This book provides an in-depth description and discussion of different multi-modal diagnostic techniques for cancer detection and treatment using exact optical methods, their comparison, and combination. Coverage includes detailed descriptions of modern state of design for novel methods of optical non-invasive cancer diagnostics; multi-modal methods for earlier cancer diagnostic enhancing the probability of effective cancer treatment; modern clinical trials with novel methods of clinical cancer diagnostics; medical and technical aspects of clinical cancer diagnostics, and long-term monitoring. Biomedical engineers, cancer researchers, and scientists will find the book to be an invaluable resource. Introduces optical imaging strategies; Focuses on multimodal optical diagnostics as a fundamental approach; Discusses novel methods of optical non-invasive cancer diagnostics.

This book describes and illustrates an approach to surgery for spinal cord tumors that is based on a refined concept of anatomic compartmentalization. The aim of this approach is to enable maximum preservation of spinal cord function through confinement of the surgical work to the involved compartment or compartments. Importantly, this involvement differs according to tumor type, and the classification favored by the author takes this fully into account. After introductory chapters on epidemiology and pathology, the anatomy of the spinal cord relevant to surgery for spinal cord tumors is discussed in detail and the proposed classification is clearly explained. The surgical approach to each of the identified anatomic compartments is then described, with attention to the roles of intraoperative mapping techniques, diffusion tensor imaging, and electrophysiologic studies in ensuring that spinal cord functions are spared. Examples of the author's experience when applying the proposed approach are presented. The book is meant for neurosurgeons at all levels of experience.

Pregnancy is a critical time for the health of the mother and the fetus, with important potential risks for both. Tools for antenatal diagnosis and pregnancy monitoring can support prevention and management of potential risks and complications. In particular, the perinatal period, spanning from the third trimester of pregnancy up to one month after birth, is the most critical for the baby. For this reason, in the last decades, biomedical engineering supported and fostered the scientific research towards the identification of new models, parameters, algorithms, and tools that can improve the quality of fetal monitoring, predict the outcomes and allow physicians to intervene in an appropriate manner to ensure a healthy future for the baby. This book follows the First International Summer School on Technologies and Signal Processing in Perinatal Medicine and reflects some of its most important master lectures. It represents a valuable guide for students and young researchers approaching this topic for the first time, as well as experienced researchers and practitioners looking for a clear representation of the themes and techniques presented by recognized experts in the field. Presents current and innovative technologies for fetal and neonatal monitoring Emphasis on both technology/signal processing and clinical aspects Offers a clear didactic approach to the subject matter

This superbly illustrated atlas serves as a basic introduction to contrast-enhanced mammography (CEM), a breakthrough functional breast imaging modality, which is rapidly growing. This book is an essential guide for the latest developments with correlative findings, practical interpretation tips, physics, and information on how contrast mammography differs from conventional 2D and 3D Full Field of View digital mammography (FFDM). It includes: * over 1000 high-quality 2D, 3D and recombined contrast mammography images representing the spectrum of breast imaging * findings obtained in the full range of benign, pre-malignant and malignant conditions, including artefacts and postoperative changes, presented with high-quality illustrations from case examples * image interpretation tips using mammographic and DCE-MRI descriptors of the BI-RADS lexicon to effectively read and interpret this advanced imaging modality * practical tips to interpret this new modality and how it is used as an adjunct to 2D mammography * details on how integration of contrast-enhanced mammography drastically changes lesion work-up and overall workflow in the department * "imaging pearls" boxes offering interpretation tips for expert clinical guidance * a case on the recently introduced CEM guided biopsy procedure The book's target audience consists of diagnostic radiologists, residents, fellows, technologists and clinicians involved in the care of breast cancer patients, including surgeons and oncologists. The goal is to provide a concise introduction to CEM and to lead to enhanced interpretation and better patient staging prior to surgery.

This is the second of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this second volume, readers will find comprehensive description and illustration of the imaging appearances of tumoral pathologies, both in the "normal liver" and in the context of chronic liver disease and liver cirrhosis. In addition, the imaging findings in relation to different treatment approaches are presented, with extensive coverage of imaging of tumor response and post-treatment changes. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

This book provides an up-to-date overview of gastrointestinal malignancies, including prevention, early detection, intervention, and life-extending therapeutics. It also assesses various biomarkers used for diagnostics, prognostics and prediction of response to chemoresistance. Further, it discusses the latest trends in the use of small-molecule targeted therapies and immunotherapies as single agents or combination with other treatments. Since resistance to radiation and chemotherapy contribute to the high recurrence and poor survival rates, improving the outcome for GI malignancies is dependent on the introduction of new biomarkers and therapeutic agents. Lastly, the book systematically investigates novel theranostics approaches using nanotechnology for the detection, diagnosis, and personalized treatment of GI malignancies.

This is the first of two volumes that together provide a comprehensive analysis of the embryology, normal anatomy, and pathology of the liver and intrahepatic biliary tract as seen on modern diagnostic imaging techniques. In this volume, readers will find fundamental information on embryology, radiological anatomy, and anatomic variants. A thorough introduction is then provided to each imaging technique, including ultrasound, computed tomography, magnetic resonance imaging, nuclear medicine techniques, angiography, and interventional radiology. The remainder of the volume is devoted to non-tumoral pathology of the liver and intra-hepatic biliary tract. For each disease, readers will find full description of the roles of individual imaging modalities and extensive illustration of the imaging appearances. The authors are world-leading experts in the field, and the book will be an ideal reference for all members of the radiology community, from residents to experts. It will also aid clinicians during their daily practice.

This book comprises select peer-reviewed papers presented at the International Conference on Biomedical Engineering Science and Technology: Roadway from Laboratory to Market (ICBEST 2018) organized by Department of Biomedical Engineering, National Institute of Technology Raipur, Chhattisgarh, India. The book covers latest research in a wide range of biomedical technologies ranging from biomechanics, biomaterials, biomedical instrumentation to tele-medicine, internet of things, bioinformatics, medical signal and image processing. The contents aim to bridge the gap between laboratory research and feasible market products by identifying potential technologies to enhance functionalities of diagnostic and therapeutic devices. The book will be of use to researchers, biomedical engineers, as well as medical practitioners.

This book explains transparency in biology with emphasis on bending and absorption, which together are the essence of transparency. The reader is provided with an understanding of why the interior of the body can be made to appear transparent through the application of elementary physics. Based on the principle of transparency, emerging imaging techniques using near-infrared light to view the body transparently are explained with examples such as cancer detection and temperature imaging of deep tissues. This book is useful to many researchers, including biologists, physicists, chemists, materials scientists, and device engineers as well as developers-all who seek a deep understanding of transparency in bioimaging.

Variability in care in emergency surgery is well known, particularly in abdominal surgery, and reducing it is fundamental to improving outcomes. It is therefore vital to identify the factors that are key to improving mortality and reducing complications in various surgical emergencies. Under the leadership of the World Society of Emergency Surgery, over 200 leading experts in emergency surgery, critical care and surgical infections established a template to help define and optimise emergency surgery, particularly that relating to the abdomen. This book refines this initial work, crystallising it into a meaningful resource for practising surgeons and health care administrators alike, and paving the way for advances in emergency surgery around the globe. This book sets a benchmark for Emergency Surgery and is a must read for those wanting their patients to do better.

Aiming at building efficient radiology operations, this book walks the reader through the entire radiology workflow, from the moment that the examination is requested to the reporting of findings. Using their practical experience, the authors draw attention to the many elements that can go wrong at each step, and explain how critical analysis and objective metrics can be used to fix broken processes. Readers will learn how to measure the efficiency of their workflows, where to find relevant data, and how to use it in the most productive ways. The book also addresses how data can be turned into insightful operational information to produce organizational change. All aspects of radiology operations are considered including ordering, scheduling, protocols, checking-in, image acquisition, image interpretation, communication, and billing. The closing section provides a deeper dive into the advanced tools and techniques that are used to analyze operations, including queuing theory, process mining and artificial intelligence.

This book provides a thorough overview of the radiologic and pathologic findings of neoplastic diseases of the biliary tract, a sound knowledge of which is essential for appropriate patient management. A key feature is the correlation of imaging findings with both gross pathologic and histopathologic findings for each disease. This is of the utmost importance in understanding true pathologic abnormalities, bearing in mind, for example, the difficulty in ascertaining disease spread and extent on the basis of pathology alone. Since the first edition of the book, conceptual understanding of neoplastic disease of the bile ducts and cholangiocarcinogenesis has evolved significantly, and in the new edition the classification of diseases is based on the most recent edition of the WHO Classification of Tumors of the Digestive System. In addition, some newly recognized pathologies are covered. The book will enhance understanding of the pathology of neoplastic diseases of the biliary tract and aid imaging interpretation. It will be a great asset for pathologists, radiologists, biliary surgeons, and gastroenterologists.

This book, written by renowned experts from across the world, provides readers with a detailed and up-to-date understanding of posterior circulation stroke and its management. Anatomy, pathophysiology, clinical syndromes, and imaging findings are clearly and thoroughly described with the aid of illustrative cases and schematic drawings. The management-oriented chapters explain all forms of treatment, including the use of antiplatelet agents and anticoagulants, thrombolysis, mechanical thrombectomy, stenting, and surgical therapy, i.e., bypass and decompression. Throughout, full account is taken of recent significant advances in knowledge and clinical practice. Stroke affecting the posterior circulation continues to pose particular challenges for clinicians. This book will help readers to avoid misdiagnosis, which still occurs far too frequently, and to manage individual patients optimally. It will be an excellent learning resource for residents in neurology, neurosurgery, radiology, interventional radiology, and vascular surgery, as well as an ideal reference for more experienced practitioners in these specialties.

This revision aid is of great practical benefit to all radiology trainees studying for their professional examinations. The carefully structured questions and answers enable trainees to undertake a systematic assessment of their knowledge; they also highlight areas where additional study is required. It is developed to complement its highly illustrated parent text, Applied Radiological Anatomy (Cambridge, 1999); but both books can be used together or independently of one another. The questions posed within are relevant and useful for radiology trainees worldwide.

This book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience. The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain's microanatomy and physiology.

This third edition overviews the essential contemporary topics of neuroengineering, from basic principles to the state-of-the-art, and is written by leading scholars in the field. The book covers neural bioelectrical measurements and sensors, EEG signal processing, brain-computer interfaces, implantable and transcranial neuromodulation, peripheral neural interfacing, neuroimaging, neural modelling, neural circuits and system identification, retinal bioengineering and prosthetics, and neural tissue engineering. Each chapter is followed by homework questions intended for classroom use. This is an ideal textbook for students at the graduate and advanced undergraduate level as well as academics, biomedical engineers, neuroscientists, neurophysiologists, and industry professionals seeking to learn the latest developments in this emerging field.Advance Praise for Neural Engineering, 3rd Edition: "A comprehensive and timely contribution to the ever growing field of neural engineering. Bin He's edited volume provides chapters that cover both the fundamentals and state-of-the-art developments by the world's leading neural engineers." Dr. Paul Sajda, Department of Biomedical Engineering, Electrical Engineering and Radiology, Columbia University "Neural Engineering, edited by Prof. He, is an outstanding book for students entering into this fast evolving field as well as experienced researchers. Its didactic and comprehensive style, with each chapter authored by leading scientific authorities, provides the ultimate reference for the field." Dr. Dario Farina, Department of Bioengineering, Imperial College London, London, UK "Neural Engineering has come of age. Major advances have made possible prosthesis for the blind, mind control for quadraplegics and direct intervention to control seizures in epilepsy patients. Neural Engineering brings together reviews by leading researchers in this flourishing field. Dr. Terrence Sejnowski, Salk Institute for Biolgical Studies and UC San Diego

Computational Biomechanics for Medicine: Solid and fluid mechanics for the benefit of patients contributions and papers from the MICCAI Computational Biomechanics for Medicine Workshop help in conjunction with Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2019) in Shenzhen, China. The content is dedicated to research in the field of methods and applications of computational biomechanics to medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, analysis of injury mechanisms, implant and prostheses design, as well as artificial organ design and medical robotics. These proceedings appeal to researchers, students and professionals in the field.

Dieses Buch bietet strukturierte und aktuellste Informationen zu allen Routineanwendungen der Mehrschicht- (Multidetektor-) Computertomographie, auch der neuesten Gerategeneration (Dual-Slice bzw. Dual-Layer).

Es enthalt ausfuhrliche Kapitel zum technischen Hintergrund und behandelt systematisch alle wichtigen Organsysteme: Herz, Kopf und Hals, Thorax und Abdomen mit parenchymalen Organen und Gastrointestinaltrakt.

Jedes Protokoll wird tabellarisch prasentiert; dies ermoglicht dem Benutzer einen schnellen Uberblick uber die gewunschten Anwendungen und die notwendigen Einstellungen des CT-Gerats.

Alle Beitrage sind verfasst von anerkannten Experten auf dem Gebiet der CT, die nicht nur ihre reiche klinische Erfahrung in jedem Anwendungsgebiet einbringen, sondern auch Anleitungen fur Indikationen, Arbeitsablauf, Nachbearbeitung und Rekonstruktionsalgorithmen erarbeitet haben."

This book presents the main cardiac pathologies, providing a helpful guide featuring clinical cases and electronic supplementary material. There are several systematic books on cardiac magnetic resonance, which approach the different pathologies and related pathophysiology in a general manner, and these are useful for readers at an early stage in their medical careers. However, when it comes to individual patients (during the acquisition of images and reporting activities) there is no book providing operative protocols or systematic descriptions of details to look for. In the eight chapters (Cardiomyopathies, Myocarditis, Ischemic Heart Disease, Valvular Heart Diseases, Cardiac Masses, Pericardial Diseases, Congenital Heart Disease, and Miscellanea), the individual pathology is illustrated with a clinical case. The cases are divided into four sections: An introduction with a short medical history and the purpose of the diagnostic CMR A detailed CMR acquisition protocol CMR images, indicating purpose, method, analysis and meaning of the image, as well as videos. Concluding paragraph with the final diagnosis reached on the basis of the findings obtained in each image This book, collecting one hundred one clinical cases covering a broad spectrum of cardiac diseases, is an invaluable tool for radiologists and cardiologists.

This book critically assesses the current state of knowledge on new and important detection technologies, e.g. mass spectrometry, tandem mass spectrometry, biosensor detection and tissue imaging, in connection with toxic chemical and biological agents. In general, the main topics discussed concern the risks and consequences of chemical and biological agents for human health in general, with special emphasis on all biochemical and metabolic pathways including the reproductive system. The exposome, genetic risks and the environment, various health hazard agents, risk assessment, environmental assessment and preparedness, and analysis of sub-lethal effects at the molecular level are also discussed. In closing, the book provides comprehensive information on the diagnosis of exposure, and on health concerns related to toxic chemical and biological agents.

This book fills the gap between the increasing demand for epilepsy surgical experience and limited training facilities in this area. It comprehensively describes surgical techniques, including tricks and pitfalls, based on the author's 30 years of experience, providing optimal and effective training for young neurosurgeons by avoiding learning by trial and error. Moreover, it also includes useful information for epileptologists and other professionals involved in the epilepsy surgical program to allow them to gain a better understanding of possibilities and limitations of epilepsy surgery.

This book summarizes the branch tracing method for bronchoscopic diagnosis. Cytopathological and histopathological diagnoses are essential to making prognoses and selecting appropriate treatment for peripheral pulmonary lesions, notably lung cancer. In order to collect cell and tissue samples from peripheral pulmonary lesions for cytopathological and histopathological diagnoses, exfoliative cytodiagnosis and biopsy under bronchoscopy with endobronchial ultrasonography (EBUS) are currently used worldwide. Bronchial Branch Tracing highlights how to identify the bronchial branches that lead to peripheral pulmonary lesions and offers a valuable guide for all respiratory physicians, as well as surgeons, who frequently perform bronchoscopies, helping them understand the method and improve their technique.

This book covers virtually all aspects of image formation in medical imaging, including systems based on ionizing radiation (x-rays, gamma rays) and non-ionizing techniques (ultrasound, optical, thermal, magnetic resonance, and magnetic particle imaging) alike. In addition, it discusses the development and application of computer-aided detection and diagnosis (CAD) systems in medical imaging. Given its coverage, the book provides both a forum and valuable resource for researchers involved in image formation, experimental methods, image performance, segmentation, pattern recognition, feature extraction, classifier design, machine learning / deep learning, radiomics, CAD workstation design, human-computer interaction, databases, and performance evaluation.

Embodying the principle of 'everything you need but still easy to read', this fully updated edition of Core Radiology is an indispensable aid for learning the fundamentals of radiology and preparing for the American Board of Radiology Core exam. Containing over 2,100 clinical radiological images with full explanatory captions and color-coded annotations, streamlined formatting ensures readers can follow discussion points effortlessly. Bullet pointed text concentrates on essential concepts, with text boxes, tables and over 400 color illustrations supporting readers' understanding of complex anatomic topics. Real-world examples are presented for the readers, encompassing the vast majority of entitles likely encountered in board exams and clinical practice. Divided into two volumes, this edition is more manageable whilst remaining comprehensive in its coverage of topics, including expanded pediatric cardiac surgery descriptions, updated brain tumor classifications, and non-invasive vascular imaging. Highly accessible and informative, this is the go-to introductory textbook for radiology residents worldwide.

This book provides a concise overview of emerging technologies in the field of modern neuroimaging. Fundamental principles of the main imaging modalities are described as well as advanced imaging techniqes including diffusion weighted imaging, perfusion imaging, arterial spin labeling, diffusion tensor imaging, intravoxel incoherent motion, MR spectroscopy, functional MRI, and artificial intelligence. The physical concepts underlying each imaging technique are carefully and clearly explained in a way suited to a medical audience without prior technical knowledge. In addition, the clinical applications of the various techniques are described with the aid of illustrative clinical examples. Helpful background information is also presented on the core principles of MRI and the evolution of neuroimaging, and important references to current medical research are highlighted. The book will meet the needs of a range of non-technological professionals with an interest in advanced neuroimaging, including radiology researchers and clinicians in the fields of neurology, neurosurgery, and psychiatry.