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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Cardiorenal Syndrome - Mechanisms, Risk and Treatment (Paperback, 2010 ed.)
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Cardiorenal Syndrome - Mechanisms, Risk and Treatment (Paperback, 2010 ed.)
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Chronic kidney disease with a worldwide prevalence of 10% in the
general population is emerging as a major public health priority.
Renal dysfunction is associated with a high risk for cardiovascular
complications. The relationship between renal insufficiency and
cardiovascular disease, termed the cardiorenal syndrome exists
whether impairment of renal function is a consequence of primary
renal parenchymal disease or primary heart disease. Several
pathophysiologic mechanisms have been postulated to explain the
relationship between renal dysfunction and cardiovascular disease.
Recent studies indicate an integrated response of the vascular
smooth muscles and glomerular mesangial cells to traditional and
uremia related cardiovascular risk factors. Traditional risk
factors can incite renal impairment and cardiac damage. As renal
function deteriorates, uremia-related risk factors play an
increasing role both in reduction in glomerular filtration rate and
cardiovascular damage. Several uremia related factors such as
uncontrolled hypertension, disturbed glucose insulin metabolism,
microalbuminuria, phosphate retention, secondary
hyperparathyroidism, myocardial and vascular calcification,
hypertensive-uremic cardiomyopathy, inflammation, oxidant injury,
and neurohormonal dysregulation have been implicated in the
pathogenesis of the cardiorenal syndrome. Recent data suggest that
management of the cardiorenal syndrome requires aggressive control
of traditional risk factors as well novel approaches to prevent or
reverse uremia -related processes. This book provides a
comprehensive update analysis of our current understanding of the
cardiorenal syndrome including epidemiology, pathophysiologic
mechanisms, and therapeutic approaches.
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