Bacterial toxins that act inside cells interact very specifically
with key components of the cell and some even manipulate the cell
in subtle ways for their own purposes. These potent toxins,
described in this 2005 book, will be of interest to both
microbiologists and cell biologists. Some of these toxins are
conventional multidomain toxins that are self-programmed to enter
cells. Others are delivered by type III mechanisms, often as a
package of potent molecules. The molecular targets for all these
toxins mediate signal transduction and the cell cycle to regulate
the crucial processes of cell growth, cell division and
differentiation. Thus these potent toxins are not only responsible
for disease, but also provide a powerful set of tools with which to
interrogate the biology of the cell. In addition such toxins may
act directly to promote carcinogenesis and hence their study is
also of interest in a wider context.
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