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Books > Science & Mathematics > Biology, life sciences > Microbiology (non-medical) > Virology
Consolidating and expanding current, fundamental notions of virology and animal cell cultivation, this practical reference examines the development of insect cell culture techniques for the production of recombinant proteins and insect pathogenic viruses.;Resolving on-the-job problems such as sparging cell damage and reduced infectivity cells, Insect Cell Culture Engineering: includes special introductory material as well as background information on insect pathogenic viruses, the molecular biology of baculoviruses and bioreactor design; offers advice on how to save time when deciding which insect cell line, bioreactor and medium to exploit; discusses the preparation of mathematical modelling in animal cell culture; addresses the concerns associated with insect cell immobilization and the use of serum-free culture media; provides insights into the protective effects of polymer additives and insect cell gene expression in pharmaceutical research; and analyzes process scale-up and reactor design.;Bridging the gap between laboratory research and pilot plant scale insect culture/baculovirus technology, Insect Cell Culture Engineering is designed as a reference for biochemical and bioprocess engineers, bioprocess technologists, biochemists, molecular and cell biologists, microbiologists, and upper-level undergraduate and graduate students in these disciplines.
The first review series in virology and published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the field. The series of eclectic volumes are valuable resources to virologists, microbiologists, immunologists, molecular biologists, pathologists, and plant researchers. Volume 91 features articles on control of plant virus diseases.
Influenza, AIDS, and Ebola: Viruses are normally defined as pathogens. Most viruses are, however, not enemies or killers. Well-known virologist and cancer researcher Karin Moelling describes surprising insights about a completely new and unexpected world of viruses. Viruses are ubiquitous, in the oceans, our environment, in animals, plants, bacteria, in our body, even in our genomes. They influence our weather, can contribute to control obesity, and can surprisingly be applied against threatening multi-resistant bacteria. The success story of the viruses started more than 3.5 billion years ago in the dawn of life when even cells did not exist. They are the superpower of life. There are more viruses on earth than stars in the sky. Viruses are everywhere. Some of them are incredibly ancient. Many viruses are hundredfold smaller than bacteria, but others are tenfold bigger and they were discovered only recently - the giant viruses, even deep within the permafrost where they were reactivated after 30,000 years.The author talks about a completely new world of viruses, which are based on the most recent, in part her own research results. Could viruses have been our oldest ancestors? Have viruses even 'invented' social behavior, do they lead to geniuses such as Mozart or Einstein - or alternatively to cancer? They can help to cure cancer. In this book, the author made a clear distinction between what is fact and what is her vision. This book is written for a general audience and not just for the experts. Its aim is to stimulate thinking, and perhaps to attract more young scientists to enter this field of research.
RNA viruses provide unique insights into the patterns and processes of evolutionary change in real time. The study of viral evolution is especially topical given the growing awareness that emerging and re-emerging diseases (most of which are caused by RNA viruses) represent a major threat to public health. However, while the study of viral evolution has developed rapidly in the last 30 years, relatively little attention has been directed toward linking work on the mechanisms of viral evolution within cells or individual hosts, to the epidemiological outcomes of these processes. This novel book fills this gap by considering the patterns and processes of viral evolution across their entire range of spatial and temporal scales. The Evolution and Emergence of RNA Viruses provides a comprehensive overview of RNA virus evolution, with a particular focus on genomic and phylogenetic approaches. This is the first book to link mechanisms of viral evolution with disease dynamics, using high-profile examples in emergence and evolution such as influenza, HIV, dengue fever, and rabies. It also reveals the underlying evolutionary processes by which emerging viruses cross species boundaries and spread in new hosts.
The second edition of "Virology" is an accessible introduction designed to enable students to understand the principles of virus structure, replication and genetics. The aim of this book is to help the reader appreciate the relevance of virology in the modern world, including the fields of vaccines, anti-viral drugs and cancer. There is also a chapter on prions. The second edition has been extensively revised and updated to reflect the many developments in virology and offers deeper insights into the subject. Newly-discovered viruses are discussed and there is an additional chapter on the influenza virus.
#1 on Amazon Charts, New York Times Bestseller, USA Today Bestseller—Over 100,000 Copies in Print! “Kent Heckenlively and Judy Mikovits are the new dynamic duo fighting corruption in science.” —Ben Garrison, America’s #1 political satirist Dr. Judy Mikovits is a modern-day Rosalind Franklin, a brilliant researcher shaking up the old boys’ club of science with her groundbreaking discoveries. And like many women who have trespassed into the world of men, she uncovered decades-old secrets that many would prefer to stay buried. From her doctoral thesis, which changed the treatment of HIV-AIDS, saving the lives of millions, including basketball great Magic Johnson, to her spectacular discovery of a new family of human retroviruses, and her latest research which points to a new golden age of health, Dr. Mikovits has always been on the leading edge of science. With the brilliant wit one might expect if Erin Brockovich had a doctorate in molecular biology, Dr. Mikovits has seen the best and worst of science. When she was part of the research community that turned HIV-AIDS from a fatal disease into a manageable one, she saw science at its best. But when her investigations questioned whether the use of animal tissue in medical research were unleashing devastating plagues of chronic diseases, such as autism and chronic fatigue syndrome, she saw science at its worst. If her suspicions are correct, we are looking at a complete realignment of scientific practices, including how we study and treat human disease. Recounting her nearly four decades in science, including her collaboration of more than thirty-five years with Dr. Frank Ruscetti, one of the founders of the field of human retrovirology, this is a behind the scenes look at the issues and egos which will determine the future health of humanity.
Exploiting powerful techniques from physics and mathematics, this book studies animal movement in ecology, with a focus on epidemic spread. Pulmonary syndrome is not only feared in epidemics of recent times, such as COVID-19, but is also characteristic of epidemics studied earlier such as Hantavirus. The Hantavirus is one of the book's central topics. Correlations between epidemic outbreaks and precipitation events like El Nino are analyzed and spatial reservoirs of infection in off-period of the epidemic, known as refugia, are studied. Predicted traveling waves of infection are successfully compared to field observations. Territoriality in scent-marking animals is presented, with parallels drawn with the theory of melting. The flocking and herding of birds and mammals are described in terms of collective excitations. For scientists interested in movement ecology and epidemic spread, this book provides effective solutions to long-standing problems.
In Loeffler's Footsteps - Viral Genomics in the Era of High-Throughput Sequencing, Volume 99, the latest in the Advances in Virus Research series, contains new information on the topic, with chapters covering Loeffler 4.0 - diagnostic metagenomics, Detection of a novel orthobunyavirus by metagenomic analysis - the situation after five years, New Squirrel and Rodent Viruses Detected by NGS, Astroviridae - A Growing Family, New Leaves in the Growing Pestivirus Tree, New BTV Serotypes and no End?, and The recently discovered Bokeloh Bat Lyssavirus - Evidence for its continued transmission in Europe. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. The series is a valuable resource for information on all topics of virus research, from bacteriophages to human viruses, with this volume focusing on genomics.
Advances in Applied Microbiology, Volume 110, the latest release in this renowned series that provides a comprehensive and authoritative review in microbiology, includes updated chapters on Multi-species biofilms for resource recovery from wastewater, Chemical imaging of biofilms with luminescent sensors, Advances in yeast fermentation biotechnology, Bacterial evasion of host defense systems, A genomic analysis on stress-responses in C. glabrata and their relevance in pathogenesis and drug resistance, and more.
Combination Therapy against Multidrug Resistance explores the potential of combination therapy as an efficient strategy to combat multi-drug resistance. Multidrug resistance (MDR) occurs when microorganisms such as bacteria, fungi, viruses, and parasites are excessively exposed to antimicrobial drugs such as antibiotics, antifungals, or antivirals, and in response the microorganism undergoes mutations or develops different resistance mechanisms to combat the drug for its survival. MDR is becoming an increasingly serious problem in both developed and developing nations. Bacterial resistance to antibiotics has developed faster than the production of new antibiotics, making bacterial infections increasingly difficult to treat, and the same is true for a variety of other diseases. Combination therapy proves to be a promising strategy as it offers potential benefits such as a broad spectrum of efficacy, greater potency than the drugs used in monotherapy, improved safety and tolerability, and reduction in the number of resistant organisms. This book considers how combination therapy can be applied in multiple situations, including cancer, HIV, tuberculosis, fungal infections, and more. Combination Therapy Against Multidrug Resistance gathers the most relevant information on the prospects of combination therapy as a strategy to combat multridrug resistance and helping to motivate the industrial sector and government agencies to invest more in research and development of this strategy as a weapon to tackle the multidrug resistance problem. It will be useful to academics and researchers involved in the development of new antimicrobial or antiinfective agents and treatment strtategies to combat multidrug resistance. Clinicians and medical nurses working in the field of infection prevention and control (IPC) will also find the book relevant
A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.
SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its "birthplace" in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.
Bluetongue may be described as an acute insect borne disease of ruminants, manifested clinically in sheep by a catarrhal inflammation of the mucous mem branes of the digestive and respiratory systems and associated with degenerative changes in the skeletal musculature. The profound emaciation and weakness which follow the acute disease are responsible for a protracted convalescence and for serious economic losses due to diminished productivity. II. Historical During the early colonisation of Africa, susceptible Merino and other European breeds of sheep were introduced into the Cape, at first by the Dutch East India Company between 1652 and 1785 and again later in 1870. A report of the Cattle and Sheep Diseases Commission (1876) records the appearance of a serious febrile disease amongst these imported sheep in which both morbidity and mortality was high (cited by HENNING, 1949). HuTCHEON (1881) gave this disease the name of "Fever" or "Epizootic Catarrh," in order to distinguish it from other clinical conditions of a similar nature encountered amongst sheep. In the first com prehensive description of this clinical syndrome and its epizootiology HuTCHEON (1902) referred to it as "Malarial Catarrhal Fever of Sheep," a designation which was obviously influenced by the mistaken belief that an intracorpuscular parasite was the primary cause of the disease. More systematic studies were conducted by SPREULL (1902; 1905), who endeavoured to immunize sheep by the simultaneous inoculation of immune serum and infective blood."
It is hardly necessary to define the concept of receptors to readers of this series, but it should be born in mind that in several instances receptors are undefined entities, whose molecular details remain to be established. On the other hand the ligand, which reco izes the receptors, has been identified and characterized in most cases. The current interest in the structure and function of biological membranes gives great expectations that in the near future we may understand the details of ligand-receptor interaction. This interaction involves two defined steps: the first, usually referred to as recognition, is followed by the second step, transduction, in which the ligand-receptor interaction is translated by the cell into a biochemical action. The present two volumes which cover prokaryotic and eukaryotic virus receptors, have been published together in order to illustrate the specificity of virus receptor recognition which appears to be a guiding principle for both bacteria and higher cells. The identification and characterization of the receptors for phages of gram-negative bacteria has to a large extent relied on the genetic techniques available for these organisms. In a similar way the availability of genetic systems has also clarified the interrelationship between animal retrovirus receptors even if the molecular structure remains to be determined. The paucity of defined genetic systems may therefore explain part of our ignorance concerning the molecular details of virus receptors on human cells and possibly also on gram positive bacteria."
The decision to write a book about the practical aspects of the baculovirus expression system stems from the numerous phone calls for help we have had, and from the many visitors to our labora tories requiring assistance to find the elusive polyhedrin-negative virus containing their favourite gene. We have also organized two expression system workshops and from the manuals we wrote for these, it seemed a logical progression to extend them into book form. We appreciate that those who are 'old-hands' at the baculovirus expression system may have differing views on some of our procedures, but the methods in this book are presented in the light of our own experiences in the laboratory and from our practical workshops, and we hope that the book will be especially useful to those new to the system. The first three chapters give the background information to the baculovirus expression system, and includes advice on how to choose the right transfer vector and discusses the various methods that are available to select recombinant viruses. The practical chapters concentrate on those aspects which are novel to the baculovirus system (insect cell culture, virus amplification and titration, etc. ) and, in general, leave the standard molecular biological techniques to the other excellent laboratory manuals that are available. However, for completeness sake and to avoid constant reference to other manuals, we have included brief details of some standard techniques where they are integral to the success of the baculovirus protocols."
Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.
A journey through the history and science of epidemics and pandemics – from measles to coronavirus. For centuries mankind has waged war against the infections that, left untreated, would have the power to wipe out communities, or even entire populations. Yet for all our advanced scientific knowledge, only one human disease – smallpox – has ever been eradicated globally. In recent years, outbreaks of Ebola and Zika have provided vivid examples of how difficult it is to contain an infection once it strikes, and the panic that a rapidly spreading epidemic can ignite. But while we chase the diseases we are already aware of, new ones are constantly emerging, like the coronavirus that spread across the world in 2020. At the same time, anti-microbial resistance is harnessing infections that we once knew how to control, enabling them to thrive once more. Meera Senthilingam presents a timely look at humanity’s ongoing battle against infection, examining the successes and failures of the past, along with how we are confronting the challenges of today, and our chances of eradicating disease in the future.
In Virus-Insect-Plant Interactions, the world's leading scientists
discuss the latest breakthroughs in understanding the biological
and ecological factors that define these complex transmission
systems and how this knowledge might be used to our advantage in
producing innovative, user and environmentally friendly approaches
to controlling the spread of plant pathogens by insects. This is an
invaluable reference work for researchers, teachers, and students.
There are many quick-reference figures and tables, the contents
pages include individual chapter abstracts, and each chapter ends
with its own bibliography.
One hundred years ago, when Martinus W. Beijerinck in Delft and Friedrich Loeffler on Riems Island discovered a new class of infectious agents in plants and animals, a new discipline was born. This book, a compilation of papers written by well-recognized scientists, gives an impression of the early days, the pioneer period and the current state of virology. Recent developments and future perspectives of this discipline are sketched against a historic background. With contributions by A. Alcami, D. Baulcombe, F. Brown, L. W. Enquist, H. Feldmann, A. Garcia-Sastre, D. Griffiths, M. C. Horzinek, A. van Kammen, H.-D. Klenk, F. A. Murphy, T. Muster, R. O'Neill, P. Palese, C. Patience, R. Rott, H.- P. Schmiedebach, S. Schneider-Schaulies, G. L. Smith, J. A. Symons, Y. Takeuchi, V. ter Meulen, P. J. W. Venables, V. E. Volchkov, V. A. Volchkova, R. A. Weiss, W. Wittmann, H. Zheng
Applied Plant Virology: Advances, Detection, and Antiviral Strategies provides an overview on recent developments and applications in the field of plant virology. The book begins with an introduction to important advances in plant virology, but then covers topics including techniques for assay detection and the diagnosis of plant viruses, the purification, isolation and characterization of plant viruses, the architecture of plant viruses, the replication of plant viruses, the physiology of virus-infected hosts, vectors of plant viruses, and the nomenclature and classification of plants. The book also discusses defense strategies by utilizing antiviral agents and management strategies of virus and viroid diseases. With contributions from an international collection of experts, this book presents a practical resource for plant virologists, plant pathologists, horticulturalists, agronomists, biotechnologists, academics and researchers interested in up-to-date technologies and information that advance the field of plant virology.
Rabies: Basis of the Disease and Its Management, Fourth Edition is an authoritative reference on the current status of rabies, including the virological, clinical, and public health aspects and management recommendations. Rabies remains one of the most important global public health problems worldwide. Although many important developments have been made over the past century to combat this disease, rabies has become a re-emergent infection in the resource-constrained countries. The Fourth Edition updates this classic reference with comprehensive coverage of the molecular virology, pathogenesis, immunology, vaccines, public health aspects, and epidemiology of rabies and is completely revised, with new chapters that will cover historical developments in rabies intervention strategies, the evolution of rabies virus, modeling rabies control, and on the strategy for rabies elimination. Rabies, Fourth Edition, provides physicians, veterinarians, public health advisors, epidemiologists, and research scientists with a single source for authoritative and up-to-date information on the diagnosis, treatment, control, and prevention of this fatal infectious virus.
Rapid developments continue to take place in the research of viruses, the causative agents of infectious diseases in humans, animals, plants, invertebrates, protozoa, fungi, and bacteria. A still growing number of more than 30,000 viruses, virus strains, and subtypes are being tracked in various specialty laboratories and culture collections. In this situation of expansion and specialization, the International Committee on Taxonomy of Viruses was founded to establish, refine and maintain a universal virus taxonomy system giving information to virologists about the characteristics of the different groups of viruses. The Committee s Sixth Report includes one order, 71 families, 11 subfamilies, and 175 genera and more than 4,000 member viruses. On 600 printed pages large amounts of molecular biologic data, illustrated by micrographs and virion diagrams, gene maps and tables give a comprehensive overview and prove helpful in teaching, in diagnostics, in scholarly research, and in the practical areas of medicine, veterinary medicine, plant pathology, insect pest management, and biotechnology. ..". est une reference indispensable pour les chercheurs, les enseignants, les medecins ou les veterinaires mais aussi pour les etudiants et d une maniere generale pour toutes les personnes interessees par la virologie . Revue de Medecine Veterinaire ..". an excellent, well presented and informative volume. The report should be an essential reference volume for any department or organization involved in the study of viruses . Quarterly"
Advances in molecular biology have enabled leaps forward in the determination of virus phylogenetic history. This detailed 1995 book results from the invitation to foremost experts to give essays on aspects of virus biology. Initial chapters cover impacts of viruses and their control. Further chapters detail genetic variation of viruses and the molecular basis of interrelations with hosts. This leads to discussions of interactions with the host at the population level, and their molecular basis and evolution. Seventeen chapters follow, by specialists on particular groups of viruses describing their impact, genetic origins, sources of variation, population genetics and interactions with hosts. Practical virologists will find the chapters on phylogenetic analysis techniques very useful. The adaptive nature of viruses makes this work highly relevant to evolutionists.
Positive-strand RNA viruses include the majority of the plant viruses, a number of insect viruses, and animal viruses, such as coronaviruses, togaviruses, flaviviruses, poliovirus, hepatitis C, and rhinoviruses. Works from more than 50 leading laboratories represent latest research on strategies for the control of virus diseases: molecular aspects of pathogenesis and virulence; genome replication and transcription; RNA recombination; RNA-protein interactions and host-virus interactions; protein expression and virion maturation; RNA replication; virus receptors; and virus structure and assembly. Highlights include analysis of the picornavirus IRES element, evidence for long term persistence of viral RNA in host cells, acquisition of new genes from the host and other viruses via copy-choice recombination, identification of molecular targets and use of structural and molecular biological studies for development of novel antiviral agents. |
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