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Books > Science & Mathematics > Biology, life sciences > Developmental biology
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Male-Mediated Developmental Toxicity (Paperback, Softcover reprint of the original 1st ed. 1994)
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Male-Mediated Developmental Toxicity (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: Reproductive Biology
Expected to ship within 10 - 15 working days
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The cause of many of the adverse reproductive outcomes and
developmental diseases among offspring is not well understood. Most
of the epidemiologic and experimental animal research has focused
on the relationship between maternal exposures including
medications, tobacco smoke, alcohol, infections, and occupation and
the occurrence of spontaneous abortion, low birth weight, and birth
defects. The potential role of paternal exposures has not been
investigated as extensively despite long-standing animal research
that demonstrates the induction of mutations in the male germ cell
after exposure to certain agents and subsequent reproductive
failure or early pregnancy loss. Given this relative lack of
interest, acquisition of epidemiologic data and the development of
a definitive model or mechanism for potential male-mediated effects
has been hindered. However, recent laboratory and epidemiologic
investigations have suggested that paternal exposures may be more
important than previously suspected. This topic has been termed by
some as "male-mediated developmental toxicity. " This is meant to
refer to the effects of exposures and other factors relating to the
male parent that result in toxicity to the conceptus and abnormal
development. The developmental endpoints of interest can include
fetal loss, congenital abnormalities, growth retardation, cancer,
and neurobehavioral effects. These effects may operate through a
variety of mechanisms including gene mutation, chromosomal
aberrations, seminal fluid transfer of toxicants and epigenetic
events.
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