Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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Clinical Applications of Immunomics (Paperback, 2009 ed.)
Loot Price: R4,229
Discovery Miles 42 290
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Clinical Applications of Immunomics (Paperback, 2009 ed.)
Series: Immunomics Reviews:, 2
Expected to ship within 10 - 15 working days
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Innate immunity is one the most evolutionally conserved systems,
designed to protect the organism from viruses and bacterial
infections, stress and many other types of attacks from the outside
world. During the past decade, the capacity of molecular biology
and information technology to produce and analyse data have grown
exponentially, rapidly reforming many aspects of immunology
research in the post-genomics era. As a result, scientific
understanding of signalling networks governing the innate immunity
response in human tissues and other organisms has evolved beyond
recognition, compared to even just a decade ago. Many strategies
have been designed over the years to identify novel proteins, which
have a crucial role in innate immunity responses by regulating
particular signalling pathways. These projects had many advantages,
including the definition of novel drug targets, as exemplified by
the recent success of anti-TNF therapy, as well as leading to a
better, system-wide understanding of the molecular control of
innate immunity. In the past few years, a new concept, Immunomics,
has been adopted to define an emerging, multidisciplinary field of
research (Schonbach, 2003). Although rapid progress has been made
to identify the proteins playing pivotal roles in the innate
immunity-related signalling pathways (for example, TIR signalling
pathways), the catalogue of proteins with a key regulatory function
identified and studied is far from completed. Novel proteins need
to be char- terised to gain a more comprehensive picture of how
signalling networks are regulated.
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