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Books > Medicine > Clinical & internal medicine > Renal medicine
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Inheritance of Kidney and Urinary Tract Diseases (Hardcover, 1990 ed.)
Loot Price: R5,393
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Inheritance of Kidney and Urinary Tract Diseases (Hardcover, 1990 ed.)
Series: Topics in Renal Medicine, 9
Expected to ship within 18 - 22 working days
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Genetic disorders have emerged as a prominent cause of morbidity
and mor tality among infants and adults. As many as 10% to 20% of
hospital admis sions and at least 10% of the mortality in this age
group are due to inherited diseases. There are at least two factors
that have brought genetic disorders into the forefront of
pediatrics. One is a great reduction in childhood mortality due to
infections and nutritional deficiency states, and the other is the
rapid progress made in the identification of genetic defects.
Amniocentesis, chorionic villus sampling, and recombinant DNA
technology have already had a tremendous impact on the practice of
medicine. This is why the first two chapters of this volume are
dedicated to general principles of molecular genetics and to a
description of the techniques used to diagnose genetic disorders at
the DNA level. The relevance of this new area of science to the
study of inherited renal diseases is reflected in the large body of
knowledge that has been generated regarding the association between
various glomerular nephritides and genetic markers such as the HLA
system, and even more impressively in the direct or indirect
identification of abnormal genes or gene products in Alport's syn
drome, autosomal dominant polycystic kidney disease, and Lowe's
syndrome. These discoveries figure prominently in the pages of this
book. Yet, the progress we have made has barely scratched the
surface of the problem."
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