sectors, offers a fresh and much-needed perspective aimed at helping create healthier controlled environments and safer devices. This comprehensive book is indispensable for industrial and academic translational researchers, device developers, and regulatory experts looking to create more effective antimicrobial products.

This books comprises of 24 chapters by experts from developed and developing countries. The book cover Argentina, Australia, Bangladesh, Brazil, Canada, Fiji, France, India, Indonesia, Italy, Japan, Malaysia, Mexico, Papua New Guinea, South Africa, Taiwan, Thailand, the UK and England, USA, West Africa, and Zambia. FOREWORD by David J. Hunter, Emeritus Professor, Newcastle University, the UK.

Diverse specialised neuroglial cells guarantee the development, preservation, and health of the central nervous system, the peripheral nervous system, the enteric nervous system, and the special senses. In the central nervous system, it is the astrocytes, oligodendrocytes, and microglia that safeguard nerve cell function and integrity that controls all behaviours and encompasses the cerebral cortex of the brain which is the root of humanity. In the peripheral nervous system, Schwann cells play the leading role, together with satellite glial cells of the sensory and autonomic ganglia, ensuring correct communication between the organs and tissues with the brain and the spinal cord. In the enteric nervous system, specialised enteric glial cells maintain all aspects of gastrointestinal function. Then there are distinctive glial cells of the special senses that ensure how the body perceives and reacts to its environment. In pathology, neuroglia strive to protect the diverse cellular components of the nervous system and are responsible for a proactive programme of posttraumatic restructuring that is aimed at recovery of life-sustaining function. Neuroglia: Function and Pathology provides a highly original and comprehensive account of the physiology and pathophysiology of glial cells in the central and peripheral nervous systems. The first part of the book provides a far-reaching description of glial cell form and function, from their evolution in invertebrates to their complexity in humans, encompassing the developmental origin of the varied glial cell types and their diversity of morphology, molecular biology and cellular physiology. The second part of the book is devoted to an all-embracing evaluation of glial cell pathophysiology, commencing with definitive explanations of the fundamental pathologies of the main glial cell types, and ending in a systematic examination of glial contributions to specific neurological diseases. This book emphasises the central roles played by the different classes of neuroglial cells in the progression and outcome of neurological disorders of the central and peripheral nervous systems and highlights potential of glial cells as therapeutic targets. The book contains more than 2500 key references from over 150 years of glial research and is superbly illustrated with over 350 original and explanatory full colour figures that describe the diverse characteristics and properties of glial cells in health and disease. Under the same cover, this book combines an authoritative reference book for research and clinical neuroscientists and at the same time serves as an instructive textbook for students of neuroscience, from undergraduates to postgraduates.

Characterization, Epidemiology and Management is the third volume in the Phytoplasma Diseases in Asian Countries series dedicated to the analysis of plant pathogens across Asia. Highlighting genomic studies and molecular approaches for rapid detection of phytoplasma diseases, the book discusses effective control measures for insect vectors across Asia. The chapters in this book discuss the latest biological controls and how best to manage and even eliminate phytoplasma diseases. This is an essential read for students, researchers and agriculturalists interested in plant pathology. Phytoplasma are microorganisms that are transmitted by insect vectors, infecting various different types of annuals and perennials and causing serious damage to crops across Asia.

This volume details the most updated concepts and experimental protocols developed by leading researchers in the field. Chapters guide readers through methods on bioinformatics tools, hepatitis c virus(HCV) cloning, culture, and purification, HCV life cycle, host immune responses, and small animal models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Hepatitis C Virus Protocols aims to ensure successful results in the further study of this vital field.

Advances in Parasitology, Volume 104, the latest in a series first published in 1963, contains comprehensive reviews on all areas of interest in contemporary parasitology. The series includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy, and life history, which help to shape current thinking and applications. This new release includes sections on Leishmania Tropica, Extracellular Vesicles in Host-Parasite Interaction, Cathepsins and Vaccines for Fascioliosis, Echinococcosis Transmission on the Tibetan Plateau, A Review of Diagnostics for STH from a Public Health Perspective, and Zoonotic Transmission of Intestinal Parasites: Implications for Control and Elimination.

Three members of the genus Yersinia are important human pathogens, causing diseases ranging from the deadly plague to relatively mild gastroenteritis. In this book, leading Yersinia researchers review the hot topics in the systems biology and control of these important bacteria.

A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.

Organ-Specific Parasitic Diseases of Dogs and Cats takes an organ-specific approach to the impact of parasitic diseases in dogs and cats. Coverage includes detailed descriptions on the key role parasites play in the pathogenesis of diseases, the manifestation of symptoms and diagnosis, and prevention and treatment strategies to counteract parasitic infections. The book provides an overview on the diagnostic evaluation of parasitic diseases, also including sections that cover parasite control, travel management, therapeutic measures and disease control strategies. With contributions from experts in the field, this book serves as a useful resource to researchers, academics and postgraduates.

COVID-19 in Alzheimer's Disease and Dementia crucially summarizes the current status of the coronavirus in patients suffering from these conditions, describing why they are a common cause of morbidity. Chapters provide a general description of COVID-19, including SARS-CoV-2 structure, function and biology and its impact on the elderly with chronic conditions, including hypertension, diabetes, obesity, kidney disease, respiratory illnesses and infectious diseases. Also discussed are the effects of the virus on the immune system. Other sections shift to the impact of COVID-19 on those with dementia or Alzheimer's disease, with special emphasis on age, gender, ethnic background and lifestyle. Bringing this focus on neurodegenerative disease in one comprehensive resource, this volume is an essential reference for neuroscientists, clinicians, biomedical scientists and all others working or interested in the field.

Three times in the last century, influenza viruses have undergone major genetic changes resulting in global pandemics that had devastating effects. The most infamous pandemic was the "Spanish Flu" which affected up to 25% of the world population and is thought to have killed at least 40 million people. In 1997 and 2003, a new influenza A virus of H5N1 subtype emerged in Asia and was transmitted directly from birds to humans with lethal outcomes. Despite monumental efforts to contain them, the H5N1 viruses expanded their territory and caused a major outbreak in wild waterfowl in China in 2005. Despite extensive, coordinated efforts by various agencies and disciplines, both national and international, we are ill-equipped for a new influenza pandemic. In fact, it is highly unlikely that adequate supplies of vaccine for the H5N1 viruses will be prepared prior to the occurrence of the next pandemic. To combat the outbreaks that will undoubtedly occur in the near future, a better understandi