Organized by body system, the new edition of this highly illustrated textbook covers the normal histological appearance of tissues in a wide range of animals, both domestic and exotic species, with relevant clinical correlates emphasizing the need to appreciate the normal in order to recognize the abnormal. In this update by two experienced veterinary pathologists and histology lecturers, new species, such as other companion mammals, aquatic species and livestock, are introduced into each chapter along with a wealth of new high-quality images. A new chapter covers epitehlial tissue and new techniques used in histology and histopathology are discussed throughout, including ISH and digital image analysis. Pathogenesis explanation is introduced in the current (and many new) cases of histopathology. The breadth of coverage-farm animals, dogs, cats, horses, birds, reptiles, amphibians, and fish-and the integration of normal and abnormal tissue provide a reference of lasting value to veterinary students as well as veterinary practitioners and pathologists needing a quick refresher.

Veterinarian's Guide to Maximizing Biopsy Results helps veterinary practitioners in obtaining high-quality biopsy samples, maximizing the results and minimizing the cost. * Details the biopsy process step by step * Includes a submission checklist to assure thoroughness * Helps clinicians avoid errors when collecting biopsy samples * Ensures high-quality samples for improved results and reduced costs * Provides practical, clinically oriented information

The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill's research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

This book describes in detail various aspects of fluoride toxicity in animals. Animals, like human beings, suffer from the toxic effects of excess fluoride intake. They show pathological changes in their teeth and bone, together with a marked reduction in appetite, productive and reproductive potentials, which can result in severe economic losses in the dairy industry. Laboratory and wild animals also suffer from this ailment. Animal suffering and economic losses alike can be minimized through early diagnosis of the problem and by adopting suitable preventive and therapeutic measures. The book details the susceptibility of different animal species, important sources of toxicity, clinical signs and symptoms, pathophysiology, diagnostic methods, preventive and therapeutic approaches. It offers a valuable resource for scientists working in the fields of toxicology, veterinary science, animal nutrition, and environmental science, as well as for public health workers, animal welfare activists, public health veterinarians, field veterinarians, medical professionals and all others interested in the subject.

Today, veterinary science experiences major development in all its fields as a consequence of continuous technological advances in diagnostic tools and breakthrough in applied genomics and biology. This book contains 33 proceedings that were selected among those presented at the 64th Italian Veterinary Science Congress held at ASTI in 2010. It provides a timely overview of the current progress made by Italian researchers and would be of great value to anyone interested in the field of veterinary science, from animal health and care to food hygiene, and from basic to applied disciplines.

This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist's Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.

Microbiology is one of the core subjects for veterinary students, and since its first publication in 2002, Veterinary Microbiology and Microbial Disease has become an essential text for students of veterinary medicine. Fully revised and expanded, this new edition updates the subject for pre-clinical and clinical veterinary students in a comprehensive manner. Individual sections deal with bacteriology, mycology and virology. Written by an academic team with many years of teaching experience, the book provides concise descriptions of groups of microorganisms and the diseases which they cause. Microbial pathogens are discussed in separate chapters which provide information on the more important features of each microorganism and its role in the pathogenesis of diseases of animals. The international and public health significance of these pathogens are reviewed comprehensively. The final section is concerned with the host and is organized according to the body system affected.

Tables, boxes and flow diagrams provide information in an easily assimilated format. This edition contains new chapters on molecular diagnostics and on infectious conditions of the skin, cardiovascular system, urinary tract and musculoskeletal system. Many new colour diagrams are incorporated into this edition and each chapter has been updated.

Key features of this edition: Twelve new chapters includedNumerous new illustrationsEach chapter has been updatedCompletely re-designed in full colourFulfils the needs of veterinary students and academics in veterinary microbiologyCompanion website with figures from the book as Powerpoints for viewing or downloading by chapter: www.wiley.com/go/quinn/veterinarymicrobiology

"Veterinary Microbiology and Microbial Disease" remains indispensable for all those studying and teaching this essential component of the veterinary curriculum.

Long acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.

1 Fleas are wingless insects with a laterally compressed body of about 1.5-4 mm length. Like all insects they possess six legs and three body segments. Taxonomically they belong to the order Siphonaptera (Eckert et al. 2000) (Table 1). This family contains several species and subspecies. Fleas represent one of the most important ectoparasites (Mehl- horn 2000; Mehlhorn et al. 2001b). At the moment there are more than 2000 described species and subspecies throughout the world (Borror et al. 1981). These species belong to the families Pulicidae, including Pulex spp., Ctenocephalides spp., Spilopsyllus spp. and Archaeopsyllus spp., or the familia Ceratophyllidae with the genuses Ceratophyllus or Nosopsyllus to mention only some of the most important veterinary and human representatives. Fleas have a history of about 60 million years and were already found on prehistoric mammals. While becoming parasitic the original exterior of the two-wing insects, also designated as the order Diptera, has changed by losing the wings in the adults, whereas the larval form still has similarity with the larva of the order Diptera (Strenger 1973). About 95% of the -2000 different flea species parasitize on mammals, 5% live on birds. Table 1. Taxonomy of fleas Systematic Taxonomy Phylum Arthropoda Tracheata (=Antennata) Subphylum Classis Insecta (Hexapoda) Ordo Siphonapterida Familia Pulicidae Familia CeratophyUidae Genus Ctenocephalides. Genus Ceratophyllus. Nosopsyllus Pulex.

Proceedings of the XIth European Conference on Animal Blood Groups and Biochemical Polymorphism Held in Warsaw, July 2-6, 1968 Organized by European Society for Animal Blood Group Research

Biofilms are implicated in many common medical problems including urinary tract infections, catheter infections, middle-ear infections, dental plaque, gingivitis, and some less common but more lethal processes such as endocarditis and infections in cystic fibrosis. However, the true importance of biofilms in the overall process of disease pathogenesis has only recently been recognized. Bacterial biofilms are one of the fundamental reasons for incipient wound healing failure in that they may impair natural cutaneous wound healing and reduce topical antimicrobial efficiency in infected skin wounds. Their existence explains many of the enigmas of microbial infection and a better grasp of the process may well serve to establish a different approach to infection control and management. Biofilms and their associated complications have been found to be involved in up to 80% of all infections. A large number of studies targeted at the bacterial biofilms have been conducted, and many of them are referred to in this book, which is the first of its kind. These clinical observations emphasize the importance of biofilm formation to both superficial and systemic infections, and the inability of current antimicrobial therapies to 'cure' the resulting diseases even when the in vitro tests suggest that they should be fully effective. In veterinary medicine the concept of biofilms and their role in the pathogenesis of disease has lagged seriously behind that in human medicine. This is all the more extraordinary when one considers that much of the research has been carried out using veterinary species in experimental situations. The clinical features of biofilms in human medicine is certainly mimicked in the veterinary species but there is an inherent and highly regrettable indifference to the failure of antimicrobial therapy in many veterinary disease situations, and this is probably at its most retrograde in veterinary wound management. Biofilms and Veterinary Medicine is specifically focused on discussing the concerns of biofilms to health and disease in animals and provides a definitive text for veterinary practitioners, medical and veterinary students, and researchers.

Learn to manage the physical and psychological well-being of your feline patients with Feline Behavioral Medicine: Prevention and Treatment. From house soiling problems to aggression, this all-new reference offers detailed guidance on assessing, treating, and preventing the full spectrum of feline behavioral problems. Material is organized by both topic and life stage for quick access to the information you need. Plus its incorporation of patient education materials, instructive images, and the latest AAFP guidelines, makes it an invaluable addition to any vet clinician s library. "This book ... will undoubtedly become THE reference in that very specific field." Reviewed by: Fabienne Dethioux on behalf of Royal Canin: Vets Today, January 2016 UNIQUE! Focus on the prevention of behavior problems is found throughout the majority of the book to show clinicians how to incorporate behavioral considerations into general practice. Comprehensive, holistic care fusing the physical and psychological well-being of feline patients serves as a foundation for all content. International team of expert contributors provides in-depth, authoritative guidance using the most up-to-date information available. Updated information on preventive advice and treatment recommendations follows the guidelines set forth by the AAFP. Client handouts and behavior questionnaires in the book help vets clearly communicate with clients about their cat's behavior.

The Fifth Chinese Peptide Symposium, hosted by Lanzhou University, was held at Lanzhou, China July 14-17, 1998, with 156 participants, including 30 scientists from abroad, representing nine countries. The four-day conference was both intense and spiritually rewarding. Our goal for CPS-98 was to provide a forum for the exchange of knowledge, cooperation and friendship between the international and Chinese scientific communities, and we believe this goal was met. The symposium consisted of 8 sessions with 42 oral and 90 poster presentations, including synthetic methods, molecular diversity and peptide libraries, structure and conformation of peptides and proteins, bioactive peptides, peptide immunology, De Novo design and synthesis of proteins and peptides, ligand-receptor interactions, the chemistry-biology-interface and challenging problems in peptides. The enthusiastic cooperation and excellent contributions were gratifying and the active response of the invited speakers contributed to the success of the symposium. The presentations were of excellent caliber and represented the most current and significant aspects of peptide science. Dr. Kit Lam of the University of Arizona and Dr. Yun-Hua Ye of Peking University were the recipients of "The Cathay Award" sponsored by the H. H. Liu Education Foundation, offered for their seminal contribution in peptide science and the Chinese Peptide Symposium. Four outstanding young scientists were selected by the organizing committee to receive awards sponsored by Haikou Nanhai Pharmaceutical Industry Co. Ltd. (Zhong He Group).

This issue will explore the latest research and clinical information concerning endocrinology of exotic pet species. The articles will cover thyroid disease in rodent species, deslorelin implants in birds, pathology of the avian panceas, non-surgical management of ferret adrenal endocrinopathy, medical management of reproductive disorders in birds, neuroendocrine regulation of calcium metabolism in reptiles, clinical aspects of the avian hypothalamic/pituitary axis, and more!

A paperback edition for the student market, this standard work of reference has been a bestseller for over 70 years. It is an essential tool for anyone with a professional or leisure interest in the care of animals. Much more than a list of veterinary terms, its practical approach ensures that readers gain an insight into the signs and symptoms of common, and less common, diseases, as well as their diagnosis and treatment. For this edition much new and updated information has been included, reflecting the numerous developments that have taken place in animal care and husbandry, and welfare. There is greatly expanded coverage of topics relating to popular breeds of dog and cat, and the inheritable conditions that might affect their health. Advances in medicine, surgery and diagnostic techniques; descriptions of newly identified diseases such as Schmallenberg virus; the resurgence of old scourges such as TB in cattle, and ongoing enzootic infections such as bird flu are also included in this edition. The growing risk of exotic diseases such as heartworm being imported following the relaxation of travel arrangements for dogs and cats is reflected in new entries. Notes on many new species being farmed or kept as companion animals are among the thousands of topics covered.

This compendium of research material on the role of oxidative stress in animal disease and morbidity examines both the general and the specific. Sourced from scientists, veterinarians, and members of the medical community from around the world, it includes chapters on our wider understanding of the corrosive function of free radicals in cell biology as well as focusing on the interplay between oxidative stress and metabolism in a variety of animal species including dogs, ruminants and birds. Since biogerontologist Denham Harman first posited that free radicals arising from the metabolic activity of oxygen play a central role in aging and disease, a mass of evidence has accumulated linking oxidative stress and biological degradation. We now understand that living in an aerobic environment inevitably leads to the production of free radicals that go on to attack biological membranes and lipoproteins via oxidation in a process called lipid peroxidation. Reacting with carbon-based molecules such as polyunsaturated fatty acids, these free radicals cause oxidative stress and tissue damage. The purpose of Studies on Veterinary Medicine is to inform clinicians, students and others of the plethora of consequences that free radical damage (ROS) has on various cells, tissues, and organs, as well as in different species of animals. The chapters also analyze the effects of oxidative stress on aging and various morbidities such as diabetes, cognitive dysfunction and heart disease. Contributors variously present their interpretation of the role played by oxidative damage in disease and assess the benefits of antioxidant therapies.

Written by well-respected experts from the UK and USA, Equine Internal Medicine: Self-Assessment Color Review Second Edition presents more than 200 interesting and challenging cases encountered in equine practice, complete with photographs, imaging, or endoscopy findings; blood or fluid smears; other ancillary tests; and, in some cases, pathologic findings. Completely revised and updated, this new edition of a bestseller contains entirely new cases, presented in random order, just as they would in practice. The cases are formatted as self-assessment problems comprising integrated questions, illustrations, and detailed explanations designed to educate as well as to provide answers. The authors include pertinent questions with each case to guide you through the case workup and treatments with in-depth answers for each case in the second half of the book. They provide a short list of pertinent references after most cases. Coverage includes neurology, cardiology, respiratory disease, gastroenterology, urology, infectious diseases, parasitology, hematology, oncology, endocrinology, reproduction, dermatology, ophthalmology, immunology, and musculoskeletal disorders, in foals and adult horses. Whether preparing for exams or continuing your professional development, this book gives you a firm foundation in how to assess, diagnose, and treat a wide variety of cases.

The field of genito-urinary oncology is rapidly evolving at virtually every level. Significant advances have been made in our understanding of the molecular and cellular events which contribute to the generation of GU malignancies. At the same time, similar advances have been made in the clinical arena which have improved the diagnosis and treatment of urologic cancers. This volume attempts to summarize those advances which most impact us as clinicians, and has been divided into three sections. Section One, 'Diagnostic advances: the use of molecular medicine in the diagnosis and prognosis of GU malignancies', details how epidemiologic studies and new molecular techniques are impacting our ability to diagnose and treat GU tumors. Section Two, 'Surgical and radiation advances', details the recent major advances in the treatment of organ-confined cancers. Section Three, 'Medical advances', addresses major issues in the treatment of metastatic disease. This volume will serve as a compendium of the advances, both at the basic science and clinical levels, which are currently impacting practicing oncologists and urologists.

Proceedings of the European Cooperation in the Field of Scientific and Technical Research (COST 825) Symposium on Mammary Gland Biology, held September 16-18, 1999, in Tours, France. It is difficult to overstate the evolutionary and functional significance of mammary tissue in biology. Substantial progress has been made by researchers in various disciplines, particularly over the last fifteen years, towards realizing the potential of this tissue to yield powerful experimental models for morphogenesis and tissue development; for cellular differentiation; for the biosynthesis and secretion of proteins, lipids, small molecules and inorganic salts; and for the coordination and regulation of these processes. More recently, the possibility of exploiting the secretory epithelial cells of mammary tissue as `cell factories' has become a reality and the recombinant production by lactating animals of an increasing number of proteins, valuable both in the pharmaceutical and `nutraceutical' fields, is in progress or under development. Also in this sphere of agricultural production, genetic as well as nutritional technologies are under investigation and exploitation to optimize milk composition for various end-uses - for instance in food process and manufacture. The possibilities of deriving health benefit from the bioactive properties of some of the minor constituents of milk are emerging to counter the highly-publicized negative health impact of excessive consumption of saturated animal fats. In human nutrition and medicine, the mammary gland is both a source of nutrition to the neonate and a potential health threat to the adult female - breast cancer remains the major single cause of female mortality in most developed countries. This volume provides a unique glimpse into our understanding, at the cutting edge of a variety of disciplines, of this versatile and extraordinary tissue, at the birth of the twenty-first century.

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.

The fourth edition of Clinical Medicine of the Dog and Cat remains the most extensively illustrated and practical small animal veterinary textbook on the market.

It continues and expands on the revolutionary problem-based approach of the previous three editions, with more than 1,100 clinical color photographs, diagrams, and tables. The book is divided into five color-coded sections—General Approach, Diagnostic Techniques, Disease of Specific Organ Systems, Multisystemic Disorders, and Elements of Therapy. For this edition:

Case studies are integrated within the relevant chapters for ease of reference

The first section on common medical problems now includes abdominal distension, peripheral edema, proteinuria, regurgitation, and seizures

Chapters on thoracic and abdominal radiographs are now included in a unique new section on Diagnostic Techniques, encouraging an integrated learning approach

The third section contains detailed medical information covering most organ systems, with several chapters completely rewritten and others comprehensively updated to include additional text and images

Additional endoscopic, radiographic, CT, and MRI images are included alongside clinical photographs; very few veterinary textbooks have such a rich emphasis on photographs

Each section has a limited number of recommended updated references

The practical information is presented with text, tables, and algorithms, while each chapter is arranged to provide the definition of each disorder, its clinical features, the differential diagnoses, the diagnostic methodology, and the treatment and prognosis. The formatting has been improved to make this textbook easy to read and comprehend. The busy veterinarian or student is thus provided with a readily available resource of important clinical information in a clear, brief manner.

Written by board-certified experts, the topics are carefully selected to make this a valuable resource for veterinary students as well as for general practitioners and small animal interns.

Table of Contents

Mikey's Maxims by Michael Schaer

SECTION I: GENERAL APPROACH

1 Client Communication and Medical History

Bobbi Conner

2 Common Clinical Problems

2.1 Abdominal distension

Steven Holloway

2.2 Cough

Elizabeth Rozanski

2.3 Diarrhea

Frederic Gaschen

2.4 Dyspnea

Claire Sharp

2.5 Dysuria

Isabelle Cattin

2.6 Epistaxis

Samantha Wigglesworth & Amber Vitalo

2.7 Fever of Unknown Origin

Robert Armentano

2.8 Icterus

Julien Dandrieux

2.9 Pallor

Elisa Mazzaferro

2.10 Peripheral edema

Stuart Walton

2.11 Pigmenturia

Leo Londoño & Michael Schaer

2.12 Polydipsia/Polyuria

Michael Schaer

2.13 Proteinuria

Laura Rayhel & Mark Acierno

2.14 Regurgitation

Roman Husnik

2.15 Seizures

Gabriel Garcia

2.16 Syncope, Episodic Weakness, Collapse

Boyd Jones

2.17 Vomiting

Frederic Gaschen

SECTION II: DIAGNOSTIC TECHNIQUES

3 Approach to Thoracic Radiographs

L. Abbi Granger

4 Approach to Abdominal Radiographs

L. Abbi Granger

SECTION III: DISEASES OF SPECIFIC ORGAN SYSTEMS

5 Diseases of the Oral Cavity and Teeth

Brook Niemiec & Erin Ribka

6 Respiratory Disorders - upper and lower

Cécile Clercx

7 Diseases of the Pleural Space

Brad Case

8 Cardiovascular Disorders

Romain Pariaut & Carley Saelinger

9 Digestive Diseases

Frederic Gaschen

10 Hepatobiliary Disease

Andrea Johnston

11 Pancreatic Disorders

Frederic Gaschen

12 Endocrine Diseases

Michael Herrtage

13 Uro-nephrology

Mark Acierno

14 Disorders of the Nervous System and Muscle

Simon Platt

15 Musculoskeletal Disorders and Injuries

Matthew Johnson, Mitchell Gillick and Steven Fox

16 Hematologic Disorders

Katie Boes, Julien Dandrieux and Claire Cannon

17 Disorders of Hemostasis

Alex Lynch

18 Dermatologic Disorders

Domenico Santoro and Amelia White

19 Ocular manifestations of systemic diseases

Ralph Hamor

SECTION IV: Multisystemic Disorders

20 Clinical Toxicology

Tina Wismer

21 Infectious Diseases

21.1 Cats

Sophie Keyte & Severine Tasker

21.2 Dogs

Stuart Walton

22 Immunologic Disorders

Michael Day

SECTION V: Elements of Therapy

23 Fluid Therapy

Leo Londoño

24 Pain Management

Beatriz Monteiro & Brad Simon

25 Nutrition of the Critically Ill Dog and Cat

Justin Shmalberg

26 Management of the Obese Dog and Cat

Alex German

The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

Global warming and globalization are the buzzwords of our time. They have nearly reached a religious status and those who deny their existence are considered modern heretics. Nevertheless, the earth has become an overcrowded village, traversable within a single day. Thus it is hardly surprising that besides persons and goods also agents of disease are easily transported daily from one end of the world to the other, threatening the health and lives of billions of humans and their animals. Agents of diseases (prions, viruses, bacteria, fungi and parasites) are not only transmitted by body contact or direct exchange of bodily fluids, but also by means of vectors which belong to the groups of licking or blood-sucking arthropods (mites, ticks, insects) that live close to humans and their houses. Without a doubt the recently accelerating globalization supports the import of agents of disease into countries where they never had been or where they had long since been eradicated, leading to a false sense of living on a "safe island." These newly imported or reintroduced diseases - called "emerging diseases" - may lead to severe outbreaks in cases where the countries are not prepared to combat them, or in cases where viruses are introduced that cannot be controlled by medications or vaccines. Arthropods are well known vectors for the spread of diseases. Thus their invasion from foreign countries and their spreading close to human dwellings must be blocked everywhere (in donor and receptor countries) using safe and effective measures. This book presents reviews on examples of such arthropod-borne emerging diseases that lurk on the fringes of our crowded megacities. The following topics show that there is an ongoing invasion of potential vectors and that control measures must be used now in order to avoid disastrous outbreaks of mass diseases.

During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino genesis. The course had this as its major objective and the re sulting book does reflect it."