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Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics
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Controlled Genetic Manipulations (Paperback, Softcover reprint of the original 1st ed. 2012)
Loot Price: R3,519
Discovery Miles 35 190
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Controlled Genetic Manipulations (Paperback, Softcover reprint of the original 1st ed. 2012)
Series: Neuromethods, 65
Expected to ship within 10 - 15 working days
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The current demand for the development of techniques for controlled
genetic manipulations is driven by the anatomical and physiological
complexity of the brain and by the need for experimental models
that can address this complexity through selective manipulation of
defined components of the system: specific neuronal populations or
selected synapses. In Controlled Genetic Manipulations, expert
researchers present detailed chapters to supply basic technical
information about controlled genetic manipulations and to provide
examples of creative implementation of this methodology when
addressing a unique biological problem. Some chapters of the book
describe the most recent developments in the basic methodology,
which includes use of Cre-recombinase, methods for delivery of
genetic material into the brain and the use of optogenetics,
whereas other chapters focus on applying these techniques to
addressing particular biological questions like structural and
functional mapping of neuronal circuits, analysis of specific
synaptic connections, modeling or gene therapy of neurological
disorders. As part of the Neuromethods series, chapters include key
implementation advice that is crucial for getting optimal results.
Authoritative and practical, Controlled Genetic Manipulations
serves as a valuable guide to a variety of techniques, provided by
many of the pioneers of the approaches.
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