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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences
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Neurotrophic Factors (Paperback, Softcover reprint of the original 1st ed. 1993)
Loot Price: R4,376
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Neurotrophic Factors (Paperback, Softcover reprint of the original 1st ed. 1993)
Series: Neuromethods, 25
Expected to ship within 10 - 15 working days
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The field of neurotrophic factors has witnessed exp- sive growth in
the past decade. As is usual in scientific in- vation, this
progress has been closely associated with methodological advances.
The introduction of molecular b- logical techniques into the
neurotrophic factor field led to the discovery of new families of
neurotrophic growth f- tors and their receptors. Production of
growth factors by recombinant technology played a crucial part. The
example of nerve growth factor, the paradigmatic neurotrophic
factor, illustrates this point. A decade ago investigators were
forced to purify small quantities of this protein from murine
salivary glands, but much larger qu- tities of recombinant nerve
growth factor are now available for experimentation as well as
clinical development. A decade ago there was a controversy about
the existence of nerve growth factor in the brain and the
immunoassays used for its measurement, but current publications
report the precise localization of gene expression for nerve growth
factor and its receptor in the brain. Neurotrophic Factors aims at
presenting the techniques that have been crucial to the realization
of these rapid advances and thus have helped propel the
neurotrophic factors field to its current status of high
visibility. These techniques range from molecular biological
methods used for cloning and production, to cell culture methods
for assessing biological activities, to animal models of nervous
system injury (nec- sary for the development of therapeutic agents
from neurotrophic factors).
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