Peptidomimetics have found wide application as bioavailable, and
often potent mimetics of natural peptides. They form the basis of
important classes of enzyme inhibitors, they act as receptor
agonists and antagonists, and they have even been used to mimic DNA
structure. Recent advances in the use of solid-phase organic
synthesis have paved the way for the preparation of libraries of
these structures to allow the rapid optimization of theri
biological properties and hence therapeutic potential. We are also
beginning to gain a greater understanding of the structural
features of this class of compounds that influence their ability to
permeate membranes, and their rate of clearance and metabolism.
This volume brings together many of these critical issues by
highlighting recent advances in a number of core
peptidomimetic-based research.
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