The purpose of this book is to provide an up to date review of the
nature and consequences of epigenetic changes in cancer.
Epigenetics literally means "above" genetics, and consists of
heritable gene expression or other phenotypic states not accounted
for by DNA base sequence. Epigenetic changes are now known to make
a large contribution to various aspects of tumorigenesis. These
changes include alterations in global and promoter specific DNA
methylation, activating and repressive histone modifications, and
changes in higher order chromatin structures. Each of these topics
will be covered in this book.
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