Advances in Parasitology, Volume 111, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. Chapters in this update include Taking the strain out of onchocerciasis: a reanalysis of blindness and transmission data does not support the existence of a savanna blinding strain of onchocerciasis in West Africa, Enterocytozoon bieneusi of animals, Taenia solium taeniasis/cysticercosis, Genomic analysis reveals predominant clonality and progressive evolution at all evolutionary scales in eukaryotic pathogens, HTLV-I and Strongyloides: the worm lurking beneath, and more.

Microbial physiology, biochemistry and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms. In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book. Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation. The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12. The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

The complement system is a group of proteins which plays a major role in the processing and removal of microorganisms and tissue breakdown products from the circulation and extracellular spaces. The system is activated by a wide range of targets, and activation leads to the production of opsonins, chemotaxis of granulocytes, cell lysis and other biological activities. Inappropriate overactivation of the system contributes to inflammatory tissue damage in the host, while inadequate activation leads to accumulation of immune complexes and other debris in the circulation, and susceptibility to infection. The biology and biochemistry of the system is now adequately understood, and attempts can be made to manipulate the activation and activities of the system for potential therapeutic purposes. The reviews in this volume summarise what is known of the ways in which the complement system can be activated, by interaction with antibodies, microorganisms, cell debris, and complex carbohydrates and how the activities and activation of the system have been modified, accidentally or by design, in vitro or in vivo by drugs, venoms, particulate carbohydrates, specific antibodies, synthetic peptides and other reagents.

HPV Gene Expression: The Antibody Response Against p53 in Cancer Patients (G. Matlashewski). Enhanced Production of WildType p53 Inhibits Growth and Differentiation of Normal Foreskin Epithelial Cells but not Cell Lines Containing Human Papillomavirus DNA (C.D. Woodworth et al.). Humoral Responses to HPV: Humoral Immune Response to Genital Human Papillomavirus Infections (L. Gissman). HPV 16 Antibodies in Cervical Cancer Patients and Healthy Control Women (V. Vonka et al.). Cell Mediated Immunity to HPV: Evolution of Class I HLA Antigen Presenting Molecules (P. Parham). Major Histocompatibility Complex Expression and Antigen Presentation in Cervical Cancer (J.S. Bartholomew et al.). Animal Models and Therapeutic Strategies: Skin Test Reactivity to Papilloma Cells Is Long Lasting in Domestic Rabbits After Regression of Cottontail Rabbit PapillomavirusInduced Papillomas (R.M. Hoepfl et al.). 42 additional articles. Index.

Hepatitis C is a liver disease caused by the hepatitis C virus (HCV) and infects approximately 75 million individuals worldwide. It is also one of the major causes of liver cancer and liver transplants. The elucidation of the HCV genome, and the development of a whole cell system to study the virus spurred the search for novel direct acting antiviral drugs to cure this disease. This global effort culminated in the development of direct acting antiviral drugs that led to cure rates approaching 100% in all patient populations after only 8-12 weeks of therapy. These efforts resulted in one of the greatest achievements in public health and provides the potential for eliminating HCV as a major disease worldwide. This volume is aimed at a broad audience of academic and industrial scientists interested in the discovery and development of drugs to treat viral diseases and those interested in reading about one of the most unique accomplishments in biomedical research. The volume will provide a one of a kind reference work that highlights the many efforts, from the discovery of the HCV virus, to the invention of breakthrough medicines and their use in the real world to cure patients. It is the companion book to the volume "HCV: The Journey from Discovery to a Cure - Volume I".

This book discusses recent developments in several laboratories studying leishmaniasis. Sequencing of the human genome, as well as of the leishmania genome, has led to significant advances in our understanding of host-immune responses against leishmania, and mechanisms of infection-induced pathology, which is responsible for morbidity and mortality. Pathogenesis of Leishmaniasis focuses on the latest basic research into leishmaniasis, but also addresses how advances in understanding can be applied to prevention, control and treatment of what the WHO has classified a neglected tropical disease.

The book is an update on contentious or unsettled issues concerning invasive diagnostic and therapeutic challenges in cancer and related disorders, focusing on the surgical approach. Topics include recommendations for the best practice in using the surgery safety checklist, surgical strategies in a variety of thoracic cancers, renal cell carcinoma, tumors of parathyroid glands, mesothelioma, and bariatric surgeries. The focus is on the diagnostic and therapeutic challenges of aggressive cancerous entities, choosing the most beneficial modes for optimal outcomes and patient survival. Chapters also address radioimaging and therapy outcomes in different intracranial lesions leading to severe neurological disabilities. The areas of medical practice addressed are still veiled in uncertainty, yet-unresolved pathogenetic background, and have a substantial component of empirical rather than evidence-based clinical approach. Pursuing and sharing new ideas and innovations is essential for improving the management and outcome. The book endeavors to disseminate and deliberate on the latest medical knowledge, studies, and advancements in surgical and diagnostic dealing with cancer. The book is addressed to physicians and surgeons, and all allied health care professionals engaged in patient care and therapy.

Readable, well-illustrated, and concise, Robbins and Kumar's Basic Pathology, 11th Edition, offers today's busy students a rich understanding of all essential pathology concepts from trusted names in the field. This updated edition thoroughly covers key pathologic processes and the time-honored tools of gross and microscopic analysis, while also retaining a strong emphasis on clinicopathologic correlations and the impact of molecular pathology on the practice of medicine. Outstanding artwork and schematic drawings, as well as a robust eBook experience with extensive additional features, make complex concepts easier to learn and retain. Includes fully updated clinical topics throughout. Features high-quality photomicrographs, gross photos, and radiologic images, as well as new artwork and over 150 new schematic diagrams that help summarize key or complex disease mechanisms. Contains a new Rapid Review section that uses bulleted summary boxes to deliver essential take-home messages and help you focus on the fundamentals. Includes tables of relevant laboratory tests for each chapter that link pathophysiology of disease and diagnostic testing. Highlights pathogenesis, morphology, and pathophysiologic content throughout. Features increased representation of diverse populations throughout the text, including clinical photographs of skin lesions in multiple skin types and a new section on the role of socially defined race in health disparities. An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud-as well as access bonus content, including case studies, additional gross and microscopic figures, and more.

Darwinian medicine looks at the ecological and evolutionary roots of disease. A disease is an interaction between a genome and its biotic or abiotic environment and therefore a disease is essentially an ecological process. Good understanding of ecology and a Darwinian way of thinking can give us novel and useful perspectives on health and disease. If we understand the disease process better, we can certainly prevent, control as well as treat diseases in a better way. Although the thought that the origins of obesity and type 2 diabetes (T2D) might lie in our hunter gatherer adaptations is not new, research over the last decade makes us rethink many of the classical concepts. Brain and behavior is increasingly being recognized as central to all the endocrine, metabolic and immunological changes that earmark type 2 diabetes and other metabolic syndrome disorders. A major change in paradigm appears to be on the horizon and the proposed book intends to speed up the paradigm shift by raising important questions, pointing out flaws and inadequacies in the prevalent paradigm and stimulating radical rethinking which would redirect and refine the line of research as well as bring some fundamental changes in drug discovery and clinical practice.

This book provides an integrated review of the human ocular microbiome. It documents the discovery of ocular surface microbes by the conventional cultivable method and next generation sequencing technologies in both healthy and diseased (keratitis, uveitis, endophthalmitis, blepharitis, conjunctivitis etc.) eyes. The book further discusses the confounding factors that influence the microbiome, mycobiome and virome. The chapters cover niche-specificity with reference to skin, eyelid- margin, hands etc. It highlights the concept of core genera, dysbiosis and discriminating genera and covers the functional relevance of the dysbiotic microbiome, mycobiome and virome with respect to ocular diseases. The book includes topics on the relevance of molecular mechanisms, including quorum-sensing and mucin metabolism to ocular disorders, such as dry eye; and, microbiome-based therapies for treating of ocular disorders like vernal keratoconjunctivitis. The book is essential for microbiologists studying the human eye, ophthalmologists treating eye infection and trauma. It also caters to students of medical microbiology and medicine.

This essential volume explores a variety of tools and protocols of structure-based (homology modeling, molecular docking, molecular dynamics, protein-protein interaction network) and ligand-based (pharmacophore mapping, quantitative structure-activity relationships or QSARs) drug design for ranking and prioritization of candidate molecules in search of effective treatment strategy against coronaviruses. Beginning with an introductory section that discusses coronavirus interactions with humanity and COVID-19 in particular, the book then continues with sections on tools and methodologies, literature reports and case studies, as well as online tools and databases that can be used for computational anti-coronavirus drug research. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical detail and implementation advice that ensures high quality results in the lab. Comprehensive and timely, In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols is an ideal reference for researchers working on the development of novel anti-coronavirus drugs for SARS-CoV-2 and for coronaviruses that will likely appear in the future.

This book reviews new promising drug targets for Neglected Tropical Diseases (NTDs), with a special focus on antiprotozoal drugs against trpyanosomatids Trypanosoma cruzi and Leishmania spp. The book offers a comprehensive overview of the most recent studied targets, and it outlines classical and new treatments and delivery strategies. Expert contributors describe new methods of analysis and bio-prospecting for new compounds, and provide a critical perspective of the translational process used in the research and development of new drug candidates. The book will appeal not only to researchers, students and professionals interested in drug development to protozoan diseases, but also to medicinal chemists in general.

It goes almost without saying that there has been a marked increase in the incidence of sexually transmitted diseases throughout the world in the past two to three decades. Indeed, despite the progress that has been made in methods of diagnosis and treatment, the sexually transmitted diseases as a whole are the most common communicable diseases and as such constitute an important health problem. The increase in incidence may be accounted for by changes in sexual behaviour, the introduction of contraceptives and the increasing mobility of the population. In addition, during the same time period, the number of infectious agents recognized as being sexually transmitted has increased considerably. These include Chlamydia trachomatis, herpes simplex virus, cytomegalovirus and hepatitis B virus. Indeed, some are as dependent on sexual transmission as the agents which cause the traditional venereal diseases and collectively they cause morbidity which has out-stripped that caused by gonorrhoea and syphilis. It could almost be said that to know the sexually transmitted diseases is to know micro biology. However, the approach taken in this book has not been to consider individual infectious agents and evaluate what they do and do not cause but to consider clinical conditions and what might be responsible for them. To cover the complete spectrum of the sexually transmitted diseases in a comprehensive way now takes a text book of massive proportion."

This multidisciplinary book discusses the manifold challenges arctic marine and terrestrial wildlife, ecosystems and people face these times. Major health threats caused by the consequences of climate change, environmental pollution and increasing tourism in northern regions around the globe are explored. The most common infectious diseases in wild and domesticated arctic animals are reviewed and the impact they could have on circumpolar ecosystems as well as on the lives of arctic people are profoundly discussed. Moreover, the book reviews arctic hunting, herding and food conservation strategies and introduces veterinary medicine in remote indigenous communities. "Arctic One Health" is authored by experts based in arctic regions spanning from North America over Europe to Asia to cover a broad range of topics and perspectives. The book addresses researchers in Veterinary Medicine, Ecology, Microbiology and Anthropology. The book contributes towards achieving the UN Sustainable Developmental Goals, in particular SDG 15, Life on Land.

Expert authors from around the world comprehensively review the current advances in plasmodium comparative genomics, highlighting the fascinating new insights into parasite evolution and molecular biology that have ensued.

Die Vitalhistologie ermAglicht die zunehmend exaktere Differenzierung onkologisch relevanter Hauttumore, sowie das Erkennen zahlreicher, mit dem bloAen Auge nicht beurteilbarer Dermatosen. In der Auflichtebene sichtbare Farb- und Strukturmerkmale kAnnen dabei ohne Excision oder FArbung entsprechend dem schnitthistologischen Pendant vitalhistologisch interpretiert und diagnostiziert werden. KostengA1/4nstige und leicht bedienbare computergesteuerte Foto- und VideogerAte ermAglichen heute den breiten Einsatz dieses Verfahrens in der Praxisroutine. Das Buch bietet in knapper und A1/4bersichtlicher Form eine systematische Darstellung der Untersuchungsmethoden sowie der allgemeinen und onkologisch relevanten Differenzierungskriterien der Vitalhistologie, illustriert durch zahlreiche hochwertige Abbildungen. ErgAnzt wird das Werk durch einen kosmetologischen Basisteil.

The alpha herpesviruses are an important group of viruses characterized by a short reproductive cycle, rapid destruction of the host cell, and the ability to replicate in a wide variety of host tissues. A key attribute of these viruses is the ability to establish lifelong latent infection in the peripheral nervous system of the natural host. Research into the molecular and cellular biology of the alpha herpesviruses has advanced greatly in recent years. Written by internationally recognized experts, this book highlights the more provocative and exciting findings in herpesvirus research. Each chapter is a review of a specific area with an emphasis on recent advances and the latest developments. The book examines multifunctional proteins, advances in DNA replication, new information on the regulation of gene expression, the emergence of new technologies, recent technological advances in fluorescent probes, the induction of apoptosis, the disruption of interferon, vaccine development, and

This volume reviews the unique and common features of rhabdoviruses, which have a very wide host range and are associated with human diseases and also infect domestic livestock and agricultural plants, causing enormous economic loss.

Since President John F. Kennedy's 1963 murder in Dallas, medical examiner and lawyer Dr. Cyril Wecht was initially inclined to accept the official theory that one person alone was responsible for the crime. But as Wecht delved into the evidence with boundless curiosity and unprecedented access, he came to understand that America had, instead, suffered a coup d'etat at the hands of rogue elements within our own government. Nobody else has Wecht's up-close and personal experience in uncovering the facts behind this assassination-and now he is sharing it with the world. Co-authored by investigative journalist Dawna Kaufmann, this comprehensive book reveals Wecht's analyses of the case's forensic and medical evidence. With his keen eye and sharp tongue, Wecht wields his scalpel on JFK's dubious autopsy report, the inept Warren Commission Report, the mishandling of crucial materials, all of the key players, and the media malpractice that has allowed the truth to remain hidden for nearly six decades.

Paris is a cosmopolitan city where roaring life, wonderful museums and excellent science can be found. It was during the XI IUMS conference held in this city that the Pseudomonas book series was ?rst envisaged. On the ?rst row of the auditorium sat a group of outstanding scientists in the ?eld, who after devoting much of their valuable time, contributed in an exceptional manner to the ?rst three volumes of the series, which saw the light simultaneously. The volumes were grouped under the generic titles of "Vol. I. Pseudomonas: Genomics, Life Style and Molecular Architecture", Vol. II. Pseudomonas: Virulence and gene regulation; Vol. III. Pseudomonas: Biosynthesis of Macromolecules and Molecular Metabolism. Soon after the completion of the ?rst three volumes, a rapid search for ar- cles containing the word Pseudomonas in the title in the last 10 years produced over 6,000 articles! Consequently, not all possible topics relevant to this genus were covered in the three ?rst volumes. Since then two other volumes were p- lished: Pseudomonas volume IV edited by Roger Levesque and Juan L. Ramos that came to being with the intention of collecting some of the most relevant emerging new issues that had not been dealt with in the three previous volumes. This v- ume was arranged after the Pseudomonas meeting organized by Roger Levesque in Quebec (Canada). It dealt with various topics grouped under a common heading: "Pseudomonas: Molecular Biology of Emerging Issues".

About 7 million people worldwide are suffering from various inherited neuromuscular diseases. Gene therapy brings the hope of treating these diseases at their genetic roots. Muscle Gene Therapy is the only book dedicated to this topic. The first edition was published in 2010 when the field was just about to enter its prime time. The progress made since then has been unprecedented. The number of diseases that have been targeted by gene therapy has increased tremendously. The gene therapy toolbox is expanded greatly with many creative novel strategies (such as genome editing and therapy with disease-modifying genes). Most importantly, clinical benefits have begun to emerge in human patients. To reflect rapid advances in the field, we have compiled the second edition of Muscle Gene Therapy with contributions from experts that have conducted gene therapy studies either in animal models and/or in human patients. The new edition offers a much needed, up-to-date overview and perspective on the foundation and current status of neuromuscular disease gene therapy. It provides a framework to the development and regulatory approval of muscle gene therapy drugs in the upcoming years. This book is a must-have for anyone who is interested in neuromuscular disease gene therapy including those in the research arena (established investigators and trainees in the fields of clinical practice, veterinary medicine and basic biomedical sciences), funding and regulatory agencies, and patient community.

This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes - such as oncogenes, proto-oncogenes, or tumor suppressor genes - in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.