THE SUNDAY TIMES BESTSELLER, now with an extra chapter. 'All I ever wanted was to be a mum - I couldn't wait and it felt as though my time was so close. But the months started to tick by, with each one ending in disappointment and frustration. And then the inevitable panic started to set in ...' Having been told by doctors that, due to Izzy's polycystic ovarian syndrome, they would have difficulty conceiving - and after two years of trying - Izzy and her husband, Harry, turned to IVF. Izzy's aim is to break through some of the taboos surrounding miscarriage, IVF and fertility issues. This brutally honest and deeply personal account acknowledges the struggles that many couples go through but will ultimately focus on the positive, life-changing results that IVF can yield. Izzy hopes that this book will be a companion to those going through similar challenges to those she has experienced. As she herself says, 'No couple should have to go through it alone and in silence.'

Part of the recognised Infertility Management Series, this handbook is a complete guide to basic laboratory procedures in assisted reproductive technology (ART). The book guides clinicians step by step through the processes, beginning with discussion on semen analysis, cryopreservation of semen samples, and semen selection, to embryo culture, selection and transfer, and oocyte and embryo vitrification. The final chapters cover time-lapse imaging - a new technology for embryo development, design and equipment for the laboratory, and future developments in ART laboratory procedures, including the development of gametes from stem cells. Compiled by a recognised team of editors and contributors, the text is enhanced by clinical photographs, illustrations and tables. Other titles in the series include: Investigating Infertility, Intrauterine Insemination, Practical Management of Male Infertility, Polycystic Ovarian Syndrome, Handbook of Ovarian Stimulation, and Abnormalities of the Pelvis. Key points Part of Infertility Management Series providing complete guide to basic laboratory procedures in ART Guides clinicians step by step through the various processes Highly illustrated with photographs, diagrams and tables Edited by recognised team of experts in reproductive medicine

Surrogacy is India's new form of outsourcing, as couples from all over the world hire Indian women to bear their children for a fraction of the cost of surrogacy elsewhere with little to no government oversight or regulation. In the first detailed ethnography of India's surrogacy industry, Amrita Pande visits clinics and hostels and speaks with surrogates and their families, clients, doctors, brokers, and hostel matrons in order to shed light on this burgeoning business and the experiences of the laborers within it. From recruitment to training to delivery, Pande's research focuses on how reproduction meets production in surrogacy and how this reflects characteristics of India's larger labor system.

Pande's interviews prove surrogates are more than victims of disciplinary power, and she examines the strategies they deploy to retain control over their bodies and reproductive futures. While some women are coerced into the business by their families, others negotiate with clients and their clinics to gain access to technologies and networks otherwise closed to them. As surrogates, the women Pande meets get to know and make the most of advanced medical discoveries. They traverse borders and straddle relationships that test the boundaries of race, class, religion, and nationality. Those who focus on the inherent inequalities of India's surrogacy industry believe the practice should be either banned or strictly regulated. Pande instead advocates for a better understanding of this complex labor market, envisioning an international model of fair-trade surrogacy founded on openness and transparency in all business, medical, and emotional exchanges.

El problema de la esterilidad e infertilidad en las parejas hoy dia esta poniendo en riesgo la capacidad de reemplazo generacional en Europa. Segun la Organizacion Mundial de la Salud (OMS), alrededor del 10 al 15% de las parejas en edad de procrear consultan al medico por problemas de esterilidad. El objetivo de este manual es actualizar los conocimientos y adiestrar en los procedimientos para evaluar la calidad del semen, ayudar al diagnostico de la subfertilidad y esterilidad de origen masculino. Va dirigido al personal en formacion y a profesionales del ambito sanitario, principalmente del laboratorio (tecnicos y facultativos) pero tambien a los clinicos prescriptores (urologos y ginecologos).

Est ce que l'avortement est un crime ou un droit? C'est peut etre la question que tu te poses et a la quelle tu n'as pas encore trouve de reponse. La lecture de cette brochure te donnera une idee Claire sur l'avortement de maniere a pouvoir repondre a cette question.

This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techniques, and molecular biology. Authors Richard Behringer, Marina Gertsenstein, Kristina Nagy, and Andras Nagy-pre-emininent leaders in their fields-have reorganized and updated this edition to include new information and protocols on: * assisted reproduction techniques for sperm and embryo cryopreservation * generation of induced pluripotent stem cells * isolation, generation, and transplantation of spermatogonial stem cell lines * in utero electroporation of gene constructs into post- implantation embryos * vibratome sectioning of live and fixed tissues for imaging thick tissue sections * whole-mount fluorescent staining methods for three-dimensional visualization. Techniques regarding recombinant DNA technology and mouse embryonic development from the previous editions have been updated and recast, as has the wealth of information on mouse laboratory strains, mouse housing and breeding, surgical procedures, assisted reproduction, handling of embryos, and micromanipulation setups. The first edition of Manipulating the Mouse Embryo appeared in 1986 as an outgrowth of Cold Spring Harbor Laboratory courses on the molecular embryology of the mouse held in the early 1980s, and authors of the first two editions included Brigid Hogan, Rosa Beddington, Frank Costantini, and Liz Lacy. Mouse embryo manipulation techniques have developed exponentially since the first edition, but then, as now, Manipulating the Mouse Embryo remains the essential practical and theoretical guide for anyone working with mice-students, lab technicians, and investigators.

The Year Book of Neonatal and Perinatal Medicine brings you abstracts of the articles that reported the year's breakthrough developments in neonatal and perinatal medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Chapters in this annual cover the most current information on all aspects of neonatal and perinatal medicine from genetics to labor and delivery to issues related to many key bodily systems (heart, respiratory, nervous system, etc.) of newborns. Other topics for 2004 include neurology, gastroenterology and nutrition, medical disorders of pregnancy, fetal evaluation, and neonatal behavior.

Assisted reproductive technology (ART) now accounts for 13% of all live births in the western world. Several procedures that may be used in the ART process are hormonal stimulation, egg retrieval, in vitro fertilisation (IVF), intra-cytoplasmic sperm injection, micro-manipulation of gametes; and exposure to culture medium. Although these techniques are considered safe, in recent years evidence has been accumulating that ART may be associated with an increased risk of birth defects, low birth weight, and genetic imprinting disorders. This book provides current research in reproductive technology with a focus on Down's Syndrome screening in assisted conception pregnancies; sexed semen technology in buffalo breeding and reproductive technologies; a nation-wide study of assisted reproductive technology and multiple births and accompanied birth defects; and assisted reproductive technologies and the risk for autism spectrum disorder.

Omdat mensen nietzelf kunnen kiezen volgens welk receptzijhun kinderwens vorm geven, is begnip en respect erg belangrijk. Dit boekje is een schitterend instrument om kinderen te introduceren in de complexe wereld van fertiliteitsbehandelingen. Het ontdoet de problematiek van de taboes waarmee fertilieteitsbehandelingen vaak nog zijn omgeven en helpt inzien dat het niet uitmaakt volgens welk recept je op de wereld gekomen bent. Kortom, een aanrader voor groot en klein"

It is estimated that more than 4.5 million couples experience infertility each year, and more than 4 million babies have been born using IVF since 1978. However, assisted reproductive technologies continue to raise many medical, social, ethical, political and religious questions, often leading to controversial and sometimes inaccurate opinions about the outcomes of pregnancies resulting from these techniques. This is the first book dedicated to pregnancies arising from assisted reproductive technologies (ART). Chapters cover the most important management issues, from early pregnancy to outcome of children resulting from ART, including gynaecological, genetic and obstetric complications. Each chapter is written and edited by leading experts in the field of human reproduction. A timely, practical and evidence-based guide to the management of ART pregnancies, based on 30 years of clinical experience, this is essential reading for reproductive and maternal-fetal specialists as well as general obstetricians and gynaecologists.

The fully revised and updated second edition of this practical handbook provides comprehensive coverage of all aspects of subfertility, including treatment and diagnosis. Each chapter is written by a recognized world expert in the field and, together, they aim to provide state of the art answers to all the problems of subfertility in a single volume. The introductory chapter provides a flow-chart approach to systematic diagnosis and treatment. Clearly written and easy to read, the subsequent chapters describe what questions to ask, how to investigate, and what each treatment requires. With an expanded international team of authors, this new edition also offers new chapters devoted to third party reproduction and in vitro maturation of oocytes. From medical students studying for examinations to consultant physicians, this volume is a 'must-have' reference for anyone dealing with couples who have fertility problems.

It is not okay to call something a miracle without even trying to understand it. This is human developmental biology (human embryology, in terms of cells and molecules) for everyone curious enough to see it through, from the perspective of the business of becoming human - as individuals and as species; making new humans; how it happens (cells do it, ALL of it); and common variations of the process.It cannot be made quite simple and be kept quite true, but we will move as far toward simple as we can without losing touch with sound evidence. Variations from the "normal" version of the process, particularly malformations and twinning and chimerism, figure prominently in the story because there is no better way to learn about the usual than to study the unusual and see what differences in the endings these observable differences at the beginnings can make.In this book, when technical terminology is the only way, or the best way, to say what needs to be said, it is defined and explained - making the words a worthwhile part of what is here to be learned.This book defines its own new field. We cannot claim to understand how anything [human] works [as human], with no effort at understanding the emergence of its form and functions. Old and new unanswered questions are waiting to be dug out from under old unquestioned answers about how becoming human unfolds. We will also address some popular and weighty, but deeply empty assertions about the circumstances and mechanisms of our beginnings and our ceaseless becoming. We will find fundamental questions from 'the humanities' unanswerable except from biology. Human developmental biology is a foundational discipline within the humanities.

The Fallopian tube has until recently been a neglected structure, bypassed by IVF and seen only as a tube that transports the egg to the uterus. More recently, its central role as the site of fertilization and early embryogenesis has been recognized, along with the major effects of tubal disease, such as chlamydia trachomatis, on fertility. Tubal surgery is an option for those women who avoid IVF because of anxiety about medication side-effects or for religious reasons. The tube is also the site for female sterilization and its reversal. This definitive guide to the Fallopian tube and its disorders collates all these topics, with authoritative text covering the spectrum of clinically relevant topics in a digestible fashion. It will be of interest to gynecologists, specialists in reproductive medicine and infertility and family planning, and others with interest in this fascinating and underestimated organ of reproduction.

Infertility is a major increasing concern. As the male factor contributes to about half of the infertility cases, sperm analysis is extremely important for diagnosis and investigation of infertility. In this book, the cytometric techniques used to evaluate sperm DNA/chromatin integrity together with some other functional properties of the male gamete are described and advantages and limitations are discussed. In addition, the authors provide an overview of how antioxidative and redox systems participate in spermatogenesis and in pathological conditions, such as heat stress, in the testes. Oxidative stress-induced damage to both oocytes in vivo and embryos in culture are also examined, as well as the role of ROS signalling in embryo development. Furthermore, endometriosis is an oestrogen-dependent disease which affects 6% to 30% of women in reproductive age and is associated with infertility in approximately 60% of cases. In this book, classic and recently proposed etiopathogenic mechanisms or endometriosis-related infertility are discussed, as well as some aspects of its clinical investigation and medical treatment. Other chapters in this book assess the capability of combining of Anti-Mullerian hormone (AMH) and embryo quality as predictors of pregnancy outcome and an examination of how the use of animal models can help us to understand the female reproductive system and the aetiology of some female infertile disorders.

How a health disaster helped give rise to the feminist health care movement

This book presents important and recent research on testosterone which is a steroid hormone from the androgen group. Testosterone is primarily secreted in the testes of males and the ovaries of females although small amounts are secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid. In both males and females, it plays key roles in health and well-being. Examples include enhanced libido, energy, immune function, and protection against osteoporosis. On average, the adult male body produces about twenty times the amount of testosterone that an adult female's body does.

Among the many applications of stem cell research are nervous system diseases, diabetes, heart disease, autoimmune diseases as well as Parkinson's disease, end-stage kidney disease, liver failure, cancer, spinal cord injury, multiple sclerosis, Parkinson's disease, and Alzheimer's disease. Stem cells are self-renewing, unspecialised cells that can give rise to multiple types all of specialised cells of the body. Stem cell research also involves complex ethical and legal considerations since they involve adult, foetal tissue and embryonic sources. This book brings together leading research from throughout the world with particular focus on stem cells and cancer research.

This title contains a book and CD. The brain has a number of nerve cells estimated at a magnitude of 10 to 100 billion, and 1014 to 1015 synapses, and therefore is the most complex organ of the human body. During fetal development the foundations of the brain are laid as billions of neurons form appropriate connections and patterns. In the adult mammalian brain, most neurons are post-mitotic, and therefore at risk for irreversible damage. As we age, atrophy of the brain occurs. As brain weight declines the volume of the brain in the 8th decade is reduced by 6 per cent -10 per cent versus the third decade, and neuronal loss occurs, up to 10,000 to 100,000 neurons are lost per day, though this estimation is being revised downward with the advance of more sophisticated measurements.