This book presents an overview of sphingolipids: biology, synthesis
and functions. The topics analysed in this book cover a broad
spectrum of functions played by sphingolipids including: the role
of sphingomyelin in the regulation of membrane physical state;
tricyclic antidepressants as modulators of sphingolipid turnover
and cell sensitivity to insulin action; sphingolipid diversity,
biosynthesis and regulation; metabolism of glycolipids at the
cell's surface: modulation and functional implications; the
specific role of sphingomyelins in cell physiology; the role of
sphingosine-based lipids using sphingolipidomics; sphingolipids and
ceramides of aqueous humor and trabecular meshwork; the effect of
membrane microdomains containing sphingolipids on lipid
peroxidation; and roles of sphingolipids in skeletal development
and homeostasis.
General
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