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Books > Medicine > Clinical & internal medicine > Respiratory medicine
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Heterogeneity in Asthma (Paperback, Softcover reprint of the original 1st ed. 2014)
Loot Price: R5,569
Discovery Miles 55 690
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Heterogeneity in Asthma (Paperback, Softcover reprint of the original 1st ed. 2014)
Series: Advances in Experimental Medicine and Biology, 795
Expected to ship within 10 - 15 working days
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Asthma is a chronic relapsing airways disease that represents a
major public health problem worldwide. Intermittent exacerbations
are provoked by airway mucosal exposure to pro-inflammatory
stimuli, with RNA viral infections or inhaled allergens
representing the two most common precipitants. In this setting,
inducible signaling pathways the airway mucosa play a central role
in the initiation of airway inflammation through production of
antimicrobial peptides (defensins), cytokines, chemokines and
arachidonic acid metabolites that coordinate the complex processes
of vascular permeability, cellular recruitment, mucous
hyper-secretion, bronchial constriction and tissue remodeling.
These signals also are responsible for leukocytic infiltration into
the submucosa, T helper-lymphocyte skewing, and allergic
sensitization. Currently, it is well appreciated that asthma is a
heterogeneous in terms of onset, exacerbants, severity, and
treatment response. Current asthma classification methods are
largely descriptive and focus on a single aspect or dimension of
the disease. An active area of investigation on how to collect, use
and visualize multidimensional profiling in asthma. This book will
overview multidimensional profiling strategies and visualization
approaches for phenotyping asthma. As an outcome, this work will
facilitate the understanding of disease etiology, prognosis and/or
therapeutic intervention.
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