A virus is not human, but the reaction to it is a measure of humanity.

America has not measured up well. Tens of thousands are dead for no reason. America is supposed to be about freedom, yet illness and fear make its citizens less free. After all, freedom is meaningless if we are too ill to think about our right to happiness or too weak to pursue it. So, if a government is making its people unhealthy it is also making them unfree.

On December 29, 2019, Timothy Snyder fell gravely ill. As he clung to life he found himself reflecting on the fragility of health, not recognized in America as a human right, but without which all rights and freedoms have no meaning. And that was before the pandemic. We have since watched understaffed and undersupplied hospitals buckling under waves of coronavirus patients. The federal government made matters worse through wilful ignorance, misinformation, and profiteering.

This passionate intervention outlines the lessons we must all learn, wherever we are, and finds glimmers of hope in dark times. Only by enshrining healthcare as a human right, elevating the authority of doctors and truth, and planning for our children's future, can everyone be properly free.

Freedom belongs to individuals. But to be free we need our health, and for our health we need one another.

Science doesn't speak for itself. Neck-deep in work that can be messy and confounding and naive in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists' reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what's good for them and what isn't. In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don'ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done-such as being one of the first to speak out against conspiracy theories linking vaccines to autism-he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial. Written with wit and passion, Offit's often humorous guide to taking on quack experts and self-appointed activists is a must-read for any American disturbed by the uptick in politicized attacks on science.

Containing important information about the coronavirus, this comprehensive, easy-to-follow primer on pandemics, epidemics, and the panics they ignite around the world also shares solutions for a safer, healthier future. "A quiet little gem of understanding in a cacophony of panic and fear." -Quill & Quire, STARRED review Authored by a leading epidemiologist, this engrossing book answers our questions about animal diseases that jump to humans-called zoonoses-including what attracts them to humans, why they have become more common in recent history, and how we can keep them at bay. Almost all pandemics and epidemics have been caused by diseases that come to us from animals, including SARS, Ebola, and-now-Covid-19. Epidemiologist, veterinarian, and ecosystem health specialist, David Waltner-Toews, gathers the latest research to profile dozens of illnesses in On Pandemics. Chapters are broken into short, dynamic explainers, each one tackling a different disease. Readers will discover: Why zoonotic diseases jump from animals to humans-and why some decide to stick around for good. How governments have responded to pandemics and epidemics throughout history, for better or for worse. The role of climate change, industrialized farming, cultural practices, biodiversity loss, and globalization in making these diseases not only possible, but inevitable outcomes of our modern lifestyles. Coronaviruses, such as those that cause SARS and Covid-19, have likely made bats their home for centuries. Until SARS came along, we didn't know they were there, nor do we know how many other death-dealing viruses might be living undetected in wildlife. On Pandemics shows the greater impact of animal-borne diseases on our world, and encourages us to re-examine our role in pandemics, if not for our own health, then for the health of our planet. Published originally in 2007 as The Chickens Fight Back: Pandemic Panics and Deadly Diseases that Jump from Animals to Humans, this book has been updated in light of the COVID-19 pandemic. "Waltner-Toews makes truly entertaining reading." -Globe and Mail "A page-turner presented with irreverent humour and many hair-raising anecdotes." -Vitality Magazine

Like other biomedical sciences, medical virology has undergone a revolution of diagnostic and scientific approaches through the advent of molecular biological techniques. Developing and maintaining an appropriate mixture of classical and molecular techniques for viral analysis is one of the challenges of medical virology today, and this volume addresses these issues. Topics covered include a broad description of "classical" techniques in viral diagnosis, nucleic acid detection by extraction and hybridization, use of the polymerase chain reaction, the application of various molecular techniques to aspects of the epidemiology of virus infections, and the principles and practical approaches to the analysis of viral evolution. The book will be of interest to students, researchers and professionals in medical virologoy, particularly hospital workers, microbiology, and molecular biology.

Exploring the broad implications of evolutionary theorist Lynn Margulis's work, this collection brings together specialists across a range of disciplines, from paleontology, molecular biology, evolutionary theory, and geobiology to developmental systems theory, archaeology, history of science, cultural science studies, and literature and science. Addressing the multiple themes that animated Margulis's science, the essays within take up, variously, astrobiology and the origin of life, ecology and symbiosis from the microbial to the planetary scale, the coupled interactions of earthly environments and evolving life in Gaia theory and earth system science, and the connections of these newer scientific ideas to cultural and creative productions. Dorion Sagan acquaints the reader with salient issues in Lynn Margulis's scientific work, the controversies they raised, and the vocabulary necessary to follow the arguments. Sankar Chatterjee synthesizes several strands of current theory for the origin of life on earth. James Strick tells the intertwined origin stories of James Lovelock's Gaia hypothesis and Margulis's serial endosymbiosis theory. Jan Sapp explores the distinct phylogenetic visions of Margulis and Carl Woese. Susan Squier examines the epigenetics of embryologist and developmental biologist C. H. Waddington. Bruce Clarke studies the convergence of ecosystem ecology, systems theory, and science fiction between the 1960s and the 1980s. James Shapiro discusses the genome evolution that results not from random changes but rather from active cell processes. Susan Oyama shows how the concept of development balances an over-emphasis on genetic coding and other deterministic schemas. Christopher Witmore studies the ways in which a concentrated animal feeding operation, or CAFO, mixes up natural resources, animal lives, and human appetites. And Peter Westbroek brings the insights of earth system science toward a new worldview essential for a proper response to global change.

From biology to economics to information theory, the theme of interdependence is in the air, framing our experiences of all sorts of everyday phenomena. Indeed, the network may be the ascendant metaphor of our time. Yet precisely because the language of interdependence has become so commonplace as to be almost banal, we miss some of its most surprising and far-reaching implications. In Interdependence, biologist Kriti Sharma offers a compelling alternative to the popular view that interdependence simply means independent things interacting. Sharma systematically shows how interdependence entails the mutual constitution of one thing by another—how all things come into being only in a system of dependence on others. In a step-by-step account filled with vivid examples, Sharma shows how a coherent view of interdependence can help make sense not only of a range of everyday experiences but also of the most basic functions of living cells. With particular attention to the fundamental biological problem of how cells pick up signals from their surroundings, Sharma shows that only an account which replaces the perspective of “individual cells interacting with external environments� with one centered in interdependent, recursive systems can adequately account for how life works. This book will be of interest to biologists and philosophers, to theorists of science, of systems, and of cybernetics, and to anyone curious about how life works. Clear, concise, and insightful, Interdependence: Biology and Beyond explicitly offers a coherent and practical philosophy of interdependence and will help shape what interdependence comes to mean in the twenty-first century.

This introductory textbook was first published in 1978. It was originally intended primarily for students who wanted to obtain a simplified picture of what viruses are like and how they can multiply and cause disease. Today, it still provides a general overall picture of virology, emphasising the underlying fundamental biochemical principles rather than detailing the complexities of different viruses or clinical problems. The mechanisms of replication and the variety of structures found in viruses are dealt with from a comparative standpoint. A working knowledge of proteins, nucleic acids and lipids is assumed.

The definitive story of COVID-19 and how global politics shape our health - from a world-leading expert and the pandemic's go-to science communicator

Professor Devi Sridhar has risen to prominence for her vital roles in communicating science to the public and speaking truth to power. In Preventable she highlights lessons learned from outbreaks past and present in a narrative that traces the COVID-19 pandemic - including her personal experience as a scientist - and sets out a vision for how we can better protect ourselves from the inevitable health crises to come.

In gripping and heartfelt prose, Sridhar exposes the varied realities of those affected and puts you in the room with key decision makers at crucial moments. She vibrantly conveys the twists and turns of a plot that saw: deadlier varients emerge (contrary to the predictions of social media pundits who argued it would mutate to a milder form); countries with weak health systems like Senegal and Vietnam fare better than countries like the US and UK (which were consistently ranked as the most prepared); and the quickest development of game-changing vaccines in history (and their unfair distribution)

Combining science, politics, ethics and economics, this definitive book dissects the global structures that determine our fate, and reveals the deep-seated economic and social inequalities at their heart - it will challenge, outrage and inspire.

Is lowering your temperature when you have a fever helpful? Do you really need to finish every course of antibiotics? Or could some of the treatments you think are healing you actually be harming you? Medicine has significantly advanced in the last few decades. But while we have learned a lot, we still rely on medical interventions that are vastly out of date and can adversely affect our health. In this game-changing book, infectious-disease expert and Rotavirus vaccine inventor Dr Offit highlights fifteen common medical interventions still recommended and practised by medical professionals, despite clear evidence that they are harmful - including the treatment of acid reflux in babies and the reliance on heart stents and knee surgery. By presenting medical alternatives, Overkill gives patients invaluable information to help them ask their doctors better questions and to advocate for their own health.

Population Biology of Vector-Borne Diseases is the first comprehensive survey of this rapidly developing field. The chapter topics provide an up-to-date presentation of classical concepts, reviews of emerging trends, synthesis of existing knowledge, and a prospective agenda for future research. The contributions offer authoritative and international perspectives from leading thinkers in the field. The dynamics of vector-borne diseases are far more intrinsically ecological compared with their directly transmitted equivalents. The environmental dependence of ectotherm vectors means that vector-borne pathogens are acutely sensitive to changing environmental conditions. Although perennially important vector-borne diseases such as malaria and dengue have deeply informed our understanding of vector-borne diseases, recent emerging viruses such as West Nile virus, Chikungunya virus, and Zika virus have generated new scientific questions and practical problems. The study of vector-borne disease has been a particularly rich source of ecological questions, while ecological theory has provided the conceptual tools for thinking about their evolution, transmission, and spatial extent. Population Biology of Vector-Borne Diseases is an advanced textbook suitable for graduate level students taking courses in vector biology, population ecology, evolutionary ecology, disease ecology, medical entomology, viral ecology/evolution, and parasitology, as well as providing a key reference for researchers across these fields.

'A big-picture forecast of how medicine stands on the threshold of a revolution that will radically change all of our lives' The Times Welcome to a revolution in the science of you! This landmark new book from award-winning scientist Daniel M. Davis explores the future of the human body. Imagine taking drugs to help you acquire new skills, or knowing years in advance the precise likelihood of developing specific cancers, or following a diet and health regime tailored to your microbiome, or even having continuous monitoring of your body's workings and well-being. Written by an award-winning scientist, this landmark book shows how these radical and disconcerting possibilities have been made real. It is at once a gripping drama of scientific ingenuity, discovery and collaboration, and a vision of the human body of dizzying complexity and wonder. 'The startling new discoveries...are radically altering our understanding of how we function and what our future holds' BRIAN COX 'Thrilling' BILL BRYSON 'Brilliant' TIM SPECTOR 'Extraordinary' ALICE ROBERTS

For three centuries, concepts of the state have been animated by one of the most powerful metaphors in politics: the body politic, a claustrophobic and bounded image of sovereignty. Climate change, neoliberalism, mass migration, and other aspects of the late Anthropocene have increasingly revealed the limitations of this metaphor. Just as the human body is not whole and separate from other bodies—comprising microbes, bacteria, water, and radioactive isotopes—Stefanie R. Fishel argues that the body politic of the state exists in dense entanglement with other communities and forms of life.  Drawing on insights from continental philosophy, science and technology studies, and international relations theory, this path-breaking book critiques the concept of the body politic on the grounds of its very materiality. Fishel both redefines and extends the metaphor of the body politic and its role in understanding an increasingly posthuman, globalized world politics. By conceiving of bodies and states as lively vessels, living harmoniously with multiplicity and the biosphere, she argues that a radical shift in metaphors can challenge a politics based on fear to open new forms of global political practice and community.  Reframing the concept of the body politic to accommodate greater levels of complexity, Fishel suggests, will result in new configurations for the political and social organization necessary to build a world in which the planet’s inhabitants do not merely live but actively thrive.

The second edition of Virology is an accessible introduction designed to enable students to understand the principles of virus structure, replication and genetics. The aim of this book is to help the reader appreciate the relevance of virology in the modern world, including the fields of vaccines, anti-viral drugs and cancer. There is also a chapter on prions. The second edition has been extensively revised and updated to reflect the many developments in virology and offers deeper insights into the subject. Newly-discovered viruses are discussed and there is an additional chapter on the influenza virus.

New antiviral drugs are urgently needed. Recent outbreaks caused by viruses with great epidemiological impact such as Zika, or extraordinary virulence such as Ebola, Nipah, Lassa, Crimean-Congo haemorrhagic fever highlight the current lack of clinically proven vaccines and treatments for these potentially catastrophic agents. Antiviral Discovery for Highly Pathogenic Emerging Viruses comprehensively outlines the state of the art in antiviral drug discovery including identification of targets, screening strategies and the current pipeline of antiviral candidates including regulatory issues. The book also addresses the challenges faced in proceeding from pre-clinical studies to animal models and clinical trials with these highly pathogenic agents. Ideal for drug discovery scientists and medicinal chemists with an interest in antiviral drug discovery and development, this book provides a complete overview of the latest progress in the field, recent advances and the challenges that remain in developing these highly pathogenic agents. Illustrated throughout with case studies this book is a valuable resource in this complex and multidisciplinary field.

Exploring the broad implications of evolutionary theorist Lynn Margulis's work, this collection brings together specialists across a range of disciplines, from paleontology, molecular biology, evolutionary theory, and geobiology to developmental systems theory, archaeology, history of science, cultural science studies, and literature and science. Addressing the multiple themes that animated Margulis's science, the essays within take up, variously, astrobiology and the origin of life, ecology and symbiosis from the microbial to the planetary scale, the coupled interactions of earthly environments and evolving life in Gaia theory and earth system science, and the connections of these newer scientific ideas to cultural and creative productions. Dorion Sagan acquaints the reader with salient issues in Lynn Margulis's scientific work, the controversies they raised, and the vocabulary necessary to follow the arguments. Sankar Chatterjee synthesizes several strands of current theory for the origin of life on earth. James Strick tells the intertwined origin stories of James Lovelock's Gaia hypothesis and Margulis's serial endosymbiosis theory. Jan Sapp explores the distinct phylogenetic visions of Margulis and Carl Woese. Susan Squier examines the epigenetics of embryologist and developmental biologist C. H. Waddington. Bruce Clarke studies the convergence of ecosystem ecology, systems theory, and science fiction between the 1960s and the 1980s. James Shapiro discusses the genome evolution that results not from random changes but rather from active cell processes. Susan Oyama shows how the concept of development balances an over-emphasis on genetic coding and other deterministic schemas. Christopher Witmore studies the ways in which a concentrated animal feeding operation, or CAFO, mixes up natural resources, animal lives, and human appetites. And Peter Westbroek brings the insights of earth system science toward a new worldview essential for a proper response to global change.

The Aedes aegypti mosquito is a recognized vector for dengue, chikungunya, and Zika arboviruses, and has had a significant dispersion in recent years across the southern hemisphere. It is a known nuisance species in the United States and is believed to have been brought to the new world on ships used for European exploration and colonization In recent years, the use of entomopathogenic fungi has proven a promising tool for the biocontrol of Culicides that threaten public health. As such, the authors systematically review studies that evaluated the main entomopathogenic genera used in the biological control of these vectors.

Baculoviruses have proven to be the most powerful and versatile eukaryotic expression vectors available. This unique laboratory manual is designed to help both beginning and experienced researchers construct and use baculovirus vector systems. It simplifies selection of the most appropriate baculovirus vector design for a given problem, then describes each step of the implementation process--from vector construction to large-scale protein production. The book provides an understanding of how the vectors work; a biological overview of cells, viruses, plasmids, and promoters; guidelines for choosing optimum vectors; protocols for growing insect cells and recombinant viruses; methods of analyzing protein products and scaling up protein production; techniques for producing proteins in insect larvae; and easy-to-use maps charting available expression vectors. This comprehensive approach has many benefits for researchers and students alike. It allows them to understand how and why the vector system works and offers a rapid comparison of options for choosing the right virus, plasmid or promoter for vector design and construction, with a minimum amount of lost time. The manual is an invaluable resource for every individual engaged in the production of proteins for any purpose.

Advances in molecular biology have enabled leaps forward in the determination of virus phylogenetic history. This detailed 1995 book results from the invitation to foremost experts to give essays on aspects of virus biology. Initial chapters cover impacts of viruses and their control. Further chapters detail genetic variation of viruses and the molecular basis of interrelations with hosts. This leads to discussions of interactions with the host at the population level, and their molecular basis and evolution. Seventeen chapters follow, by specialists on particular groups of viruses describing their impact, genetic origins, sources of variation, population genetics and interactions with hosts. Practical virologists will find the chapters on phylogenetic analysis techniques very useful. The adaptive nature of viruses makes this work highly relevant to evolutionists.

Written for advanced undergraduate students, this book is a practical, in-depth guide to plant virology. Beginning with an introduction to viruses and their classification, the text describes virus pathology, including how viruses enter and move through plant cells and induce disease. Subsequent chapters discuss how viruses spread in the field and how to measure this. Throughout, the book remains reader-friendly, using focus boxes for clear, easy-to-obtain information, enabling students to quickly access relevant information but supply sufficient detail for advanced studies. In addition to basic information on virus biology there is an additional focus on applied virology, ideal for students undertaking agricultural studies for whom study of disease and its control is essential.

Your ability to fight off infections and viruses is determined by your immune system. It may be that you fall ill more frequently than those around you. But this is not something you just have to live with - your immune resilience can be improved. Clinical nutritionist Romilly Hodges offers science-based nutritional and lifestyle advice on how to build your immune resilience. Exploring how our bodies protect us from disease, Immune Resilience will allow you to identify ways you can build your body's defences. A personalised programme covering diet, lifestyle and stress will help you achieve this. Did you know that sleep is connected to immune memory? And that good germs increase your immunity? You can even undertake exercises that boost immunity. With healthy recipes, a supplements guide and information on specific infections, Immune Resilience allows you to take control of your health.

As the COVID-19 pandemic has affected every corner of the world, changing our relationship to our communities, to our jobs, and to each other, the most pressing question has been-when will it end? Researchers around the globe are urgently trying to answer this question by racing to test and distribute a vaccine that could end the greatest public health threat of our time. In How to Make a Vaccine, an expert who has firsthand experience developing vaccines tells an optimistic story of how three hundred years of vaccine discovery and a century and a half of immunology research have come together at this powerful moment-and will lead to multiple COVID-19 vaccines. Dr. John Rhodes draws on his experience as an immunologist, including working alongside a young Anthony Fauci, to unravel the mystery of how vaccines are designed, tested, and produced at scale for global deployment. Concise and accessible, this book describes in everyday language how the immune system evolved to combat infection, how viruses responded by evolving ways to evade our defenses, and how vaccines do their work. That history, and the pace of current research developments, make Rhodes hopeful that multiple vaccines will protect us. Today the complex workings of the immune system are well understood. The tools needed by biomedical scientists stand ready to be used, and more than 160 vaccine candidates have already been produced. But defeating COVID-19 won't be the end of the story: Rhodes describes how discoveries today are also empowering scientists to combat future threats to global health, including a recent breakthrough in the development of genetic vaccines, which have never before been used in humans. As the world prepares for a vaccine, Rhodes offers a current and informative look at the science and strategies that deliver solutions to the crisis.