Virus Entry, Volume 104, the latest release in the Advances in Virus Research series, highlights new advances in the field, with this new volume presenting interesting chapters on plant virus cell-to-cell entry, plant virus entry via insect transmission, VSV/Rabies virus entry, Papovavirus entry, New approaches to study fusion proteins, Hantavirus receptors, Gamma Herpesvirus entry, and many other interesting topics.

Advances in Applied Microbiology, Volume 106, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters covering The role and regulation of the stress activated sigma factor SigB in the saprophytic and host-associated life stages of the pathogen Listeria monocytogenes, Bacterial synthesis of Se nanoparticles, Siderophores in environmental research, Methods to reduce spoilage and microbial contamination of plant produce, Nitrogen cycling during wastewater treatment, Oxalic acid, a molecule at crossroads of bacterial-fungal interactions, and Bacterial spores, from ecology to biotechnology.

Advances in Virus Research, Volume 103, the latest in the Advances in Virus Research series, contains new, informative updates on the topic. First published in 1953, this series covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology. Updates to this release include a Review on phage genes that affect bacterial phenotypes, Phage lysis: new perspectives on the bacterial cell envelope, CRISPRs as the adaptive immune system of archaea and bacteria, CRESS viruses, Tupanviruses, and Giant virus evolution, amongst other topics.

As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been-when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment-and will lead to multiple COVID-19 vaccines. Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won't be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans. As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.

As doctors and biologists have learned, to their dismay, infectious disease is a moving target: new diseases emerge every year, old diseases evolve into new forms, and ecological and socioeconomic upheavals change the transmission pathways by which disease spread. By taking an approach focused on the general evolutionary and ecological dynamics of disease, this Very Short Introduction provides a general conceptual framework for thinking about disease. Ecology and evolution provide the keys to answering the 'where', 'why', 'how', and 'what' questions about any particular infectious disease: where did it come from? How is it transmitted from one person to another, and why are some individuals more susceptible than others? What biochemical, ecological, and evolutionary strategies can be used to combat the disease? Is it more effective to block transmission at the population level, or to block infection at the individual level? Through a series of case studies, Benjamin Bolker and Marta L. Wayne introduce the major ideas of infectious disease in a clear and thoughtful way, emphasising the general principles of infection, the management of outbreaks, and the evolutionary and ecological approaches that are now central to much research about infectious disease. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

"The most revealing pandemic book yet."-The Atlantic The definitive, inside account of the Trump Administration's response to the Covid-19 pandemic from White House Coronavirus Response Coordinator and Coronavirus Task Force member, Dr. Deborah Birx. In late February 2020, Dr. Deborah Birx-a lifelong federal health official who had worked at the CDC, the State Department, and the US Army across multiple presidential administrations-was asked to join the Trump White House Coronavirus Task Force and assist the already faltering federal response to the Covid-19 pandemic. For weeks, she'd been raising the alarm behind the scenes about what she saw happening in public-from the apparent lack of urgency at the White House to the routine downplaying of the risks to Americans. Once in the White House, she was tasked with helping fix the broken federal approach and making President Trump see the danger this virus posed to all of us. Silent Invasion is the story of what she witnessed and lived for the next year-an eye-opening, inside account, detailed here for the first time, of the Trump Administration's response to the greatest public health crisis in modern times. Regarded with suspicion in the West Wing from day one, Dr. Birx goes beyond the media speculation and political maneuvering to show what she was really up against in the Trump White House. Digging into the hard-fought victories, the costly mistakes, and the human drama surrounding the administration's efforts, she examines the forces that crippled efforts to control the virus and explores why these blunders continue to haunt us today. And yet amid the agonizing missteps were bright spots that point the way forward-the fastest vaccine creation in history, governors that put their citizens' health first, and Tribal Nations that demonstrated the powerful role of community in curbing spread, despite their criminally underfunded healthcare systems. Collectively these successes reveal the valiant work of many who were committed to saving lives, as well as highlighting the dire need to reform our public health institutions, so they are nimble and resilient enough to confront the next pandemic. With the pandemic now moving into its third year confounding two presidential administrations, Dr. Birx presents a story at once urgent and frustratingly unfinished, as Covid-19 continues to put thousands of American lives at risk. The end result is the most comprehensive and extensive accounting to date of the Trump Administration's struggle to control the biggest health crisis in generations-a revelatory look at how we can learn from our mistakes and prevent this from happening again.

For decades, the Clinical Virology Manual has been the definitive source of the latest information and procedures for the physician and the clinical laboratory virologist. This edition is thoroughly revised and updated by noted experts. These updates address the modernization of clinical virology and new developments in the field.

To date textbooks on viruses infecting fish, crustaceans and molluscs, the three main aquatic animal farmed groups, have been on the whole "diseases-centric" and individual viral diseases selected based on "epizoo-centric" approaches with little to no coverage of the basic biology of the viruses, in contrast to textbooks on viruses infecting terrestrial - farmed, pet, and free-range (wild) - animals and humans. Despite considerable advances in animal virology in recent years coupled with an economically important global aquaculture industry, knowledge of viruses of animal aquaculture is still sparse and in some cases outdated although these viruses are closely related to well-known virus families. The last book in fish virology (Fish viruses and fish viral diseases 1988, Wolf, K.) was published in the 1980s. A lot of work has been done on fish viruses and many new aquatic animal viruses continue to be discovered. Aquaculture Virology provides the current state of knowledge of aquatic animal viruses within the current virus classification and taxonomic context thereby allowing the reader to draw on the principles of general virology. This book is a systematic and concise resource useful to anyone involved with or looking to move into aquaculture and fisheries. Clinical veterinarians, aquaculture disease practitioners, biologists, farmers, and all those in industry, government or academia who are interested in aquatic animal virology will find this book extremely useful.

The second edition of Virology is an accessible introduction designed to enable students to understand the principles of virus structure, replication and genetics. The aim of this book is to help the reader appreciate the relevance of virology in the modern world, including the fields of vaccines, anti-viral drugs and cancer. There is also a chapter on prions. The second edition has been extensively revised and updated to reflect the many developments in virology and offers deeper insights into the subject. Newly-discovered viruses are discussed and there is an additional chapter on the influenza virus.

Science doesn't speak for itself. Neck-deep in work that can be messy and confounding and naive in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists' reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what's good for them and what isn't. In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don'ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done-such as being one of the first to speak out against conspiracy theories linking vaccines to autism-he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial. Written with wit and passion, Offit's often humorous guide to taking on quack experts and self-appointed activists is a must-read for any American disturbed by the uptick in politicized attacks on science.

Containing important information about the coronavirus, this comprehensive, easy-to-follow primer on pandemics, epidemics, and the panics they ignite around the world also shares solutions for a safer, healthier future. "A quiet little gem of understanding in a cacophony of panic and fear." -Quill & Quire, STARRED review Authored by a leading epidemiologist, this engrossing book answers our questions about animal diseases that jump to humans-called zoonoses-including what attracts them to humans, why they have become more common in recent history, and how we can keep them at bay. Almost all pandemics and epidemics have been caused by diseases that come to us from animals, including SARS, Ebola, and-now-Covid-19. Epidemiologist, veterinarian, and ecosystem health specialist, David Waltner-Toews, gathers the latest research to profile dozens of illnesses in On Pandemics. Chapters are broken into short, dynamic explainers, each one tackling a different disease. Readers will discover: Why zoonotic diseases jump from animals to humans-and why some decide to stick around for good. How governments have responded to pandemics and epidemics throughout history, for better or for worse. The role of climate change, industrialized farming, cultural practices, biodiversity loss, and globalization in making these diseases not only possible, but inevitable outcomes of our modern lifestyles. Coronaviruses, such as those that cause SARS and Covid-19, have likely made bats their home for centuries. Until SARS came along, we didn't know they were there, nor do we know how many other death-dealing viruses might be living undetected in wildlife. On Pandemics shows the greater impact of animal-borne diseases on our world, and encourages us to re-examine our role in pandemics, if not for our own health, then for the health of our planet. Published originally in 2007 as The Chickens Fight Back: Pandemic Panics and Deadly Diseases that Jump from Animals to Humans, this book has been updated in light of the COVID-19 pandemic. "Waltner-Toews makes truly entertaining reading." -Globe and Mail "A page-turner presented with irreverent humour and many hair-raising anecdotes." -Vitality Magazine

Viruses have limited genome-coding capacities and must therefore rely on their host cells to facilitate every step of the infection cycle from the replication of their genomes, transcription and translation of mRNAs to virus assembly. Aimed at virologists and cell biologists"Viruses and the Nucleus" provides a comprehensive and cohesive overview of this fascinating and fast moving field. It compares and contrasts the ways in which DNA viruses, retroviruses and RNA viruses interact with the host cell nucleus to bring about replication and how they subvert the host cell function to proliferate and survive.

Written by a team of leading experts in the field, this multi-authored text begins with an introduction to the key nuclear process that effect virus biology including cell cycle, transcription, splicing and protein trafficking. It then goes on to explore the advances that have been made in understanding the ways in which specific viruses interact with nuclear sub-structures such as the nucleolus and ND10s, and the implications this interrelationship has for the cell cycle as a whole.

('Key Features' bullet points to be put in one box) Comprehensive cross disciplinary coverage of the interrelationship between cell biology and virology. Written by leading experts, this authorative book provides an up to date overview of this highly active field. Covers the latest research areas including virus interactions with sub-nuclear structures, virus protein trafficking into and out of the nucleus and subversion of host-cell function through specific nuclear interactions.

Viruses and the Nucleus will be an invaluable resource for students of virology, microbiology and cell biology aswell as those who work within the industry.

Advances in Applied Microbiology, Volume 107, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas, with this updated volume including chapters covering the roles and applications of siderophores, biological oxidation of iron sulphides, production of biomass and biofuel feedstocks from microalgae, advances in the microbial ecology of biohydrometallurgy, bacterial synthesis of Se nanoparticles, and siderophores in environmental research, amongst other discussions.

Viral, Parasitic, Bacterial, and Fungal Infections: Antimicrobial, Host Defense, and Therapeutic Strategies highlight diverse types of infections, including viral, bacterial, parasitic, fungal, and the therapeutic efficacy of antibiotics, antivirals, antifungals and other medications, nutraceuticals, and phytotherapeutics. This book addresses the molecular, pathophysiological, and cellular pathways involved in the process of infection. It also examines the host defense mechanisms modulated by innate and adaptive immunity. The book starts off with an introduction, which includes etiology, pathophysiology, and diagnosis of infections. It then goes on to cover a wide spectrum of salient features involved in viral, bacterial, parasitic, and fungal infections and effective therapeutic strategies. In addition, there is a complete section of eight chapters elaborating the detailed aspects of COVID-19 infections, Mucormycosis, Omicron, and strategic vaccines and therapeutics. The book further goes on to discuss novel antibiotics, vaccines, bromhexine, boron compounds, phytotherapeutics, and aspects on boosting immune competence. Contributed by experts in the fields of viral, parasitic, bacterial, and fungal infections, the book comprehensively details the various types of infections such as herpes and COVID-19, their molecular mechanisms, and treatment strategies for those engaged in the research of infectious diseases.

Exploring the broad implications of evolutionary theorist Lynn Margulis's work, this collection brings together specialists across a range of disciplines, from paleontology, molecular biology, evolutionary theory, and geobiology to developmental systems theory, archaeology, history of science, cultural science studies, and literature and science. Addressing the multiple themes that animated Margulis's science, the essays within take up, variously, astrobiology and the origin of life, ecology and symbiosis from the microbial to the planetary scale, the coupled interactions of earthly environments and evolving life in Gaia theory and earth system science, and the connections of these newer scientific ideas to cultural and creative productions. Dorion Sagan acquaints the reader with salient issues in Lynn Margulis's scientific work, the controversies they raised, and the vocabulary necessary to follow the arguments. Sankar Chatterjee synthesizes several strands of current theory for the origin of life on earth. James Strick tells the intertwined origin stories of James Lovelock's Gaia hypothesis and Margulis's serial endosymbiosis theory. Jan Sapp explores the distinct phylogenetic visions of Margulis and Carl Woese. Susan Squier examines the epigenetics of embryologist and developmental biologist C. H. Waddington. Bruce Clarke studies the convergence of ecosystem ecology, systems theory, and science fiction between the 1960s and the 1980s. James Shapiro discusses the genome evolution that results not from random changes but rather from active cell processes. Susan Oyama shows how the concept of development balances an over-emphasis on genetic coding and other deterministic schemas. Christopher Witmore studies the ways in which a concentrated animal feeding operation, or CAFO, mixes up natural resources, animal lives, and human appetites. And Peter Westbroek brings the insights of earth system science toward a new worldview essential for a proper response to global change.

From biology to economics to information theory, the theme of interdependence is in the air, framing our experiences of all sorts of everyday phenomena. Indeed, the network may be the ascendant metaphor of our time. Yet precisely because the language of interdependence has become so commonplace as to be almost banal, we miss some of its most surprising and far-reaching implications. In Interdependence, biologist Kriti Sharma offers a compelling alternative to the popular view that interdependence simply means independent things interacting. Sharma systematically shows how interdependence entails the mutual constitution of one thing by another—how all things come into being only in a system of dependence on others. In a step-by-step account filled with vivid examples, Sharma shows how a coherent view of interdependence can help make sense not only of a range of everyday experiences but also of the most basic functions of living cells. With particular attention to the fundamental biological problem of how cells pick up signals from their surroundings, Sharma shows that only an account which replaces the perspective of “individual cells interacting with external environments� with one centered in interdependent, recursive systems can adequately account for how life works. This book will be of interest to biologists and philosophers, to theorists of science, of systems, and of cybernetics, and to anyone curious about how life works. Clear, concise, and insightful, Interdependence: Biology and Beyond explicitly offers a coherent and practical philosophy of interdependence and will help shape what interdependence comes to mean in the twenty-first century.

Plant Virus-Host Interaction: Molecular Approaches and Viral Evolution, Second Edition, provides comprehensive coverage of molecular approaches for virus-host interaction. The book contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, synergism with pivotal coverage of RNA silencing, and the counter-defensive strategies used by viruses to overcome the silencing response in plants. This new edition introduces new, emerging proteins involved in host-virus interactions and provides in-depth coverage of plant virus genes' interactions with host, localization and expression. With contributions from leading experts, this is a comprehensive reference for plant virologists, molecular biologists and others interested in characterization of plant viruses and disease management.

Rhinovirus Infections: Rethinking the Impact on Human Health and Disease provides a timely review of the impact of rhinovirus infections on human health. It identifies disease mechanisms relating to the virus, human host and environmental factors. This viewpoint allows us to look forward to the development of treatments for a virus for which treatment options are currently non-existent. By providing detailed insights into this virus, its host and the environmental factors that play into rhinovirus induced diseases, this book explains disease mechanisms and summarizes existing and developing therapeutic approaches for better research, diagnosis and potential treatments.

Exploring the broad implications of evolutionary theorist Lynn Margulis's work, this collection brings together specialists across a range of disciplines, from paleontology, molecular biology, evolutionary theory, and geobiology to developmental systems theory, archaeology, history of science, cultural science studies, and literature and science. Addressing the multiple themes that animated Margulis's science, the essays within take up, variously, astrobiology and the origin of life, ecology and symbiosis from the microbial to the planetary scale, the coupled interactions of earthly environments and evolving life in Gaia theory and earth system science, and the connections of these newer scientific ideas to cultural and creative productions. Dorion Sagan acquaints the reader with salient issues in Lynn Margulis's scientific work, the controversies they raised, and the vocabulary necessary to follow the arguments. Sankar Chatterjee synthesizes several strands of current theory for the origin of life on earth. James Strick tells the intertwined origin stories of James Lovelock's Gaia hypothesis and Margulis's serial endosymbiosis theory. Jan Sapp explores the distinct phylogenetic visions of Margulis and Carl Woese. Susan Squier examines the epigenetics of embryologist and developmental biologist C. H. Waddington. Bruce Clarke studies the convergence of ecosystem ecology, systems theory, and science fiction between the 1960s and the 1980s. James Shapiro discusses the genome evolution that results not from random changes but rather from active cell processes. Susan Oyama shows how the concept of development balances an over-emphasis on genetic coding and other deterministic schemas. Christopher Witmore studies the ways in which a concentrated animal feeding operation, or CAFO, mixes up natural resources, animal lives, and human appetites. And Peter Westbroek brings the insights of earth system science toward a new worldview essential for a proper response to global change.

'A big-picture forecast of how medicine stands on the threshold of a revolution that will radically change all of our lives' The Times Welcome to a revolution in the science of you! This landmark new book from award-winning scientist Daniel M. Davis explores the future of the human body. Imagine taking drugs to help you acquire new skills, or knowing years in advance the precise likelihood of developing specific cancers, or following a diet and health regime tailored to your microbiome, or even having continuous monitoring of your body's workings and well-being. Written by an award-winning scientist, this landmark book shows how these radical and disconcerting possibilities have been made real. It is at once a gripping drama of scientific ingenuity, discovery and collaboration, and a vision of the human body of dizzying complexity and wonder. 'The startling new discoveries...are radically altering our understanding of how we function and what our future holds' BRIAN COX 'Thrilling' BILL BRYSON 'Brilliant' TIM SPECTOR 'Extraordinary' ALICE ROBERTS

For three centuries, concepts of the state have been animated by one of the most powerful metaphors in politics: the body politic, a claustrophobic and bounded image of sovereignty. Climate change, neoliberalism, mass migration, and other aspects of the late Anthropocene have increasingly revealed the limitations of this metaphor. Just as the human body is not whole and separate from other bodies—comprising microbes, bacteria, water, and radioactive isotopes—Stefanie R. Fishel argues that the body politic of the state exists in dense entanglement with other communities and forms of life.  Drawing on insights from continental philosophy, science and technology studies, and international relations theory, this path-breaking book critiques the concept of the body politic on the grounds of its very materiality. Fishel both redefines and extends the metaphor of the body politic and its role in understanding an increasingly posthuman, globalized world politics. By conceiving of bodies and states as lively vessels, living harmoniously with multiplicity and the biosphere, she argues that a radical shift in metaphors can challenge a politics based on fear to open new forms of global political practice and community.  Reframing the concept of the body politic to accommodate greater levels of complexity, Fishel suggests, will result in new configurations for the political and social organization necessary to build a world in which the planet’s inhabitants do not merely live but actively thrive.

Viruses: Molecular Biology, Host Interactions, and Applications to Biotechnology provides an up-to-date introduction to human, animal and plant viruses within the context of recent advances in high-throughput sequencing that have demonstrated that viruses are vastly greater and more diverse than previously recognized. It covers discoveries such as the Mimivirus and its virophage which have stimulated new discussions on the definition of viruses, their place in the current view, and their inherent and derived 'interactomics' as defined by the molecules and the processes by which virus gene products interact with themselves and their host's cellular gene products. Further, the book includes perspectives on basic aspects of virology, including the structure of viruses, the organization of their genomes, and basic strategies in replication and expression, emphasizing the diversity and versatility of viruses, how they cause disease and how their hosts react to such disease, and exploring developments in the field of host-microbe interactions in recent years. The book is likely to appeal, and be useful, to a wide audience that includes students, academics and researchers studying the molecular biology and applications of viruses