Systems Analysis of Chromatin-Related Protein Complexes in Cancer (Hardcover, 2014 ed.)

Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned "on" or "off" and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.

General

Imprint:	Springer-Verlag New York
Country of origin:	United States
Release date:	August 2013
First published:	2014
Editors:	Andrew Emili • Jack Greenblatt • Shoshana Wodak
Dimensions:	235 x 155 x 23mm (L x W x T)
Format:	Hardcover
Pages:	316
Edition:	2014 ed.
ISBN-13:	978-1-4614-7930-7
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology > General
LSN:	1-4614-7930-4
Barcode:	9781461479307

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