Advances in Applied Microbiology, Volume 112, continues the comprehensive reach of this widely read and authoritative review source in microbiology. Users will find invaluable references and information on a variety of areas. Chapters in this new release include discussions of Microbial mercury transformation: focus on molecules and functions, Peptidoglycan Biosynthesis, Clockwork microbial worlds , Molecular engineering to improve the levels of bioproducts from agricultural and forestry waste by filamentous fungi, Multi-species Biofilms for Resource Recovery from Wastewater, Evasion of host defenses by intracellular Staphylococcus aureus, A genomic analysis on stress-responses in C. glabrata and their relevance in pathogenesis and drug resistance, and more.

Advances in Cancer Research, Volume 148, the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research.

Immunotherapy of Cancer, Volume 143, the latest release in the Advances in Cancer Research series, provides invaluable information on the exciting and fast-moving field of cancer research. Contributions from leading experts in the field make this a must have update on the topic.

Approx.542 pages

Influenza, AIDS, and Ebola: Viruses are normally defined as pathogens. Most viruses are, however, not enemies or killers. Well-known virologist and cancer researcher Karin Moelling describes surprising insights about a completely new and unexpected world of viruses. Viruses are ubiquitous, in the oceans, our environment, in animals, plants, bacteria, in our body, even in our genomes. They influence our weather, can contribute to control obesity, and can surprisingly be applied against threatening multi-resistant bacteria. The success story of the viruses started more than 3.5 billion years ago in the dawn of life when even cells did not exist. They are the superpower of life. There are more viruses on earth than stars in the sky. Viruses are everywhere. Some of them are incredibly ancient. Many viruses are hundredfold smaller than bacteria, but others are tenfold bigger and they were discovered only recently - the giant viruses, even deep within the permafrost where they were reactivated after 30,000 years.The author talks about a completely new world of viruses, which are based on the most recent, in part her own research results. Could viruses have been our oldest ancestors? Have viruses even 'invented' social behavior, do they lead to geniuses such as Mozart or Einstein - or alternatively to cancer? They can help to cure cancer. In this book, the author made a clear distinction between what is fact and what is her vision. This book is written for a general audience and not just for the experts. Its aim is to stimulate thinking, and perhaps to attract more young scientists to enter this field of research.

Molecular Virology of Human Pathogenic Viruses presents robust coverage of the key principles of molecular virology while emphasizing virus family structure and providing key context points for topical advances in the field. The book is organized in a logical manner to aid in student discoverability and comprehension and is based on the author's more than 20 years of teaching experience. Each chapter will describe the viral life cycle covering the order of classification, virion and genome structure, viral proteins, life cycle, and the effect on host and an emphasis on virus-host interaction is conveyed throughout the text. Molecular Virology of Human Pathogenic Viruses provides essential information for students and professionals in virology, molecular biology, microbiology, infectious disease, and immunology and contains outstanding features such as study questions and recommended journal articles with perspectives at the end of each chapter to assist students with scientific inquiries and in reading primary literature.

Hepatobiliary cancer refers to primary malignant tumors originating in cells of the liver, bile ducts, and gallbladder. Globally, primary liver cancer, which includes hepatocellular carcinoma (~75 % of all cases) and intrahepatic biliary cancer or cholangiocarcinoma (~10-15 % 0f all cases) is the 6th most commonly diagnosed cancer and 3rd leading cause of cancer deaths worldwide. The vast majority of these highly malignant cancers are diagnosed at an advanced stage where treatment options are limited and patient survival outcomes are poor. The biological and therapeutic challenges posed by hepatobililiary cancers such as hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are daunting, emphasizing a critical need to review and assess current and evolving basic, translational, and clinical research focused on addressing the critical obstacles that continue to limit progress towards achieving significant improvements in HCC and CCA clinical management and patient survival outcomes. Towards this goal, this special edition of Advances in Cancer Research is focused on providing a comprehensive, timely and authoritative reviews covering such topics of significant scientific and clinical relevance, including hepatobiliary cancer risk mechanisms and risk-predictive molecular biomarkers; causes and functional intricacies of inter- and intratumor heterogeneity; novel insights into the role of tumor microenvironment and key signaling pathways in promoting hepatobiliary cancer progression, therapeutic resistance and immunosuppression; emerging biomarkers of HCC and CCA prognosis; advances in molecular genomics for personalizing tumor classification and targeted therapies; innovative preclinical cell culture modeling for hepatobiliary cancer drug discovery; and current and emerging trends in hepatobiliary cancer molecular therapeutic targeting and immunotherapies.

A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Laboratory Techniques in Rabies Diagnosis, Research and Prevention provides a basic understanding of the current trends in rabies. It establishes a new facility for rabies surveillance, vaccine and antibody manufacturing. It offers clarity about the choice of laboratory methods for diagnosis and virus typing, of systems for producing monoclonal and polyclonal antibodies and of methods for testing potency of vaccines and antibodies. The book covers advancements in the classical methods described as well as recent methods and approaches pertaining to rabies diagnosis and research.

SARS was the ?rst new plague of the twenty-?rst century. Within months, it spread worldwide from its "birthplace" in Guangdong Province, China, affecting over 8,000 people in 25 countries and territories across ?ve continents. SARS exposed the vulnerability of our modern globalised world to the spread of a new emerging infection. SARS (or a similar new emerging disease) could neither have spread so rapidly nor had such a great global impact even 50 years ago, and arguably, it was itself a product of our global inter-connectedness. Increasing af?uence and a demand for wild-game as exotic food led to the development of large trade of live animal and game animal markets where many species of wild and domestic animals were co-housed, providing the ideal opportunities for inter-species tra- mission of viruses and other microbes. Once such a virus jumped species and attacked humans, the increased human mobility allowed the virus the opportunity for rapid spread. An infected patient from Guangdong who stayed for one day at a hotel in Hong Kong led to the transmission of the disease to 16 other guests who travelled on to seed outbreaks of the disease in Toronto, Singapore, and Vietnam, as well as within Hong Kong itself. The virus exploited the practices used in modern intensive care of patients with severe respiratory disease and the weakness in infection control practices within our health care systems to cause outbreaks within hospitals, further amplifying the spread of the disease. Health-care itself has become a two-edged sword.

Advances in Virus Research serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Bluetongue may be described as an acute insect borne disease of ruminants, manifested clinically in sheep by a catarrhal inflammation of the mucous mem branes of the digestive and respiratory systems and associated with degenerative changes in the skeletal musculature. The profound emaciation and weakness which follow the acute disease are responsible for a protracted convalescence and for serious economic losses due to diminished productivity. II. Historical During the early colonisation of Africa, susceptible Merino and other European breeds of sheep were introduced into the Cape, at first by the Dutch East India Company between 1652 and 1785 and again later in 1870. A report of the Cattle and Sheep Diseases Commission (1876) records the appearance of a serious febrile disease amongst these imported sheep in which both morbidity and mortality was high (cited by HENNING, 1949). HuTCHEON (1881) gave this disease the name of "Fever" or "Epizootic Catarrh," in order to distinguish it from other clinical conditions of a similar nature encountered amongst sheep. In the first com prehensive description of this clinical syndrome and its epizootiology HuTCHEON (1902) referred to it as "Malarial Catarrhal Fever of Sheep," a designation which was obviously influenced by the mistaken belief that an intracorpuscular parasite was the primary cause of the disease. More systematic studies were conducted by SPREULL (1902; 1905), who endeavoured to immunize sheep by the simultaneous inoculation of immune serum and infective blood."

Viral Diseases of Field and Horticultural Crops details the fundamental and applied aspects of the viral diseases of field and horticultural crops. The book opens with a historical introduction to plant virology, important plant virologists, and landmarks. It continues with systematic coverage of viral diseases, their economic significance, disease symptoms, host range, mode of transmission, diagnostic techniques, geographic distribution, epidemiology, yield losses, and control and management of the disease. Contributions from an international group of virologists with a wide range of academic, research, professional, and specialized backgrounds in plant virology makes Viral Diseases of Field and Horticultural Crops a comprehensive and must-have resource for those engaged in the study and research of plant virology, microbiology, and plant pathology particularly viral diseases and their impact on field and horticultural crops.

The decision to write a book about the practical aspects of the baculovirus expression system stems from the numerous phone calls for help we have had, and from the many visitors to our labora tories requiring assistance to find the elusive polyhedrin-negative virus containing their favourite gene. We have also organized two expression system workshops and from the manuals we wrote for these, it seemed a logical progression to extend them into book form. We appreciate that those who are 'old-hands' at the baculovirus expression system may have differing views on some of our procedures, but the methods in this book are presented in the light of our own experiences in the laboratory and from our practical workshops, and we hope that the book will be especially useful to those new to the system. The first three chapters give the background information to the baculovirus expression system, and includes advice on how to choose the right transfer vector and discusses the various methods that are available to select recombinant viruses. The practical chapters concentrate on those aspects which are novel to the baculovirus system (insect cell culture, virus amplification and titration, etc. ) and, in general, leave the standard molecular biological techniques to the other excellent laboratory manuals that are available. However, for completeness sake and to avoid constant reference to other manuals, we have included brief details of some standard techniques where they are integral to the success of the baculovirus protocols."

It is hardly necessary to define the concept of receptors to readers of this series, but it should be born in mind that in several instances receptors are undefined entities, whose molecular details remain to be established. On the other hand the ligand, which reco izes the receptors, has been identified and characterized in most cases. The current interest in the structure and function of biological membranes gives great expectations that in the near future we may understand the details of ligand-receptor interaction. This interaction involves two defined steps: the first, usually referred to as recognition, is followed by the second step, transduction, in which the ligand-receptor interaction is translated by the cell into a biochemical action. The present two volumes which cover prokaryotic and eukaryotic virus receptors, have been published together in order to illustrate the specificity of virus receptor recognition which appears to be a guiding principle for both bacteria and higher cells. The identification and characterization of the receptors for phages of gram-negative bacteria has to a large extent relied on the genetic techniques available for these organisms. In a similar way the availability of genetic systems has also clarified the interrelationship between animal retrovirus receptors even if the molecular structure remains to be determined. The paucity of defined genetic systems may therefore explain part of our ignorance concerning the molecular details of virus receptors on human cells and possibly also on gram positive bacteria."

Plant RNA Viruses: Molecular Pathogenesis and Management provides wide-ranging coverage on the recognition and signaling events between plants and RNA viruses. The book examines the molecular biology of signaling, host-virus interaction, RNA virus diversity, and how plants and cellular pathogens interact. Sections cover Virus Diversity and Diagnosis, Virus-Host Interactions and Virus Management. Specific chapters discuss classification and nomenclature of viruses, detail the molecular characteristics of viral genomes, highlight the viral manipulation of cellular key regulatory systems for successful virus infection, and discuss the movement of plant viruses into plant cells. Additional topics include RNA plant viruses and host interaction, detection and diversity of plant RNA viruses, and strategies for combating and management of plant viruses. With contributions from an international group of experts, the book is a comprehensive reference for those in research, academia, industry and anybody engaging in the study of plant viruses at the molecular level.

COVID-19 Viral Sepsis: Impact on Disparities, Disability, and Health Outcomes introduces the concepts of viral sepsis, its origins, and its implications. COVID-19 is a leading cause of viral sepsis with considerable impact on morbidity and mortality. Early recognition of signs and symptoms of COVID-19 can potentially impact patient outcomes. The book opens with an introduction and overview of sepsis, its clinical manifestations, prevention, and management. It goes on to discuss viral sepsis and sepsis caused by COVID-19. COVID-19, its diagnosis, management, sequelae, long-term consequences, challenges, and opportunities round out the coverage. Users will find valuable key principles related to the recognition, prevention, diagnosis and treatment of sepsis due to COVID-19.

Published since 1953, "Advances in Virus Research" covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. The impact factor for 2007 is 3.120, placing it 9th in the highly competitive category of virology.

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

Using different viral models, molecular pathways regulated by viral genes and their role in the pathogenesis of infection are analyzed. The book also offers an update of known signaling pathways in apoptosis and their role in normal and infected cells. Special emphasis is given to molecular pathways underlying viral transformation and oncogenesis and how research in this area is opening opportunities in cancer therapy.

This book provides overviews and updates on basic research, diagnosis, epidemiology, and public health on enteric viruses, as well as on treatment and intervention to prevent their waterborne transmission. Data are presented and interpreted by leading researchers in the field in 13 chapters. An essential resource for virologists, epidemiologists, medical and public health professionals, graduate students and postdoctoral scientists at various levels of their careers.
Key Topics Include:
* Ecology of enteric viruses
* Intervention measures from risk assessment to virus disinfection practices
* Cutting edge technology on procedures for virus detection and monitoring in water and the water environment
* Quality assurance and quality control measures in water virology
* Legal regulations regarding viruses in the environment

Epigenetic Regulation of Cancer in Response to Chemotherapy, Volume 158 of the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

A virologist's insight into how viruses evolve and why global epidemics are inevitable.

In 1993 a previously healthy young man was drowning in the middle of a desert, in fluids produced by his own lungs. This was the beginning of the terrifying Sin Nombre hantavirus epidemic and the start of a scientific journey that would forever change our understanding of what it means to be human. After witnessing the Sin Nombre outbreak, Dr Frank Ryan began researching viral evolution and was astonished to discover that it's inextricable from the evolution of all life on Earth. From AIDS and Ebola to the common cold, Ryan explores the role of the virus within every ecosystem on the planet.

His gripping conclusions shed new light on the natural world, proving that what doesn't kill you really does make you (and your species) stronger.

One hundred years ago, when Martinus W. Beijerinck in Delft and Friedrich Loeffler on Riems Island discovered a new class of infectious agents in plants and animals, a new discipline was born. This book, a compilation of papers written by well-recognized scientists, gives an impression of the early days, the pioneer period and the current state of virology. Recent developments and future perspectives of this discipline are sketched against a historic background. With contributions by A. Alcami, D. Baulcombe, F. Brown, L. W. Enquist, H. Feldmann, A. Garcia-Sastre, D. Griffiths, M. C. Horzinek, A. van Kammen, H.-D. Klenk, F. A. Murphy, T. Muster, R. O'Neill, P. Palese, C. Patience, R. Rott, H.- P. Schmiedebach, S. Schneider-Schaulies, G. L. Smith, J. A. Symons, Y. Takeuchi, V. ter Meulen, P. J. W. Venables, V. E. Volchkov, V. A. Volchkova, R. A. Weiss, W. Wittmann, H. Zheng

Rapid developments continue to take place in the research of viruses, the causative agents of infectious diseases in humans, animals, plants, invertebrates, protozoa, fungi, and bacteria. A still growing number of more than 30,000 viruses, virus strains, and subtypes are being tracked in various specialty laboratories and culture collections. In this situation of expansion and specialization, the International Committee on Taxonomy of Viruses was founded to establish, refine and maintain a universal virus taxonomy system giving information to virologists about the characteristics of the different groups of viruses. The Committee s Sixth Report includes one order, 71 families, 11 subfamilies, and 175 genera and more than 4,000 member viruses. On 600 printed pages large amounts of molecular biologic data, illustrated by micrographs and virion diagrams, gene maps and tables give a comprehensive overview and prove helpful in teaching, in diagnostics, in scholarly research, and in the practical areas of medicine, veterinary medicine, plant pathology, insect pest management, and biotechnology. ..". est une reference indispensable pour les chercheurs, les enseignants, les medecins ou les veterinaires mais aussi pour les etudiants et d une maniere generale pour toutes les personnes interessees par la virologie . Revue de Medecine Veterinaire ..". an excellent, well presented and informative volume. The report should be an essential reference volume for any department or organization involved in the study of viruses . Quarterly"